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Depression Health Center

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Picture of Antidepressants Too Rosy?

Review Shows "Selective" Reporting of Studies Inflates Effectiveness of Antidepressants
WebMD Health News
Reviewed by Louise Chang, MD

Jan. 16, 2008 -- Commonly prescribed antidepressants may not work as well as published studies suggest, according to new research. "Selective" reporting of study results inflates the effectiveness of antidepressants, researchers found.

"I don't want people to think these drugs are not effective, that's not the take-away," Erick Turner, MD, the study's lead author, tells WebMD. "The drugs are still effective, but less so than what would be apparent from the medical literature."

His team found that some negative studies didn't get published, and some study results on effectiveness are inflated.

"Selective publication exaggerated the efficacy of the drugs by 32% overall," says Turner, an assistant professor of psychiatry and pharmacology at Oregon Health & Science University in Portland and medical director of the Portland VA Mood Disorders Program. "But for individual drugs, the efficacy [reported in published studies] increased from between 11% to 69%." The study is published this week in The New England Journal of Medicine.

Study Details: Effectiveness of Antidepressants

Turner decided to do the study after his three-year stint at the FDA, working as a reviewer on drug studies from 1998 to 2001.

For the study, he and his colleagues zeroed in on 12 antidepressants that had been approved by the FDA between 1987 and 2004. They looked at 74 FDA-registered studies involving 12,564 patients, comparing the FDA reviews of the studies with study results published in medical journals.

The published results on the effectiveness of antidepressants didn't always jibe with the FDA review of the study. For instance:

  • The FDA viewed 38 studies as positive, and all but one were published in medical journals.
  • Of the 36 other studies viewed by the FDA as having negative or questionable results, 22 were not published and 11 were published in a way that Turner's team believed reported a positive outcome. (That might be accomplished, Turner says, by looking at statistics differently or using a different rating system for depression, for instance.)
  • While the FDA reviews concluded that 51% of the studies had positive results for the antidepressants, the published literature reported that 94% of the studies had positive results.
  • Among the drugs looked at were Prozac, Cymbalta, Paxil, and Zoloft.
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