Antidepressant Paxil Also May Affect Personality
Paxil May Improve Neuroticism and Extraversion in Depressed People
WebMD News Archive
Paxil's Potent Punch continued...
The researchers write that patients taking Paxil “reported 6.8 times as much
change on neuroticism and 3.5 times as much change on extraversion as placebo
patients matched for depression improvement.”
Patients taking Paxil became “less shy, more vivacious ... less sensitive to
rejection” and stress and generally felt more stable emotionally, Tang tells
“To most psychiatrists our findings would be very surprising,” he says.
“They traditionally think of [SSRIs] as antidepressants first and foremost, and
the effect on personality as negligible or by-products of depression
improvements,” Yang says. “We are now finding that the effect on personality is
very substantial and clearly not a by-product of depression improvement.”
He tells WebMD the results “may make many people uncomfortable” because they
raise “the possibility of using these drugs to normalize personality for
millions of non-depressed people.”
DeRubeis tells WebMD the study suggests that “important and noticeable
effects” of SSRIs have gone undetected.
“The magnitude of change in personality was markedly larger than that
observed in the standard measures of depressive symptom severity,” and patients
taking placebo “did not evidence the change in personality that would be
expected if change in depression caused change in personality.”
Depression 'More Than Just Mood'
Claude Robert Cloninger, MD, a professor of psychiatry, genetics, and
psychology at Washington University in St. Louis, tells WebMD that the
conclusions of the new study “confirm earlier work showing that particular
personality traits are indicators of vulnerability to depression.”
However, the Tang study “is new in that it ... focuses on the improvements
in personality resulting from antidepressant treatment. Being less neurotic and
more extraverted is a healthier and happier profile.”
“What this work does well is show” that depression is “not just a matter of
mood” and that SSRIs “are not specific just for depression,” Cloninger tells