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Brain Stimulation Plus Drug May Fight Depression

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WebMD News from HealthDay

By Steven Reinberg

HealthDay Reporter

WEDNESDAY, Feb. 6 (HealthDay News) -- Treating major depression safely and affordably is a challenge. Now, Brazilian researchers have found that two techniques often used individually produce better results when used together.

The researchers paired the antidepressant Zoloft (sertraline) and a type of noninvasive brain stimulation called transcranial direct current stimulation (tDCS) to treat people with moderate to severe symptoms of major depression.

Transcranial direct current stimulation appears to be just as effective a treatment as Zoloft, but the two together are even more effective, said lead researcher Dr. Andre Russowsky Brunoni, from the Clinical Research Center at University Hospital of the University of Sao Paulo.

This painless treatment uses a low-intensity electrical current to stimulate specific parts of the brain. Previously, it has been tested for various conditions, such as stroke, anxiety, pain and Parkinson's disease, the researchers said.

Dr. Sarah Hollingsworth Lisanby, chair of the department of psychiatry and behavioral sciences at Duke University School of Medicine, is enthusiastic about the findings.

Lisanby said the advent of technologies such as noninvasive brain stimulation is "one of the exciting new developments" in treating depression.

Transcranial direct current stimulation is one of a family of approaches that uses electrical or magnetic fields to stimulate the brain to alter brain function, she said.

"These techniques offer great promise for people with depression, because we know, unfortunately, medications aren't always effective, and psychotherapy isn't always effective, so having effective alternatives is important," Lisanby said.

She noted the current study's two-pronged approach addresses both aspects of brain action. The drug affects the chemical aspects of brain function, while the electrical stimulation targets the brain's electrical activity.

"Because the brain is an electro/chemical organ, using both electrical and chemical approaches to treat it makes intuitive sense," she said.

For the report, published online Feb. 6 in JAMA Psychiatry, Brunoni's team divided 120 patients with major depression who had never taken antidepressants to take Zoloft or an inactive placebo every day with or without electrical brain stimulation, or with sham stimulation.

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