Niacin Deficiency

Niacin deficiency is a condition that occurs when a person doesn't get enough or can't absorb niacin or its amino acid precursor, tryptophan. In the United States, niacin deficiency is exceedingly rare. However, there have been outbreaks of niacin deficiency in areas of the world where food is scarce.

Also known as vitamin B3 or nicotinic acid, niacin is one of eight B vitamins. Like all B vitamins, niacin plays a role in converting carbohydrates into glucose, metabolizing fats and proteins, and keeping the nervous system working properly. Niacin also helps the body make sex- and stress-related hormones and improves circulation and cholesterol levels.

Tryptophan is one of the amino acids that makes up protein. Your liver can convert tryptophan from high-protein foods like meats and milk into niacin.

Niacin Deficiency Symptoms

Symptoms of mild niacin deficiency include:

Severe deficiency, called pellagra, can cause symptoms related to the skin, digestive system, and nervous system. They include:

If not treated, pellagra can lead to death. Pellagra can be reversible with niacin supplementation prescribed under the supervision by your doctor.

Niacin Deficiency Causes

In the 1800s, pellagra was common among poor Americans whose diets consisted mostly of corn, molasses, and salt pork -- all poor sources of niacin. Today, most people in the developed world get plenty of niacin in their diets. Niacin deficiency is more likely to be caused by problems that affect absorption of niacin or tryptophan. The most common cause is alcoholism. Other possible causes include disorders of the digestive system and prolonged treatment with the tuberculosis drug isoniazid (Laniazid, Nydrazid).

Niacin Deficiency Treatments

The recommend daily allowance (RDA) for niacin is 16 milligrams per day for men and 14 milligrams per day for women. Good sources of niacin include red meat, fish, poultry, fortified breads and cereals, and enriched pasta and peanuts.

If you don't eat a lot of niacin-rich foods or if you have a medical condition that affects the absorption of niacin or tryptophan, speak to your doctor. Niacin supplements or multivitamin/mineral supplements, which usually contain at least 20 milligrams of niacin, can help prevent niacin deficiency.

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Supplements of niacin such as nicotinic acid or nicotinamide are approved by the FDA for treating and preventing niacin deficiency. Under the supervision of a doctor, high doses of over-the-counter or prescription niacin or nicotinic acid can be used to treat high cholesterol, including high triglycerides. The most common side effect of niacin supplementation is flushing.  Other side effects include nausea, vomiting, pruritus, hives, abnormally high liver enzymes, and constipation. However, too much nicotinic acid or niacin can be harmful. Avoid taking more than your doctor prescribes or recommends. If you are taking doses of more than 100 milligrams per day, doctors recommend periodic liver function tests.

If you have a history of gout, you should should be careful with how much niacin you consume because it is also known to elevate serum uric acid concentration.

WebMD Medical Reference Reviewed by Carmen Patrick Mohan on May 18, 2017

Sources

SOURCES:
MedlinePlus: "Pellagra."
University of Maryland Medical Center: "Vitamin B3 (Niacin)."
University of Florida Institute of Food and Agricultural Sciences Extension: "Facts about Niacin."Oregon State University Linus Pauling Institute: "Niacin."
MedlinePlus: "Niacin (vitamin B3, nicotinic acid), Niacinamide."

Merck Manual: "Niacin"

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