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    Sirolimus; Temsirolimus/Tacrolimus

    This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

    Medical warning:

    Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

    How the interaction occurs:

    It is not know how this interaction occurs.

    What might happen:

    The amount of tacrolimus in your blood may decrease and it may not work as well. You may have a higher risk of developing kidney problems or diabetes and your body may have trouble healing wounds.If you take these medicines together after receiving a liver or lung transplant, your transplanted organ may be damaged.

    What you should do about this interaction:

    If your healthcare professionals (e.g. doctor or pharmacist) believe that this combination of medicines is the best therapy for you, they will closely monitor you while you are taking these medicines. Let your doctor know right away if you have any changes in your condition or if you develop a wound that does not heal properly or as soon as expected. Discuss any concerns you have with your healthcare professionals.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


    1.Torisel (temsirolimus) US prescribing information. Wyeth Pharmaceuticals, Inc. July, 2016.

    2.Filler G, Womiloju T, Feber J, Lepage N, Christians U. Adding sirolimus to tacrolimus-based immunosuppression in pediatric renal transplant recipients reduces tacrolimus exposure. Am J Transplant 2005 Aug; 5(8):2005-10.

    3.Dear Healthcare Provider letter on Rapamune (sirolimus). Wyeth Laboratories February, 2003.

    4.Rapamune (sirolimus) US prescribing information. Wyeth Pharmaceuticals November, 2015.

    5.Prograf (tacrolimus) US prescribing information. Fujisawa Healthcare, Inc. September, 2013.

    Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

    CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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