Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Heart Health Center

Font Size

Gene Tweak May Keep Hearts Younger

Turning Off the P13K Gene Helped Maintain Heart Function in Aging Mice
WebMD Health News

Oct. 12, 2009 -- A certain form of the P13K gene could be a key to keeping the heart young and preventing age-related heart failure, Japanese researchers report.

Those scientists, who included Yasutaka Inuzaka, MD, of Kyoto University, studied mice in which one form of the P13K gene was suppressed.

Compared to normal mice, the mice with the suppressed form of the P13K gene had worse heart function when they were young, but better cardiac function when they were old.

That form of the P13K gene could play a role in the aging of the heart, Inuzaka and colleagues report.

Inuzaka's team only studied the mice until they were 20 months old, because after that point, tumors (especially in the lungs) became more common in the strain of mice the researchers had chosen to use for this experiment.

But if scientists can find a way to affect the P13K gene safely and keep the aging heart young, that could help prevent age-related heart failure, notes Tetsuo Shioi, MD, PhD, of Kyoto University.

Shioi, Inuzaka and colleagues haven't studied the P13K gene in people yet. Details of their lab tests on mice appear online in the journal Circulation.

Today on WebMD

hdl letters stacked up
How to boost your ‘good’ cholesterol.
Learn the causes.
Compressed heart
5 habits to change.
heart rate
What’s normal? What’s not?
Lower Cholesterol 02
Heart Foods Slideshow
Compressed heart
doctor looking at xrays
Heart Disease And Ed
Lowering Cholesterol Slideshow
lowering blood pressure
Wide Awake For Heart Surgery