Change in the menstrual cycle is the most common side effect. You may have irregular bleeding or spotting. After a year of use, about 50% of women will stop getting their periods. Their periods usually return when they no longer get the shots.
Long-term use of Depo-Provera may lead to loss of bone mineral density, which makes osteoporosis more likely. This risk is greater if you've taken the shot for longer than 2 years, especially if osteoporosis runs in your family, you drink a lot, you smoke, or you have other risk factors for the condition.
Can I Get Pregnant After I Stop Using Depo-Provera?
You can become pregnant as soon as 3 to 4 months after your last shot. But it takes some women up to a year or 2 to conceive after they stop using this type of birth control. This time frame seems unrelated to how long you used the shot.
What Are the Advantages of Depo-Provera?
You don't have to remember to take it every day or use it before sex.
It provides long-term protection as long as you get the shot every 3 months.