The cervix is a cylinder-shaped neck of tissue that connects the vagina and uterus. Located at the lowermost portion of the uterus, the cervix is composed primarily of fibromuscular tissue. There are two main portions of the cervix:
- The part of the cervix that can be seen from inside the vagina during a gynecologic examination is known as the ectocervix. An opening in the center of the ectocervix, known as the external os, opens to allow passage between the uterus and vagina.
- The endocervix, or endocervical canal, is a tunnel through the cervix, from the external os into the uterus.
The overlapping border between the endocervix and ectocervix is called the transformation zone.
The cervix produces cervical mucus that changes in consistency during the menstrual cycle to prevent or promote pregnancy.
During childbirth, the cervix dilates widely to allow the baby to pass through. During menstruation, the cervix opens a small amount to permit passage of menstrual flow.
- Cervical cancer: Most cervical cancer is caused by infection by the human papillomavirus (HPV). Regular Pap tests can prevent cervical cancer in most women.
- Cervical incompetence: Early opening, or dilation, of the cervix during pregnancy that can lead to premature delivery. Previous procedures on the cervix are often responsible.
- Cervicitis: Inflammation of the cervix, usually caused by infection. Chlamydia, gonorrhea, and herpes are some of the sexually transmitted infections that can cause cervicitis.
- Cervical dysplasia: Abnormal cells in the cervix that can become cervical cancer. Cervical dysplasia is frequently discovered on Pap test.
- Cervical intraepithelial neoplasia (CIN): Another name for cervical dysplasia.
- Cervix polyps: Small growths on the part of the cervix where it connects to the vagina. Polyps are painless and usually harmless, but they can cause vaginal bleeding.
- Pelvic inflammatory disease (PID): Infection of the cervix, known as cervicitis, may spread into the uterus and fallopian tubes. Pelvic inflammatory disease can damage a woman's reproductive organs and make it more difficult for them to become pregnant.
- Human papillomavirus (HPV) infection: Human papillomaviruses are a group of viruses, including certain types that cause cervical cancer. Less dangerous types of the virus cause genital and cervical warts.
- Pap test: A sample of cells is taken from a woman's cervix and examined for signs of changes. Pap tests may detect cervical dysplasia or cervical cancer.
- Cervical biopsy: A health care provider takes a sample of tissue, or biopsy, from the cervix to check for cervical cancer or other conditions. Cervical biopsy is often done during colposcopy.
- Colposcopy: A follow-up test for an abnormal Pap test. A gynecologist views the cervix with a magnifying glass, known as a colposcope, and may take a biopsy of any areas that do not look healthy.
- Cone biopsy: A cervical biopsy in which a cone-shaped wedge of tissue is removed from the cervix and examined under a microscope. Cone biopsy is performed after an abnormal Pap test, both to identify and to remove dangerous cells in the cervix.
- Computed tomography (CT scan): A CT scanner takes multiple X-rays, and a computer creates detailed images of the cervix and other structures in the abdomen and pelvis. CT scanning is often used to determine whether cervical cancer has spread, and if so, how far.
- Magnetic resonance imaging (MRI scan): An MRI scanner uses a high-powered magnet and a computer to create high-resolution images of the cervix and other structures in the abdomen and pelvis. Like CT scans, MRI scans can be used to look for the spread of cervical cancer.
- Positron emission tomography (PET scan): A test to look for spread or recurrence of cervical cancer. A solution, known as a tracer solution, containing a mildly radioactive chemical is injected into the veins. The PET scan takes pictures as this solution moves through the body. Any areas of cancer take up the tracer and "light up" on scanner images.
- HPV DNA test: Cervical cells can be tested for the presence of DNA from human papillomavirus (HPV). This test can identify whether the types of HPV that can cause cervical cancer are present.
- Cervical cerclage: In women with cervical incompetence, the cervix can be sewn closed. This can prevent early opening of the cervix during pregnancy, which can cause premature delivery.
- Antibiotics: Medications that can kill the bacteria that causes infections of the cervix and reproductive organs. Antibiotics may be taken orally or given through a vein, or intravenously, for serious infections.
- Cryotherapy: An extremely cold probe is placed against abnormal areas on the cervix. Freezing kills the abnormal cells, preventing them from becoming cervical cancer.
- Laser therapy: A high-energy laser is used to burn areas of abnormal cells in the cervix. The abnormal cells are destroyed, preventing them from becoming cervical cancer.
- Cervical cancer vaccine: To prevent cervical cancer, a vaccine against certain strains of the human papillomavirus (HPV) is recommended for most adolescent girls and young women.
- Chemotherapy: Cancer medications that are usually injected into a vein. Chemotherapy is usually given for cervical cancer that is believed to have spread.
- Total Hysterectomy: Surgical removal of the uterus and cervix. If cervical cancer has not spread, hysterectomy can offer a complete cure.
- Cone biopsy: A cervical biopsy that removes a cone-shaped wedge of tissue from the cervix. Because a large portion of the cervix is removed, cone biopsy can help prevent or treat cervical cancer.
- Loop electrosurgical excision procedure (LEEP): An electrified wire loop is touched against abnormal cells in the cervix. The electrical current destroys the cells, preventing or treating cervical cancer.
- Radiation therapy: Using radioactive energy to kill cervical cancer cells. Radiation therapy is given as a beam from outside the body or in small pellets implanted in the cervix, known as brachytherapy.