Accutane May Not Increase Depression
Study Shows Teens Taking the Acne Drug Had Less Depression Than Those Getting Other Treatments
WebMD News Archive
May 16, 2005 -- A small study fails to link the use of the controversial
acne drug Accutane to severe depression or suicide. The findings are reported
in the May issue of the journal Archives of Dermatology.
For years, critics have said Accutane can cause serious depression and
increase suicide in teens. A U.S. congressman blames the drug for his
as does a Florida mother whose
But the drug's manufacturer has long contended that Accutane does not
increase the risk of depression and suicide, and a newly published study
appears to back that up.
Teens in the study who took the drug showed far fewer signs of depression
three and four months after beginning treatment than they did before starting
"This certainly backs up what we have seen in our practices,"
pediatric dermatologist Elaine Siegfried, MD, tells WebMD. "Most
dermatologists are in agreement that Accutane is a miracle drug for acne. I
have treated many thousands of patients with it, and I have never seen
clinically significant mood alterations in any of my treated patients."
Accutane was approved in 1982 for the treatment of serious acne that doesn't
respond to other treatment. Its safety has been the subject of heated debate
ever since. A synthetic derivative of vitamin A, the drug is well known to
cause serious birth defects in up to a third of babies born to women who use it
As a result, women of childbearing years who take Accutane are required to
use at least two forms of birth control while on the drug.
But while Accutane has long been suspected of causing depression, there is
no direct proof to back up the claim, says psychiatrist Douglas G. Jacobs, who
is a consultant to the drug's manufacturer, Roche Labs. Roche is a WebMD
"I have spent more time reviewing the studies than anyone and there is
just no evidence that Accutane causes depression or increases the risk of
suicide," Jacobs tells WebMD.