Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

SAM-e is a compound that's made naturally in the body and plays an important role in normal bodily function. A synthesized form of SAM-e is considered a supplement in the U.S., but SAM-e has been sold as a prescription drug in parts of Europe for decades. Its scientific name is S-adenosylmethionine. SAM-e is also known as ademetionine and SAMe.

Why do people take SAM-e?

SAM-e has good evidence as a treatment for osteoarthritis pain. Some studies have found that oral SAM-e is as effective as NSAID painkillers, such as ibuprofen and Celebrex. SAM-e takes longer to act than drugs do, but it also has fewer side effects than NSAIDs.

SAM-e has also been used to treat depression for many years. Some studies have found that SAM-e might work as well as tricyclic antidepressants in relieving symptoms. However, many of these studies were flawed or too small to be conclusive.

Other uses of SAM-e have not been studied as thoroughly. There's some evidence that SAM-e might help ease the pain of fibromyalgia and spinal cord damage caused by HIV. SAM-e may also help control cholestasis -- a buildup of bile in the liver -- particularly in pregnant women during the third trimester. One trial suggested that SAM-e might be helpful for adults with ADHD. However, more research needs to be done.

Some people use SAM-e as a treatment for other conditions, such as liver disease, Alzheimer's disease, pain, migraine, and bursitis. We don't know the potential risks or benefits of these uses.

How much SAM-e should you take?

There is no established ideal dose of SAM-e. For depression, many studies have used between 400-1,600 milligrams daily. For osteoarthritis, 600-1,200 milligrams daily of SAM-e divided into three doses is common. Ask your doctor for advice. Sometimes, the dose of SAM-e is increased gradually over a few weeks. This can help reduce side effects such as restlessness or anxiety.

Can you get SAM-e naturally from foods?

There are no food sources of SAM-e.

Savings Poll

How do you save money on vitamins and supplements?

View Results