Yaz Approved for Severe PMS
First Birth Control Pill Shown Effective for Premenstrual Dysphoric Disorder
WebMD News Archive
Oct. 6, 2006 -- Yaz has become the first birth control pill to gain FDA
approval for treating premenstrual dysphoric disorder (PMDD), the most severe
form of PMS.
The FDA based its action on clinical trial results showing that Yaz cut PMDD
symptoms by at least half. Women taking Yaz reported twice as much improvement
in PMDD symptoms as women taking inactive placebo pills.
Yaz improved both physical and emotional symptoms of PMDD, including
interpersonal relationships, work productivity, and enjoyment of hobbies and
Like other birth control pills, Yaz uses the female hormones estrogen and
progestin. Unlike other versions of the pill, Yaz uses a form of progestin that
has unique properties. This, plus its 24-day dosing regimen, may help account
for its positive effect on PMDD, says Andrea Rapkin, MD, in a news release from
Berlex Inc., the U.S. affiliate of Schering that manufactures Yaz.
"For my PMDD patients who need a treatment to reduce their symptoms -- as
well as a safe and effective contraceptioncontraception to prevent pregnancypregnancy -- YAZ is an important option that can
meet both of their health care needs in a single pill," says Rapkin, professor
of obstetrics and gynecology at UCLA's David Geffen School of Medicine.
While most women have some PMS symptoms, PMDD occurs when these symptoms are
at their most severe. PMDD affects about 5% of women.
PMDD: PMS Squared
Think of PMDD as PMS squared. Women with PMDD have at least five severe
premenstrual symptoms. These may include:
- Feelings of sadness, hopelessness, or worthlessness
- Anxiety or tension
- Unstable mood and frequent crying
- Persistent irritability causing conflict in relationships
- Loss of interest in usual activities or relationships
- Lack of concentration
- Lack of energy
- Changes in appetite, possibly including cravings or binge eating
- Sleeping too much or too little
- Feeling out of control
- Physical symptoms including breast tenderness, breast swelling, headache,
joint/muscle aches, bloating, and weight gain.
At least one of the first four symptoms must be present for a diagnosis of
PMDD. The symptoms occur during the week before a woman's period and resolve
within a few days after her period starts.
Because PMDD is so severe, doctors usually prescribe antidepressants,
antianxiety medications, hormonal treatments, and/or water pills. While doctors
have used other oral contraceptives as treatments for PMDD, Yaz is the first
drug of this class to receive specific FDA approval for this purpose.
The most common side effects seen in women taking Yaz are headache and