Atypical Antipsychotics for Bipolar Depression

Medically Reviewed by Smitha Bhandari, MD on April 14, 2020

Newer "atypical" antipsychotics work differently than other available drugs, and some (but not all) have been show to help treat depression in bipolar disorder. Currently, only quetiapine (Seroquel), lurasidone (Latuda), and the combination of olanzapine (Zyprexa) plus fluoxetine (Prozac), are approved by the FDA to treat bipolar depression. Initial studies also support the use of cariprazine (Vraylar) to treat bipolar depression, but more studies are needed before the FDA could consider its possible approval for an indication to treat bipolar depression. Other atypical antipsychotics are currently being studied to determine if they have antidepressant properties for treating or preventing bipolar depression.

Show Sources


Massachusetts General Hospital Bipolar Clinic & Research Program. "Bipolar Disorder (Mania)."

American Psychiatric Association: "Practice Guideline for the Treatment of Patients With Bipolar Disorder."

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