Coping With Chronic Illnesses and Depression

Medically Reviewed by Jennifer Casarella, MD on September 27, 2020

For millions of people, chronic illnesses and depression are facts of life. A chronic illness is a condition that lasts for a very long time and usually cannot be cured completely, although some forms of depression and other illnesses can be managed through diet, exercise, and certain medications. Examples of chronic illnesses include diabetes, heart disease, arthritis, kidney disease, HIV/AIDS, lupus, and multiple sclerosis.

Many people with chronic illness experience depression. In fact, depression is one of the most common complications of many chronic illnesses. It is estimated that up to one-third of individuals with a serious medical condition experience symptoms of depression.

It's not hard to see how the stresses associated with a chronic illness can trigger clinical depression in people with a biological vulnerability to a mood disorder. Serious illness can cause tremendous changes in lifestyle, and limit an individual’s mobility and independence. Chronic illness may make it impossible to pursue the activities one enjoys and can undermine self-confidence and a sense of hope in the future. It is not surprising, then, that people with chronic illness often experience a certain amount of despair and sadness. In some cases, the physical effects of the illness itself or side effects of medication may also lead to depression.

What Chronic Conditions Trigger Depression?

Although any illness can trigger depressed feelings, the risk of chronic illness and clinical depression increases with the severity of the illness and the level of life disruption it causes. The risk of getting depression is generally 10% to 25% for women and 5% to 12% for men. However, those with chronic illnesses face a much higher risk -- between 25% and 33%.

Depression associated with a chronic medical illness often aggravates the condition, especially if the illness causes pain and fatigue, or limits a person’s ability to interact with others. Depression can intensify pain, as well as fatigue and sluggishness. The combination of chronic illness and depression also can cause people to isolate themselves, which is likely to exacerbate the depression.

Research on chronic illnesses and depression indicates that depression rates are high among patients with chronic conditions:


What Are the Symptoms?

In people with chronic illnesses and depression, patients themselves and their family members often overlook the symptoms of depression assuming that feeling sad is normal for someone struggling with disease. Symptoms of depression are also frequently masked by other medical problems, resulting in treatment for the symptoms -- but not the underlying depression. The physical symptoms of depression -- such as changes in energy, appetite, or sleep -- also can be harder to assess in people with medical conditions that also affect those functions. When both chronic illnesses and depression are present, it is extremely important to treat both at the same time. Learn more about qualifying for disability benefits for depression.

Chronic Illness and Depression Treatment Options

Treatment of depression in chronically, medically ill patients is similar to treatment of depression in other people. Early diagnosis and treatment can reduce distress as well as the risk of complications and suicide for those with chronic illness and depression. In many patients, depression treatment can produce an improvement in the patient’s overall medical condition, a better quality of life, and a greater likelihood of sticking to a long-term treatment plan.

If the depressive symptoms are related to the physical illness or the side effects of medication, treatment may need to be adjusted or changed. When the depression is a separate problem, it can be treated on its own. More than 80% of people with depression can be treated successfully with medicine, psychotherapy, or a combination of both. Antidepressant drugs usually begin to have a positive effect within a matter of weeks. It is important to work closely with a physician or psychiatrist to find the most effective medication.

Tips for Coping With Chronic Illnesses and Depression

Depression, disability, and chronic illness form a vicious cycle. Chronic medical conditions can bring on bouts of depression, which, in turn interfere with successful treatment of the disease. Learn more about qualifying for disability for depression.

Living with a chronic illness is a tremendous challenge, and periods of grief and sadness are to be expected as you come to grips with your condition and its implications. But if you find that your depression persists or that you are having trouble sleeping or eating or have lost interest in the activities you normally enjoy, normal sadness can give way to clinical depression, which is a treatable condition.

To avoid depression:

  • Try not to isolate yourself. Reach out to family and friends. If you don’t have a solid support system, take steps to build one. Ask your doctor or therapist for referrals to a support group and other community resources.
  • Learn as much as you can about your condition. Knowledge is power when it comes to getting the best treatment available and maintaining a sense of autonomy and control.
  • Make sure that you have medical support from experts you trust and can talk to openly about your ongoing questions and concerns.
  • If you suspect that your medication is causing you to be depressed, consult your doctor about alternative treatments. Don't stop a medication on your own without discussing your concerns with your doctor.
  • If you are in chronic pain, talk with your physician about alternative pain management.
  • As much as is possible, remain engaged in the activities you enjoy. Doing so will keep you connected as well as boost your self-confidence and sense of community.
  • If you think you may be clinically depressed, don't wait to get help. Ask your primary care doctor for a referral to a psychiatrist or other mental health professional with experience in treating depression in people with medical illnesses, and get the treatment you need to take care of yourself.


WebMD Medical Reference


SOURCES: National Institute of Mental Health: "What is Depression?" National Institute of Mental Health: "Questions and Answers about the NIMH Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Study." SAMHSA's National Mental Health Information Center American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders: DSM-IV-TR, American Psychiatric Pub, 2000.

Fieve, R. Bipolar II, Rodale Books, 2006.

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