Health Benefits of Glutathione

Glutathione is a peptide found in plants and animals. It is a powerful antioxidant produced by the liver to protect the body against free radicals, peroxides, and heavy metals. Glutathione also eliminates poisons such as drugs and pollutants from our bodies.

Low glutathione levels have been associated with higher risks of cancer, Type 2 diabetes, hepatitis, and Parkinson’s disease. You can take glutathione as a supplement or boost glutathione production in the body. Taking curcumin, selenium, vitamin C, and vitamin E can help the liver create glutathione. Sulfur-containing foods like meat and certain vegetables can also boost production.

Health Benefits

Glutathione is essential for the immune system’s proper functioning and is vital in building and repairing tissue. It acts as an important antioxidant, which helps protect your body from damage to cells caused by free radicals.

Also, glutathione can provide health benefits like:

Coronary Endothelial Dysfunction

Endothelial cells are responsible for controlling the relaxation and contraction of blood vessels, and the dilation and constriction of arteries affect blood pressure. People with or without atherosclerosis can develop a type of cardiovascular condition where endothelial cells become damaged and no longer function properly, increasing the risk arrhythmia and stroke.

One study examined how glutathione can help reduce blood pressure in people with coronary endothelial dysfunction. Participants who received glutathione infusions saw increased blood vessel diameter and blood flow, which together significantly reduce coronary risk factors.

Preterm Infant Lung Health

Low glutathione levels are a contributing factor in the development of chronic lung disease. Some preterm infants are unable to produce enough glutathione, increasing their risk of having persistent lung problems.

One study used an intratracheal administration of glutathione to raise levels in preterm infants. The treatment increased glutathione levels to more than four times that of the levels before treatment. Results showed a lowering of oxidative stress markers, which are indicators of an imbalance between antioxidants and free radicals. This lowering of oxidative stress significantly reduced the risks of treated infants developing subsequent lung disease.

Chronic Ear Infections

Many children are plagued with chronic infections of the ear, which can cause stress and sleepless nights for many parents. Glutathione offers hope as a possible treatment for chronic ear infections.

Continued

Sixty children participated in a clinical trial to determine glutathione's effectiveness in reducing the incidence of ear infections. After receiving daily doses of aerosol glutathione administered nasally for two weeks, 66% of the treatment group reported significant improvement. This study suggests that glutathione could be a promising alternative to surgery.

Cystic Fibrosis

Thirty thousand American children and adults have cystic fibrosis, a disease where the body overproduces mucus. This disease affects the digestive system, the pancreas, and lung function.

Researchers determined that glutathione can help alleviate the symptoms of cystic fibrosis. For eight weeks, study subjects received daily treatments of inhaled glutathione or a placebo, using a nebulizer to turn liquid medicine into a mist, which makes it easy to inhale. The treatment group showed a significant increase in measured peak expiratory airflow — the amount of air they exhaled. Also, people who were part of the glutathione treatment study reported improvement in their cough frequency, mucus production, stamina, and general wellness.

Health Risks

Glutathione supplementation is generally recognized as safe, but research hasn’t confirmed whether it’s safe if you’re pregnant or breastfeeding.

Using glutathione long-term has been linked to lower zinc levels, which might be a benefit if your levels are high, but if you’re looking to increase your zinc, keep this potential effect in mind.

Because glutathione is often inhaled, it can be a concern for people with asthma, possibly triggering asthma attacks. An oral supplement may be a better choice.

There are no reported drug interactions with glutathione. It’s always best to talk with your doctor before adding a new supplement to your regimen.

Amounts and Dosage

Glutathione supplements can be taken orally or through inhalation or injection. Inhalation is the preferred route for treating lung conditions. Intravenous glutathione is often administered to mitigate the side effects of chemotherapy.

There is no recommended daily allowance for glutathione. Check supplement formulations with your doctor to make sure the dosages in them are appropriate for you. 

Food sources containing sulfur can help to boost glutathione production in the body. These foods include:

  • meat
  • broccoli
  • asparagus
  • spinach
  • garlic
  • almonds
WebMD Medical Reference Reviewed by Dan Brennan, MD on November 08, 2020

Sources

SOURCES:

Biological Trace Element Research: “Enhancing Glutathione Synthesis can Decrease Zinc-Medicated Toxicity.”

Biology of the Neonate: “Reduction of oxidative stress marker in lung fluid of preterm infants after administration of intra-tracheal liposomal glutathione.”

Chest: “A pilot study of the effect of inhaled buffered reduced glutathione on the clinical status of patients with cystic fibrosis.”

Circulation: “Intracoronary infusion of reduced glutathione improves endothelial vasomotor response to acetylcholine in human coronary circulation.”

Integrative Medicine: “Glutathione!”

Journal of the American Heart Association: “Coronary Endothelial Dysfunction Is Associated With Increased Risk of Incident Atrial Fibrillation.”

The Laryngoscope: “Management of chronic otitis media with effusion: the role of glutathione.

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