PROGRAF Side Effects by Likelihood and Severity

COMMON side effects

If experienced, these tend to have a Severe expression i

  • an infection
  • low amount of magnesium in the blood
  • high levels of potassium in the blood
  • anemia
  • low levels of white blood cells
  • a blood disorder
  • a toxic effect on the central nervous system, which consists of the brain and spinal cord
  • escape of fluid into the lungs
  • damage to the kidneys
  • decreased kidney function
  • seizures
  • difficulty sleeping
  • high blood sugar

If experienced, these tend to have a Less Severe expression i

  • irritation of the stomach or intestines
  • constipation
  • dizziness
  • muscle tremors
  • decreased appetite
  • headache
  • nausea
  • vomiting
  • diarrhea
  • nervousness
  • generalized weakness
  • anxious feelings

INFREQUENT side effects

If experienced, these tend to have a Severe expression i

  • an infection due to a fungus
  • a hormone disorder where the body produces high levels of cortisol called Cushing's syndrome
  • low amount of potassium in the blood
  • high blood pressure
  • cardiomyopathy, a disease of the heart muscle
  • osteoporosis, a condition of weak bones
  • trouble breathing

If experienced, these tend to have a Less Severe expression i

  • high amount of triglyceride in the blood
  • canker sores
  • indigestion
  • urinary tract infection
  • excessive sweating
  • pain
  • numbness
  • abdominal bloating
  • a feeling of pins and needles on skin
  • intense abdominal pain

RARE side effects

If experienced, these tend to have a Severe expression i

  • an unusual viral infection called cytomegalovirus infection
  • an infection due to a virus
  • squamous cell carcinoma
  • a type of blood disorder where the red blood cells burst called hemolytic anemia
  • hemolytic uremic syndrome, a condition that affects the kidney and the blood
  • a type of blood disorder with a decrease in all types of blood cells called pancytopenia
  • a type of blood clotting disorder called disseminated intravascular coagulation
  • low platelet count and bleeding from immune response
  • decreased blood platelets
  • very low levels of granulocytes, a type of white blood cell
  • low levels of a type of white blood cell called neutrophils
  • high levels of white blood cells
  • paralysis
  • temporary blindness
  • vision loss
  • optic neuropathy, a disease of the optic nerve
  • angina, a type of chest pain
  • a clot in the lung
  • pulmonary hypertension
  • fluid in the covering of the heart or pericardium
  • hypertrophic cardiomyopathy
  • abnormal heart electrical signals
  • torsades de pointes, a type of abnormal heart rhythm
  • atrial fibrillation
  • atrial flutter
  • ventricular fibrillation, a heart rhythm disorder
  • slow heartbeat
  • prolonged QT interval on EKG
  • chronic heart failure
  • left ventricular hypertrophy
  • blood clot in a deep vein of the extremities
  • thrombotic thrombocytopenic purpura, a type of blood disorder
  • bleeding
  • a stomach ulcer
  • inflammation of the lining of the stomach and intestines
  • liver tissue death
  • inflammation of the liver called hepatitis
  • cholangitis, an infection resulting from gallstones
  • blockage of a bile duct
  • acute inflammation of the pancreas
  • kidney failure
  • inflammation of the bladder with hemorrhage
  • a skin disorder with blistering and peeling skin called toxic epidermal necrolysis
  • a skin disorder with blistering and peeling skin called Stevens-Johnson syndrome
  • a condition with muscle tissue breakdown called rhabdomyolysis
  • coma
  • aphasia, a loss of the ability to speak and understand language
  • an inability to completely empty the bladder
  • abnormal liver function tests
  • a significant type of allergic reaction called anaphylaxis
  • disorder of lymphoid tissue after transplant
  • graft-versus-host disease
  • basal cell carcinoma of the skin
  • malignant lymphoma
  • a rupture in the wall of the stomach or intestine
  • supraventricular premature beats
  • lung tissue problem
  • progressive multifocal leukoencephalopathy, a type of brain infection
  • a type of brain disorder called posterior reversible encephalopathy syndrome
  • kidney problems due to BK polyomavirus
  • high blood levels of the amylase enzyme
  • hemiparesis
  • pure red cell aplasia
  • limp or flaccid paralysis

If experienced, these tend to have a Less Severe expression i

  • mood changes
  • visual sensitivity to light
  • a stuffy and runny nose
  • a type of stomach irritation called gastritis
  • increased sensitivity of the skin to the sun
  • darkening of the skin
  • arthritis
  • muscle pain
  • pain in the arms or legs
  • drowsiness
  • delirium
  • fainting
  • a type of speech disorder called dysarthria
  • hiccups
  • involuntary leakage of urine
  • impaired wound healing

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.