Seasonal Depression Tied to Serotonin

People With Seasonal Affective Disorder May Have Less of the Brain Chemical in Winter

Medically Reviewed by Louise Chang, MD on September 19, 2007
From the WebMD Archives

Sept. 19, 2007 -- People with seasonal affective disorder (SAD) may have lower levels of the brain chemical serotonin in winter than other people, according to a new study.

But those lower serotonin levels bounce back to normal if their seasonal depression is treated -- and in summer.

Researchers say the finding could lead to improved treatments for SAD, which is a form of seasonal depression that worsens in winter and improves in summer. Symptoms include weight gain, increased need for sleep, irritability, and inability to concentrate.

SAD Tied to Serotonin Levels

Previous studies have shown that in depression the brain has too little serotonin, but it’s not known exactly why.

In this study, researchers at the Medical University of Vienna looked at how the brain removes serotonin through the serotonin transporter and compared the rate of removal in 73 people with untreated seasonal affective disorder and 70 healthy people.

The results, published in Neuropsychopharmacology, showed serotonin was removed from the brain at a faster rate among those with seasonal depression, causing serotonin levels to drop below normal. But serotonin removal rates returned to normal with treatment and during the summer months.

Researchers say the results could help identify people at risk for seasonal depression and more effective treatments.

Currently available treatments for seasonal affective disorder include increased exposure to light sources, such as natural sunlight or a light box, and antidepressants.

Show Sources

SOURCES: Willeit, M. Neuropsychopharmacology, Sept. 19, 2007 advance online publication. News release, Nature Journals.

© 2007 WebMD, Inc. All rights reserved. View privacy policy and trust info