CHRYSIN

OTHER NAME(S):

5,7-Chrysin, 5,7-Dihydroxyflavone, 5,7-dihydroxy-2-phenyl-4H-chromen-4-one, Chrysine, Flavone X, Flavonoid, Flavonoïde, Galangin Flavanone, Galangine Flavanone.

Overview

Overview Information

Chrysin belongs to a class of chemicals called flavonoids. It occurs naturally in various plants and substances, such as the passionflower, silver linden, and some geranium species; and in honey and bee propolis (glue).

Chrysin is used for bodybuilding, for treating anxiety, inflammation, gout, HIV/AIDS, erectile dysfunction (ED), and baldness. It is also used for preventing cancer.

How does it work?

Athletes are interested in chrysin for bodybuilding because laboratory research suggested that chrysin might increase the male hormone called testosterone and improve bodybuilding results. But research in humans hasn't found any effect on testosterone levels. The amount of chrysin that is absorbed from the intestine may be very small, which would make treatment effects unlikely.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Athletic performance. Early research shows that taking chrysin in combination with steroids and other supplements for 8 weeks does not improve resistance training in athletes.
  • Anxiety.
  • Inflammation.
  • Gout.
  • HIV infection/AIDS.
  • Impotence.
  • Baldness.
  • Preventing cancer.
  • Other conditions.
More evidence is needed to rate the effectiveness of chrysin for these uses.

Side Effects

Side Effects & Safety

There isn't enough information to know if chrysin is safe or what the possible side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking chrysin if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding disorder: Chrysin might increase bleeding. There is some concern that it might increase the risk of bruising and bleeding in people with bleeding disorders.

Surgery: Chrysin might slow blood clotting. There is concern that it might increase the risk of extra bleeding during and after surgery. Stop taking chrysin at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications for estrogen sensitive cancers (Aromatase inhibitors) interacts with CHRYSIN

    Some types of cancer are affected by hormones in the body. Estrogen sensitive cancers are cancers that are affected by estrogen levels in the body. Medications for estrogen sensitive cancers help decrease estrogen in the body. Chrysin might also decrease estrogen in the body. Taking chrysin along with medications for estrogen sensitive cancers might decrease estrogen in the body too much.
    Some medications for estrogen sensitive cancers include aminoglutethimide (Cytadren), anastrozole (Arimidex), exemestane (Aromasin), letrozole (Femara), and others.

Minor Interaction

Be watchful with this combination

!
  • Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with CHRYSIN

    Some medications are changed and broken down by the liver.
    Chrysin might decrease how quickly the liver breaks down some medications. Taking chrysin along with some medications that are changed by the liver might increase the effects and side effects of some medications. Before taking chrysin talk to your healthcare provider if you take any medications that are changed by the liver.
    Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.

  • Medications changed by the liver (Glucuronidated Drugs) interacts with CHRYSIN

    The body breaks down some medications to get rid of them. The liver helps break down these medications. Chrysin might increase how quickly some medications are changed by the liver. This could decrease how well some of these medications work.
    Some of these medications changed by the liver include acetaminophen, atorvastatin (Lipitor), diazepam (Valium), digoxin, entacapone (Comtan), estrogen, irinotecan (Camptosar), lamotrigine (Lamictal), lorazepam (Ativan), lovastatin (Mevacor), meprobamate, morphine, oxazepam (Serax), and others.

Dosing

Dosing

The appropriate dose of chrysin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chrysin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

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