CISSUS QUADRANGULARIS

OTHER NAME(S):

Adamant Creeper, Asthisamharaka, Asthisanghata, Asthisonhara, Chadhuri, Chaudhari, Cissus, Cissus Extract, Cissus Formula, Cissus Formulation, C. Quadrangularis, Cissus Quadrangularis, Cissus Quadrangularis Extract, Devil's Backbone, CORE, CQ, CQE, CQR-300, Extrait de Cissus, Hadjod, Hadjora, Harbhanga, Harishankar, Harsankari, Hasjora, Kandavalli, Kandavela, Mangaroli, Nalleru, Namunungwa, Phet Cha Sung Khaat, Phet Sang Kat, Phet Sangkhat, Pirandai, Quadrangularis, Samroi To, San Cha Khuat, Stemmed Vine, Vajrangi, Vajravalli, Vedhari, Veld Grape, Veldt-grape, Vitis quadrangularis, Winged Treebine.<br/><br/>

Overview

Overview Information

Cissus quadrangularis is a vine that grows in Africa and parts of Asia. It is one of the most commonly used medicinal plants in Thailand, and is also used in traditional African and Ayurvedic medicine. All parts of the plant are used for medicine.

Cissus quadrangularis is used for obesity, diabetes, a cluster of heart disease risk factors called "metabolic syndrome," and high cholesterol. It has also been used for bone fractures, gout, rheumatoid arthritis, allergies, loss of appetite (anorexia), weak bones (osteoporosis), scurvy, cancer, upset stomach, hemorrhoids, peptic ulcer disease (PUD), painful menstrual periods, asthma, seizures, malaria, wound healing, and pain. Cissus quadrangularis is also used in bodybuilding supplements as an alternative to anabolic steroids.

How does it work?

There is not enough information to know how Cissus quadrangularis might work for medicinal purposes in people. Test tube studies and research in animals show that it has antioxidant, analgesic, and anti-inflammatory properties. It might have activity against the organism that causes malaria.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Bone fractures. Early research shows that taking Cissus quadrangularis can decrease pain and swelling and improve healing in people with jaw fractures. Other early research shows that applying a formula containing Cissus quadrangularis and other ingredients to the skin improves fracture healing in some people. It is unclear is the effects of this product are due to Cissus quadrangularis or the other ingredients, which include calcium, vitamin D, and boswellia. Other research shows that taking Cissus quadrangularis, ashwagandha, and holy basil by mouth for 6 months improves bone mineral density (BMD) in some people. Whether this increase in BMD reduces the chance for fractures is not known.
  • Hemorrhoids. Early research shows that taking Cissus quadrangularis tablets by mouth twice daily for 7 days does not improve hemorrhoid symptoms.
  • Joint pain. Early research shows that taking Cissus quadrangularis twice daily for 8 weeks decreases pain and stiffness in men with joint pain caused by exercise.
  • Obesity and weight loss. Early research shows that taking Cissus quadrangularis extract, alone or with other ingredients, reduces weight in some people who are obese and overweight. However, this research is generally low quality.
  • Bone defects caused by gum disease. Early research shows that adding Cissus quadrangularis to a material called hydroxyapatite, which is used in dentistry to treat tissue loss caused by gum disease, does not improve tissue regrowth in people with specific bone defects called periodontal intrabony defects.
  • Allergies.
  • Asthma.
  • Bodybuilding.
  • Cancer.
  • Diabetes.
  • Gout.
  • Heart disease risk factors that occur together (metabolic syndrome).
  • High cholesterol.
  • Loss of appetite (anorexia).
  • Malaria.
  • Osteoporosis.
  • Pain.
  • Painful menstrual periods.
  • Peptic ulcer disease (PUD)..
  • Rheumatoid arthritis.
  • Scurvy.
  • Seizures.
  • Upset stomach.
  • Wound healing.
  • Other conditions.
More evidence is needed to rate the effectiveness of Cissus quadrangularis for these uses.

Side Effects

Side Effects & Safety

Cissus quadrangularis is POSSIBLY SAFE when taken by mouth appropriately short-term (for up to 6-10 weeks). Cissus quadrangularis can cause side effects such as headache, intestinal gas, dry mouth, diarrhea, and insomnia. But there is not enough information to know how often these side effects might occur.

The long-term safety of Cissus quadrangularis is not known.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking Cissus quadrangularis if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Diabetes: Cissus quadrangularis might lower blood sugar. Taking Cissus quadrangularis along with medications for diabetes might lower blood sugar too much. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar levels closely if you have diabetes and use Cissus quadrangularis.

Surgery: Cissus quadrangularis might lower blood sugar and could interfere with blood sugar control during and after surgical procedures. Stop using Cissus quadrangularis at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

We currently have no information for CISSUS QUADRANGULARIS Interactions.

Dosing

Dosing

The appropriate dose of Cissus quadrangularis depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for Cissus quadrangularis. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

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  • Panpimanmas, S., Sithipongsri, S., Sukdanon, C., and Manmee, C. Experimental comparative study of the efficacy and side effects of Cissus quadrangularis L. (Vitaceae) to Daflon (Servier) and placebo in the treatment of acute hemorrhoids. J Med Assoc.Thai. 2010;93(12):1360-1367. View abstract.
  • Parisuthiman, D., Singhatanadgit, W., Dechatiwongse, T., and Koontongkaew, S. Cissus quadrangularis extract enhances biomineralization through up-regulation of MAPK-dependent alkaline phosphatase activity in osteoblasts. In Vitro Cell Dev.Biol.Anim 2009;45(3-4):194-200. View abstract.
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  • Potu, B. K., Nampurath, G. K., Rao, M. S., and Bhat, K. M. Effect of Cissus quadrangularis Linn on the development of osteopenia induced by ovariectomy in rats. Clin Ter. 2011;162(4):307-312. View abstract.
  • Potu, B. K., Rao, M. S., Kutty, N. G., Bhat, K. M., Chamallamudi, M. R., and Nayak, S. R. Petroleum ether extract of Cissus quadrangularis (LINN) stimulates the growth of fetal bone during intra uterine developmental period: a morphometric analysis. Clinics.(Sao Paulo) 2008;63(6):815-820. View abstract.
  • Potu, B. K., Rao, M. S., Nampurath, G. K., Chamallamudi, M. R., Nayak, S. R., and Thomas, H. Anti-osteoporotic activity of the petroleum ether extract of Cissus quadrangularis Linn. in ovariectomized Wistar rats. Chang Gung.Med J 2010;33(3):252-257. View abstract.
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  • Srisook, K., Palachot, M., Mongkol, N., Srisook, E., and Sarapusit, S. Anti-inflammatory effect of ethyl acetate extract from Cissus quadrangularis Linn may be involved with induction of heme oxygenase-1 and suppression of NF-kappaB activation. J Ethnopharmacol. 2-16-2011;133(3):1008-1014. View abstract.
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  • Viswanatha Swamy, A. H., Kulkarni, R. V., Thippeswamy, A. H., Koti, B. C., and Gore, A. Evaluation of hepatoprotective activity of Cissus quadrangularis stem extract against isoniazid-induced liver damage in rats. Indian J Pharmacol. 2010;42(6):397-400. View abstract.
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More Resources for CISSUS QUADRANGULARIS

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.