MOTHERWORT

OTHER NAME(S):

Agripalma, Agripaume, Agripaume Cardiaque, Cardiaire, Cardiaque, Cheneuse, Chinese Motherwort, Creneuse, Herba Leonuri, Herbe aux Tonneliers, HjÀrtstilla, Leonuri Cardiacae Herba, Leonurus, Leonurus artemisia, Leonurus cardiaca, Leonurus cardica, Leonurus japonicus, Leonurus heterophyllus, Leonurus sibiricus, Lion's Ear, Lion's Tail, Mother's Wort, Oreille de Lion, Patte de Sorcier, Pustyrnik Obyknovennyj, Queue de Lion, Qinghao, Qiancengta, Sanjiaohuma, Stachys artemisia, Throw-Wort, Tianzhima, Tougucao, Yema, Yi Mu Cao, Yimuhao.<br/><br/>

Overview

Overview Information

Motherwort is a plant. The parts that grow above the ground are used to make medicine.

Motherwort is used for heart conditions, including heart failure, irregular heartbeat, and heart symptoms due to anxiety. It is also used for the absence of menstrual periods, painful menstrual periods, menopause symptoms, intestinal gas (flatulence), cancer, sleep problems, asthma, and over-active thyroid (hyperthyroidism).

Some people apply motherwort directly to the skin for wounds, itching and shingles.

How does it work?

Motherwort can reduce inflammation and has antioxidant and antimicrobial effects. It also stimulates uterine contractions.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Alcoholism. Early research shows that taking motherwort along with valerian, hops, and lemon balm might improve sleep in men going through alcohol withdrawal.
  • Anxiety. Early research suggests that taking a motherwort tincture by mouth for 10 days can decrease anxiety.
  • High blood pressure. Early research suggests that taking a motherwort extract by mouth for 28 days can decrease blood pressure in people whose blood pressure is too high.
  • Menopausal symptoms. Early research suggests that taking a combination of motherwort, burdock, dong quai, licorice root, and wild yam by mouth for 12 weeks may reduce menopausal symptoms, such as hot flashes, sleep problems, mood changes, and vaginal dryness.
  • Post-partum bleeding. Early research suggests that injecting motherwort into the uterus along with oxytocin during a Cesarean section (C-section), then injecting motherwort into the muscle after the C-section, reduces blood loss compared with using oxytocin alone. However, when motherwort is injected into the uterus and muscles without oxytocin, it appears to increase bleeding after a C-section when compared to oxytocin alone.
  • Cancer.
  • Heart conditions (fast heart rate, abnormal rhythm).
  • Intestinal gas (flatulence).
  • Itching.
  • Lack of menstrual periods.
  • Over-active thyroid (hyperthyroidism).
  • Painful menstrual periods.
  • Shingles.
  • Other uses.
More evidence is needed to rate the effectiveness of motherwort for these uses.

Side Effects

Side Effects & Safety

Motherwort is POSSIBLY SAFE for most people when taken by mouth appropriately. Side effects include diarrhea, stomach irritation, and uterine bleeding. Contact with the skin can cause rashes and increased sensitivity to the sun.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Taking motherwort by mouth during pregnancy is LIKELY UNSAFE and should be avoided. Motherwort can stimulate the uterus and might cause a miscarriage.

There is not enough reliable information about the safety of taking motherwort if you are breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

Major Interaction

Do not take this combination

!
  • Sedative medications (CNS depressants) interacts with MOTHERWORT

    Motherwort might cause sleepiness and drowsiness. Medications that cause sleepiness are called sedatives. Taking motherwort along with sedative medications might cause too much sleepiness.<br><nb>Some sedative medications include clonazepam (Klonopin), lorazepam (Ativan), phenobarbital (Donnatal), zolpidem (Ambien), and others.

Dosing

Dosing

The appropriate dose of motherwort depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for motherwort. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Bai Li, Cao Yun, and Wang Jinling. Clinical study on the application of integrated traditional and western medicine in treating chronic renal failure. Chinese Journal of Information on Traditional Chinese Medicine 2005;12(9):14-15.
  • Bernatoniene, J., Kucinskaite, A., Masteikova, R., Kalveniene, Z., Kasparaviciene, G., and Savickas, A. The comparison of anti-oxidative kinetics in vitro of the fluid extract from maidenhair tree, motherwort and hawthorn. Acta Pol.Pharm. 2009;66(4):415-421. View abstract.
  • Boblitz N, Schrader E Henneicke-von Zepelin HH Wustenberg P. Benefit of a fixed drug combination containing St John's Wort and Black Cohosh for climacteric patients- results of a randomized clinical trial. Focus Altern Complement Ther 1999;5:85.
  • Chang Dong, Lao Shaoxian, Fan Yawei, Lu Weijie, Tao Yongsheng, and Yin Xuhong. The effects of Yijiling in combination with western medicine on treating diarrhoea type irritable bowel syndrome. Chinese Journal of Information on Traditional Chinese Medicine 2003;10(12):4-6.
  • Chao, Z., Ma, L. L., and Zhou, X. J. [Determination of stachydrine and leonurine in Herba Leonuri by ion- pair reversed-phase high-performance liquid chromatography.]. Di Yi.Jun.Yi.Da.Xue.Xue.Bao. 2004;24(11):1223-1226. View abstract.
  • Chinwala, M. G., Gao, M., Dai, J., and Shao, J. In vitro anticancer activities of Leonurus heterophyllus sweet (Chinese motherwort herb). J.Altern.Complement Med. 2003;9(4):511-518. View abstract.
  • Davis SR, Briganti EM Chen RQ Dalais FS Bailey M Burger HG. The effects of Chinese medicinal herbs on postvasomotor symptoms of Australian women. MJA 2001;174:68-71.
  • De Leo, V, La Marca, A., Lanzetta, D., Palazzi, S., Torricelli, M., Facchini, C., and Morgante, G. [Assessment of the association of Kava-Kava extract and hormone replacement therapy in the treatment of postmenopause anxiety]. Minerva Ginecol. 2000;52(6):263-267. View abstract.
  • Fokina, G. I., Frolova, T. V., Roikhel', V. M., and Pogodina, V. V. [Experimental phytotherapy of tick-borne encephalitis]. Vopr.Virusol. 1991;36(1):18-21. View abstract.
  • Guo, J., Song, C. S., and Han, Q. [Clinical observation on ziyin tongbi decoction in treating benign prostatic hyperplasia]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2008;28(12):1082-1085. View abstract.
  • Hao RuiFang. The application of integrated Traditional Chinese Medicine and western medicine in the treatment of steroid-dependent nephrotic syndrome in children. Chinese Journal of Information on Traditional Chinese Medicine 2007;14(7):66-67.
  • Hudson TS, Standish L Breed C et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopath Med 1999;7:73-77.
  • Hudson TS, Standish L, Breed C, and et al. Clinical and endocrinological effects of a menopausal botanical formula. J Naturopathic Med 1998;7(1):73-77.
  • Huntley, A. L. and Ernst, E. A systematic review of herbal medicinal products for the treatment of menopausal symptoms. Menopause. 2003;10(5):465-476. View abstract.
  • Jeri AR. The use of an isoflavone supplement to relieve hot flushes. The Female Patient 2002;27:35-37.
  • Kuang LiJun and Zhou XiaoYan. The application of Wenshenhuoxuetang in the treatment of primary dysmenorrheal. Chinese Journal of Information on Traditional Chinese Medicine 2007;14(2):61-62.
  • Lehmann-Willenbrock VE, Reiedel HH. Klinische und endokrinologische Untersuchungen zur Therapie ovarieller Ausfallserscheinungen nach Hysterektomie unter Belassung der Adnexe. Zent bl Gynakol 1988;110(611):618.
  • Li Majian and Zhang Shumin. The effects of Traditional Chinese Medicine on antibody levels in women with recurrent spontaneous abortion (RSA). Chinese Journal of Information on Traditional Chinese Medicine 2005;12(7):59-60.
  • Li Wei and Ren Ke. The application of Xiaoyaosanjiajian in the treatment of idiopathic edema. Chinese Journal of Information on Traditional Chinese Medicine 2005;12(11):70-71.
  • Lin, J. H., Lin, Q. D., Liu, X. H., Yan, J. Y., He, J., Li, L., Gu, H., Sun, L. Z., Zhang, J. P., Yu, S., Ma, Y. Y., Niu, J. M., Xia, Y., Zhao, S. C., Li, W., Wang, H. L., and Wang, B. S. [Multi-center study of motherwort injection to prevent postpartum hemorrhage after caesarian section]. Zhonghua Fu Chan Ke.Za Zhi. 2009;44(3):175-178. View abstract.
  • Liu Juan. The effects of Bushenhuoxuezhuyuntang on the development of ovarian follicle and endometrium. Chinese Journal of Information on Traditional Chinese Medicine 2006;13(10):14-16.
  • Masteikova, R., Muselik, J., Bernatoniene, J., Majiene, D., Savickas, A., Malinauskas, F., Bernatoniene, R., Peciura, R., Chalupova, Z., and Dvorackova, K. [Antioxidant activity of tinctures prepared from hawthorn fruits and motherwort herb]. Ceska.Slov.Farm. 2008;57(1):35-38. View abstract.
  • Ovanesov, K. B., Ovanesova, I. M., and Arushanian, E. B. [Effects of melatonin and motherwort tincture on the emotional state and visual functions in anxious subjects]. Eksp.Klin.Farmakol. 2006;69(6):17-19. View abstract.
  • Shen QiaoYun. The application of Bushenhuayutiaojingfang in the treatment of polycystic ovarian syndrome (PCOS). Chinese Journal of Information on Traditional Chinese Medicine 2007;14(2):56-57.
  • Shi YiYing. The application of Liqihuoxuetang in the treatment of idiopathic edema. Chinese Journal of Information on Traditional Chinese Medicine 2007;14(5):75.
  • Song, E. F., Xiang, Q., Ren, K. M., Hu, J. C., Wu, F., Gong, M. F., Zhang, H., and Bi, H. M. Clinical effect and action mechanism of Weicao Capsule in treating gout. Chin J.Integr.Med. 2008;14(2):103-106. View abstract.
  • Stoll W. Phytotherapeuticum beeinflusst atrophisches Vaginalepithel. Doppelblindversuch Cimicifuga versus Ostrogenpraparat. Therapeutikon 1987;1-15.
  • Su XiuHai, Wang XiaoYun, and Li Ye. Using Tangshenning granule to treat 108 patients with diabetic nephropathy. Chinese Journal of Information on Traditional Chinese Medicine 2012;9(8):38-39.
  • Sun YanMin, Ma ChunMing, Bai ZhanQing, Lu Zhen, and Wang ZongFan. The application of Traditional Chinese Medicine in the treatment of asthma in children. Chinese Journal of Information on Traditional Chinese Medicine 2006;13(8):51-52.
  • Tao, J., Zhang, P., Liu, G., Yan, H., Bu, X., Ma, Z., Wang, N., Wang, G., and Jia, W. Cytotoxicity of Chinese motherwort (YiMuCao) aqueous ethanol extract is non-apoptotic and estrogen receptor independent on human breast cancer cells. J.Ethnopharmacol. 3-18-2009;122(2):234-239. View abstract.
  • Wang Jing, Zhu NingYun, and Zhang Rui. The application of Fumingtang in the treatment of vitreous haemorrhage caused by diabetes. Chinese Journal of Information on Traditional Chinese Medicine 2007;14(3):64.
  • Wang S-M, Li R-H, Zhang W-L, Zhou G-Q, and Gao Y-J. [Effects of zishen huoxue liangban decoction combined with huoba huagen on biochemical indexes of patients with systemic lupus erythematosus at active phase]. (The Cochrane Controlled Trials Register (CCTR/CENTRAL)).In: The Cochrane Library 2006;1
  • Wang Shoufu, Li Qiufeng, Xu Yi, and Shen Jinling. The effects of Shenqiqiangxin Mix on heart functions and quality of life in patients with chronic heart failure. Chinese Journal of Information on Traditional Chinese Medicine 2005;12(9):70-71.
  • Wang Yuwen. The application of Fukedeshengdan in the treatment of menstrual disorder. Chinese Journal of Information on Traditional Chinese Medicine 2006;13(3):62-63.
  • Wang Yuwen. The application of Jiaweishenghuatang in the treatment of bleeding after drug induced abortion. Chinese Journal of Information on Traditional Chinese Medicine 2005;12(11):67.
  • Wang YuYing and Niu BaoGuo. The application of integrated Traditional Chinese Medicine and western medicine in the treatment of chronic pelvic inflammatory disease. Chinese Journal of Information on Traditional Chinese Medicine 2006;13(7):53.
  • Wang, XZ. Curative effect of motherwort and oxtocin on the prevention of postpartum hemorrhage. Chinese Journal of Pharmacoepidemiology (China) 2010;19
  • Warnecke G, Pfaender H, Gerster G, Gracza E. Wirksamkeit von Kawa-Kawa-Extrakt beim klimakterischen Syndrom. Zeitschrift Phytotherapie 1990;11:81-86.
  • Warnecke G. Beeinflussung klimakterischer Beschwerden durch ein Phytotherapeutikum. Erfolgreiche therapie mit Cimicifuga Monoextrackt. Medwelt 1985;36:871-874.
  • Widy-Tyszkiewicz E, Schminda R. A randomized double blind study of sedative effects of phytotherapeutic containing valerian, hops, balm and motherwort versus placebo. Herba Polonica 1997;43(2):154.
  • Wu Qiuling and Liao Xiaoling. The application of Kongzigongtang in the treatment of bleeding after drug induced abortion. Chinese Journal of Information on Traditional Chinese Medicine 2005;12(12):61-62.
  • Yang Wei. Advances in the application of Traditional Chinese Medicine (TCM) to treat infertility caused by luteal phase defect (LPD). Chinese Journal of Information on Traditional Chinese Medicine 2007;14(1):94-95.
  • Yarnell, E and Abascal, K. Botanicals for regulating heart rhythms. Alternative & Complementary Therapies (England) 2003;9:125-129.
  • Yu Huiqing and Li Fei. The combination of Traditional Chinese Medicine with western medicine in the treatment of dilatation cardiomyopathy. Chinese Journal of Information on Traditional Chinese Medicine 2003;10(6):61-62.
  • Zhang DingHua. The effects of Tangshenkang on the parameters of haemorheology and blood lipids of patients with diabetes. Chinese Journal of Information on Traditional Chinese Medicine 2006;13(3):71.
  • Zhang GuoXin, Wang XiuFen, Zhang Ping, and Wu YunXia. The clinical study of Shenhuangcao Mixture in treating early renal injury. Chinese Journal of Information on Traditional Chinese Medicine 2002;9(12):16-17.
  • Zhang GuoXin, Wu YunXia, Cheng BinLin, Yao Jian, and Xi Bin. Using Senghuangcao decoction to treat chronic renal failure. Chinese Journal of Information on Traditional Chinese Medicine 2002;9(2):45-46.
  • Zhang, S. Q., Zhou, C. C., Cong, D. D., Sui, S. G., and Liu, X. D. Treatment of prostatic hypertrophy with zhi bai kuncao tang (decoction of anemarrhena rhizome, phellodendron bark and motherwort). J.Tradit.Chin Med. 1988;8(4):254-256. View abstract.
  • Zhou Qin, Yang ChuanZhong, and Ye ZhiYong. The application of integrated Traditional Chinese Medicine and western medicine in the treatment of hepatocirrhosis with ascites. Chinese Journal of Information on Traditional Chinese Medicine 2007;14(4):73.
  • . Liu W, Ma S, Pan W, Tan W. Combination of motherwort injection and oxytocin for the prevention of postpartum hemorrhage after cesarean section. J Matern Fetal Neonatal Med 2016;29(15):2490-3. View abstract.
  • Baber RJ, Templeman C, Morton T, et al. Randomized placebo-controlled trial of an isoflavone supplement and menopausal symptoms in women. Climacteric 1999;2:85-92.. View abstract.
  • Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications, 2000.
  • Chenoy R, Hussain S, Tayob Y, et al. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing (abstract). BMJ 1994;308:501-3. View abstract.
  • Hirata JD, Swiersz LM, Zell B, et al. Does dong quai have estrogenic effects in postmenopausal women? A double-blind, placebo-controlled trial. Fertil Steril 1997;68:981-6. View abstract.
  • Jacobson JS, Troxel AB, Evans J, et al. Randomized trial of black cohosh for the treatment of hot flashes among women with a history of breast cancer. J Clin Oncol 2001;19:2739-45. View abstract.
  • Knight DC, Howes JB, Eden JA. The effect of Promensil, an isoflavone extract, on menopausal symptoms. Climacteric 1999;2:79-84.. View abstract.
  • Komesaroff PA, Black CV, Cable V, et al. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 2001;4:144-50.. View abstract.
  • Liu XH, Pan LL, Zhu YZ. Active chemical compounds of traditional Chinese medicine Herba Leonuri: implications for cardiovascular diseases. Clin Exp Pharmacol Physiol 2012;39(3):274-82. View abstract.
  • Shang X, Pan H, Wang X, He H, Li M. Leonurus japonicus Houtt: ethnopharmacology, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol 2014;152(1):14-32. View abstract.
  • Shikov AN, Pozharitskaya ON, Makarov VG, et al. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res 2011;25:540-3. View abstract.
  • Sitarek P, Rijo P, Garcia C, et al. Antibacterial, anti-inflammatory, antioxidant, and antiproliferative properties of essential oils from hairy and normal roots of Leonurus sibiricus L. and their chemical composition. Oxid Med Cell Longev 2017; 7384061. View abstract.
  • Tahmouzi S, Ghodsi M. Optimum extraction of polysaccharides from motherwort leaf and its antioxidant and antimicrobial activities. Carbohydrate Polymers 2014;112:396-403. View abstract.
  • van de Weijer P, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush symptoms compared with placebo. Maturitas 2002;42:187-93. View abstract.
  • Warnecke G. [Psychosomatic dysfunctions in the female climacteric. Clinical effectiveness and tolerance of Kava extract WS 1490]. Fortschr Med 1991;109:119-22. View abstract.
  • Wiklund IK, Mattsson LA, Lindgren R, et al. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Int J Clin Pharmacol Res 1999;19:89-99.. View abstract.
  • Wojtyniak K, Szymanski M, Matlawska I. Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res 2013;27(8):1115-20. View abstract.
  • Zou QZ, Bi RG, Li JM, et al. Effect of motherwort on blood hyperviscosity. Am J Chin Med 1989;17:65-70. View abstract.

More Resources for MOTHERWORT

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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