Fleur de Muscade, Jaatipatree, Jaiphal, Jatikosha, Jatipatra, Jatipatri, Jatiphal, Jatiphala, Jatiphalam, Javitri, Jayapatri, Mace, Macis, Muscade, Muscade et Macis, Muscadier, Muskatbuam, Myristica, Myristicae Aril, Myristica fragrans, Myristica officinalis, Noix de Muscade, Noix de Muscade et Macis, Nuez Moscada, Nuez Moscada y Macis.<br/><br/>
Overview InformationNutmeg and mace are plant products. Nutmeg is the shelled, dried seed of the plant Myristica fragrans, and mace is the dried net-like covering of the shell of the seed.
Mace is taken by mouth for diarrhea, nausea, vomiting, stomach spasms and pain, and intestinal gas. It is also taken by mouth for treating cancer, kidney disease, increasing menstrual flow; causing a miscarriage, and as a hallucinogen.
Mace is applied to the skin to kill pain, especially pain caused by achy joints (rheumatism).
In foods, mace is used as a spice and flavoring.
How does it work?Mace contains chemicals that might affect the central nervous system. Mace might also kill bacteria and fungi.
Uses & Effectiveness
Insufficient Evidence for
- Gum disease (gingivitis). Early research suggests that chewing gum containing mace extract after every meal for 3 weeks reduces gum inflammation, bleeding, and plaque in people with gum disease.
- Increasing menstrual flow.
- Intestinal gas.
- Kidney disease.
- Producing hallucinations.
- Stomach problems.
- Other conditions.
Side Effects & SafetyMace is POSSIBLY SAFE when taken by mouth and used appropriately. Mace is a commonly used spice in foods.
Mace is POSSIBLY UNSAFE when taken in doses larger than amounts found in foods. Mace contains the chemical myristicin which has been linked to hallucinations and other mental side effects. People who have taken larger doses of nutmeg have experienced nausea, dry mouth, dizziness, irregular heartbeat, agitation and hallucinations. Because mace also contains myristicin, in theory, it might cause these same side effects.
There is not enough reliable information available to know if mace is safe to apply on the skin or what the side effects might be.
Special Precautions & Warnings:Pregnancy and breast-feeding: Mace is POSSIBLY UNSAFE when taken by mouth in doses larger than amounts found in foods. In pregnant women, it might cause miscarriages or birth defects.
There is not enough reliable information about the safety of taking mace if you are breast feeding. Stay on the safe side and avoid use.
Weakened immune system: Mace might reduce immune function. In theory, taking large doses of mace can worsen immune function for people who already have a weakened immune system.
We currently have no information for MACE Interactions.
- For gum disease (gingivitis): Chewing gum containing mace extract has been used after every meal for 3 weeks.
- Bhamarapravati, S., Pendland, S. L., and Mahady, G. B. Extracts of spice and food plants from Thai traditional medicine inhibit the growth of the human carcinogen Helicobacter pylori. In Vivo 2003;17(6):541-544. View abstract.
- Culikova, V. Assortment of the plants in the Medieval diet in Czech countries (based on archaeobotanical finds). Acta Univ Carol.Med (Praha) 2000;41(1-4):105-118. View abstract.
- Dooms-Goossens, A., Dubelloy, R., and Degreef, H. Contact and systemic contact-type dermatitis to spices. Dermatol Clin 1990;8(1):89-93. View abstract.
- Hasheminejad, G. and Caldwell, J. Genotoxicity of the alkenylbenzenes alpha- and beta-asarone, myristicin and elimicin as determined by the UDS assay in cultured rat hepatocytes. Food Chem.Toxicol. 1994;32(3):223-231. View abstract.
- Maralhas, A., Monteiro, A., Martins, C., Kranendonk, M., Laires, A., Rueff, J., and Rodrigues, A. S. Genotoxicity and endoreduplication inducing activity of the food flavouring eugenol. Mutagenesis 2006;21(3):199-204. View abstract.
- Miller, E. C., Swanson, A. B., Phillips, D. H., Fletcher, T. L., Liem, A., and Miller, J. A. Structure-activity studies of the carcinogenicities in the mouse and rat of some naturally occurring and synthetic alkenylbenzene derivatives related to safrole and estragole. Cancer Res 1983;43(3):1124-1134. View abstract.
- Park, S., Lee, D. K., and Yang, C. H. Inhibition of fos-jun-DNA complex formation by dihydroguaiaretic acid and in vitro cytotoxic effects on cancer cells. Cancer Lett. 5-15-1998;127(1-2):23-28. View abstract.
- Phillips, D. H., Reddy, M. V., and Randerath, K. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. II. Newborn male B6C3F1 mice. Carcinogenesis 1984;5(12):1623-1628. View abstract.
- Randerath, K., Haglund, R. E., Phillips, D. H., and Reddy, M. V. 32P-post-labelling analysis of DNA adducts formed in the livers of animals treated with safrole, estragole and other naturally-occurring alkenylbenzenes. I. Adult female CD-1 mice. Carcinogenesis 1984;5(12):1613-1622. View abstract.
- Sastre, J., Olmo, M., Novalvos, A., Ibanez, D., and Lahoz, C. Occupational asthma due to different spices. Allergy 1996;51(2):117-120. View abstract.
- Singh, A. and Singh, S. P. Modulatory potential of smokeless tobacco on the garlic, mace or black mustard-altered hepatic detoxication system enzymes, sulfhydryl content and lipid peroxidation in murine system. Cancer Lett. 9-16-1997;118(1):109-114. View abstract.
- Smith, R. L., Adams, T. B., Doull, J., Feron, V. J., Goodman, J. I., Marnett, L. J., Portoghese, P. S., Waddell, W. J., Wagner, B. M., Rogers, A. E., Caldwell, J., and Sipes, I. G. Safety assessment of allylalkoxybenzene derivatives used as flavouring substances - methyl eugenol and estragole. Food Chem.Toxicol 2002;40(7):851-870. View abstract.
- Yadav, A. S. and Bhatnagar, D. Free radical scavenging activity, metal chelation and antioxidant power of some of the Indian spices. Biofactors 2007;31(3-4):219-227. View abstract.
- Yadav, A. S. and Bhatnagar, D. Modulatory effect of spice extracts on iron-induced lipid peroxidation in rat liver. Biofactors 2007;29(2-3):147-157. View abstract.
- Abernethy MK, Becker LB. Acute nutmeg intoxication. Am J Emerg Med 1992;10:429-30. View abstract.
- Ahmad A, Thompson HS. Nutmeg mydriasis. JAMA. 1975;234(3):274. View abstract.
- Archer AW. Determination of safrole and myristicin in nutmeg and mace by high-performance liquid chromatography. J Chromatogr. 1988;438(1):117-21. View abstract.
- Barceloux DG. Nutmeg (Myristica fragrans Houtt.). Dis Mon. 2009;55(6):373-9. View abstract.
- Carstairs SD, Cantrell FL. The spice of life: an analysis of nutmeg exposures in California. Clin Toxicol (Phila) 2011;49:177-80. View abstract.
- Checker R, Chatterjee S, Sharma D, et al. Immunomodulatory and radioprotective effects of lignans derived from fresh nutmeg mace (Myristica fragrans) in mammalian splenocytes. Int Immunopharmacol. 2008;8(5):661-669. View abstract.
- Chhabra SK, Rao AR. Transmammary modulation of xenobiotic metabolizing enzymes in liver of mouse pups by mace (Myristica fragrans Houtt.). J Ethnopharmacol. 1994;42(3):169-77. View abstract.
- Dinakar HS. Acute psychosis associated with nutmeg toxicity. Med Times 1977;105:63-4.
- Duan L, Tao HW, Hao XJ, Gu QQ, Zhu WM. Cytotoxic and antioxidative phenolic compounds from the traditional Chinese medicinal plant, Myristica fragrans. Planta Med. 2009;75(11):1241-5. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
- Forrest JE, Heacock RA, Forrest TP. Diarylpropanoids from nutmeg and mace (Myristica fragrans Houtt.). J Chem Soc Perkin 1. 1974;2:205-9. View abstract.
- Forrest JE, Heacock RA, Forrest TP. Identification of the major components of the essential oil of mace. J Chromatography 1972;69(1):115-121. View abstract.
- Forrest JE, Heacock RA. A chromatographic comparison of the constituents of nutmeg and mace (Myristica fragrans Houtt.) with those of marihuana and hashish (Cannabis sativa L.). J Chromatogr. 1974;89(1):113-7. View abstract.
- Forrest JE, Heacock RA. Nutmeg and mace, the psychotropic spices from Myristica fragrans. Lloydia. 1972;35(4):440-449. View abstract.
- Fundarò A, Cassone MC. [Action of essential oils of chamomile, cinnamon, absinthium, mace and origanum on operant conditioning behavior of the rat]. Boll Soc Ital Biol Sper. 1980;56(22):2375-80. View abstract.
- Grover JK, Khandkar S, Vats V, Dhunnoo Y, Das D. Pharmacological studies on Myristica fragrans--antidiarrheal, hypnotic, analgesic and hemodynamic (blood pressure) parameters. Methods Find Exp Clin Pharmacol. 2002;24(10):675-80. View abstract.
- Hallstrom H, Thuvander A. Toxicological evaluation of myristicin. Nat Toxins 1997;5:186-92. View abstract.
- Hattori M, Hada S, Watahiki A, et al. Studies on dental caries prevention by traditional medicines. X. Antibacterial action of phenolic components from mace against Streptococcus mutans. Chem Pharm Bull (Tokyo). 1986;34(9):3885-93. View abstract.
- Hussain SP, Rao AR. Chemopreventive action of mace (Myristica fragrans, Houtt) on methylcholanthrene-induced carcinogenesis in the uterine cervix in mice. Cancer Lett. 1991;56(3):231-234. View abstract.
- Inder WJ, Swanney MP, Donald RA, et al. The effect of glycerol and desmopressin on exercise performance and hydration in triathletes. Med Sci Sports Exerc 1998;30:1263-9. View abstract.
- Jaiswal P, Singh DK. Molluscicidal activity of nutmeg and mace (Myristica fragrans Houtt.) against the vector snail Lymnaea acuminata. J Herbs Spices Medicinal Plant 2009;15(2):177-186.
- Jannu LN, Hussain SP, Rao AR. Chemopreventive action of mace (Myristica fragrans, Houtt) on DMBA-induced papillomagenesis in the skin of mice. Cancer Lett. 1991;56(1):59-63. View abstract.
- Jeong HG, Lee SS, Kim HK, Yang KH. Murine Cyp1a-1 induction in mouse hepatoma Hepa-1C1C7 cells by myristicin. Biochem Biophys Res Commun. 1997;233(3):619-22. View abstract.
- Jeong HG, Yun CH. Induction of rat hepatic cytochrome P450 enzymes by myristicin. Biochem Biophys Res Commun 1995;217:966-71. View abstract.
- Kumari MV, Rao AR. Effects of mace (Myristica fragrans, Houtt.) on cytosolic glutathione S-transferase activity and acid soluble sulfhydryl level in mouse liver. Cancer Lett. 1989;46(2):87-91. View abstract.
- Lee BK, Kim JH, Jung JW, et al. Myristicin-induced neurotoxicity in human neuroblastoma SK-N-SH cells. Toxicol Lett. 2005;157(1):49-56. View abstract.
- Lee HS, Jeong TC, Kim JH. In vitro and in vivo metabolism of myristicin in the rat. J Chromatogr B Biomed Sci Appl. 1998;705(2):367-72. View abstract.
- Leiter E, Hitchcock G, Godwin S, et al. Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat. AANA J. 2011;79(2):109-14. View abstract.
- Maloney C. Indonesia's great frontier and migration policy. UFSI Rep. 1987;(30):1-11. View abstract.
- Maya KM, Zachariah TJ, Krishnamoorthy B. Chemical composition of essential oil of nutmeg (Myristica frangrans Houtt.) accessions. J Spices Aromatic Crops 2004;13(2):135-139.
- McKenna A, Nordt SP, Ryan J. Acute nutmeg poisoning. Eur J Emerg Med 2004;11:240-1. View abstract.
- Nakamura N, Kiuchi F, Tsuda Y, Kondo K. Studies on crude drugs effective on visceral larva migrans. V. The larvicidal principle in mace (aril of Myristica fragrans). Chem Pharm Bull (Tokyo). 1988;36(7):2685-8. View abstract.
- Orabi KY, Mossa JS, el Feraly FS. Isolation and characterization of two antimicrobial agents from mace (Myristica fragrans). J.Nat.Prod. 1991;54(3):856-859. View abstract.
- Oswald EO, Fishbein L, Corbett BJ, Walker MP. Urinary excretion of tertiary amino methoxy methylenedioxy propiophenones as metabolites of myristicin in the rat and guinea pig. Biochim Biophys Acta. 1971;244(2):322-8.
- Ozaki Y, Soedigdo S, Wattimena YR, Suganda AG. Antiinflammatory effect of mace, aril of Myristica fragrans Houtt., and its active principles. Jpn.J.Pharmacol. 1989;49(2):155-163. View abstract.
- Panayotopoulos DJ, Chisholm DD. Hallucinogenic effect of nutmeg. Br Med J 1970;1:754. View abstract.
- Paul S, Hwang JK, Kim HY, Jeon WK, Chung C, Han JS. Multiple biological properties of macelignan and its pharmacological implications. Arch Pharm Res. 2013;36(3):264-72. View abstract.
- Pooja V, Sanwal H, Goyal A, Sandashwani AB, Srivastava AK. Activity of Myristica frangrans and its effect against filamentous and non-filamentous fungus. Int J Pharm Pharmaceut Sci 2011;4(1):17-20.
- Randerath K, Putman KL, Randerath E. Flavor constituents in cola drinks induce hepatic DNA adducts in adult and fetal mice. Biochem Biophys Res Commun. 1993;192(1):61-8. View abstract.
- Sangalli BC, Chiang W. Toxicology of nutmeg abuse. Clin Toxicol 2000;38:671-8. View abstract.
- Sell AB, Carlini EA. Anesthetic action of methyleugenol and other eugenol derivatives. Pharmacology. 1976;14(4):367-77. View abstract.
- Shulgin AT. Possible implication of myristicin as a psychotropic substance. Nature. 1966;210(5034):380-4. View abstract.
- Stein U, Greyer H, Hentschel H. Nutmeg (myristicin) poisoning-report on a fatal case and a series of cases recorded by a poison information centre. Forensic Sci Int 2001;118:87-90. View abstract.
- Uragoda CG. Symptoms in spice workers. J Trop Med Hyg. 1992;95(2):136-9. View abstract.
- Van Gils C, Cox PA. Ethnobotany of nutmeg in the Spice Islands. J Ethnopharmacol. 1994;42(2):117-24. View abstract.
- Venables GS, Evered D, Hall R. Letter: Nutmeg poisoning. Br Med J 1976;1:96. View abstract.
- Yoshinuma N, Nozawa T, Okutsu S, et al. [Clinical effects of chewing gum containing egg-white lysozyme and mace extract]. Nihon Shishubyo Gakkai Kaishi. 1989;31(3):941-7. View abstract.
- Yun CH, Lee HS, Lee HY, et al. Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin. Toxicol Lett. 2003;137(3):143-50. View abstract.
Have you ever purchased MACE?
Did you or will you purchase this product in-store or online?
Where did you or where do you plan to purchase this product?
Where did you or where do you plan to purchase this product?
What factors influenced or will influence your purchase? (check all that apply)
Where did you or where do you plan to purchase this product?
Do you buy vitamins online or instore?
What factors are most important to you? (check all that apply)