GOAT'S RUE

OTHER NAME(S):

Faux-Indigo, French Honeysuckle, French Lilac, Galega, Galéga, Galéga Officinal, Galega bicolor, Galega officinalis, Galega patula, Galegae Officinalis Herba, Geissrautenkraut, Goat's Rue Herb, Italian Fitch, Lavan&egrave;se, Lilas d’Espagne, Lilas Français, Rue-de-Ch&egrave;vre, Rue des Ch&egrave;vres, Sainfoin d’Espagne.<br/><br/>

Overview

Overview Information

Goat's rue is a plant. The parts that grow above the ground are used to make medicine. Be careful not to confuse goat's rue (Galega officinalis) with rue (Ruta graveolens).

Goat's rue is used along with conventional treatment for diabetes and as a diuretic.

In combination with other herbs, goat's rue is used to stimulate the adrenal gland and pancreas; to protect the liver; for digestion problems; and to start the flow of breast milk. Some people use herbal combinations that include goat’s rue as a tonic and for “blood purification.”

How does it work?

Goat's rue contains a chemical that may lower blood sugar in a test tube. But it is unclear if goat's rue has this effect when taken by people.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Diabetes.
  • Blood purification.”
  • Digestive problems.
  • Other uses.
More evidence is needed to rate the effectiveness of goat's rue for these uses.

Side Effects

Side Effects & Safety

There isn't enough information to know whether goat's rue is safe. No harmful effects have been reported in humans, but fatal poisoning has occurred in grazing animals that ate large quantities of goat's rue.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking goat’s rue if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

Bleeding conditions: Goat’s rue might slow blood clotting and increase the risk of bleeding. In theory, goat’s rue might make bleeding disorders worse.

Diabetes: Goat's rue might lower blood sugar levels in some people. Watch for signs of low blood sugar (hypoglycemia) and monitor your blood sugar carefully if you have diabetes and use goat’s rue.

Surgery: Goat's rue might affect blood sugar levels. There is concern that it might interfere with blood sugar control during and after surgery. Stop using goat’s rue at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications for diabetes (Antidiabetes drugs) interacts with GOAT'S RUE

    Goat's rue might decrease blood sugar. Diabetes medications are also used to lower blood sugar. Taking goat's rue along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.<br /> Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Dosing

Dosing

The appropriate dose of goat's rue depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for goat's rue. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Petricic, J. and Kalodera, Z. Galegin in the goat's rue herb: toxicity, antidiabetic activity and content determination. Acta Pharm Jugosl 1982;32:219-223.
  • PUFAHL, K. and SCHREIBER, K. [Isolation of a new guanidine derivative from goat's rue, Galega officinalis L.]. Experientia 7-15-1961;17:302-303. View abstract.
  • Atanasov, A. T. and Spasov, V. Inhibiting effect of desalted extract from Galega officinalis L. on platelet aggregation. Folia Med.(Plovdiv.) 1999;41(1):46-50. View abstract.
  • Atanasov, A. T. and Tchorbanov, B. Anti-platelet fraction from Galega officinalis L. inhibits platelet aggregation. J.Med.Food 2002;5(4):229-234. View abstract.
  • Atanasov, A. T. and Tchorbanov, B. J. Antiplatelet aggregation activity of a fraction isolated from Galega officinalis L. J Herbs Spices Medicinal Plant 2002;10(2):63-71.
  • Atanasov, A. T. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Medicinal Plant 1995;3:71-76.
  • Atanasov, A. T., Chorbanov, B. P., and Dimitrov, B. D. Anti-aggregation activity of crude water extract of Galega officinalis L. fractionated on Sephadex G-25 and Sepharose 4B. Folia Med.(Plovdiv.) 2002;44(1-2):45-49. View abstract.
  • Bailey, C. J. and Day, C. Metformin: its botanical background. Pract Diab Int 2004;21(3):115-117.
  • Barger, G. and White, F. D. Galuteolin, a New Glucoside from Galega Officinalis. Biochem.J 1923;17(6):836-838. View abstract.
  • Cavaliere, C. Glucophage: Diabetic drug based on traditional herb celebrates 50 years of use. HerbalGram 2008;76:44-49.
  • Champavier, Y., Allais, D. P., Chulia, A. J., and Kaouadji, M. Acetylated and non-acetylated flavonol triglycosides from Galega officinalis. Chem.Pharm Bull.(Tokyo) 2000;48(2):281-282. View abstract.
  • FERRARI, G. [New method of preparation of galegine from the seeds of Galega officinalis.]. Farmaco 1950;5(5):544-545. View abstract.
  • Gonzalez-Andres, F., Redondo, P. A., Pescador, R., and Urbano, B. Management of Galega officinalis L. and preliminary results on its potential for milk production improvement in sheep. New Zealand Journal of Agricultural Research 2004;47:233-245.
  • Hadden, D. R. Goat's rue - French lilac - Italian fitch - Spanish sainfoin: gallega officinalis and metformin: the Edinburgh connection. J R.Coll.Physicians Edinb. 2005;35(3):258-260. View abstract.
  • Keeler, R. F., Baker, D. C., and Evans, J. O. Individual animal susceptibility and its relationship to induced adaptation or tolerance in sheep to Galega officinalis L. Vet.Hum.Toxicol. 1988;30(5):420-423. View abstract.
  • Keeler, R. F., Baker, D. C., and Panter, K. E. Concentration of galegine in Verbesina encelioides and Galega oficinalis and the toxic and pathologic effects induced by the plants. J Environ.Pathol.Toxicol.Oncol. 1992;11(2):11-17. View abstract.
  • Keeler, R. F., Johnson, A. E., Stuart, L. D., and Evans, J. O. Toxicosis from and possible adaptation to Galega officinalis in sheep and the relationship to Verbesina encelioides toxicosis. Vet.Hum.Toxicol. 1986;28(4):309-315. View abstract.
  • LAPYNINA, L. A. [ON FLAVONOID COMPOSITION OF GALEGA OFFICINALIS.]. Farm.Zh. 1965;20:57-62. View abstract.
  • Misbin, R. I. The phantom of lactic acidosis due to metformin in patients with diabetes. Diabetes Care 2004;27(7):1791-1793. View abstract.
  • Mooney, M. H., Fogarty, S., Stevenson, C., Gallagher, A. M., Palit, P., Hawley, S. A., Hardie, D. G., Coxon, G. D., Waigh, R. D., Tate, R. J., Harvey, A. L., and Furman, B. L. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br.J Pharmacol. 2008;153(8):1669-1677. View abstract.
  • Neef, H., Augustijns, P., Declercq, P., Declerck, P. J., and Laekeman, G. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells. Pharmaceutical and Pharmacological Letters 1996;6:86-89.
  • Palit, P., Furman, B. L., and Gray, A. I. Novel weight-reducing activity of Galega officinalis in mice. J Pharm Pharmacol. 1999;51(11):1313-1319. View abstract.
  • Pundarikakshudu, K., Patel, J. K., Bodar, M. S., and Deans, S. G. Anti-bacterial activity of Galega officinalis L. (Goat's Rue). J Ethnopharmacol. 2001;77(1):111-112. View abstract.
  • Puyt, J. D., Faliu, L., Keck, G., Gedfrain, J. C., Pinault, L., and Tainturier, D. Fatal poisoning of sheep by Galega officinalis (French honeysuckle). Vet.Hum.Toxicol. 1981;23(6):410-412. View abstract.
  • Rasekh, H. R., Nazari, P., Kamli-Nejad, M., and Hosseinzadeh, L. Acute and subchronic oral toxicity of Galega officinalis in rats. J Ethnopharmacol. 2-28-2008;116(1):21-26. View abstract.
  • Reuter, G. [ARGININE AS THE FIRST STAGE OF GALEGINE IN GALEGA OFFICINALIS L. ON THE BIOCHEMISTRY AND PHYSIOLOGY OF GALEGINE IN GALEGA OFFICINALIS L. III.]. Arch.Pharm (Weinheim) 1963;296:516-522. View abstract.
  • Reuter, G. and Barthel, A. [Guanidino-acetic acid as precursor of galegin in Galega officinalis L]. Pharmazie 1967;22(5):261. View abstract.
  • Reuter, G., Barthel, A., and Steiniger, J. [Metabolism of guanidine acetic acid in Galega officinalis L]. Pharmazie 1969;24(6):358. View abstract.
  • Schafer, J. and Stein, M. [On the variability of substances contained in the goat's rue (Galega officinalis L.)]. Naturwissenschaften 1967;54(8):205. View abstract.
  • SCHREIBER, K., AURICH, O., and PUFAHL, K. [Isolation of peganine from goat's-rue, Galega officinalis L.]. Arch.Pharm 1962;295/67:271-275. View abstract.
  • Vuksan, V. and Sievenpiper, J. L. Herbal remedies in the management of diabetes: lessons learned from the study of ginseng. Nutr.Metab Cardiovasc.Dis. 2005;15(3):149-160. View abstract.
  • Atanasov AT. Effect of Galega officinalis L. extract on platelet aggregation in rats. J Herbs Spices Med Plants 1995;3:71-6.
  • Huxtable CR, Dorling RR, Colegate SM. Identification of galegine, an isoprenyl guanidine, as the toxic principle of Schoenus asperocarpus (poison sedge). Aust Vet J 1993;70:169-71. View abstract.
  • Lemus, I., Garcia, R., Delvillar, E., and Knop, G. Hypoglycaemic activity of four plants used in Chilean popular medicine. Phytother Res 1999;13(2):91-94. View abstract.
  • Neef H, Augustijns P, Declercq P, et al. Inhibitory effects of Galega officinalis on glucose transport across monolayers of human intestinal epithelial cells (Caco-2). Pharm Pharmacol Lett 1996;6:86-9.
  • Atanasov, A. T. and Spasov, V. Inhibiting and disaggregating effect of gel-filtered Galega officinalis L. herbal extract on platelet aggregation. J.Ethnopharmacol. 2000;69(3):235-240. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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