LYSINE

OTHER NAME(S):

Hydrochlorure de L-Lysine, L-2,6-diaminohexanoic acid, L-Lysine, L-Lysine HCl, L-Lysine Hydrochloride, L-Lysine Monohydrochloride, Lisina, Lys, Lysine Hydrochloride, Lysine Monohydrochloride, Monochlohydrate de L-Lysine, Monochlohydrate de Lysine.<br/><br/>

Overview

Overview Information

Lysine is an amino acid (building block of protein). People use it to make medicine.

Lysine is used for preventing and treating cold sores (caused by the virus called herpes simplex labialis). It is taken by mouth or applied directly to the skin for this use.

Lysine is also taken by mouth to improve athletic performance.

How does it work?

Lysine seems to prevent the herpes virus from growing.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Cold sores (herpes simplex labialis). Research suggests that lysine seems to reduce cold sores when taken by mouth and also when applied as a cream to the skin. However, some research suggests that it does not reduce the severity or recurrence of cold sores.

Insufficient Evidence for

  • Canker sores. Early research suggests that taking 500 mg of lysine daily prevents canker sores and 4000 mg daily decreases the length of canker sores.
  • Diabetes. Some evidence shows that taking lysine daily for 2 months does not affect bloodsugar levels in people with diabetes. However, other early research suggests that taking lysine twice daily for 2 months decreases blood sugar levels compared to before treatment in diabetes patients.
  • Stress. Early research suggests that eating wheat that contains added lysine reduces stress in females and anxiety in males.
  • Improving athletic performance.
More evidence is needed to rate the effectiveness of lysine for this use.

Side Effects

Side Effects & Safety

Lysine is POSSIBLY SAFE for most people when taken by mouth at recommended doses for up to one year, or when applied to the skin short-term. It can cause side effects such as stomach pain and diarrhea.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking lysine if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Kidney disease: There is one report of kidney disease linked with taking lysine supplements. If you have a kidney disease, check with your healthcare provider before taking lysine.

Osteoporosis: Using Lysine with calcium supplements might increase calcium absorption.

Intolerance to lysinuric protein: Lysine supplementation might cause diarrhea and stomach cramps in children who are intolerant to lysinuric protein.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Calcium supplements interacts with LYSINE

    Lysine can increase how much calcium the body absorbs. Taking calcium along with lysine can increase the amount of calcium in the body. Avoid taking large amounts of calcium and lysine at the same time.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For cold sores (herpes simplex labialis): 1000 mg daily for 12 months and 1000 mg three times daily for 6 months.
APPLIED TO THE SKIN:
  • For treating cold sores (herpes simplex labialis): a specific combination of lysine plus zinc oxide and 14 other ingredients (Super Lysine Plus +) applied every 2 hours for 11 days has been used.

View References

REFERENCES:

  • Kaminaga T, Yasukawa K, Kanno H, et al. Inhibitory effects of lanostane-type triterpene acids, the components of Poria cocos, on tumor promotion by 12-O tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin. Oncology 1996;53:382-5. View abstract.
  • McCune MA, Perry HO, Muller SA, O'Fallon WM. Treatment of recurrent herpes simplex infections with L-lysine monohydrochloride. Cutis 1984;34:366-73. View abstract.
  • Messina V. Nutritional and health benefits of dried beans. Am J Clin Nutr. 2014 Jul;100 Suppl 1:437S-42S. View abstract.
  • Milman N, Scheibel J, Jessen O. Lysine prophylaxis in recurrent herpes simplex labialis: a double-blind, controlled crossover study. Acta Derm Venereol 1980;60:85-7. View abstract.
  • Natarajan Sulochana K., Lakshmi, S., Punitham, R., Arokiasamy, T., Sukumar, B., and Ramakrishnan, S. Effect of oral supplementation of free amino acids in type 2 diabetic patients-- a pilot clinical trial. Med Sci Monit. 2002;8(3):CR131-CR137. View abstract.
  • Cuellar MJ, Giner RM, Recio MC, et al. Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions. Chem Pharm Bull (Tokyo) 1997;45:492-4. View abstract.
  • Fuchs SM, Heinemann C, Schliemann-Willers S, Härtl H, Fluhr JW, Elsner P. Assessment of anti-inflammatory activity of Poria cocos in sodium lauryl sulphate-induced irritant contact dermatitis. Skin Res Technol. 2006 Nov;12(4):223-7. View abstract.
  • Gong QM, Wang SL, Gan C. [A clinical study on the treatment of acute upper digestive tract hemorrhage with wen-she decoction]. Chung Hsi I Chieh Ho Tsa Chih 1989;9:272-3, 260. View abstract.
  • Hattori T, Hayashi K, Nagao T, et al. Studies on antinephritic effects of plant components (3): Effect of pachyman, a main component of Poria cocos Wolf on original-type anti-GBM nephritis in rats and its mechanisms. Jpn J Pharmacol 1992;59:89-96. View abstract.
  • Jang TR, Kao MF, Chen CH, Hsieh KC, Lai WY, Chen YY. Alleviating effects of dehydration under no hyperthermia on the immunomodulatory response to the polysaccharide fraction from fu-ling (Poria cocos) in male collegiate wrestlers. Chin Med J (Engl). 2011 Feb;124(4):530-6. View abstract.
  • Lukkarinen M, Näntö-Salonen K, Pulkki K, Aalto M, Simell O. Oral supplementation corrects plasma lysine concentrations in lysinuric protein intolerance. Metabolism. 2003 Jul;52(7):935-8. View abstract.
  • Lo JC, Chertow GM, Rennke H, Seifter JL. Fanconi's syndrome and tubulointerstitial nephritis in association with L-lysine ingestion. Am J Kidney Dis 1996;28:614-7. View abstract.
  • Rajantie J, Simell O, Rapola J, Perheentupa J. Lysinuric protein intolerance: a two-year trial of dietary supplementation therapy with citrulline and lysine. J Pediatr. 1980 Dec;97(6):927-32. View abstract.
  • Singh BB, Udani J, Vinjamury Sp, et al. Safety and effectiveness of an L-lysine, zinc, and herbal-based product on the treatment of facial and circumoral herpes. Altern Med Rev 2005;10:123-7. View abstract.
  • Smriga M, Ghosh S, Mouneimne Y, et al. Lysine fortification reduces anxiety and lessens stress in family members in economically weak communities in Northwest Syria. Proc.Natl.Acad.Sci.U.S.A 6-1-2004;101(22):8285-8288. View abstract.
  • Smriga M, Torii K. L-Lysine acts like a partial serotonin receptor 4 antagonist and inhibits serotonin-mediated intestinal pathologies and anxiety in rats. Proc Natl Acad Sci U S A. 2003 Dec 23;100(26):15370-5. View abstract.
  • Sulochana KN, Rajesh M, Ramakrishnan S. Insulin receptor tyrosine kinase activity in monocytes of type 2 diabetes mellitus patients receiving oral L-lysine. Indian J Biochem Biophys. 2001 Oct;38(5):331. View abstract.
  • Thein DJ, Hurt WC. Lysine as a prophylactic agent in the treatment of recurrent herpes simplex labialis. Oral Surg Oral Med Oral Pathol 1984;58:659-66. View abstract.
  • Unni US, , Raj T, , Sambashivaiah S, , Kuriyan R, , Uthappa S, , Vaz M, , Regan MM, , Kurpad AV. The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, , insulin sensitivity and leucine kinetics in young men. Clin Nutr. 2012 Dec;31(6):903-10. View abstract.
  • Walsh DE, Griffith RS, and Behforooz A. Subjective response to lysine in the therapy of herpes simplex. J.Antimicrob.Chemother. 1983;12(5):489-496. View abstract.
  • Wass C, , Klamer D, , Katsarogiannis E, , Pålsson E, , Svensson L, , Fejgin K, , Bogren IB, , Engel JA, , Rembeck B. L-lysine as adjunctive treatment in patients with schizophrenia: a single-blinded, , randomized, , cross-over pilot study. BMC Med. 2011 Apr 18;9:40. View abstract.
  • Wright EF. Clinical effectiveness of lysine in treating recurrent aphthous ulcers and herpes labialis. Gen.Dent. 1994;42(1):40-42. View abstract.
  • Wu G. Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition. J Anim Sci Biotechnol. 2014 Jun 14;5(1):34. View abstract.
  • Zeinoddini A, , Ahadi M, , Farokhnia M, , Rezaei F, , Tabrizi M, , Akhondzadeh S. L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, , placebo-controlled, , randomized trial. J Psychiatr Res. 2014 Dec;59:125-31. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.