LYSINE

OTHER NAME(S):

Hydrochlorure de L-Lysine, L-2,6-diaminohexanoic acid, L-Lysine, L-Lysine HCl, L-Lysine Hydrochloride, L-Lysine Monohydrochloride, Lisina, Lys, Lysine Hydrochloride, Lysine Monohydrochloride, Monochlohydrate de L-Lysine, Monochlohydrate de Lysine.<br/><br/>

Overview

Overview Information

Lysine is an amino acid (building block of protein). People use it to make medicine.

Lysine is used for preventing and treating cold sores (caused by the virus called herpes simplex labialis). It is taken by mouth or applied directly to the skin for this use.

Lysine is also taken by mouth to improve athletic performance.

How does it work?

Lysine seems to prevent the herpes virus from growing.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Cold sores (herpes simplex labialis). Research suggests that lysine seems to reduce cold sores when taken by mouth and also when applied as a cream to the skin. However, some research suggests that it does not reduce the severity or recurrence of cold sores.

Insufficient Evidence for

  • Canker sores. Early research suggests that taking 500 mg of lysine daily prevents canker sores and 4000 mg daily decreases the length of canker sores.
  • Diabetes. Some evidence shows that taking lysine daily for 2 months does not affect bloodsugar levels in people with diabetes. However, other early research suggests that taking lysine twice daily for 2 months decreases blood sugar levels compared to before treatment in diabetes patients.
  • Stress. Early research suggests that eating wheat that contains added lysine reduces stress in females and anxiety in males.
  • Improving athletic performance.
More evidence is needed to rate the effectiveness of lysine for this use.

Side Effects

Side Effects & Safety

Lysine is POSSIBLY SAFE for most people when taken by mouth at recommended doses for up to one year, or when applied to the skin short-term. It can cause side effects such as stomach pain and diarrhea.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking lysine if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Kidney disease: There is one report of kidney disease linked with taking lysine supplements. If you have a kidney disease, check with your healthcare provider before taking lysine.

Osteoporosis: Using Lysine with calcium supplements might increase calcium absorption.

Intolerance to lysinuric protein: Lysine supplementation might cause diarrhea and stomach cramps in children who are intolerant to lysinuric protein.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Calcium supplements interacts with LYSINE

    Lysine can increase how much calcium the body absorbs. Taking calcium along with lysine can increase the amount of calcium in the body. Avoid taking large amounts of calcium and lysine at the same time.

Dosing

Dosing

The following doses have been studied in scientific research:

BY MOUTH:

  • For cold sores (herpes simplex labialis): 1000 mg daily for 12 months and 1000 mg three times daily for 6 months.
APPLIED TO THE SKIN:
  • For treating cold sores (herpes simplex labialis): a specific combination of lysine plus zinc oxide and 14 other ingredients (Super Lysine Plus +) applied every 2 hours for 11 days has been used.

View References

REFERENCES:

  • Zeinoddini A, , Ahadi M, , Farokhnia M, , Rezaei F, , Tabrizi M, , Akhondzadeh S. L-lysine as an adjunct to risperidone in patients with chronic schizophrenia: a double-blind, , placebo-controlled, , randomized trial. J Psychiatr Res. 2014 Dec;59:125-31. View abstract.
  • Wei W, Shu S, Zhu W, Xiong Y, Peng F. The Kinome of Edible and Medicinal Fungus Wolfiporia cocos. Front Microbiol. 2016 Sep 21;7:1495. View abstract.
  • Yang DJ. [Tinnitus treated with combined traditional Chinese medicine and Western medicine]. Chung Hsi I Chieh Ho Tsa Chih 1989;9:270-1, 259-60. View abstract.
  • Yasukawa K, Kaminaga T, Kitanaka S, et al. 3 beta-p-hydroxybenzoyldehydrotumulosic acid from Poria cocos, and its anti-inflammatory effect. Phytochemistry 1998;48:1357-60. View abstract.
  • Wu G. Dietary requirements of synthesizable amino acids by animals: a paradigm shift in protein nutrition. J Anim Sci Biotechnol. 2014 Jun 14;5(1):34. View abstract.
  • Wright EF. Clinical effectiveness of lysine in treating recurrent aphthous ulcers and herpes labialis. Gen.Dent. 1994;42(1):40-42. View abstract.
  • [The effect of L-lysine added to diet on growth and development of normal children (author's transl)]. Zhonghua Yi.Xue.Za Zhi. 1982;62(1):11-12. View abstract.
  • Doraiswamy, T. R., Singh, N., and Daniel, V. A. Effects of supplementing ragi (Eleusine coracana) diets with lysine or leaf protein on the growth and nitrogen metabolism of children. Br.J.Nutr. 1969;23(4):737-743. View abstract.
  • Heinrichs, W., Fauth, U., Seufert, W., and Halmagyi, M. [Effect of L-lysine-induced amino acid imbalance on nitrogen balance in patients treated by total parenteral nutrition]. Infusionsther.Klin.Ernahr. 1987;14(6):252-255. View abstract.
  • Kagan, C. Letter: Lysine therapy for herpes simplex. Lancet 1-26-1974;1(7848):137. View abstract.
  • Matsuda, I., Arashima, S., Imanishi, Y., Yamamoto, J., Akaboshi, I., Shinozuka, S., and Nagata, N. Lysine intolerance in a variant form of citrullinemia. Pediatr.Res. 1979;13(10):1134-1136. View abstract.
  • Metges, C. C., Eberhard, M., and Petzke, K. J. Synthesis and absorption of intestinal microbial lysine in humans and non-ruminant animals and impact on human estimated average requirement of dietary lysine. Curr Opin Clin Nutr Metab Care 2006;9(1):37-41. View abstract.
  • Miller, C. S. and Foulke, C. N. Use of lysine in treating recurrent oral herpes simplex infections. Gen.Dent. 1984;32(6):490-493. View abstract.
  • Milman, N., Jessen, O., and Scheibel, J. [Lysine therapy of recurrent herpes simplex labialis]. Ugeskr.Laeger 10-22-1979;141(43):2960-2962. View abstract.
  • Milman, N., Scheibel, J., and Jessen, O. Failure of lysine treatment in recurrent herpes simplex labialis. Lancet 10-28-1978;2(8096):942. View abstract.
  • Pellett, P. L. and Ghosh, S. Lysine fortification: past, present, and future. Food Nutr.Bull. 2004;25(2):107-113. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.