Angipars, Casse Lunettes, Common Melilot, Couronne Royale, Field Melilot, Hart's Tree, Hay Flower, Herbe aux Puces, King's Clover, Luzerne Bâtarde, Melilot, Mélilot, Mélilot des Champs, Mélilot Commun, Mélilot Jaune, Mélilot Officinal, Mélilot Vulgaire, Meliloti Herba, Meliloto, Melilotus, Melilotus altissimus, Melilotus arvensis, Melilotus macrorrhizus, Melilotus officinalis, Melilotus vulgaris, Petit-Trèfle Jaune, Pratelle, Sweet Lucerne, Sweet Melilot, Tall Melilot, Thé de Jardin, Trébol de Olor, Trèfle des Mouches, Trifolium macrorrhizum, Trifolium officinale, Wild Laburnum, Yellow Melilot, Yellow Sweet Clover.


Overview Information

Sweet clover is an herb. The flowering branches and leaves are used to make medicine. Be careful not to confuse sweet clover with red clover.

Sweet clover is commonly used by mouth to increase the loss of water from the body through the urine (as a diuretic). It is also used for varicose veins and to relieve symptoms of poor blood circulation (chronic venous insufficiency) including leg pain and heaviness, nerve pain in people with diabetes, and fluid retention (edema). However, there is limited scientific research to support these and other uses of sweet clover.

How does it work?

Sweet clover contains ingredients that can thin the blood and help wounds heal.


Uses & Effectiveness?

Insufficient Evidence for

  • Problems with circulation including leg cramps and swelling (chronic venous insufficiency). Sweet clover might help with symptoms of chronic venous insufficiency, but better studies are needed to be sure.
  • Nerve pain associated with diabetes. Taking sweet clover extract does not seem to help with nerve pain in patient with diabetes, but better studies are needed to be sure.
  • Bruises, when applied to the skin.
  • Hemorrhoids.
  • Varicose veins.
  • Water retention (edema).
  • Other conditions.
More evidence is needed to rate the effectiveness of sweet clover for these uses.

Side Effects

Side Effects & Safety

Sweet clover is POSSIBLY SAFE for most people when used appropriately. It is POSSIBLY UNSAFE when used in large amounts due to the risk for liver damage and bleeding problems.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of sweet clover during pregnancy and breast-feeding. Stay on the safe side and avoid use until more is known.

Liver disease: There is some concern that sweet clover might make liver disease worse. If you have liver problems, get medical advice before starting sweet clover. Also, be sure to have liver function tests done.

Surgery: Sweet clover might slow blood clotting. Some physicians worry that it might increase bleeding during or after surgery. Stop using sweet clover at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Medications that can harm the liver (Hepatotoxic drugs) interacts with SWEET CLOVER

    Large amounts of sweet clover might harm the liver. Taking sweet clover along with medication that can harm the liver can increase the risk of liver damage. Do not take sweet clover if you are taking medications that can harm the liver.

    Some medications that can harm the liver include acetaminophen (Tylenol and others), amiodarone (Cordarone), carbamazepine (Tegretol), isoniazid (INH), methotrexate (Rheumatrex), methyldopa (Aldomet), fluconazole (Diflucan), itraconazole (Sporanox), erythromycin (Erythrocin, Ilosone, others), phenytoin (Dilantin), lovastatin (Mevacor), pravastatin (Pravachol), simvastatin (Zocor), and many others.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with SWEET CLOVER

    Sweet clover might slow blood clotting. Taking sweet clover along with medications that also slow clotting might increase the chances of bruising and bleeding.

    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



The appropriate dose of sweet clover depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for sweet clover. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Bakhshayeshi S, Madani SP, Hemmatabadi M, et al. Effects of Semelil (ANGIPARS) on diabetic peripheral neuropathy: a randomized, double-blind placebo-controlled clinical trial. Daru: Journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2011;19(1):65.
  • Cornara L, Xiao J, Burlando B. Therapeutic potential of temperate forage legumes: a review. Crit Rev Food Sci Nutr 2016;56 Suppl 1:S149-61. View abstract.
  • Hogan RP III. Hemorrhagic diathesis caused by drinking an herbal tea. JAMA 1983;249:2679-80.
  • Tamura S, Warabi Y, Matsubara S. Severe liver dysfunction possibly caused by the combination of interferon beta-1b therapy and melilot (sweet clover) supplement. J Clin Pharm Ther 2012;37(6):724-5. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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