JIAOGULAN - Uses, Side Effects, and More

Chen, J. C., Chung, J. G., and Chen, L. D. Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells. Cytobios 1999;100(393):37-48. View abstract.

Chen, J. C., Lu, K. W., Lee, J. H., Yeh, C. C., and Chung, J. G. Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. Anticancer Res 2006;26(6B):4313-4326. View abstract.

Chou, S. C., Chen, K. W., Hwang, J. S., Lu, W. T., Chu, Y. Y., Lin, J. D., Chang, H. J., and See, L. C. The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease. Altern Ther Health Med 2006;12(3):34-39. View abstract.

Han, M. Q., Liu, J. X., and Gao, H. [Effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(3):147-149. View abstract.

Hou, J., Liu, S., Ma, Z., Lang, X., Wang, J., Wang, J., and Liang, Z. Effects of gynostemma pentaphyllum makino on the immunological function of cancer patients. J.Tradit.Chin Med. 1991;11(1):47-52. View abstract.

Huang, T. H., Li, Y., Razmovski-Naumovski, V., Tran, V. H., Li, G. Q., Duke, C. C., and Roufogalis, B. D. Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. J Biomed Sci 2006;13(4):535-548. View abstract.

Huang, T. H., Razmovski-Naumovski, V., Salam, N. K., Duke, R. K., Tran, V. H., Duke, C. C., and Roufogalis, B. D. A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum. Biochem Pharmacol 11-1-2005;70(9):1298-1308. View abstract.

Liu, X., Ye, W., Mo, Z., Yu, B., Wu, H., Zhao, S., Che, C., and Hsiao, W. L. Three dammarane-type saponins from Gynostemma pentaphyllum. Planta Med 2005;71(9):880-884. View abstract.

Takagi, J., Imada, T., Kikuchi, T., Saito, Y., and Inada, Y. A new platelet aggregation factor from Gynostemma pentaphyllum Makino. Chem.Pharm.Bull.(Tokyo) 1985;33(12):5568-5571. View abstract.

Wang, Q. F., Chen, J. C., Hsieh, S. J., Cheng, C. C., and Hsu, S. L. Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Lett 9-26-2002;183(2):169-178. View abstract.

Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8.. View abstract.

Chiranthanut N, Teekachunhatean S, Panthong A, Khonsung P, Kanjanapothi D, Lertprasertsuk N. Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino. J Ethnopharmacol. 2013 Aug 26;149(1):228-34. doi: 10.1016/j.jep.2013.06.027. View abstract.

Choi EK, Won YH, Kim SY, et al. Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 2019;52:198-205. View abstract.

Hu X, et al. Antilipemic effect of Gynostemma pentaphyllum in patients. Fujian Med J 1988;10:4-6.

Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7. View abstract.

Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383. View abstract.

Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313. View abstract.

la Cour B, Molgaard P, Yi Z. Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol 1995;46:125-9. View abstract.

Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. View abstract.

Lin L, Lau BH. Protection of vascular endothelial cells from hydrogen peroxide-induced oxidant injury by gypenosides, saponins, of Gynostemma pentaphyllum. Phytother Res 1993;7:299-304.

Lokman EF, Gu HF, Wan Mohamud WN, Östenson CG. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evid Based Complement Alternat Med. 2015;2015:120572. doi: 10.1155/2015/120572. View abstract.

Mastinu A, Bonini SA, Premoli M, et al. Protective effects of Gynostemma pentaphyllum (var. Ginpent) against lipopolysaccharide-induced inflammation and motor alteration in mice. Molecules 2021;26(3):570. View abstract.

Park SH, Huh TL, Kim SY, Oh MR, Tirupathi Pichiah PB, Chae SW, Cha YS. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial. Obesity (Silver Spring). 2014 Jan;22(1):63-71. doi: 10.1002/oby.20539. Epub 2013 Sep 5. View abstract.

Rao A, Clayton P, Briskey D. The effect of an orally-dosed Gynostemma pentaphyllum extract (ActivAMP®) on body composition in overweight, adult men and women: a double-blind, randomised, placebo-controlled study. J Hum Nutr Diet 2021. View abstract.

Takagi J, Imada T, Kikuchi T, et al. A new platelet aggregation factor from gynostemma pentaphyllum Makino. Chem Pharm Bull (Tokyo) 1985;33:5568-71.

Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80. View abstract.

Wang Z, Zhao X, Liu X, et al. Anti-diabetic activity evaluation of a polysaccharide extracted from Gynostemma pentaphyllum. Int J Biol Macromol. 2019;126:209-14. View abstract.

Zhou H, et al. Treatment of hyperlipidemia with Gynostemma pentaphyllum jiaogulan. Hunan Med J 1991;8:259-60.