Adaptogen, Adaptogène, Amachazuru, Dungkulcha, Fairy Herb, Ginseng du Sud, Gynostemma, Gynostemma pedatum, Gynostemma pentaphyllum, Herbe de l'Immortalité, Immortality Herb, Jiao Chu Lan, Jiao Gu Lan, Miracle Grass, Penta Tea, Plante de l'Immortalité, Southern Ginseng, Thé de l'Immortalité, Vitis pentaphylla, Xian Cao, Xianxao.


Overview Information

Jiaogulan is a plant that grows wild in parts of Asia. The leaf is used to make medicine. Jiaogulan is sometimes referred to as "Southern Ginseng" because it grows primarily in south central China and is used in similar ways as ginseng.

People commonly use jiaogulan by mouth for high cholesterol, diabetes, liver disease, obesity, and many other conditions, but there is no good scientific evidence supporting most of these uses.

How does it work?

Jiaogulan contains substances that might help reduce cholesterol levels.


Uses & Effectiveness?

Possibly Effective for

Insufficient Evidence for

  • Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Taking jiaogulan by mouth does not seem to improve liver function, body mass index, cholesterol levels, kidney function, or blood sugar in people with a type of liver disease called nonalcoholic fatty liver disease.
  • Obesity.Taking jiaogulan by mouth might improve weight loss by a small amount in people who are obese.
  • Stress. Early research shows that taking jiaogulan might improve feelings of anxiety during stressful situations in people who often feel stressed and anxious.
  • Aging.
  • Athletic performance.
  • Back pain.
  • Cancer.
  • Constipation.
  • Cough.
  • Gallstones.
  • Heart disease.
  • High blood pressure.
  • Insomnia.
  • Long-term swelling (inflammation) of the airways in the lungs (chronic bronchitis).
  • Memory.
  • Pain.
  • Stomach ulcers.
  • Swelling (inflammation) of the nasal cavity and sinuses (rhinosinusitis).
  • Swelling (inflammation) of the stomach (gastritis).
  • Other conditions.
More evidence is needed to rate the effectiveness of jiaogulan for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Jiaogulan is POSSIBLY SAFE when taken for up to 4 months. In some people, it may cause side effects such as severe nausea and increased bowel movements. There isn't enough reliable information to know if jiaogulan is safe when used for longer than 4 months or what the side effects might be.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Jiaogulan is POSSIBLY UNSAFE when taken by mouth during pregnancy. One of the chemicals in jiaogulan has been linked to possible birth defects. There isn't enough reliable information to known if jiaogulan is safe to use when breast-feeding. Stay on the safe side and avoid use.

"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Jiaogulan might cause the immune system to become more active. This could increase the symptoms of auto-immune diseases. If you have an auto-immune condition, it's best to avoid using jiaogulan until more is known.

Bleeding disorders: Jiaogulan may slow blood clotting. There is a concern that it might make bleeding disorders worse.

Diabetes: Jiaogulan might cause blood sugar to become too low if taken by people with diabetes who are controlling their blood sugar with insulin or medications. Use with caution if you have diabetes.

Surgery: Jiaogulan might slow blood clotting. There is some concern that it might increase the risk of bleeding during and after surgery. Stop using jiaogulan at least 2 weeks before a scheduled surgery.



Moderate Interaction

Be cautious with this combination

  • Medications that decrease the immune system (Immunosuppressants) interacts with JIAOGULAN

    Jiaogulan increases the immune system. By increasing the immune system jiaogulan might decrease the effectiveness of medications that decrease the immune system.
    Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with JIAOGULAN

    Jiaogulan might slow blood clotting. Taking jiaogulan along with medications that also slow clotting might increase the chances of bruising and bleeding.

    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.



The following doses have been studied in scientific research:



  • For diabetes: 3 grams of jiaogulan tea in 60 mL of water has been taken twice daily for up to 12 weeks.
  • For high cholesterol: 10 mg of jiaogulan extract has been taken three times daily.

View References


  • Chen, J. C., Chung, J. G., and Chen, L. D. Gypenoside induces apoptosis in human Hep3B and HA22T tumour cells. Cytobios 1999;100(393):37-48. View abstract.
  • Chen, J. C., Lu, K. W., Lee, J. H., Yeh, C. C., and Chung, J. G. Gypenosides induced apoptosis in human colon cancer cells through the mitochondria-dependent pathways and activation of caspase-3. Anticancer Res 2006;26(6B):4313-4326. View abstract.
  • Chou, S. C., Chen, K. W., Hwang, J. S., Lu, W. T., Chu, Y. Y., Lin, J. D., Chang, H. J., and See, L. C. The add-on effects of Gynostemma pentaphyllum on nonalcoholic fatty liver disease. Altern Ther Health Med 2006;12(3):34-39. View abstract.
  • Han, M. Q., Liu, J. X., and Gao, H. [Effects of 24 Chinese medicinal herbs on nucleic acid, protein and cell cycle of human lung adenocarcinoma cell]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 1995;15(3):147-149. View abstract.
  • Hou, J., Liu, S., Ma, Z., Lang, X., Wang, J., Wang, J., and Liang, Z. Effects of gynostemma pentaphyllum makino on the immunological function of cancer patients. J.Tradit.Chin Med. 1991;11(1):47-52. View abstract.
  • Huang, T. H., Li, Y., Razmovski-Naumovski, V., Tran, V. H., Li, G. Q., Duke, C. C., and Roufogalis, B. D. Gypenoside XLIX isolated from Gynostemma pentaphyllum inhibits nuclear factor-kappaB activation via a PPAR-alpha-dependent pathway. J Biomed Sci 2006;13(4):535-548. View abstract.
  • Huang, T. H., Razmovski-Naumovski, V., Salam, N. K., Duke, R. K., Tran, V. H., Duke, C. C., and Roufogalis, B. D. A novel LXR-alpha activator identified from the natural product Gynostemma pentaphyllum. Biochem Pharmacol 11-1-2005;70(9):1298-1308. View abstract.
  • Liu, X., Ye, W., Mo, Z., Yu, B., Wu, H., Zhao, S., Che, C., and Hsiao, W. L. Three dammarane-type saponins from Gynostemma pentaphyllum. Planta Med 2005;71(9):880-884. View abstract.
  • Takagi, J., Imada, T., Kikuchi, T., Saito, Y., and Inada, Y. A new platelet aggregation factor from Gynostemma pentaphyllum Makino. Chem.Pharm.Bull.(Tokyo) 1985;33(12):5568-5571. View abstract.
  • Wang, Q. F., Chen, J. C., Hsieh, S. J., Cheng, C. C., and Hsu, S. L. Regulation of Bcl-2 family molecules and activation of caspase cascade involved in gypenosides-induced apoptosis in human hepatoma cells. Cancer Lett 9-26-2002;183(2):169-178. View abstract.
  • Chan LY, Chiu PY, Lau TK. An in-vitro study of ginsenoside Rb(1)-induced teratogenicity using a whole rat embryo culture model. Hum Reprod 2003;18:2166-8.. View abstract.
  • Chiranthanut N, Teekachunhatean S, Panthong A, Khonsung P, Kanjanapothi D, Lertprasertsuk N. Toxicity evaluation of standardized extract of Gynostemma pentaphyllum Makino. J Ethnopharmacol. 2013 Aug 26;149(1):228-34. doi: 10.1016/j.jep.2013.06.027. View abstract.
  • Choi EK, Won YH, Kim SY, et al. Supplementation with extract of Gynostemma pentaphyllum leaves reduces anxiety in healthy subjects with chronic psychological stress: a randomized, double-blind, placebo-controlled clinical trial. Phytomedicine. 2019;52:198-205. View abstract.
  • Hu X, et al. Antilipemic effect of Gynostemma pentaphyllum in patients. Fujian Med J 1988;10:4-6.
  • Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Antidiabetic effect of Gynostemma pentaphyllum tea in randomly assigned type 2 diabetic patients. Horm Metab Res. 2010;42(5):353-7. View abstract.
  • Huyen VT, Phan DV, Thang P, Hoa NK, Ostenson CG. Gynostemma pentaphyllum Tea Improves Insulin Sensitivity in Type 2 Diabetic Patients. J Nutr Metab. 2013;2013:765383. doi: 10.1155/2013/765383. View abstract.
  • Huyen VT, Phan DV, Thang P, Ky PT, Hoa NK, Ostenson CG. Antidiabetic effect of add-on Gynostemma pentaphyllum extract therapy with sulfonylureas in type 2 diabetic patients. Evid Based Complement Alternat Med 2012; 452313. View abstract.
  • la Cour B, Molgaard P, Yi Z. Traditional Chinese medicine in treatment of hyperlipidaemia. J Ethnopharmacol 1995;46:125-9. View abstract.
  • Li Y, Lin W, Huang J, Xie Y, Ma W. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chin Med. 2016 Sep 27;11:43. Review. View abstract.
  • Lin L, Lau BH. Protection of vascular endothelial cells from hydrogen peroxide-induced oxidant injury by gypenosides, saponins, of Gynostemma pentaphyllum. Phytother Res 1993;7:299-304.
  • Lokman EF, Gu HF, Wan Mohamud WN, Östenson CG. Evaluation of Antidiabetic Effects of the Traditional Medicinal Plant Gynostemma pentaphyllum and the Possible Mechanisms of Insulin Release. Evid Based Complement Alternat Med. 2015;2015:120572. doi: 10.1155/2015/120572. View abstract.
  • Mishra RN and Joshi D. Jiao Gu Lan (Gynostemma pentaphyllum): The Chinese rasayan- current research scenario. Int J Res Pharm Biomed Sci. 2011 Oct-Dec;2(4): 1483-1502.
  • Park SH, Huh TL, Kim SY, Oh MR, Tirupathi Pichiah PB, Chae SW, Cha YS. Antiobesity effect of Gynostemma pentaphyllum extract (actiponin): a randomized, double-blind, placebo-controlled trial. Obesity (Silver Spring). 2014 Jan;22(1):63-71. doi: 10.1002/oby.20539. Epub 2013 Sep 5. View abstract.
  • Takagi J, Imada T, Kikuchi T, et al. A new platelet aggregation factor from gynostemma pentaphyllum Makino. Chem Pharm Bull (Tokyo) 1985;33:5568-71.
  • Tan H, Liu ZL, Liu MJ. [Antithrombotic effect of Gynostemma pentaphyllum]. Zhingguo Zhong Xi Yi Jie He Za Zhi 1993;13:278-80. View abstract.
  • Wang Z, Zhao X, Liu X, et al. Anti-diabetic activity evaluation of a polysaccharide extracted from Gynostemma pentaphyllum. Int J Biol Macromol. 2019;126:209-14. View abstract.
  • Zhou H, et al. Treatment of hyperlipidemia with Gynostemma pentaphyllum jiaogulan. Hunan Med J 1991;8:259-60.

Vitamins Survey

Have you ever purchased JIAOGULAN?

Did you or will you purchase this product in-store or online?

Where did you or where do you plan to purchase this product?

Where did you or where do you plan to purchase this product?

What factors influenced or will influence your purchase? (check all that apply)

Vitamins Survey

Where did you or where do you plan to purchase this product?

Do you buy vitamins online or instore?

What factors are most important to you? (check all that apply)

This survey is being conducted by the WebMD marketing sciences department.Read More

More Resources for JIAOGULAN

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty .