Overview

Resveratrol is a chemical mostly found in red grapes and products made from these grapes (wine, juice). It may be helpful for hay fever and weight loss.

Resveratrol might have many effects in the body, including expanding blood vessels and reducing blood clotting. It may also decrease pain and swelling, reduce levels of sugar in the blood, and help the body fight against disease.

Resveratrol is most commonly used for high cholesterol, cancer, heart disease, and many other conditions. But there is no strong evidence to support resveratrol for any use.

How does it work ?

Uses & Effectiveness ?

Possibly Effective for

Possibly Ineffective for

  • Heart disease. People who consume higher amounts of dietary resveratrol do not seem to have a lower risk of heart disease compared to people who consume lower amounts. Also, taking resveratrol by mouth does not seem to improve levels of cholesterol or blood fats called triglycerides in people at risk for heart disease.
  • High cholesterol. Taking resveratrol by mouth does not improve levels of cholesterol or blood fats called triglycerides.
  • A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome). Taking resveratrol by mouth doesn't seem to lower blood pressure, blood sugar, or cholesterol in people with metabolic syndrome.
  • Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Taking resveratrol by mouth doesn't improve liver function, liver scarring, or cholesterol levels in people with NAFLD.
There is interest in using resveratrol for a number of other purposes, but there isn't enough reliable information to say whether it might be helpful.

Side Effects

When taken by mouth: People often consume resveratrol in small amounts in foods. Resveratrol supplements are possibly safe when taken by mouth in doses up to 1500 mg daily for up to 3 months. Higher doses of up to 2000-3000 mg daily have been used safely for 2-6 months. But these higher doses are more likely to cause stomach upset.

When applied to the skin: Resveratrol is possibly safe when used for up to 30 days.
When sprayed into the nose: Resveratrol is possibly safe when used for up to 4 weeks.

Special Precautions and Warnings

Pregnancy and breast-feeding: Resveratrol is likely safe when used in amounts found in some foods. However, during pregnancy and breast-feeding, the source of resveratrol is important. Resveratrol is found in grape skins, grape juice, wine, and other food sources. Wine should not be used as a source of resveratrol when pregnant or breast-feeding.

Children: People often consume resveratrol in small amounts in foods. But there isn't enough reliable information to know if it safe to take by mouth in larger amounts. Resveratrol is possibly safe in children when sprayed in the nose for up to 2 months.

Bleeding disorders: Resveratrol might slow blood clotting and increase the risk of bleeding in people with bleeding disorders.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Resveratrol might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don't use resveratrol.

Surgery: Resveratrol might increase the risk of bleeding during and after surgery. Stop using resveratrol at least 2 weeks before a scheduled surgery.

Interactions ?

    Moderate Interaction

    Be cautious with this combination

  • Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with RESVERATROL

    Resveratrol might slow blood clotting. Taking resveratrol along with medications that also slow clotting might increase the chances of bruising and bleeding.

    Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

  • Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with RESVERATROL

    Some medications are changed and broken down by the liver.

    Resveratrol might decrease how quickly the liver breaks down some medications. Taking resveratrol along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking resveratrol, talk to your healthcare provider if you are taking any medications that are changed by the liver.

    Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.

Dosing

Resveratrol has most often been used by adults in doses of 250-1000 mg by mouth daily for up to 3 months. It is also sometimes used in nasal sprays. Speak with a healthcare provider to find out what dose might be best for a specific condition.
View References

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2018.