2-Oxopropanoate, 2-Oxopropanoic acid, 2-Oxypropanoic Acid, Acetylformic Acid, Acide Acétylformique, Acide Alpha-Kéto, Acide Oxo-2 Propanoïque, Acide Pyruvique, Alpha-Keto Acid, Alpha-Ketopropionic Acid, Calcium Pyruvate, Calcium Pyruvate Monohydrate, Creatine Pyruvate, Magnesium Pyruvate, Monohydrate de Pyruvate de Calcium, Piruvato, Potassium Pyruvate, Proacemic Acid, Pyruvate de Calcium, Pyruvate de Créatine, Pyruvate de Magnésium, Pyruvate de Sodium, Pyruvic Acid, Sodium Pyruvate.<br/><br/>
Overview InformationThe body produces pyruvate when it breaks down sugar (glucose). Pyruvate is available as a supplement.
Pyruvate is used for weight loss and obesity, high cholesterol, cataracts, cancer, and improving athletic performance.
Some people apply pyruvic acid, a liquid form of pyruvate, to the skin to reduce wrinkles and other signs of aging. Pyruvic acid is sometimes applied to the skin as a facial peel.
How does it work?Pyruvate might contribute to weight loss by increasing the breakdown of fat.
In addition, pyruvic acid seems to cause the outer layer of skin cells to slough off, which accounts for its use in reversing aging due to exposure to the sun.
Uses & Effectiveness
Possibly Effective for
- Aging skin. Applying a 50% pyruvic acid skin peel once a week for 4 weeks seems to smooth skin, decrease wrinkles, and decrease dark spots associated with aging due to sun exposure.
Insufficient Evidence for
- Alcohol-related liver disease. Early research suggests that giving sodium pyruvate intravenously (by IV) for 25 days improves measures of liver function in people with alcohol-related liver disease.
- Long term lung disease (chronic obstructive pulmonary disease, COPD). Early research shows that inhaling sodium pyruvate using a nebulizer for 6 weeks may improve lung function in people with COPD.
- Congestive heart failure (CHF). Early research suggests that injecting pyruvate into the artery that feeds blood into the heart may improve symptoms and heart function in people with heart failure.
- Coronary artery bypass graft (CABG) surgery. Early research suggests that adding pyruvate to a solution that is used to help stop the heart during a CABG surgery improves recovery and may reduce heart complications after surgery.
- Scaly, flaky skin (ichthyosis). Early research suggests that topically applying a Eucerin skin cream containing 5% pyruvate for at least 2 weeks helps increase skin shedding in people with scaly, flaky skin.
- Weight loss and obesity. So far, early studies disagree about the effectiveness of pyruvate for weight loss. Some results show pyruvate may help increase weight loss and decrease body fat, while other results show no effect.
- Other conditions.
Side Effects & SafetyPyruvate is POSSIBLY SAFE when taken by mouth or inhaled using a nebulizer for up to six weeks. Side effects such as stomach upset, gas, bloating, and diarrhea can occur when large amounts are taken.
Pyruvic acid facial peels are POSSIBLY SAFE when applied by a healthcare professional. It can cause severe skin burning and should be applied only to small patches of skin at a time.
Special Precautions & Warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking pyruvate if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
A heart condition called cardiomyopathy: One death was associated with intravenous use in a child who had cardiomyopathy.
Diarrhea: Taking high amounts of pyruvate by mouth might worsen diarrhea.
Irritable bowel syndrome (IBS): Taking high amounts of pyruvate by mouth might worsen symptoms of IBS.
We currently have no information for PYRUVATE Interactions.
The following doses have been studied in scientific research:
APPLIED TO THE SKIN:
- For aging skin: A 50% pyruvic acid peel applied once weekly for 4 weeks.
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- Votto, J. J., Bowen, J. B., Barton, R. W., and Thrall, R. S. Inhaled sodium pyruvate improved FEV1 and decreased expired breath levels of nitric oxide in patients with chronic obstructive pulmonary disease. J Aerosol Med Pulm.Drug Deliv. 2008;21(4):329-334. View abstract.
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- Chandra, P., Hegde, K. R., and Varma, S. D. Possibility of topical antioxidant treatment of cataracts: corneal penetration of pyruvate in humans. Ophthalmologica 2009;223(2):136-138. View abstract.
- Devamanoharan, P. S., Henein, M., Ali, A. H., and Varma, S. D. Attenuation of sugar cataract by ethyl pyruvate. Mol.Cell Biochem. 1999;200(1-2):103-109. View abstract.
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- Hermann, H. P., Pieske, B., Schwarzmuller, E., Keul, J., Just, H., and Hasenfuss, G. Haemodynamic effects of intracoronary pyruvate in patients with congestive heart failure: an open study. Lancet 4-17-1999;353(9161):1321-1323. View abstract.
- Ing, T. S., Yang, M. L., Yang, V. L., Wong, F. K., Cheng, Y. L., Guddeti, S. R., and Yu, A. W. Effect of an pyruvate-based peritoneal dialysis solution on the pH of a residual peritoneal dialysis fluid. Artif.Organs 1996;20(3):264-266. View abstract.
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- Kalariya, N. M., Reddy, A. B., Ansari, N. H., Vankuijk, F. J., and Ramana, K. V. Preventive Effects of Ethyl Pyruvate on Endotoxin-induced Uveitis in Rats. Invest Ophthalmol.Vis.Sci. 5-6-2011; View abstract.
- Knott, E. M., Ryou, M. G., Sun, J., Heymann, A., Sharma, A. B., Lei, Y., Baig, M., Mallet, R. T., and Olivencia-Yurvati, A. H. Pyruvate-fortified cardioplegia suppresses oxidative stress and enhances phosphorylation potential of arrested myocardium. Am J Physiol Heart Circ.Physiol 2005;289(3):H1123-H1130. View abstract.
- Knott, E. M., Sun, J., Lei, Y., Ryou, M. G., Olivencia-Yurvati, A. H., and Mallet, R. T. Pyruvate mitigates oxidative stress during reperfusion of cardioplegia-arrested myocardium. Ann.Thorac.Surg. 2006;81(3):928-934. View abstract.
- Levy, S. B. and Goldsmith, L. A. Sodium pyruvate treatment for hyperkeratotic disorders. South.Med.J. 1979;72(3):307-310. View abstract.
- Mallet, R. T., Squires, J. E., Bhatia, S., and Sun, J. Pyruvate restores contractile function and antioxidant defenses of hydrogen peroxide-challenged myocardium. J Mol.Cell Cardiol. 2002;34(9):1173-1184. View abstract.
- Mallet, R. T., Sun, J., Knott, E. M., Sharma, A. B., and Olivencia-Yurvati, A. H. Metabolic cardioprotection by pyruvate: recent progress. Exp.Biol Med (Maywood.) 2005;230(7):435-443. View abstract.
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