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Overview InformationGrapes are the fruit of grapevines. Vitis vinifera and Vitis labrusca are two common grapevine species. Vitis labrusca is commonly known as Concord grapes. The whole fruit, skin, leaves and seed of the grape plant are used as medicine. Grape seeds are by-products of the manufacturing of wine. Be careful not to confuse grape with grapefruit, and other similar sounding medicines.
Extracts from grape leaves and grape seeds are most commonly used for poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Grape products are also commonly used for diseases of the heart and blood vessels, high blood pressure, high cholesterol, and many other conditions. But there is limited scientific evidence to support these uses.
How does it work?Grape contains flavonoids, which can have antioxidant effects, lower the levels of low density lipoproteins (LDLs, or "bad cholesterol"), relax blood vessels, and reduce the risk of coronary heart disease. The antioxidants in grape might help to prevent heart disease and have other potentially beneficial effects. Red grape varieties provide more antioxidants than white or blush grape varieties.
Grape leaf might reduce inflammation and have astringent effects. In other words, grape leaf seems to be able to draw tissue together, which could help stop bleeding and diarrhea. These properties appear to be greatest in the red leaves.
Uses & Effectiveness
Possibly Effective for
- Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI). Taking grape seed extract or proanthocyanidin, a chemical in grape seeds, by mouth seems to reduce symptoms of CVI such as tired or heavy legs, tension, and tingling and pain. Research suggests that taking a specific grape leaf extract by mouth decreases leg swelling after 6 weeks.
- Eye stress. Taking grape seed extract by mouth might help decrease stress on the eyes from glare.
Possibly Ineffective for
- Hay fever. Taking grape seed extract for 8 weeks before ragweed pollen season does not seem to decrease seasonal allergy symptoms or the need to use allergy medications.
- Nausea and vomiting caused by cancer drug treatment. Taking 4 ounces of chilled Concord grape juice 30 minutes before meals for a week following each cycle of chemotherapy does not seem to reduce nausea or vomiting caused by chemotherapy.
- Lower urinary tract symptoms (LUTS). The term LUTS is typically used to describe symptoms associated with overactive bladder. Drinking Concord grade juice doesn't seem to improve these symptoms in older men.
- Breast pain (mastalgia). Taking proanthocyanidin, a chemical found in grape seed extract, three times daily for 6 months does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer.
- Obesity. Drinking Concord grape juice or taking grape seed extract or grape pomace does not seem to reduce weight in overweight people. However, it might help to lower cholesterolcontrol blood sugar.
Insufficient Evidence for
- Aging skin. Early research shows that taking a specific combination product containing grape skin extract, marine collagen peptides, coenzyme Q10, luteolin, and selenium for 2 months might improve some markers of aging skin such as elasticity. But it doesn't seem to improve skin moisture or how the skin appears based on age.
- Hardening of the arteries (atherosclerosis). Early research shows that taking a specific product containing grape seed oil, garlic, hops, green tea, and antioxidants for 1 year might help prevent cholesterol plaques from forming in the arteries. But it doesn't appear to prevent the growth of plaques already present in the arteries. It also doesn't appear to improve levels of cholesterol.
- Athletic performance. Early research shows that taking 400 mg of grape extract daily for one month might increase an athlete's overall power when jumping, but not the initial power or maintaining power. Other early research shows that drinking juice prepared from whole grape powder does not improve how well the body uses oxygen or running ability.
- Eczema (atopic dermatitis). Early research shows that applying a cream containing vitamin E and chemicals found in grapes and green tea doesn't reduce symptoms of eczema.
- Heart disease. There is some early evidence that drinking grape juice or red wine might reduce risk factors linked with heart disease, such as inflammation, clot formation, and oxidative damage to blood fats. But it's not known if grape products specifically reduce heart disease risk.
- Memory and thinking skills (cognitive function). Early research shows that drinking Concord grape juice helps middle-aged women focus while driving. Also taking a grape fruit extract for 12 weeks seems to improve attention, language, and memory in older people without age-related memory problems. It's unclear if grape improves mental function or memory in older people with age-related memory problems.
- Decline in memory and thinking skills in older people that is more than what is normal for their age. Most early research suggests that grape does not improve mental function or memory in older people with memory problems.
- Colon cancer, rectal cancer. Taking a product containing grape seed extract and other ingredients while being treated with cancer drugs seems to help prevent colon and rectal cancer from progressing. But it doesn't seem to improve survival.
- Vision problems in people with diabetes (diabetic retinopathy). Early evidence suggests that taking a specific grape seed extract product containing 100-200 mg of a chemical called proanthocyanidin daily can slow the progression of eye damage caused by diabetes.
- High cholesterol. Taking grape seed extract alone or with chromium might reduce some measures of cholesterol in people with high cholesterol. But it doesn't seem to improve high-density lipoprotein (HDL or "good") cholesterol or lower blood fats called triglycerides. And when taken with chromium, it's possible that any cholesterol improvement is due to chromium not grape seed extract.
- High blood pressure. Most research has evaluated grape seed extract or isolated chemicals from grape called polyphenols in people with high blood pressure. Single studies show conflicting results. But analyses of multiple studies suggests that grape seed extract or grape polyphenols can slightly lower blood pressure in healthy people or those with high blood pressure. They seem to work best in people who are obese or those with metabolic syndrome. It might take 8 weeks for benefits to be seen. But people with high blood pressure should lean away from taking high doses of grape seed extract with vitamin C. This combination might worsen blood pressure.
- Dark skin patches on the face (melasma). Early research suggests that taking grape seed extract by mouth for 6-11 months reduces dark skin discolorations in Japanese women.
- Symptoms of menopause. Taking grape seed extract daily for 8 weeks seems to reduce hot flashes, anxiety, and some physical symptoms of menopause. It may also improve lean body mass and diastolic blood pressure (the bottom number in a blood pressure reading). But grape seed extract doesn't seem to improve insomnia or depression.
- A grouping of symptoms that increase the risk of diabetes, heart disease, and stroke (metabolic syndrome). Metabolic syndrome is a cluster of conditions that increase the risk for heart disease. Early research in men suggests that whole grapes might improve some of the risk factors associated with metabolic syndrome, such as high blood pressure and decreased blood flow. Drinking grape juice for one month also seems to improve blood flow in teenagers with metabolic syndrome. And taking a specific product containing grape seed extract for 4 weeks seems to lower blood pressure in people with metabolic syndrome. But it is not known if these changes decrease the risk for diabetes or other aspects of metabolic syndrome.
- Minor bleeding. An epiostomy is a surgical cut used to enlarge the opening of the vagina to aid in childbirth. Early research shows that using a product called Ankaferd blood stopper, which contains alpinia, licorice, thyme, stinging nettle, and grape vine helps to reduce bleeding during epiostomy repair. But it doesn't reduce surgical time.
- Muscle soreness. Early research shows that drinking juice prepared from grape powder for 6 weeks before an arm exercise test does not reduce pain or swelling one or two days after the exercise.
- Ability to see in low-light conditions. Early research suggests that grape seed extract containing chemicals called proanthocyanidins might improve night vision.
- Build up of fat in the liver in people who drink little or no alcohol (nonalcoholic fatty liver disease or NAFLD). Research shows that taking grape seed extract for 3 months improves some blood tests of liver damage in people with nonalcoholic fatty liver disease.
- Premenstrual syndrome (PMS). Early research suggests that taking a specific grape seed extract product might reduce PMS symptoms, including pain and swelling.
- Wound healing. Early research shows that applying cream containing 2% grape seed extract reduces the time for wound healing after removal of skin lesions.
- Age-related macular degeneration (AMD).
- Attention deficit-hyperactivity disorder (ADHD).
- Canker sores.
- Chronic fatigue syndrome (CFS).
- Heavy menstrual periods.
- Liver damage.
- Treating varicose veins.
- Other conditions.
Side Effects & SafetyWhen taken by mouth: Grape is LIKELY SAFE when consumed in amounts commonly found in foods. But keep in mind that, due to its size and shape, whole grapes are a potential choking hazard for children aged 5 years and younger. To reduce the risk, whole grapes should be cut in half or quartered before being served to children.
Grape is POSSIBLY SAFE when taken by mouth in medicinal amounts. Grape seed extracts have been used safely in studies for up to 14 weeks. Eating large quantities of grapes, dried grapes, raisins, or sultanas might cause diarrhea. Some people have allergic reactions to grapes and grape products. Some other potential side effects include stomach upset, indigestion, nausea, vomiting, cough, dry mouth, sore throat, infections, headache, and muscular problems.
When applied to the skin: There isn't enough reliable information to know if grape is safe or what the side effects might be.
When used in the vagina: There isn't enough reliable information to know if grape is safe or what the side effects might be.
Special Precautions & Warnings:Pregnancy and breast-feeding: There isn't enough reliable information to know if grape is safe to use in medicinal amounts when pregnant or breast-feeding. Stay on the safe side and avoid using more than amounts normally found in foods.
Bleeding conditions: Grape might slow blood clotting. Taking grape might increase the chances of bruising and bleeding in people with bleeding conditions. However, there are no reports of this occurring in humans.
Surgery: Grape might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using medicinal amounts of grape at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with GRAPE
Some medications are changed and broken down by the liver.<br/><br/> Grape juice might increase how quickly the liver breaks down some medications. Taking grape along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking grape talk to your healthcare provider if you take any medications that are changed by the liver.<br/><br/> Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
Phenacetin interacts with GRAPE
The body breaks down phenacetin to get rid of it. Drinking grape juice might increase how quickly the body breaks down phenacetin. Taking phenacetin along with grape juice might decrease the effectiveness of phenacetin.
Warfarin (Coumadin) interacts with GRAPE
Warfarin (Coumadin) is used to slow blood clotting. Grape seed might also slow blood clotting. Taking grape seed along with warfarin (Coumadin) might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
The following doses have been studied in scientific research:
- A standardized red vine grape extract knows as AS 195 360 mg or 720 mg once daily for 6 to 12 weeks has been used.
- A specific grape seed extract containing proanthocyanidin 150-300 mg daily for one month has also been used. Proanthocyanidin is one of the active ingredients in grape.
- A specific grape seed extract containing proanthocyanidin 200 mg daily for 5 weeks has been used.
- Grape seed extract proanthocyanidin at a dose of 300 mg per day has also been used.
- A review of evidence on red vine leaf extract in the prevention and management of venous disease. J Wound Care 2006;15(9):393-396. View abstract.
- Agarwal, C., Sharma, Y., Zhao, J., and Agarwal, R. A polyphenolic fraction from grape seeds causes irreversible growth inhibition of breast carcinoma MDA-MB468 cells by inhibiting mitogen-activated protein kinases activation and inducing G1 arrest and differentiation. Clin.Cancer Res 2000;6(7):2921-2930. View abstract.
- Agarwal, C., Singh, R. P., and Agarwal, R. Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis 2002;23(11):1869-1876. View abstract.
- Agarwal, C., Tyagi, A., and Agarwal, R. Gallic acid causes inactivating phosphorylation of cdc25A/cdc25C-cdc2 via ATM-Chk2 activation, leading to cell cycle arrest, and induces apoptosis in human prostate carcinoma DU145 cells. Mol.Cancer Ther 2006;5(12):3294-3302. View abstract.
- Agarwal, C., Veluri, R., Kaur, M., Chou, S. C., Thompson, J. A., and Agarwal, R. Fractionation of high molecular weight tannins in grape seed extract and identification of procyanidin B2-3,3'-di-O-gallate as a major active constituent causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis 2007;28(7):1478-1484. View abstract.
- Albers, A. R., Varghese, S., Vitseva, O., Vita, J. A., and Freedman, J. E. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler.Thromb.Vasc.Biol. 2004;24(11):e179-e180. View abstract.
- Amsellem M, Masson JM, Negui B, and et al. [Endotelon in the treatment of venolymphatic problems in premenstrual syndrome. Multicenter study on 165 patients]. Tempo Medical 1987;282 :46-51.
- Araghi-Niknam M, Hosseini S, Larson D, and et al. Pine bark extract reduces platelet aggregation. Integr Med 2000;2(2):73-77.
- Arne JL. [Contribution to the study of procyanidolic oligomers: Endotelon in diabetic retinopathy (based on 30 cases).]. Gaz Med France 1982;89(30):3610-3614.
- Bagchi, D., Garg, A., Krohn, R. L., Bagchi, M., Tran, M. X., and Stohs, S. J. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol.Pharmacol 1997;95(2):179-189. View abstract.
- Banerjee, B. and Bagchi, D. Beneficial effects of a novel ih636 grape seed proanthocyanidin extract in the treatment of chronic pancreatitis. Digestion 2001;63(3):203-206. View abstract.
- Barona, J., Blesso, C. N., Andersen, C. J., Park, Y., Lee, J., and Fernandez, M. L. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients. 2012;4(12):1945-1957. View abstract.
- Barthomeuf, C., Lamy, S., Blanchette, M., Boivin, D., Gingras, D., and Beliveau, R. Inhibition of sphingosine-1-phosphate- and vascular endothelial growth factor-induced endothelial cell chemotaxis by red grape skin polyphenols correlates with a decrease in early platelet-activating factor synthesis. Free Radic.Biol.Med 2-15-2006;40(4):581-590. View abstract.
- Baruch, J. [Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients]. Ann.Chir Plast.Esthet. 1984;29(4):393-395. View abstract.
- Bejaoui, H., Mathieu, F., Taillandier, P., and Lebrihi, A. Ochratoxin A removal in synthetic and natural grape juices by selected oenological Saccharomyces strains. J Appl.Microbiol. 2004;97(5):1038-1044. View abstract.
- Benjamin, S., Sharma, R., Thomas, S. S., and Nainan, M. T. Grape seed extract as a potential remineralizing agent: a comparative in vitro study. J Contemp.Dent.Pract. 2012;13(4):425-430. View abstract.
- Boissin, J. P., Corbe, C., and Siou, A. [Chorioretinal circulation and dazzling: use of procyanidol oligomers (Endotelon)]. Bull.Soc.Ophtalmol.Fr. 1988;88(2):173-179. View abstract.
- Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. J Allergy Clin Immunol 1999;103(2 Pt 1):262-266. View abstract.
- Brooker, S., Martin, S., Pearson, A., Bagchi, D., Earl, J., Gothard, L., Hall, E., Porter, L., and Yarnold, J. Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration. Radiother.Oncol 2006;79(1):45-51. View abstract.
- Cabras, P., Angioni, A., Caboni, P., Garau, V. L., Melis, M., Pirisi, F. M., and Cabitza, F. Distribution of folpet on the grape surface after treatment. J Agric.Food Chem 2000;48(3):915-916. View abstract.
- Caillet, S., Salmieri, S., and Lacroix, M. Evaluation of free radical scavenging properties of grape phenolic extracts by a fast colorimetric method. Acta Horticulturae 2007;744:425-429.
- Castilla, P., Davalos, A., Teruel, J. L., Cerrato, F., Fernandez-Lucas, M., Merino, J. L., Sanchez-Martin, C. C., Ortuno, J., and Lasuncion, M. A. Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients. Am J Clin.Nutr. 2008;87(4):1053-1061. View abstract.
- Castilla, P., Echarri, R., Davalos, A., Cerrato, F., Ortega, H., Teruel, J. L., Lucas, M. F., Gomez-Coronado, D., Ortuno, J., and Lasuncion, M. A. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin.Nutr. 2006;84(1):252-262. View abstract.
- Castillo-Pichardo, L., Martinez-Montemayor, M. M., Martinez, J. E., Wall, K. M., Cubano, L. A., and Dharmawardhane, S. Inhibition of mammary tumor growth and metastases to bone and liver by dietary grape polyphenols. Clin.Exp.Metastasis 2009;26(6):505-516. View abstract.
- Chang, W. C. and Hsu, F. L. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins. Prostaglandins Leukot.Essent.Fatty Acids 1989;38(3):181-188. View abstract.
- Chaves, A. A., Joshi, M. S., Coyle, C. M., Brady, J. E., Dech, S. J., Schanbacher, B. L., Baliga, R., Basuray, A., and Bauer, J. A. Vasoprotective endothelial effects of a standardized grape product in humans. Vascul.Pharmacol. 2009;50(1-2):20-26. View abstract.
- Cheah, K. Y., Howarth, G. S., Yazbeck, R., Wright, T. H., Whitford, E. J., Payne, C., Butler, R. N., and Bastian, S. E. Grape seed extract protects IEC-6 cells from chemotherapy-induced cytotoxicity and improves parameters of small intestinal mucositis in rats with experimentally-induced mucositis. Cancer Biol.Ther 2009;8(4):382-390. View abstract.
- Cherniack, E. P. A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders. Br J Nutr 2012;108(5):794-800. View abstract.
- Chidambara Murthy, K. N., Singh, R. P., and Jayaprakasha, G. K. Antioxidant activities of grape (Vitis vinifera) pomace extracts. J Agric.Food Chem 10-9-2002;50(21):5909-5914. View abstract.
- Chou, E. J., Keevil, J. G., Aeschlimann, S., Wiebe, D. A., Folts, J. D., and Stein, J. H. Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol 9-1-2001;88(5):553-555. View abstract.
- Chuang, C. C., Shen, W., Chen, H., Xie, G., Jia, W., Chung, S., and McIntosh, M. K. Differential effects of grape powder and its extract on glucose tolerance and chronic inflammation in high-fat-fed obese mice. J Agric.Food Chem 12-26-2012;60(51):12458-12468. View abstract.
- Clifton, P. M. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. J Biomed.Biotechnol. 2004;2004(5):272-278. View abstract.
- Coimbra, S. R., Lage, S. H., Brandizzi, L., Yoshida, V., and da Luz, P. L. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients. Braz.J Med Biol.Res 2005;38(9):1339-1347. View abstract.
- Corbe, C., Boissin, J. P., and Siou, A. [Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers (Endotelon)]. J Fr.Ophtalmol. 1988;11(5):453-460. View abstract.
- Cox, J. and Grigg, M. Small bowel obstruction by an intact grape. J Am Geriatr.Soc 1986;34(7):550. View abstract.
- Dartenuc P, Marache P, and Choussat H. [Capillary resistance in geriatry. Study of a microangioprotector: endotelon.]. Bordeaux Medicale 1980;13:903-907.
- Davalos, A., Fernandez-Hernando, C., Cerrato, F., Martinez-Botas, J., Gomez-Coronado, D., Gomez-Cordoves, C., and Lasuncion, M. A. Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. J Nutr. 2006;136(7):1766-1773. View abstract.
- Day, A. P., Kemp, H. J., Bolton, C., Hartog, M., and Stansbie, D. Effect of concentrated red grape juice consumption on serum antioxidant capacity and low-density lipoprotein oxidation. Ann.Nutr.Metab 1997;41(6):353-357. View abstract.
- de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. View abstract.
- de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314. View abstract.
- De, Groote D., Van, Belleghem K., Deviere, J., Van, Brussel W., Mukaneza, A., and Amininejad, L. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Ann Nutr Metab 2012;61(1):15-24. View abstract.
- Delacroix P. [Double-blind study of Endotelon in chronic venous insufficiency] [translated from French]. La Revue de Medecine 1981;31(27-28):1793-1802.
- Dhanalakshmi, S., Agarwal, R., and Agarwal, C. Inhibition of NF-kappaB pathway in grape seed extract-induced apoptotic death of human prostate carcinoma DU145 cells. Int J Oncol. 2003;23(3):721-727. View abstract.
- Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin.Nutr. 2010;92(5):1052-1059. View abstract.
- Engelbrecht, A. M., Mattheyse, M., Ellis, B., Loos, B., Thomas, M., Smith, R., Peters, S., Smith, C., and Myburgh, K. Proanthocyanidin from grape seeds inactivates the PI3-kinase/PKB pathway and induces apoptosis in a colon cancer cell line. Cancer Lett. 12-8-2007;258(1):144-153. View abstract.
- Faircloth, D. E. and Robison, W. J. Obstruction of the sigmoid colon by grape seeds. JAMA 11-27-1981;246(21):2430. View abstract.
- Fang, M., Liu, R., Xiao, Y., Li, F., Wang, D., Hou, R., and Chen, J. Biomodification to dentin by a natural crosslinker improved the resin-dentin bonds. J Dent. 2012;40(6):458-466. View abstract.
- Feringa, H. H., Laskey, D. A., Dickson, J. E., and Coleman, C. I. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet.Assoc. 2011;111(8):1173-1181. View abstract.
- Fromantin M. [OPC in the treatment of capillary weakness and retinopathy in diabetics. A propos of 26 cases]. Med Int 1982;16(11):432-434.
- Gamsky, T. E., McCurdy, S. A., Samuels, S. J., and Schenker, M. B. Reduced FVC among California grape workers. Am Rev.Respir.Dis 1992;145(2 Pt 1):257-262. View abstract.
- Gazzani, G., Daglia, M., and Papetti, A. Food components with anticaries activity. Curr Opin Biotechnol. 2012;23(2):153-159. View abstract.
- Green, B., Yao, X., Ganguly, A., Xu, C., Dusevich, V., Walker, M. P., and Wang, Y. Grape seed proanthocyanidins increase collagen biodegradation resistance in the dentin/adhesive interface when included in an adhesive. J Dent. 2010;38(11):908-915. View abstract.
- Haniadka, R., Popouri, S., Palatty, P. L., Arora, R., and Baliga, M. S. Medicinal plants as antiemetics in the treatment of cancer: a review. Integr.Cancer Ther. 2012;11(1):18-28. View abstract.
- Hansen, A. S., Marckmann, P., Dragsted, L. O., Finne Nielsen, I. L., Nielsen, S. E., and Gronbaek, M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. Eur.J Clin.Nutr. 2005;59(3):449-455. View abstract.
- Hashemi, M., Kelishadi, R., Hashemipour, M., Zakerameli, A., Khavarian, N., Ghatrehsamani, S., and Poursafa, P. Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome. Cardiol Young. 2010;20(1):73-77. View abstract.
- Henriet, J. P. [Veno-lymphatic insufficiency. 4,729 patients undergoing hormonal and procyanidol oligomer therapy]. Phlebologie. 1993;46(2):313-325. View abstract.
- Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582. View abstract.
- Hsu, C. P., Lin, Y. H., Chou, C. C., Zhou, S. P., Hsu, Y. C., Liu, C. L., Ku, F. M., and Chung, Y. C. Mechanisms of grape seed procyanidin-induced apoptosis in colorectal carcinoma cells. Anticancer Res 2009;29(1):283-289. View abstract.
- Hsu, Y. L., Liang, H. L., Hung, C. H., and Kuo, P. L. Syringetin, a flavonoid derivative in grape and wine, induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway. Mol.Nutr.Food Res 2009;53(11):1452-1461. View abstract.
- Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. View abstract.
- Islam, S. M., Hiraishi, N., Nassar, M., Sono, R., Otsuki, M., Takatsura, T., Yiu, C., and Tagami, J. In vitro effect of hesperidin on root dentin collagen and de/re-mineralization. Dent.Mater.J 2012;31(3):362-367. View abstract.
- Jimenez, J. P., Serrano, J., Tabernero, M., Arranz, S., Diaz-Rubio, M. E., Garcia-Diz, L., Goni, I., and Saura-Calixto, F. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition 2008;24(7-8):646-653. View abstract.
- Kalus, U., Koscielny, J., Grigorov, A., Schaefer, E., Peil, H., and Kiesewetter, H. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R.D. 2004;5(2):63-71. View abstract.
- Kamiyama, M., Kishimoto, Y., Tani, M., Andoh, K., Utsunomiya, K., and Kondo, K. Inhibition of low-density lipoprotein oxidation by Nagano purple grape (Vitis viniferaxVitis labrusca). J Nutr.Sci.Vitaminol.(Tokyo) 2009;55(6):471-478. View abstract.
- Kar, P., Laight, D., Rooprai, H. K., Shaw, K. M., and Cummings, M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet.Med 2009;26(5):526-531. View abstract.
- Katsuzaki, H., Hibasami, H., Ohwaki, S., Ishikawa, K., Imai, K., Date, K., Kimura, Y., and Komiya, T. Cyanidin 3-O-beta-D-glucoside isolated from skin of black Glycine max and other anthocyanins isolated from skin of red grape induce apoptosis in human lymphoid leukemia Molt 4B cells. Oncol.Rep. 2003;10(2):297-300. View abstract.
- Kaur, M., Agarwal, R., and Agarwal, C. Grape seed extract induces anoikis and caspase-mediated apoptosis in human prostate carcinoma LNCaP cells: possible role of ataxia telangiectasia mutated-p53 activation. Mol.Cancer Ther 2006;5(5):1265-1274. View abstract.
- Kaur, M., Singh, R. P., Gu, M., Agarwal, R., and Agarwal, C. Grape seed extract inhibits in vitro and in vivo growth of human colorectal carcinoma cells. Clin Cancer Res 10-15-2006;12(20 Pt 1):6194-6202. View abstract.
- Keevil, J. G., Osman, H. E., Reed, J. D., and Folts, J. D. Grape juice, but not orange juice or grapefruit juice, inhibits human platelet aggregation. J Nutr. 2000;130(1):53-56. View abstract.
- Khoshbaten, M., Aliasgarzadeh, A., Masnadi, K., Farhang, S., Tarzamani, M. K., Babaei, H., Kiani, J., Zaare, M., and Najafipoor, F. Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change. Saudi.J Gastroenterol. 2010;16(3):194-197. View abstract.
- Kim, E. J., Park, H., Park, S. Y., Jun, J. G., and Park, J. H. The grape component piceatannol induces apoptosis in DU145 human prostate cancer cells via the activation of extrinsic and intrinsic pathways. J Med Food 2009;12(5):943-951. View abstract.
- Koo, M., Kim, S. H., Lee, N., Yoo, M. Y., Ryu, S. Y., Kwon, D. Y., and Kim, Y. S. 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera. Fitoterapia 2008;79(3):204-206. View abstract.
- Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. View abstract.
- Kuo, P. L. and Hsu, Y. L. The grape and wine constituent piceatannol inhibits proliferation of human bladder cancer cells via blocking cell cycle progression and inducing Fas/membrane bound Fas ligand-mediated apoptotic pathway. Mol.Nutr.Food Res 2008;52(4):408-418. View abstract.
- La, V. D., Bergeron, C., Gafner, S., and Grenier, D. Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities. J Periodontol. 2009;80(11):1875-1882. View abstract.
- Lafay, S., Jan, C., Nardon, K., Lemaire, B., Ibarra, A., Roller, M., Houvenaeghel, M., Juhel, C., and Cara, L. Grape extract improves antioxidant status and physical performance in elite male athletes. Journal of Sports Science & Medicine 2009;8(3):468.
- Lagrue, G., Olivier-Martin, F., and Grillot, A. [A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies (author's transl)]. Sem Hop 9-18-1981;57(33-36):1399-1401. View abstract.
- Larrosa, M., Tomas-Barberan, F. A., and Espin, J. C. The grape and wine polyphenol piceatannol is a potent inducer of apoptosis in human SK-Mel-28 melanoma cells. Eur.J Nutr. 2004;43(5):275-284. View abstract.
- Leifert, W. R. and Abeywardena, M. Y. Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutr.Res 2008;28(12):842-850. View abstract.
- Lekakis, J., Rallidis, L. S., Andreadou, I., Vamvakou, G., Kazantzoglou, G., Magiatis, P., Skaltsounis, A. L., and Kremastinos, D. T. Polyphenolic compounds from red grapes acutely improve endothelial function in patients with coronary heart disease. Eur.J Cardiovasc.Prev.Rehabil. 2005;12(6):596-600. View abstract.
- Lesbre FX and Tigaud JD. [The effect of Endotelon on the capillary fragility index of a specified controlled group: cirrhosis patients]. Gazette Medicale de France 1983;90(24):2333-2337.
- Li, Q. Z., Cho, H. S., Jeun, S. H., Kim, K. J., Choi, S. J., and Sung, K. W. Effects of grape seed proanthocyanidin on 5-hydroxytryptamine(3) receptors in NCB-20 neuroblastoma cells. Biol.Pharm Bull. 2011;34(7):1109-1115. View abstract.
- Li, S., Zhong, J., and Sun, F. [Study on the protective effect of grape procyanidins on DNA damage induced by irradiation]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2000;34(3):131-133. View abstract.
- Liu, J. Y. and Zhong, J. Y. [Study on protective effect of grape procyanidins in radiation injury in radiation-contacted persons]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2008;42(4):264-267. View abstract.
- Liu, T., Zhao, J., Li, H., and Ma, L. Evaluation on anti-hepatitis viral activity of Vitis vinifer L. Molecules. 2010;15(10):7415-7422. View abstract.
- Lluis, L., Munoz, M., Nogues, M. R., Sanchez-Martos, V., Romeu, M., Giralt, M., Valls, J., and Sola, R. Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds. Food Chem Toxicol. 2011;49(6):1450-1454. View abstract.
- Maffei, Facino R., Carini, M., Aldini, G., Bombardelli, E., Morazzoni, P., and Morelli, R. Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung. 1994;44(5):592-601. View abstract.
- Mahadeswaraswamy, Y. H., Nagaraju, S., Girish, K. S., and Kemparaju, K. Local tissue destruction and procoagulation properties of Echis carinatus venom: inhibition by Vitis vinifera seed methanol extract. Phytother.Res 2008;22(7):963-969. View abstract.
- Mantena, S. K., Baliga, M. S., and Katiyar, S. K. Grape seed proanthocyanidins induce apoptosis and inhibit metastasis of highly metastatic breast carcinoma cells. Carcinogenesis 2006;27(8):1682-1691. View abstract.
- Marguerie, C. and Drouet, M. [Occupational eosinophilic lung in a grape grower: role of sulfites]. Allerg.Immunol.(Paris) 1995;27(5):163-167. View abstract.
- Matias, A. A., Serra, A. T., Silva, A. C., Perdigao, R., Ferreira, T. B., Marcelino, I., Silva, S., Coelho, A. V., Alves, P. M., and Duarte, C. M. Portuguese winemaking residues as a potential source of natural anti-adenoviral agents. Int.J Food Sci.Nutr. 2010;61(4):357-368. View abstract.
- McCurdy, S. A., Wiggins, P., Schenker, M. B., Munn, S., Shaieb, A. M., Weinbaum, Z., Goldsmith, D., McGillis, S. T., Berman, B., and Samuels, S. Assessing dermatitis in epidemiologic studies: occupational skin disease among California grape and tomato harvesters. Am J Ind.Med 1989;16(2):147-157. View abstract.
- Meunier, M. T., Villie, F., Jonadet, M., Bastide, J., and Bastide, P. Inhibition of angiotensin I converting enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Med 1987;53(1):12-15. View abstract.
- Monsieur, R. and Van, Snick G. [Efficacy of the red vine leaf extract AS 195 in Chronic Venous Insufficiency]. Praxis.(Bern.1994.) 1-25-2006;95(6):187-190. View abstract.
- Murgov, I., Acikbas, M., and Nikolova, R. Antimicrobial activity of citric acid and grape seed extract on pathogenic microorganisms and lactobacilli. Scientific Works of the University of Food Technologies - Plovdiv 2008;55(1):367-372.
- Nair, N., Mahajan, S., Chawda, R., Kandaswami, C., Shanahan, T. C., and Schwartz, S. A. Grape seed extract activates Th1 cells in vitro. Clin.Diagn.Lab Immunol. 2002;9(2):470-476. View abstract.
- Natella, F., Belelli, F., Gentili, V., Ursini, F., and Scaccini, C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric.Food Chem 12-18-2002;50(26):7720-7725. View abstract.
- Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. Drug Metab Pharmacokinet. 2004;19(4):280-289. View abstract.
- Nomoto, H., Iigo, M., Hamada, H., Kojima, S., and Tsuda, H. Chemoprevention of colorectal cancer by grape seed proanthocyanidin is accompanied by a decrease in proliferation and increase in apoptosis. Nutr Cancer 2004;49(1):81-88. View abstract.
- Nuttall SL, Kendall MJ, Bombardelli E, and et al. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. Journal of Clinical Pharmacology and Therapeutics 1998;23:385-389.
- O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374. View abstract.
- Olas, B., Wachowicz, B., Tomczak, A., Erler, J., Stochmal, A., and Oleszek, W. Comparative anti-platelet and antioxidant properties of polyphenol-rich extracts from: berries of Aronia melanocarpa, seeds of grape and bark of Yucca schidigera in vitro. Platelets. 2008;19(1):70-77. View abstract.
- Oliveira-Freitas, V. L., Dalla, Costa T., Manfro, R. C., Cruz, L. B., and Schwartsmann, G. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr. 2010;20(5):309-313. View abstract.
- Ozturk, H. S., Kacmaz, M., Cimen, M. Y., and Durak, I. Red wine and black grape strengthen blood antioxidant potential. Nutrition 1999;15(11-12):954-955. View abstract.
- Pan, X., Dai, Y., Li, X., Niu, N., Li, W., Liu, F., Zhao, Y., and Yu, Z. Inhibition of arsenic-induced rat liver injury by grape seed exact through suppression of NADPH oxidase and TGF-beta/Smad activation. Toxicol.Appl.Pharmacol. 8-1-2011;254(3):323-331. View abstract.
- Parienti J and Pareinti-Amsellem J. [Post-traumatic edemas in sports: a controlled test of endotelon]. Gaz Med France 1983;90(3):231-235.
- Park, M. K., Park, J. S., Cho, M. L., Oh, H. J., Heo, Y. J., Woo, Y. J., Heo, Y. M., Park, M. J., Park, H. S., Park, S. H., Kim, H. Y., and Min, J. K. Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3(+) regulatory and IL-17(+) pathogenic T cell in autoimmune arthritis. Immunol.Lett. 3-30-2011;135(1-2):50-58. View abstract.
- Park, Y. K., Kim, J. S., and Kang, M. H. Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: double-blind, placebo controlled intervention trial. Biofactors 2004;22(1-4):145-147. View abstract.
- Park, Y. K., Lee, S. H., Park, E., Kim, J. S., and Kang, M. H. Changes in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementation. Ann.N.Y.Acad.Sci. 2009;1171:385-390. View abstract.
- Pecking A, Desperez-Curely JP, and Megret G. OPC (Endotelon) in the treatment of post-therapy lymphedemas of the upper extremities. Int'l d'Antiologie 1989.
- Piper, J., Kohler, S., Niestroj, M., and Malek, F. A. Medical nutrition therapy of patients with atherosclerotic vascular diseases and hypertension by means of perilla oil and black grape extract as dietary food for special medical purposes. Diätetische Intervention mit Perilla-Öl und Rotweintrauben-Extrakt als ergänzende bilanzierte Diät bei Patienten mit atherosklerotischen Gefässerkrankungen und Bluthochdruck 2005;20(1):20-26.
- Pires, K. M., Valenca, S. S., Resende, A. C., Porto, L. C., Queiroz, E. F., Moreira, D. D., and de Moura, R. S. Grape skin extract reduced pulmonary oxidative response in mice exposed to cigarette smoke. Med Sci.Monit. 2011;17(8):BR187-BR195. View abstract.
- Preuss, H. G., Wallerstedt, D., Talpur, N., Tutuncuoglu, S. O., Echard, B., Myers, A., Bui, M., and Bagchi, D. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med 2000;31(5-6):227-246. View abstract.
- Punathil, T. and Katiyar, S. K. Inhibition of non-small cell lung cancer cell migration by grape seed proanthocyanidins is mediated through the inhibition of nitric oxide, guanylate cyclase, and ERK1/2. Mol.Carcinog. 2009;48(3):232-242. View abstract.
- Rababah, T. M., Al-u'datt, M., Almajwal, A., Brewer, S., Feng, H., Al-Mahasneh, M., Ereifej, K., and Yang, W. Evaluation of the nutraceutical, physiochemical and sensory properties of raisin jam. J Food Sci 2012;77(6):C609-C613. View abstract.
- Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.Surg. 2011;41(4):540-547. View abstract.
- Rao, A. V., Shen, H., Agarwal, A., Yatcilla, M. T., and Agarwal, S. Bioabsorption and in vivo antioxidant properties of grape extract biovin((r)): a human intervention study. J Med Food 2000;3(1):15-22. View abstract.
- Rawn, D. F., Roscoe, V., Krakalovich, T., and Hanson, C. N-methyl carbamate concentrations and dietary intake estimates for apple and grape juices available on the retail market in Canada. Food Addit.Contam 2004;21(6):555-563. View abstract.
- Richard, T., Poupard, P., Nassra, M., Papastamoulis, Y., Iglesias, M. L., Krisa, S., Waffo-Teguo, P., Merillon, J. M., and Monti, J. P. Protective effect of epsilon-viniferin on beta-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. Bioorg.Med Chem 5-15-2011;19(10):3152-3155. View abstract.
- Rosa, C. A., Magnoli, C. E., Fraga, M. E., Dalcero, A. M., and Santana, D. M. Occurrence of ochratoxin A in wine and grape juice marketed in Rio de Janeiro, Brazil. Food Addit.Contam 2004;21(4):358-364. View abstract.
- Rowe, C. A., Nantz, M. P., Nieves, C., Jr., West, R. L., and Percival, S. S. Regular consumption of concord grape juice benefits human immunity. J Med Food 2011;14(1-2):69-78. View abstract.
- Samet, J. M. and Coultas, D. B. Reduced forced vital capacity in California grape workers. What does it mean? Am Rev.Respir.Dis 1992;145(2 Pt 1):255-256. View abstract.
- Sandra, D., Radha, M., Harishkumar, M., Yuichi, N., Sayuri, O., and Masugi, M. Downregulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 by grape seed proanthocyanidin extract. Phytomedicine. 2010;17(1):42-46. View abstract.
- Sano, A., Uchida, R., Saito, M., Shioya, N., Komori, Y., Tho, Y., and Hashizume, N. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol.(Tokyo) 2007;53(2):174-182. View abstract.
- Sarrat L. [Therapeutic relief of functional problems of the lower legs by Endotelon, a microangioprotector]. Bordeaux Med 1981;14:685-688.
- Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschung. 2003;53(4):243-246. View abstract.
- Shanmuganayagam, D., Beahm, M. R., Osman, H. E., Krueger, C. G., Reed, J. D., and Folts, J. D. Grape seed and grape skin extracts elicit a greater antiplatelet effect when used in combination than when used individually in dogs and humans. J Nutr. 2002;132(12):3592-3598. View abstract.
- Sharma, S. D. and Katiyar, S. K. Dietary grape-seed proanthocyanidin inhibition of ultraviolet B-induced immune suppression is associated with induction of IL-12. Carcinogenesis 2006;27(1):95-102. View abstract.
- Shivashankara, A. R., Azmidah, A., Haniadka, R., Rai, M. P., Arora, R., and Baliga, M. S. Dietary agents in the prevention of alcohol-induced hepatotoxicty: preclinical observations. Food Funct. 2012;3(2):101-109. View abstract.
- Sivaprakasapillai, B., Edirisinghe, I., Randolph, J., Steinberg, F., and Kappagoda, T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism 2009;58(12):1743-1746. View abstract.
- Skarpan´ska-Stejnborn, A., Basta, P., Pilaczyn´ska-Szczesniak, L., and Horoszkiewicz-Hassan, M. Black grape extract supplementation attenuates blood oxidative stress in response to acute exercise. Biology of Sport 2010;27(1):41-46.
- Skovgaard, G. R., Jensen, A. S., and Sigler, M. L. Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr 2006;60(10):1201-1206. View abstract.
- Soyeux, A., Seguin, J. P., Le, Devehat C., and Bertrand, A. [Endotelon. Diabetic retinopathy and hemorheology (preliminary study)]. Bull.Soc Ophtalmol.Fr. 1987;87(12):1441-1444. View abstract.
- Su, X. and D'Souza, D. H. Grape seed extract for control of human enteric viruses. Appl.Environ.Microbiol. 2011;77(12):3982-3987. View abstract.
- Suppasrivasuseth, J., Bellantone, R. A., Plakogiannis, F. M., and Stagni, G. Permeability and retention studies of (-)epicatechin gel formulations in human cadaver skin. Drug Dev Ind Pharm 2006;32(9):1007-1017. View abstract.
- Tao, H. Y., Wu, C. F., Zhou, Y., Gong, W. H., Zhang, X., Iribarren, P., Zhao, Y. Q., Le, Y. Y., and Wang, J. M. The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes. Cell Mol.Immunol. 2004;1(1):50-56. View abstract.
- Tebib K et al. Polymeric grape seed tannins prevent plasma cholesterol changes in high-cholesterol-fed rats. Food Chem 1994;49:403-406.
- Thebaut JF, Thebaut P, and Vin F. Study of Endotelon in the functional manifestations of peripheral venous insufficiency. Results of a double-blind study of 92 patients. Gazette Medicale 1985;92(1):96-100.
- Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Garcia-Almagro, F. J., Aviles-Plaza, F., Parra, S., Yanez-Gascon, M. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol.Nutr Food Res 2012;56(5):810-821. View abstract.
- Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Yanez-Gascon, M. J., Garcia-Almagro, F. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 8-1-2012;110(3):356-363. View abstract.
- Trotta, M., Cesaretti, M., Conzi, R., Derchi, L. E., and Borgonovo, G. Elderly male with mesogastric pain. Small bowel obstruction caused by an intact fresh grape. Ann.Emerg.Med 2011;58(4):e1-e2. View abstract.
- Tyagi, A., Agarwal, R., and Agarwal, C. Grape seed extract inhibits EGF-induced and constitutively active mitogenic signaling but activates JNK in human prostate carcinoma DU145 cells: possible role in antiproliferation and apoptosis. Oncogene 3-6-2003;22(9):1302-1316. View abstract.
- Uchino, R., Madhyastha, R., Madhyastha, H., Dhungana, S., Nakajima, Y., Omura, S., and Maruyama, M. NFkappaB-dependent regulation of urokinase plasminogen activator by proanthocyanidin-rich grape seed extract: effect on invasion by prostate cancer cells. Blood Coagul.Fibrinolysis 2010;21(6):528-533. View abstract.
- Urios, P., Grigorova-Borsos, A. M., and Sternberg, M. Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. Eur J Nutr 2007;46(3):139-146. View abstract.
- van Mierlo, L. A., Zock, P. L., van der Knaap, H. C., and Draijer, R. Grape polyphenols do not affect vascular function in healthy men. J Nutr. 2010;140(10):1769-1773. View abstract.
- Vayalil, P. K., Mittal, A., and Katiyar, S. K. Proanthocyanidins from grape seeds inhibit expression of matrix metalloproteinases in human prostate carcinoma cells, which is associated with the inhibition of activation of MAPK and NF kappa B. Carcinogenesis 2004;25(6):987-995. View abstract.
- Veluri, R., Singh, R. P., Liu, Z., Thompson, J. A., Agarwal, R., and Agarwal, C. Fractionation of grape seed extract and identification of gallic acid as one of the major active constituents causing growth inhibition and apoptotic death of DU145 human prostate carcinoma cells. Carcinogenesis 2006;27(7):1445-1453. View abstract.
- Verin MM, Vildy A, and Maurin JF. [Retinopathies and OPC]. Bordeaux Medicale 1978;11(16):1467-1474.
- Vidhya, S., Srinivasulu, S., Sujatha, M., and Mahalaxmi, S. Effect of grape seed extract on the bond strength of bleached enamel. Oper.Dent. 2011;36(4):433-438. View abstract.
- Vigna, G. B., Costantini, F., Aldini, G., Carini, M., Catapano, A., Schena, F., Tangerini, A., Zanca, R., Bombardelli, E., Morazzoni, P., Mezzetti, A., Fellin, R., and Maffei, Facino R. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism 2003;52(10):1250-1257. View abstract.
- Vitseva, O., Varghese, S., Chakrabarti, S., Folts, J. D., and Freedman, J. E. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc.Pharmacol. 2005;46(4):445-451. View abstract.
- Wang, Y. J., Thomas, P., Zhong, J. H., Bi, F. F., Kosaraju, S., Pollard, A., Fenech, M., and Zhou, X. F. Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse. Neurotox.Res 2009;15(1):3-14. View abstract.
- Ward, N. C., Croft, K. D., Puddey, I. B., and Hodgson, J. M. Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans. J Agric.Food Chem 8-25-2004;52(17):5545-5549. View abstract.
- Wen, W., Lu, J., Zhang, K., and Chen, S. Grape seed extract inhibits angiogenesis via suppression of the vascular endothelial growth factor receptor signaling pathway. Cancer Prev.Res (Phila) 2008;1(7):554-561. View abstract.
- Winter, C. K. and Kurtz, P. H. Factors influencing grape worker susceptibility to skin rashes. Bull.Environ.Contam Toxicol. 1985;35(3):418-426. View abstract.
- Xie, Q., Bedran-Russo, A. K., and Wu, C. D. In vitro remineralization effects of grape seed extract on artificial root caries. J Dent. 2008;36(11):900-906. View abstract.
- Yamakoshi, J., Kataoka, S., Koga, T., and Ariga, T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1999;142(1):139-149. View abstract.
- Yamakoshi, J., Sano, A., Tokutake, S., Saito, M., Kikuchi, M., Kubota, Y., Kawachi, Y., and Otsuka, F. Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res 2004;18(11):895-899. View abstract.
- Yamasaki, R., Dekio, S., and Jidoi, J. Contact dermatitis from grape bud. Contact Dermatitis 1985;12(4):226-227. View abstract.
- Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., and Fernandez, M. L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005;135(8):1911-1917. View abstract.
- Zhang, F. J., Yang, J. Y., Mou, Y. H., Sun, B. S., Ping, Y. F., Wang, J. M., Bian, X. W., and Wu, C. F. Inhibition of U-87 human glioblastoma cell proliferation and formyl peptide receptor function by oligomer procyanidins (F2) isolated from grape seeds. Chem Biol.Interact. 5-15-2009;179(2-3):419-429. View abstract.
- Zhang, F. J., Yang, J. Y., Mou, Y. H., Sun, B. S., Wang, J. M., and Wu, C. F. Oligomer procyanidins from grape seeds induce a paraptosis-like programmed cell death in human glioblastoma U-87 cells. Pharm Biol. 2010;48(8):883-890. View abstract.
- Agarwal C, Sharma Y, Agarwal R. Anticarcinogenic effect of a polyphenolic fraction isolated from grape seeds in human prostate carcinoma DU145 cells: modulation of mitogenic signaling and cell-cycle regulators and induction of G1 arrest and apoptosis. Mol Carcinog 2000;28:129-38.. View abstract.
- Anon. OPCs (Oligomeric Proanthocyanidins). The Natural Pharmacist 2000. http://www.tnp.com/substance.asp?ID=181. (Accessed 3 June 2000).
- Bagchi D, Bagchi M, Stohs SJ, et al. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci 2002;957:260-70.
- Barona J, Aristizabal JC, Blesso CN, et al. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 2012;142:1626-32. View abstract.
- Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. View abstract.
- Berry AC, Nakshabendi R, Abidali H, et al. Adverse effects of grape seed extract supplement: A clinical case and long-term follow-up. J Diet Suppl. 2016;13(2):232-5. View abstract.
- BIBRA working group. Anthocyanins. Toxicity profile. BIBRA Toxicol Int 1991;6.
- Bombardelli E, Morazzoni P. Vitis vinifera L. Fitoterapia 1995;LXVI:291-317.
- Calapai G, Bonina F, Bonina A, et al. A randomized, double-blinded, clinical trial on effects of a Vitis vinifera extract on cognitive function in healthy older adults. Front Pharmacol. 2017;8:776. View abstract.
- Chen WT, Yang TS, Chen HC, et al. Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer. Nutr Res. 2014;34(7):585-94. View abstracts.
- Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
- Chisholm A, Mann J, Skeaff M, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr 1998;52:12-6. View abstract.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- De Luca C, Mikhal'chik EV, Suprun MV, et al. Skin antiageing and systemic redox effects of supplementation with marine collagen peptides and plant-derived antioxidants: a single-blind case-control clinical study. Oxid Med Cell Longev. 2016;2016:4389410. View abstract.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Eyi, E. G., Engin-Ustun, Y., Kaba, M., and Mollamahmutoglu, L. Ankaferd blood stopper in episiotomy repair. Clin Exp Obstet Gynecol 2013;40(1):141-143. View abstract.
- Freedman JE, Parker C, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001;103:2792-8.. View abstract.
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. View abstract.
- Gupta H, Pawar D, Riva A, et al. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Phytother Res 2012;26:265-272. View abstract.
- Han HJ, Jung UJ, Kim HJ, et al. Combined supplementation with grape pomace and omija fruit ethanol extracts dose-dependently improves body composition, plasma lipid profiles, inflammatory status, and antioxidant capacity in overweight and obese subjects. J Med Food. 2016;19(2):170-80. View abstract.
- Hemmati AA, Foroozan M, Houshmand G, et al. The topical effect of grape seed extract 2% cream on surgery wound healing. Glob J Health Sci 2014;7(3):52-8. View abstract.
- Hodgson JM, Croft KD, Woodman RJ, et al. Effects of vitamin E, vitamin C and polyphenols on the rate of blood pressure variation: results of two randomised controlled trials. Br J Nutr. 2014;112(9):1551-61. View abstract.
- Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung 2000;50:109-17. View abstract.
- Krochmal A, Grierson W. Brief history of grape growing in the United States. Econ Bot 1961;15(2):114-118.
- Lamport DJ, Lawton CL, Merat N, et al. Concord grape juice, cognitive function, and driving performance: a 12-wk, placebo-controlled, randomized crossover trial in mothers of preteen children. Am J Clin Nutr. 2016;103(3):775-83. View abstract.
- Lee J, Torosyan N, Silverman DH. Examining the impact of grape consumption on brain metabolism and cognitive function in patients with mild decline in cognition: A double-blinded placebo controlled pilot study. Exp Gerontol. 2017;87(Pt A):121-128. View abstract.
- Lumsden AJ, Cooper JG. The choking hazard of grapes: a plea for awareness. Arch Dis Child. 2017;102(5):473-474. View abstract.
- Martínez-Maqueda D, Zapatera B, Gallego-Narbón A, Vaquero MP, Saura-Calixto F, Pérez-Jiménez J. A 6-week supplementation with grape pomace to subjects at cardiometabolic risk ameliorates insulin sensitivity, without affecting other metabolic syndrome markers. Food Funct. 2018;9(11):6010-6019. View abstract.
- Meng X, Maliakal P, Lu H, et al. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 2004;52:935-42. View abstract.
- Meyer AS, Yi OS, Pearson DA, et al. Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes (Vitis vinifera). J Agric Food Chem 1997;45:1638-43.
- Myasoedova VA, Kirichenko TV, Melnichenko AA, et al. Anti-atherosclerotic effects of a phytoestrogen-rich herbal preparation in postmenopausal women.Int J Mol Sci. 2016;17(8). View abstract.
- Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 1998;23:385-89. View abstract.
- O'Connor PJ, Caravalho AL, Freese EC, Cureton KJ. Grape consumption's effects on fitness, muscle injury, mood, and perceived health. Int J Sport Nutr Exerc Metab 2013;23(1):57-64. View abstract.
- Park E, Edirisinghe I, Choy YY, Waterhouse A, Burton-Freeman B. Effects of grape seed extract beverage on blood pressure and metabolic indices in individuals with pre-hypertension: a randomised, double-blinded, two-arm, parallel, placebo-controlled trial. Br J Nutr. 2016;115(2):226-38. View abstract.
- Pataki T, Bak I, Kovacs P, et al. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr 2002;75:894-9.
- Patrizi A, Raone B, Neri I, et al. Randomized, controlled, double-blind clinical study evaluating the safety and efficacy of MD2011001 cream in mild-to-moderate atopic dermatitis of the face and neck in children, adolescents and adults. J Dermatolog Treat. 2016;27(4):346-50. View abstract.
- Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York, NY: William Morrow and Co., 1999.
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. View abstract.
- Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41. View abstract.
- Razavi SM, Gholamin S, Eskandari A, et al. Red grape seed extract improves lipid profiles and decreases oxidized low-density lipoprotein in patients with mild hyperlipidemia. J Med Food. 2013;16(3):255-8. View abstract.
- Snow LA, Hovanec L, Brandt J. A controlled trial of aromatherapy for agitation in nursing home patients with dementia. J Altern Complement Med 2004;10(3):431-7. View abstract.
- Spettel S, Chughtai B, Feustel P, Kaufman A, Levin RM, De E. A prospective randomized double-blind trial of grape juice antioxidants in men with lower urinary tract symptoms. Neurourol Urodyn. 2013;32(3):261-5. View abstract.
- Stein JH, Keevil JG, Wiebe DA, et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999;100:1050-5.. View abstract.
- Su T, Wilf P, Huang Y, Zhang S, Zhou Z. The natural origins of some popular varieties of fruit. Sci Rep 2015;5:16794. View abstract.
- Terauchi M, Horiguchi N, Kajiyama A, et al. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause 2014;21(9):990-6. View abstract.
- This P, Lacombe T, Thomas MR. Historical origins and genetic diversity of wine grapes. Trends Genet 2006;22(9):511-9. View abstract.
- Urquiaga I, Troncoso D, Mackenna MJ, et al. The consumption of beef burgers prepared with wine grape pomace flour improves fasting glucose, plasma antioxidant levels, and oxidative damage markers in humans: A controlled trial. Nutrients. 2018;10(10). pii: E1388. View abstract.
- Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
- Wahner-Roedler DL, Bauer BA, Loehrer LL, Cha SS, Hoskin TL, Olson JE. The effect of grape seed extract on estrogen levels of postmenopausal women: a pilot study. J Diet Suppl. 2014;11(2):184-97. View abstract.
- Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. View abstract.
- Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. View abstract.
- Young, J. F., Dragsted, L. O., Daneshvar, B., Lauridsen, S. T., Hansen, M., and Sandstrom, B. The effect of grape-skin extract on oxidative status. Br J Nutr 2000;84(4):505-513. View abstract.
- Zhang H, Liu S, Li L, et al. The impact of grape seed extract treatment on blood pressure changes: A meta-analysis of 16 randomized controlled trials. Medicine (Baltimore). 2016;95(33):e4247. View abstract.
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