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Overview InformationGrapes are the fruit of grapevines. Vitis vinifera and Vitis labrusca are two common grapevine species. Vitis labrusca is commonly known as Concord grapes. The whole fruit, skin, leaves and seed of the grape plant are used as medicine. Grape seeds are by-products of the manufacturing of wine. Be careful not to confuse grape with grapefruit, and other similar sounding medicines.
Extracts from grape leaves and grape seeds may help patients with swelling in the legs due to poor blood flow (chronic venous insufficiency). Grape products are also commonly used for diseases of the heart and blood vessels, high blood pressure, high cholesterol, and many other conditions. But there is limited scientific evidence to support these uses.
How does it work?Grape contains flavonoids, which can have antioxidant effects, lower the levels of low density lipoproteins (LDLs, or “bad cholesterol”), relax blood vessels, and reduce the risk of coronary heart disease. The antioxidants in grape might help to prevent heart disease and have other potentially beneficial effects. Red grape varieties provide more antioxidants than white or blush grape varieties.
Grape leaf might reduce inflammation and have astringent effects. In other words, grape leaf seems to be able to draw tissue together, which could help stop bleeding and diarrhea. These properties appear to be greatest in the red leaves.
Uses & Effectiveness
Possibly Effective for
- Poor blood flow in the legs (chronic venous insufficiency). Taking grape seed extract or proanthocyanidin, a chemical in grape seeds, by mouth seems to reduce symptoms of chronic venous insufficiency such as tired or heavy legs, tension, and tingling and pain. Research suggests that taking a specific grape leaf extract by mouth decreases leg swelling after 6 weeks.
- Eye stress. Taking grape seed extract by mouth might help decrease stress on the eyes from glare.
Possibly Ineffective for
- Hay fever. Taking grape seed extract for 8 weeks before ragweed pollen season does not seem to decrease seasonal allergy symptoms or the need to use allergy medications.
- Nausea and vomiting caused by chemotherapy. Taking 4 ounces of chilled Concord grape juice 30 minutes before meals for a week following each cycle of chemotherapy does not seem to reduce nausea or vomiting caused by chemotherapy.
- Tissue hardness and pain caused by radiation. Taking proanthocyanidin, a chemical found in grape seed extract, three times daily for 6 months does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer.
- Weight loss. Drinking Concord grape juice for 12 weeks does not seem to reduce weight in overweight people.
Insufficient Evidence for
- Age-related mental decline. Early research shows that drinking Concord grape juice daily for 12 weeks can improve verbal learning but not verbal recall in older people with age-related mental decline.
- Athletic performance. Early research shows that taking 400 mg of grape extract daily for one month might increase an athlete’s overall power when jumping, but not the initial power or maintenance of power. Other early research shows that drinking juice prepared from 46 grams of freeze-dried whole grape powder daily for 6 weeks does not improve oxygen uptake or the ability to perform work during a running exercise.
- Heart disease. There is some early evidence that drinking grape juice or red wine might reduce risk factors linked with heart disease, such as inflammation, clot formation, and oxidative damage to blood fats. But it’s not known if grape products specifically reduce heart disease risk.
- Eye damage caused by diabetes (diabetic retinopathy). Early evidence suggests that taking a specific grape seed extract product containing 100-200 mg of a chemical called proanthocyanidin daily can slow the progression of eye damage caused by diabetes.
- High cholesterol. Some research shows that taking 100 mg of grape seed extract twice daily for up to 2 months does not lower cholesterol levels in people with high cholesterol. However, other research shows that grape seed extract might lower cholesterol when taken in combination with other ingredients, including chromium or a mixture of policosanol, tomato extract, and evening primrose oil.
- High blood pressure. Most research shows that grape seed extract does not reduce blood pressure in healthy people or people with high blood pressure. However, in men with metabolic syndrome, taking freeze-dried, dehydrated whole grapes for 20 days seems to lower blood pressure. Metabolic syndrome is a cluster of conditions, including high blood pressure, that increase the risk for heart disease. Some studies have evaluated the effects of grape juice on blood pressure but results are mixed.
- Dark skin patches on the face (melasma). Early research suggests that taking grape seed extract by mouth for 6-11 months reduces dark skin discolorations in Japanese women.
- Menopausal symptoms. Taking grape seed extract containing 200 mg of the chemical proanthocyanidin daily for 8 weeks seems to reduce hot flashes, anxiety, and some physical symptoms of menopause. This dose and a lower dose (100 mg/day) also seem to improve lean body mass and diastolic blood pressure (the bottom number in a blood pressure reading). But grape seed extract doesn’t seem to improve insomnia or depression.
- Metabolic syndrome. Metabolic syndrome is a cluster of conditions that increase the risk for heart disease. Early research suggests that whole grapes might improve some of the risk factors associated with metabolic syndrome in men. Taking freeze-dried, dehydrated whole grapes for 30 days seems to lower blood pressure and increases blood flow. Also, drinking grape juice for one month seems to improve blood flow in teenagers with metabolic syndrome. However, it is not known if these changes decrease the risk for diabetes or other aspects of metabolic syndrome. Also, other research shows that taking a specific product containing grape seed extract for 4 weeks does not reduce blood pressure in people with metabolic syndrome.
- Muscle soreness. Early research shows that drinking juice prepared from 46 grams of freeze-dried whole grapes per day for 6 weeks before an arm exercise test does not reduce pain or swelling one or two days after the exercise.
- Poor night vision. Early research suggests that grape seed extract containing chemicals called proanthocyanidins might improve night vision.
- Nonalcoholic fatty liver disease. Research shows that taking grape seed extract 1000 mg twice daily for 3 months improves some but not all markers of liver damage compared to vitamin C supplementation in people with nonalcoholic fatty liver disease.
- Premenstrual syndrome (PMS). Early research suggests that taking a specific grape seed extract product might reduce PMS symptoms, including pain and swelling.
- Wound healing. Early research shows that applying cream containing 2% grape seed extract reduces the time for wound healing after removal of skin lesions.
- Treating varicose veins.
- Attention deficit-hyperactivity disorder (ADHD).
- Chronic fatigue syndrome (CFS).
- Heavy menstrual periods.
- Age-related macular degeneration (AMD).
- Canker sores.
- Liver damage.
- Other conditions.
Side Effects & SafetyGrape is LIKELY SAFE when consumed in amounts commonly found in foods.
Grape is POSSIBLY SAFE when taken by mouth in medicinal amounts. Grape seed extracts have been used safely in studies for up to 14 weeks. Eating large quantities of grapes, dried grapes, raisins, or sultanas might cause diarrhea. Some people have allergic reactions to grapes and grape products. Some other potential side effects include stomach upset, indigestion, nausea, vomiting, cough, dry mouth, sore throat, infections, headache, and muscular problems.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of grape in medicinal amounts (supplements or amounts that are higher than normal food amounts) during pregnancy and breast-feeding. Stay on the safe side and avoid using more than amounts normally found in foods.
Bleeding conditions: Grape might slow blood clotting. Taking grape might increase the chances of bruising and bleeding in people with bleeding conditions. However, there are no reports of this occurring in humans.
Surgery: Grape might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using medicinal amounts of grape at least 2 weeks before a scheduled surgery.
Be cautious with this combination
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with GRAPE
Some medications are changed and broken down by the liver.<br/><br/> Grape juice might increase how quickly the liver breaks down some medications. Taking grape along with some medications that are changed by the liver can decrease the effectiveness of some medications. Before taking grape talk to your healthcare provider if you take any medications that are changed by the liver.<br/><br/> Some of these medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), theophylline, zileuton (Zyflo), zolmitriptan (Zomig), and others.
Phenacetin interacts with GRAPE
The body breaks down phenacetin to get rid of it. Drinking grape juice might increase how quickly the body breaks down phenacetin. Taking phenacetin along with grape juice might decrease the effectiveness of phenacetin.
Warfarin (Coumadin) interacts with GRAPE
Warfarin (Coumadin) is used to slow blood clotting. Grape seed might also slow blood clotting. Taking grape seed along with warfarin (Coumadin) might increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
The following doses have been studied in scientific research:
- For poor blood flow in the legs (chronic venous insufficiency):
- A standardized red vine grape extract knows as AS 195 360 mg or 720 mg once daily for 6 to 12 weeks has been used. A specific grape seed extract containing proanthocyanidin 150-300 mg daily for one month has also been used. Proanthocyanidin is one of the active ingredients in grape.
- For reducing eye stress due to glare:
- A specific grape seed extract containing proanthocyanidin 200 mg daily for 5 weeks has been used.
- Grape seed extract proanthocyanidin at a dose of 300 mg per day has also been used.
- A review of evidence on red vine leaf extract in the prevention and management of venous disease. J Wound Care 2006;15(9):393-396. View abstract.
- Albers, A. R., Varghese, S., Vitseva, O., Vita, J. A., and Freedman, J. E. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler.Thromb.Vasc.Biol. 2004;24(11):e179-e180. View abstract.
- Amsellem M, Masson JM, Negui B, and et al. [Endotelon in the treatment of venolymphatic problems in premenstrual syndrome. Multicenter study on 165 patients]. Tempo Medical 1987;282 :46-51.
- Araghi-Niknam M, Hosseini S, Larson D, and et al. Pine bark extract reduces platelet aggregation. Integr Med 2000;2(2):73-77.
- Arne JL. [Contribution to the study of procyanidolic oligomers: Endotelon in diabetic retinopathy (based on 30 cases).]. Gaz Med France 1982;89(30):3610-3614.
- Bagchi, D., Garg, A., Krohn, R. L., Bagchi, M., Tran, M. X., and Stohs, S. J. Oxygen free radical scavenging abilities of vitamins C and E, and a grape seed proanthocyanidin extract in vitro. Res Commun Mol Pathol.Pharmacol 1997;95(2):179-189. View abstract.
- Banerjee, B. and Bagchi, D. Beneficial effects of a novel ih636 grape seed proanthocyanidin extract in the treatment of chronic pancreatitis. Digestion 2001;63(3):203-206. View abstract.
- Barona, J., Blesso, C. N., Andersen, C. J., Park, Y., Lee, J., and Fernandez, M. L. Grape consumption increases anti-inflammatory markers and upregulates peripheral nitric oxide synthase in the absence of dyslipidemias in men with metabolic syndrome. Nutrients. 2012;4(12):1945-1957. View abstract.
- Baruch, J. [Effect of Endotelon in postoperative edema. Results of a double-blind study versus placebo in 32 female patients]. Ann.Chir Plast.Esthet. 1984;29(4):393-395. View abstract.
- Bejaoui, H., Mathieu, F., Taillandier, P., and Lebrihi, A. Ochratoxin A removal in synthetic and natural grape juices by selected oenological Saccharomyces strains. J Appl.Microbiol. 2004;97(5):1038-1044. View abstract.
- Benjamin, S., Sharma, R., Thomas, S. S., and Nainan, M. T. Grape seed extract as a potential remineralizing agent: a comparative in vitro study. J Contemp.Dent.Pract. 2012;13(4):425-430. View abstract.
- Boissin, J. P., Corbe, C., and Siou, A. [Chorioretinal circulation and dazzling: use of procyanidol oligomers (Endotelon)]. Bull.Soc.Ophtalmol.Fr. 1988;88(2):173-179. View abstract.
- Brito, FF., Martinez, A., Palacios, R., Mur, P., Gomez, E., Galindo, P. A., Borja, J., and Martinez, J. Rhinoconjunctivitis and asthma caused by vine pollen: a case report. J Allergy Clin Immunol 1999;103(2 Pt 1):262-266. View abstract.
- Brooker, S., Martin, S., Pearson, A., Bagchi, D., Earl, J., Gothard, L., Hall, E., Porter, L., and Yarnold, J. Double-blind, placebo-controlled, randomised phase II trial of IH636 grape seed proanthocyanidin extract (GSPE) in patients with radiation-induced breast induration. Radiother.Oncol 2006;79(1):45-51. View abstract.
- Cabras, P., Angioni, A., Caboni, P., Garau, V. L., Melis, M., Pirisi, F. M., and Cabitza, F. Distribution of folpet on the grape surface after treatment. J Agric.Food Chem 2000;48(3):915-916. View abstract.
- Caillet, S., Salmieri, S., and Lacroix, M. Evaluation of free radical scavenging properties of grape phenolic extracts by a fast colorimetric method. Acta Horticulturae 2007;744:425-429.
- Castilla, P., Davalos, A., Teruel, J. L., Cerrato, F., Fernandez-Lucas, M., Merino, J. L., Sanchez-Martin, C. C., Ortuno, J., and Lasuncion, M. A. Comparative effects of dietary supplementation with red grape juice and vitamin E on production of superoxide by circulating neutrophil NADPH oxidase in hemodialysis patients. Am J Clin.Nutr. 2008;87(4):1053-1061. View abstract.
- Castilla, P., Echarri, R., Davalos, A., Cerrato, F., Ortega, H., Teruel, J. L., Lucas, M. F., Gomez-Coronado, D., Ortuno, J., and Lasuncion, M. A. Concentrated red grape juice exerts antioxidant, hypolipidemic, and antiinflammatory effects in both hemodialysis patients and healthy subjects. Am J Clin.Nutr. 2006;84(1):252-262. View abstract.
- Chang, W. C. and Hsu, F. L. Inhibition of platelet aggregation and arachidonate metabolism in platelets by procyanidins. Prostaglandins Leukot.Essent.Fatty Acids 1989;38(3):181-188. View abstract.
- Chaves, A. A., Joshi, M. S., Coyle, C. M., Brady, J. E., Dech, S. J., Schanbacher, B. L., Baliga, R., Basuray, A., and Bauer, J. A. Vasoprotective endothelial effects of a standardized grape product in humans. Vascul.Pharmacol. 2009;50(1-2):20-26. View abstract.
- Cherniack, E. P. A berry thought-provoking idea: the potential role of plant polyphenols in the treatment of age-related cognitive disorders. Br J Nutr 2012;108(5):794-800. View abstract.
- Chidambara Murthy, K. N., Singh, R. P., and Jayaprakasha, G. K. Antioxidant activities of grape (Vitis vinifera) pomace extracts. J Agric.Food Chem 10-9-2002;50(21):5909-5914. View abstract.
- Chou, E. J., Keevil, J. G., Aeschlimann, S., Wiebe, D. A., Folts, J. D., and Stein, J. H. Effect of ingestion of purple grape juice on endothelial function in patients with coronary heart disease. Am J Cardiol 9-1-2001;88(5):553-555. View abstract.
- Clifton, P. M. Effect of Grape Seed Extract and Quercetin on Cardiovascular and Endothelial Parameters in High-Risk Subjects. J Biomed.Biotechnol. 2004;2004(5):272-278. View abstract.
- Coimbra, S. R., Lage, S. H., Brandizzi, L., Yoshida, V., and da Luz, P. L. The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients. Braz.J Med Biol.Res 2005;38(9):1339-1347. View abstract.
- Corbe, C., Boissin, J. P., and Siou, A. [Light vision and chorioretinal circulation. Study of the effect of procyanidolic oligomers (Endotelon)]. J Fr.Ophtalmol. 1988;11(5):453-460. View abstract.
- Dartenuc P, Marache P, and Choussat H. [Capillary resistance in geriatry. Study of a microangioprotector: endotelon.]. Bordeaux Medicale 1980;13:903-907.
- Davalos, A., Fernandez-Hernando, C., Cerrato, F., Martinez-Botas, J., Gomez-Coronado, D., Gomez-Cordoves, C., and Lasuncion, M. A. Red grape juice polyphenols alter cholesterol homeostasis and increase LDL-receptor activity in human cells in vitro. J Nutr. 2006;136(7):1766-1773. View abstract.
- Day, A. P., Kemp, H. J., Bolton, C., Hartog, M., and Stansbie, D. Effect of concentrated red grape juice consumption on serum antioxidant capacity and low-density lipoprotein oxidation. Ann.Nutr.Metab 1997;41(6):353-357. View abstract.
- de Lange, D. W., Scholman, W. L., Kraaijenhagen, R. J., Akkerman, J. W., and van de Wiel, A. Alcohol and polyphenolic grape extract inhibit platelet adhesion in flowing blood. Eur.J Clin.Invest 2004;34(12):818-824. View abstract.
- de Lange, D. W., Verhoef, S., Gorter, G., Kraaijenhagen, R. J., van de Wiel, A., and Akkerman, J. W. Polyphenolic grape extract inhibits platelet activation through PECAM-1: an explanation for the French paradox. Alcohol Clin.Exp.Res 2007;31(8):1308-1314. View abstract.
- De, Groote D., Van, Belleghem K., Deviere, J., Van, Brussel W., Mukaneza, A., and Amininejad, L. Effect of the intake of resveratrol, resveratrol phosphate, and catechin-rich grape seed extract on markers of oxidative stress and gene expression in adult obese subjects. Ann Nutr Metab 2012;61(1):15-24. View abstract.
- Delacroix P. [Double-blind study of Endotelon in chronic venous insufficiency] [translated from French]. La Revue de Medecine 1981;31(27-28):1793-1802.
- Dohadwala, M. M., Hamburg, N. M., Holbrook, M., Kim, B. H., Duess, M. A., Levit, A., Titas, M., Chung, W. B., Vincent, F. B., Caiano, T. L., Frame, A. A., Keaney, J. F., Jr., and Vita, J. A. Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin.Nutr. 2010;92(5):1052-1059. View abstract.
- Fang, M., Liu, R., Xiao, Y., Li, F., Wang, D., Hou, R., and Chen, J. Biomodification to dentin by a natural crosslinker improved the resin-dentin bonds. J Dent. 2012;40(6):458-466. View abstract.
- Feringa, H. H., Laskey, D. A., Dickson, J. E., and Coleman, C. I. The effect of grape seed extract on cardiovascular risk markers: a meta-analysis of randomized controlled trials. J Am Diet.Assoc. 2011;111(8):1173-1181. View abstract.
- Fromantin M. [OPC in the treatment of capillary weakness and retinopathy in diabetics. A propos of 26 cases]. Med Int 1982;16(11):432-434.
- Gazzani, G., Daglia, M., and Papetti, A. Food components with anticaries activity. Curr Opin Biotechnol. 2012;23(2):153-159. View abstract.
- Green, B., Yao, X., Ganguly, A., Xu, C., Dusevich, V., Walker, M. P., and Wang, Y. Grape seed proanthocyanidins increase collagen biodegradation resistance in the dentin/adhesive interface when included in an adhesive. J Dent. 2010;38(11):908-915. View abstract.
- Haniadka, R., Popouri, S., Palatty, P. L., Arora, R., and Baliga, M. S. Medicinal plants as antiemetics in the treatment of cancer: a review. Integr.Cancer Ther. 2012;11(1):18-28. View abstract.
- Hansen, A. S., Marckmann, P., Dragsted, L. O., Finne Nielsen, I. L., Nielsen, S. E., and Gronbaek, M. Effect of red wine and red grape extract on blood lipids, haemostatic factors, and other risk factors for cardiovascular disease. Eur.J Clin.Nutr. 2005;59(3):449-455. View abstract.
- Hashemi, M., Kelishadi, R., Hashemipour, M., Zakerameli, A., Khavarian, N., Ghatrehsamani, S., and Poursafa, P. Acute and long-term effects of grape and pomegranate juice consumption on vascular reactivity in paediatric metabolic syndrome. Cardiol Young. 2010;20(1):73-77. View abstract.
- Henriet, J. P. [Veno-lymphatic insufficiency. 4,729 patients undergoing hormonal and procyanidol oligomer therapy]. Phlebologie. 1993;46(2):313-325. View abstract.
- Hollis, J. H., Houchins, J. A., Blumberg, J. B., and Mattes, R. D. Effects of concord grape juice on appetite, diet, body weight, lipid profile, and antioxidant status of adults. J Am Coll.Nutr. 2009;28(5):574-582. View abstract.
- Hsu, Y. L., Liang, H. L., Hung, C. H., and Kuo, P. L. Syringetin, a flavonoid derivative in grape and wine, induces human osteoblast differentiation through bone morphogenetic protein-2/extracellular signal-regulated kinase 1/2 pathway. Mol.Nutr.Food Res 2009;53(11):1452-1461. View abstract.
- Ingersoll, G. L., Wasilewski, A., Haller, M., Pandya, K., Bennett, J., He, H., Hoffmire, C., and Berry, C. Effect of concord grape juice on chemotherapy-induced nausea and vomiting: results of a pilot study. Oncol.Nurs.Forum 2010;37(2):213-221. View abstract.
- Islam, S. M., Hiraishi, N., Nassar, M., Sono, R., Otsuki, M., Takatsura, T., Yiu, C., and Tagami, J. In vitro effect of hesperidin on root dentin collagen and de/re-mineralization. Dent.Mater.J 2012;31(3):362-367. View abstract.
- Jimenez, J. P., Serrano, J., Tabernero, M., Arranz, S., Diaz-Rubio, M. E., Garcia-Diz, L., Goni, I., and Saura-Calixto, F. Effects of grape antioxidant dietary fiber in cardiovascular disease risk factors. Nutrition 2008;24(7-8):646-653. View abstract.
- Kalus, U., Koscielny, J., Grigorov, A., Schaefer, E., Peil, H., and Kiesewetter, H. Improvement of cutaneous microcirculation and oxygen supply in patients with chronic venous insufficiency by orally administered extract of red vine leaves AS 195: a randomised, double-blind, placebo-controlled, crossover study. Drugs R.D. 2004;5(2):63-71. View abstract.
- Kar, P., Laight, D., Rooprai, H. K., Shaw, K. M., and Cummings, M. Effects of grape seed extract in Type 2 diabetic subjects at high cardiovascular risk: a double blind randomized placebo controlled trial examining metabolic markers, vascular tone, inflammation, oxidative stress and insulin sensitivity. Diabet.Med 2009;26(5):526-531. View abstract.
- Khoshbaten, M., Aliasgarzadeh, A., Masnadi, K., Farhang, S., Tarzamani, M. K., Babaei, H., Kiani, J., Zaare, M., and Najafipoor, F. Grape seed extract to improve liver function in patients with nonalcoholic fatty liver change. Saudi.J Gastroenterol. 2010;16(3):194-197. View abstract.
- Koo, M., Kim, S. H., Lee, N., Yoo, M. Y., Ryu, S. Y., Kwon, D. Y., and Kim, Y. S. 3-Hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibitory effect of Vitis vinifera. Fitoterapia 2008;79(3):204-206. View abstract.
- Krikorian, R., Nash, T. A., Shidler, M. D., Shukitt-Hale, B., and Joseph, J. A. Concord grape juice supplementation improves memory function in older adults with mild cognitive impairment. Br J Nutr. 2010;103(5):730-734. View abstract.
- La, V. D., Bergeron, C., Gafner, S., and Grenier, D. Grape seed extract suppresses lipopolysaccharide-induced matrix metalloproteinase (MMP) secretion by macrophages and inhibits human MMP-1 and -9 activities. J Periodontol. 2009;80(11):1875-1882. View abstract.
- Lafay, S., Jan, C., Nardon, K., Lemaire, B., Ibarra, A., Roller, M., Houvenaeghel, M., Juhel, C., and Cara, L. Grape extract improves antioxidant status and physical performance in elite male athletes. Journal of Sports Science & Medicine 2009;8(3):468.
- Lagrue, G., Olivier-Martin, F., and Grillot, A. [A study of the effects of procyanidol oligomers on capillary resistance in hypertension and in certain nephropathies (author's transl)]. Sem Hop 9-18-1981;57(33-36):1399-1401. View abstract.
- Leifert, W. R. and Abeywardena, M. Y. Grape seed and red wine polyphenol extracts inhibit cellular cholesterol uptake, cell proliferation, and 5-lipoxygenase activity. Nutr.Res 2008;28(12):842-850. View abstract.
- Lesbre FX and Tigaud JD. [The effect of Endotelon on the capillary fragility index of a specified controlled group: cirrhosis patients]. Gazette Medicale de France 1983;90(24):2333-2337.
- Li, Q. Z., Cho, H. S., Jeun, S. H., Kim, K. J., Choi, S. J., and Sung, K. W. Effects of grape seed proanthocyanidin on 5-hydroxytryptamine(3) receptors in NCB-20 neuroblastoma cells. Biol.Pharm Bull. 2011;34(7):1109-1115. View abstract.
- Li, S., Zhong, J., and Sun, F. [Study on the protective effect of grape procyanidins on DNA damage induced by irradiation]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2000;34(3):131-133. View abstract.
- Liu, J. Y. and Zhong, J. Y. [Study on protective effect of grape procyanidins in radiation injury in radiation-contacted persons]. Zhonghua Yu Fang Yi.Xue.Za Zhi. 2008;42(4):264-267. View abstract.
- Lluis, L., Munoz, M., Nogues, M. R., Sanchez-Martos, V., Romeu, M., Giralt, M., Valls, J., and Sola, R. Toxicology evaluation of a procyanidin-rich extract from grape skins and seeds. Food Chem Toxicol. 2011;49(6):1450-1454. View abstract.
- Maffei, Facino R., Carini, M., Aldini, G., Bombardelli, E., Morazzoni, P., and Morelli, R. Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis vinifera. A mechanism for their capillary protective action. Arzneimittelforschung. 1994;44(5):592-601. View abstract.
- Mahadeswaraswamy, Y. H., Nagaraju, S., Girish, K. S., and Kemparaju, K. Local tissue destruction and procoagulation properties of Echis carinatus venom: inhibition by Vitis vinifera seed methanol extract. Phytother.Res 2008;22(7):963-969. View abstract.
- Marguerie, C. and Drouet, M. [Occupational eosinophilic lung in a grape grower: role of sulfites]. Allerg.Immunol.(Paris) 1995;27(5):163-167. View abstract.
- Meunier, M. T., Villie, F., Jonadet, M., Bastide, J., and Bastide, P. Inhibition of angiotensin I converting enzyme by flavanolic compounds: in vitro and in vivo studies. Planta Med 1987;53(1):12-15. View abstract.
- Monsieur, R. and Van, Snick G. [Efficacy of the red vine leaf extract AS 195 in Chronic Venous Insufficiency]. Praxis.(Bern.1994.) 1-25-2006;95(6):187-190. View abstract.
- Murgov, I., Acikbas, M., and Nikolova, R. Antimicrobial activity of citric acid and grape seed extract on pathogenic microorganisms and lactobacilli. Scientific Works of the University of Food Technologies - Plovdiv 2008;55(1):367-372.
- Nair, N., Mahajan, S., Chawda, R., Kandaswami, C., Shanahan, T. C., and Schwartz, S. A. Grape seed extract activates Th1 cells in vitro. Clin.Diagn.Lab Immunol. 2002;9(2):470-476. View abstract.
- Natella, F., Belelli, F., Gentili, V., Ursini, F., and Scaccini, C. Grape seed proanthocyanidins prevent plasma postprandial oxidative stress in humans. J Agric.Food Chem 12-18-2002;50(26):7720-7725. View abstract.
- Nishikawa, M., Ariyoshi, N., Kotani, A., Ishii, I., Nakamura, H., Nakasa, H., Ida, M., Nakamura, H., Kimura, N., Kimura, M., Hasegawa, A., Kusu, F., Ohmori, S., Nakazawa, K., and Kitada, M. Effects of continuous ingestion of green tea or grape seed extracts on the pharmacokinetics of midazolam. Drug Metab Pharmacokinet. 2004;19(4):280-289. View abstract.
- Nuttall SL, Kendall MJ, Bombardelli E, and et al. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. Journal of Clinical Pharmacology and Therapeutics 1998;23:385-389.
- O'Byrne, D. J., Devaraj, S., Grundy, S. M., and Jialal, I. Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults. Am J Clin.Nutr. 2002;76(6):1367-1374. View abstract.
- Oliveira-Freitas, V. L., Dalla, Costa T., Manfro, R. C., Cruz, L. B., and Schwartsmann, G. Influence of purple grape juice in cyclosporine bioavailability. J Ren Nutr. 2010;20(5):309-313. View abstract.
- Ozturk, H. S., Kacmaz, M., Cimen, M. Y., and Durak, I. Red wine and black grape strengthen blood antioxidant potential. Nutrition 1999;15(11-12):954-955. View abstract.
- Parienti J and Pareinti-Amsellem J. [Post-traumatic edemas in sports: a controlled test of endotelon]. Gaz Med France 1983;90(3):231-235.
- Park, M. K., Park, J. S., Cho, M. L., Oh, H. J., Heo, Y. J., Woo, Y. J., Heo, Y. M., Park, M. J., Park, H. S., Park, S. H., Kim, H. Y., and Min, J. K. Grape seed proanthocyanidin extract (GSPE) differentially regulates Foxp3(+) regulatory and IL-17(+) pathogenic T cell in autoimmune arthritis. Immunol.Lett. 3-30-2011;135(1-2):50-58. View abstract.
- Park, Y. K., Kim, J. S., and Kang, M. H. Concord grape juice supplementation reduces blood pressure in Korean hypertensive men: double-blind, placebo controlled intervention trial. Biofactors 2004;22(1-4):145-147. View abstract.
- Park, Y. K., Lee, S. H., Park, E., Kim, J. S., and Kang, M. H. Changes in antioxidant status, blood pressure, and lymphocyte DNA damage from grape juice supplementation. Ann.N.Y.Acad.Sci. 2009;1171:385-390. View abstract.
- Pecking A, Desperez-Curely JP, and Megret G. OPC (Endotelon) in the treatment of post-therapy lymphedemas of the upper extremities. Int'l d'Antiologie 1989.
- Piper, J., Kohler, S., Niestroj, M., and Malek, F. A. Medical nutrition therapy of patients with atherosclerotic vascular diseases and hypertension by means of perilla oil and black grape extract as dietary food for special medical purposes. Diätetische Intervention mit Perilla-Öl und Rotweintrauben-Extrakt als ergänzende bilanzierte Diät bei Patienten mit atherosklerotischen Gefässerkrankungen und Bluthochdruck 2005;20(1):20-26.
- Preuss, H. G., Wallerstedt, D., Talpur, N., Tutuncuoglu, S. O., Echard, B., Myers, A., Bui, M., and Bagchi, D. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hypercholesterolemic subjects: a pilot study. J Med 2000;31(5-6):227-246. View abstract.
- Rababah, T. M., Al-u'datt, M., Almajwal, A., Brewer, S., Feng, H., Al-Mahasneh, M., Ereifej, K., and Yang, W. Evaluation of the nutraceutical, physiochemical and sensory properties of raisin jam. J Food Sci 2012;77(6):C609-C613. View abstract.
- Rabe, E., Stucker, M., Esperester, A., Schafer, E., and Ottillinger, B. Efficacy and tolerability of a red-vine-leaf extract in patients suffering from chronic venous insufficiency--results of a double-blind placebo-controlled study. Eur.J Vasc.Endovasc.Surg. 2011;41(4):540-547. View abstract.
- Rao, A. V., Shen, H., Agarwal, A., Yatcilla, M. T., and Agarwal, S. Bioabsorption and in vivo antioxidant properties of grape extract biovin((r)): a human intervention study. J Med Food 2000;3(1):15-22. View abstract.
- Rawn, D. F., Roscoe, V., Krakalovich, T., and Hanson, C. N-methyl carbamate concentrations and dietary intake estimates for apple and grape juices available on the retail market in Canada. Food Addit.Contam 2004;21(6):555-563. View abstract.
- Richard, T., Poupard, P., Nassra, M., Papastamoulis, Y., Iglesias, M. L., Krisa, S., Waffo-Teguo, P., Merillon, J. M., and Monti, J. P. Protective effect of epsilon-viniferin on beta-amyloid peptide aggregation investigated by electrospray ionization mass spectrometry. Bioorg.Med Chem 5-15-2011;19(10):3152-3155. View abstract.
- Rosa, C. A., Magnoli, C. E., Fraga, M. E., Dalcero, A. M., and Santana, D. M. Occurrence of ochratoxin A in wine and grape juice marketed in Rio de Janeiro, Brazil. Food Addit.Contam 2004;21(4):358-364. View abstract.
- Rowe, C. A., Nantz, M. P., Nieves, C., Jr., West, R. L., and Percival, S. S. Regular consumption of concord grape juice benefits human immunity. J Med Food 2011;14(1-2):69-78. View abstract.
- Sandra, D., Radha, M., Harishkumar, M., Yuichi, N., Sayuri, O., and Masugi, M. Downregulation of urokinase-type plasminogen activator and plasminogen activator inhibitor-1 by grape seed proanthocyanidin extract. Phytomedicine. 2010;17(1):42-46. View abstract.
- Sano, A., Uchida, R., Saito, M., Shioya, N., Komori, Y., Tho, Y., and Hashizume, N. Beneficial effects of grape seed extract on malondialdehyde-modified LDL. J Nutr Sci Vitaminol.(Tokyo) 2007;53(2):174-182. View abstract.
- Sarrat L. [Therapeutic relief of functional problems of the lower legs by Endotelon, a microangioprotector]. Bordeaux Med 1981;14:685-688.
- Schaefer, E., Peil, H., Ambrosetti, L., and Petrini, O. Oedema protective properties of the red vine leaf extract AS 195 (Folia vitis viniferae) in the treatment of chronic venous insufficiency. A 6-week observational clinical trial. Arzneimittelforschung. 2003;53(4):243-246. View abstract.
- Sharma, S. D. and Katiyar, S. K. Dietary grape-seed proanthocyanidin inhibition of ultraviolet B-induced immune suppression is associated with induction of IL-12. Carcinogenesis 2006;27(1):95-102. View abstract.
- Shivashankara, A. R., Azmidah, A., Haniadka, R., Rai, M. P., Arora, R., and Baliga, M. S. Dietary agents in the prevention of alcohol-induced hepatotoxicty: preclinical observations. Food Funct. 2012;3(2):101-109. View abstract.
- Sivaprakasapillai, B., Edirisinghe, I., Randolph, J., Steinberg, F., and Kappagoda, T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism 2009;58(12):1743-1746. View abstract.
- Skarpan´ska-Stejnborn, A., Basta, P., Pilaczyn´ska-Szczesniak, L., and Horoszkiewicz-Hassan, M. Black grape extract supplementation attenuates blood oxidative stress in response to acute exercise. Biology of Sport 2010;27(1):41-46.
- Skovgaard, G. R., Jensen, A. S., and Sigler, M. L. Effect of a novel dietary supplement on skin aging in post-menopausal women. Eur J Clin Nutr 2006;60(10):1201-1206. View abstract.
- Soyeux, A., Seguin, J. P., Le, Devehat C., and Bertrand, A. [Endotelon. Diabetic retinopathy and hemorheology (preliminary study)]. Bull.Soc Ophtalmol.Fr. 1987;87(12):1441-1444. View abstract.
- Suppasrivasuseth, J., Bellantone, R. A., Plakogiannis, F. M., and Stagni, G. Permeability and retention studies of (-)epicatechin gel formulations in human cadaver skin. Drug Dev Ind Pharm 2006;32(9):1007-1017. View abstract.
- Tao, H. Y., Wu, C. F., Zhou, Y., Gong, W. H., Zhang, X., Iribarren, P., Zhao, Y. Q., Le, Y. Y., and Wang, J. M. The grape component resveratrol interferes with the function of chemoattractant receptors on phagocytic leukocytes. Cell Mol.Immunol. 2004;1(1):50-56. View abstract.
- Tebib K et al. Polymeric grape seed tannins prevent plasma cholesterol changes in high-cholesterol-fed rats. Food Chem 1994;49:403-406.
- Thebaut JF, Thebaut P, and Vin F. Study of Endotelon in the functional manifestations of peripheral venous insufficiency. Results of a double-blind study of 92 patients. Gazette Medicale 1985;92(1):96-100.
- Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Garcia-Almagro, F. J., Aviles-Plaza, F., Parra, S., Yanez-Gascon, M. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. Consumption of a grape extract supplement containing resveratrol decreases oxidized LDL and ApoB in patients undergoing primary prevention of cardiovascular disease: a triple-blind, 6-month follow-up, placebo-controlled, randomized trial. Mol.Nutr Food Res 2012;56(5):810-821. View abstract.
- Tome-Carneiro, J., Gonzalvez, M., Larrosa, M., Yanez-Gascon, M. J., Garcia-Almagro, F. J., Ruiz-Ros, J. A., Garcia-Conesa, M. T., Tomas-Barberan, F. A., and Espin, J. C. One-year consumption of a grape nutraceutical containing resveratrol improves the inflammatory and fibrinolytic status of patients in primary prevention of cardiovascular disease. Am J Cardiol. 8-1-2012;110(3):356-363. View abstract.
- Urios, P., Grigorova-Borsos, A. M., and Sternberg, M. Flavonoids inhibit the formation of the cross-linking AGE pentosidine in collagen incubated with glucose, according to their structure. Eur J Nutr 2007;46(3):139-146. View abstract.
- van Mierlo, L. A., Zock, P. L., van der Knaap, H. C., and Draijer, R. Grape polyphenols do not affect vascular function in healthy men. J Nutr. 2010;140(10):1769-1773. View abstract.
- Verin MM, Vildy A, and Maurin JF. [Retinopathies and OPC]. Bordeaux Medicale 1978;11(16):1467-1474.
- Vidhya, S., Srinivasulu, S., Sujatha, M., and Mahalaxmi, S. Effect of grape seed extract on the bond strength of bleached enamel. Oper.Dent. 2011;36(4):433-438. View abstract.
- Vigna, G. B., Costantini, F., Aldini, G., Carini, M., Catapano, A., Schena, F., Tangerini, A., Zanca, R., Bombardelli, E., Morazzoni, P., Mezzetti, A., Fellin, R., and Maffei, Facino R. Effect of a standardized grape seed extract on low-density lipoprotein susceptibility to oxidation in heavy smokers. Metabolism 2003;52(10):1250-1257. View abstract.
- Wang, Y. J., Thomas, P., Zhong, J. H., Bi, F. F., Kosaraju, S., Pollard, A., Fenech, M., and Zhou, X. F. Consumption of grape seed extract prevents amyloid-beta deposition and attenuates inflammation in brain of an Alzheimer's disease mouse. Neurotox.Res 2009;15(1):3-14. View abstract.
- Ward, N. C., Croft, K. D., Puddey, I. B., and Hodgson, J. M. Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans. J Agric.Food Chem 8-25-2004;52(17):5545-5549. View abstract.
- Xie, Q., Bedran-Russo, A. K., and Wu, C. D. In vitro remineralization effects of grape seed extract on artificial root caries. J Dent. 2008;36(11):900-906. View abstract.
- Yamakoshi, J., Kataoka, S., Koga, T., and Ariga, T. Proanthocyanidin-rich extract from grape seeds attenuates the development of aortic atherosclerosis in cholesterol-fed rabbits. Atherosclerosis 1999;142(1):139-149. View abstract.
- Yamakoshi, J., Sano, A., Tokutake, S., Saito, M., Kikuchi, M., Kubota, Y., Kawachi, Y., and Otsuka, F. Oral intake of proanthocyanidin-rich extract from grape seeds improves chloasma. Phytother Res 2004;18(11):895-899. View abstract.
- Zern, T. L., Wood, R. J., Greene, C., West, K. L., Liu, Y., Aggarwal, D., Shachter, N. S., and Fernandez, M. L. Grape polyphenols exert a cardioprotective effect in pre- and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005;135(8):1911-1917. View abstract.
- Agarwal C, Sharma Y, Agarwal R. Anticarcinogenic effect of a polyphenolic fraction isolated from grape seeds in human prostate carcinoma DU145 cells: modulation of mitogenic signaling and cell-cycle regulators and induction of G1 arrest and apoptosis. Mol Carcinog 2000;28:129-38.. View abstract.
- Anon. OPCs (Oligomeric Proanthocyanidins). The Natural Pharmacist 2000. http://www.tnp.com/substance.asp?ID=181. (Accessed 3 June 2000).
- Bagchi D, Bagchi M, Stohs SJ, et al. Cellular protection with proanthocyanidins derived from grape seeds. Ann N Y Acad Sci 2002;957:260-70.
- Barona J, Aristizabal JC, Blesso CN, et al. Grape polyphenols reduce blood pressure and increase flow-mediated vasodilation in men with metabolic syndrome. J Nutr 2012;142:1626-32. View abstract.
- Bernstein DI, Bernstein CK, Deng C, et al. Evaluation of the clinical efficacy and safety of grapeseed extract in the treatment of fall seasonal allergic rhinitis: a pilot study. Ann Allergy Asthma Immunol 2002;88:272-8.. View abstract.
- BIBRA working group. Anthocyanins. Toxicity profile. BIBRA Toxicol Int 1991;6.
- Bombardelli E, Morazzoni P. Vitis vinifera L. Fitoterapia 1995;LXVI:291-317.
- Chevallier A. The Encyclopedia of Medicinal Plants. London, UK: Dorling Kindersley, Ltd., 1996.
- Chisholm A, Mann J, Skeaff M, et al. A diet rich in walnuts favourably influences plasma fatty acid profile in moderately hyperlipidaemic subjects. Eur J Clin Nutr 1998;52:12-6. View abstract.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
- Freedman JE, Parker C, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001;103:2792-8.. View abstract.
- Greenblatt DJ, von Moltke LL, Perloff ES, et al. Interaction of flurbiprofen with cranberry juice, grape juice, tea, and fluconazole: in vitro and clinical studies. Clin Pharmacol Ther 2006;79:125-33. View abstract.
- Gupta H, Pawar D, Riva A, et al. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Phytother Res 2012;26:265-272. View abstract.
- Hemmati AA, Foroozan M, Houshmand G, et al. The topical effect of grape seed extract 2% cream on surgery wound healing. Glob J Health Sci 2014;7(3):52-8. View abstract.
- Kiesewetter H, Koscielny J, Kalus U, et al. Efficacy of orally administered extract of red vine leaf AS 195 (folia vitis viniferae) in chronic venous insufficiency (stages I-II). A randomized, double-blind, placebo-controlled trial. Arzneimittelforschung 2000;50:109-17. View abstract.
- Krochmal A, Grierson W. Brief history of grape growing in the United States. Econ Bot 1961;15(2):114-118.
- Meng X, Maliakal P, Lu H, et al. Urinary and plasma levels of resveratrol and quercetin in humans, mice, and rats after ingestion of pure compounds and grape juice. J Agric Food Chem 2004;52:935-42. View abstract.
- Meyer AS, Yi OS, Pearson DA, et al. Inhibition of human low-density lipoprotein oxidation in relation to composition of phenolic antioxidants in grapes (Vitis vinifera). J Agric Food Chem 1997;45:1638-43.
- Nuttall SL, Kendall MJ, Bombardelli E, Morazzoni P. An evaluation of the antioxidant activity of a standardized grape seed extract, Leucoselect. J Clin Pharm Ther 1998;23:385-89. View abstract.
- O'Connor PJ, Caravalho AL, Freese EC, Cureton KJ. Grape consumption's effects on fitness, muscle injury, mood, and perceived health. Int J Sport Nutr Exerc Metab 2013;23(1):57-64. View abstract.
- Pataki T, Bak I, Kovacs P, et al. Grape seed proanthocyanidins improved cardiac recovery during reperfusion after ischemia in isolated rat hearts. Am J Clin Nutr 2002;75:894-9.
- Peirce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York, NY: William Morrow and Co., 1999.
- Putter M, Grotemeyer KH, Wurthwein G, et al. Inhibition of smoking-induced platelet aggregation by aspirin and pycnogenol. Thromb Res 1999;95:155-61. View abstract.
- Ras RT, Zock PL, Zebregs YE, et al. Effect of polyphenol-rich grape seed extract on ambulatory blood pressure in subjects with pre- and stage I hypertension. Br J Nutr 2013;110(12):2234-41. View abstract.
- Snow LA, Hovanec L, Brandt J. A controlled trial of aromatherapy for agitation in nursing home patients with dementia. J Altern Complement Med 2004;10(3):431-7. View abstract.
- Stein JH, Keevil JG, Wiebe DA, et al. Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation 1999;100:1050-5.. View abstract.
- Su T, Wilf P, Huang Y, Zhang S, Zhou Z. The natural origins of some popular varieties of fruit. Sci Rep 2015;5:16794. View abstract.
- Terauchi M, Horiguchi N, Kajiyama A, et al. Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study. Menopause 2014;21(9):990-6. View abstract.
- This P, Lacombe T, Thomas MR. Historical origins and genetic diversity of wine grapes. Trends Genet 2006;22(9):511-9. View abstract.
- Vaswani SK, Hamilton RG, Carey RN, et al. Anaphylaxis recurrent urticaria and angioedema from grape hypersensitivity. J Allergy Clin Immunol 1998;101:S31.
- Ward NC, Hodgson JM, Croft KD, et al. The combination of vitamin C and grape-seed polyphenols increases blood pressure: a randomized, double-blind, placebo-controlled trial. J Hypertens 2005;23:427-34.. View abstract.
- Xiao Dong S, Zhi Ping Z, Zhong Xiao W, et al. Possible enhancement of the first-pass metabolism of phenacetin by ingestion of grape juice in Chinese subjects. Br J Clin Pharmacol 1999;48:638-40. View abstract.
- Young, J. F., Dragsted, L. O., Daneshvar, B., Lauridsen, S. T., Hansen, M., and Sandstrom, B. The effect of grape-skin extract on oxidative status. Br J Nutr 2000;84(4):505-513. View abstract.