OMEGA-6 FATTY ACIDS
Acides Gras Essentiels N-6, Acides Gras Oméga-6, Acides Gras Omégas 6, Acides Gras Polyinsaturés, Acidos Grasos Omega 6, AGE, AGPI, Huiles d'Oméga 6, N-6, N-6 EFAs, N-6 Essential Fatty Acids, Omega 6, Omega-6 Polyunsaturated Fatty Acids, Omega 6 Oils, Polyunsaturated Fatty Acids, PUFAs.<br/><br/>
Overview InformationOmega-6 fatty acids are types of fats. Some types are found in vegetable oils, including corn, evening primrose seed, safflower, and soybean oils. Other types of omega-6 fatty acids are found in black currant seed, borage seed, and evening primrose oils.
Omega-6 fatty acids are used for many conditions, but so far, the best information that science can provide is that putting arachidonic acid, a particular omega-6 fatty acid, in infant formula doesn't improve infant development. Not enough research has been done on omega-6 fatty acids to judge whether or not they are effective for other uses.
Most of the information we have on omega-6 fatty acid supplements comes from studying specific omega-6 fatty acids or plant oils containing omega-6 fatty acids. See the separate listings for gamma linolenic acid, as well as evening primrose, borage, and black currant.
How does it work?Omega-6 fatty acids are found everywhere in the body. They help with the function of all cells. If people don't eat enough omega-6 fatty acids, cells won't work properly. Too much omega-6 fatty acids can change the way cells react and have harmful effects on cells in the heart and blood vessels.
Uses & Effectiveness
Possibly Ineffective for
- Multiple sclerosis (MS). Taking omega-6 fatty acids does not seem to prevent the progression of MS.
- Infant development. Adding the omega-6 fatty acid arachidonic acid along with an omega-3 fatty acid called docosahexaenoic acid (DHA) to infant formula does not seem to improve brain development, vision, or growth in infants.
Insufficient Evidence for
- Attention deficit-hyperactivity disorder (ADHD). Early research suggests that taking a combination of omega-3 and omega-6 fatty acids twice daily for 3-6 months does not improve symptoms of ADHD.
- Heart disease. Population research suggests that different kinds of omega-6 fatty acids affect the heart and blood vessels differently. In the body, some kinds appear to be protective whereas others might worsen the disease. However, the omega-6 fatty acids shown to be more harmful when found in higher amounts in the body are not the ones typically eaten in the diet or found in supplements. How our body makes these types of omega-6 fatty acids is dependent on other health and lifestyle factors.
- A lung disease called COPD. Early research suggests that breathing problems are worse in people with COPD who eat large amounts of omega-6 fatty acids.
- Developmental coordination disorder (DCD). Early research suggests that taking a combination of omega-6 and omega-3 fatty acids for 3 months can improve reading, spelling, and behavior, but not coordination or movement in children with DCD.
- Diabetes. Early research suggests that people who have more linoleic acid, a type of omega-6 fatty acid, in their body are less likely to develop diabetes than people with less.
- Diarrhea in infants. Early research suggests that infants fed formula supplemented with an omega-6 fatty acid called arachidonic acid and an omega-3 fatty acid called docosahexaenoic acid (DHA) for the first year of life have a lower risk of diarrhea.
- Respiratory illness in infants. Early research suggests that infants fed formula supplemented with an omega-6 fatty acid called arachidonic acid and an omega-3 fatty acid called docosahexaenoic acid (DHA) for the first year of life have a lower risk of lung problems.
- Reducing the risk of heart disease.
- Lowering bad cholesterol levels (LDL).
- Increasing good cholesterol levels (HDL).
- Reducing the risk of cancer.
- Eyelid swelling.
- To improve recovery after laser eye surgery.
- Other conditions.
Side Effects & SafetyOmega-6 fatty acids are LIKELY SAFE when consumed by adults and children over the age of 12 months as part of the diet in amounts between 5% and 10% of daily calories. However, there is not enough reliable information available to know if omega-6 fatty acids are safe to use as medicine.
Special Precautions & Warnings:Pregnancy and breast-feeding: Omega-6 fatty acids are LIKELY SAFE when consumed as part of the diet in amounts between 5% and 10% of daily calories. There is not enough reliable information about the safety of taking omega-6 fatty acid supplements if you are pregnant or breast-feeding. Stay on the safe side and avoid use.
High triglycerides (a type of cholesterol): Omega-6 fatty acids can raise triglyceride levels. Do not use omega-6 fatty acids if your triglycerides are too high.
We currently have no information for OMEGA-6 FATTY ACIDS Interactions.
The appropriate dose of omega-6 fatty acids depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for omega-6 fatty acids. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
- Nielsen, A. A., Nielsen, J. N., Gronbaek, H., Eivindson, M., Vind, I., Munkholm, P., Brandslund, I., and Hey, H. Impact of enteral supplements enriched with omega-3 fatty acids and/or omega-6 fatty acids, arginine and ribonucleic acid compounds on leptin levels and nutritional status in active Crohn's disease treated with prednisolone. Digestion 2007;75(1):10-16. View abstract.
- Okuyama, H., Ichikawa, Y., Sun, Y., Hamazaki, T., and Lands, W. E. Cancers common in the USA are stimulated by omega 6 fatty acids and large amounts of animal fats, but suppressed by omega 3 fatty acids and cholesterol. World Rev Nutr Diet. 2007;96:143-149. View abstract.
- Peck, M. D., Mantero-Atienza, E., Miguez-Burbano, M. J., Lu, Y., Fletcher, M. A., Shor-Posner, G., and Baum, M. K. The esterified plasma fatty acid profile is altered in early HIV-1 infection. Lipids 1993;28(7):593-597. View abstract.
- Pinna, A., Piccinini, P., and Carta, F. Effect of oral linoleic and gamma-linolenic acid on meibomian gland dysfunction. Cornea 2007;26(3):260-264. View abstract.
- Querques, G., Russo, V., Barone, A., Iaculli, C., and Delle, Noci N. [Efficacy of omega-6 essential fatty acid treatment before and after photorefractive keratectomy]. J Fr Ophtalmol. 2008;31(3):282-286. View abstract.
- Raz, R. and Gabis, L. Essential fatty acids and attention-deficit-hyperactivity disorder: a systematic review. Dev.Med Child Neurol. 2009;51(8):580-592. View abstract.
- Richardson, A. J., Cyhlarova, E., and Ross, M. A. Omega-3 and omega-6 fatty acid concentrations in red blood cell membranes relate to schizotypal traits in healthy adults. Prostaglandins Leukot.Essent.Fatty Acids 2003;69(6):461-466. View abstract.
- Simopoulos, A. P. The omega-6/omega-3 fatty acid ratio, genetic variation, and cardiovascular disease. Asia Pac.J Clin Nutr 2008;17 Suppl 1:131-134. View abstract.
- Socha, P., Koletzko, B., Swiatkowska, E., Pawlowska, J., Stolarczyk, A., and Socha, J. Essential fatty acid metabolism in infants with cholestasis. Acta Paediatr. 1998;87(3):278-283. View abstract.
- Sonestedt, E., Gullberg, B., and Wirfalt, E. Both food habit change in the past and obesity status may influence the association between dietary factors and postmenopausal breast cancer. Public Health Nutr 2007;10(8):769-779. View abstract.
- Tso, P. and Hayashi, H. The physiology and regulation of the intestinal absorption and transport of omega-3 and omega-6 fatty acids. Adv.Prostaglandin Thromboxane Leukot.Res 1989;19:623-626. View abstract.
- Ventura, H. O., Milani, R. V., Lavie, C. J., Smart, F. W., Stapleton, D. D., Toups, T. S., and Price, H. L. Cyclosporine-induced hypertension. Efficacy of omega-3 fatty acids in patients after cardiac transplantation. Circulation 1993;88(5 Pt 2):II281-II285. View abstract.
- Yamada, T., Strong, J. P., Ishii, T., Ueno, T., Koyama, M., Wagayama, H., Shimizu, A., Sakai, T., Malcom, G. T., and Guzman, M. A. Atherosclerosis and omega-3 fatty acids in the populations of a fishing village and a farming village in Japan. Atherosclerosis 2000;153(2):469-481. View abstract.
- Delgado GE, März W, Lorkowski S, von Schacky C, Kleber ME. Omega-6 fatty acids: opposing associations with risk-The Ludwigshafen Risk and Cardiovascular Health Study. J Clin Lipidol 2017;11(4):1082-90.e14. View abstract.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids (Macronutrients). Washington, DC: National Academy Press, 2002. Available at: http://www.nap.edu/books/0309085373/html/.
- Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Energy, Carbohydrate. Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acids. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/books/0309069351/html/
- Gibson RA. Long-chain polyunsaturated fatty acids and infant development (editorial). Lancet 1999;354:1919.
- Godley PA. Essential fatty acid consumption and risk of breast cancer. Breast Cancer Res Treat 1995;35:91-5. View abstract.
- Jasani B, Simmer K, Patole SK, Rao SC. Long chain polyunsaturated fatty acid supplementation in infants born at term. Cochrane Database Syst Rev 2017;3:CD000376. View abstract.
- Lapillonne A, Pastor N, Zhuang W, Scalabrin DMF. Infants fed formula with added long chain polyunsaturated fatty acids have reduced incidence of respiratory illnesses and diarrhea during the first year of life. BMC Pediatr. 2014;14:168. View abstract.
- Lee E, Kim H, Kim H, Ha EH, Chang N. Association of maternal omega-6 fatty acid intake with infant birth outcomes: Korean Mothers and Children's Environmental Health (MOCEH). Nutr J 2018;17(1):47. View abstract.
- Lemoine Soto CM, Woo H, Romero K, et al. Association of omega-3 and omega-6 fatty acid intake with inflammation and respiratory outcomes in COPD. Am J Resp Crit Care Med. 2018;197:A3139.
- Leventhal LJ, Boyce EG, Zurier RB. Treatment of rheumatoid arthritis with gammalinolenic acid. Ann Intern Med 1993;119:867-73. View abstract.
- Lucas A, Stafford M, Morley R, et al. Efficacy and safety of long-chain polyunsaturated fatty acid supplementation of infant-formula milk: a randomized trial. Lancet 1999;354:1948-54. View abstract.
- Malloy MJ, Kane JP. Agents used in hyperlipidemia. In: B. Katzung, ed. Basic and Clinical Pharmacology. 4th ed. Norwald, CT: Appleton and Lange, 1989.
- Moon K, Rao SC, Schulzke SM, Patole SK, Simmer K. Longchain polyunsaturated fatty acid supplementation in preterm infants. Cochrane Database Syst Rev 2016;12:CD000375. View abstract.
- Newcomer LM, King IB, Wicklund KG, Stanford JL. The association of fatty acids with prostate cancer risk. Prostate 2001;47:262-8. View abstract.
- Noguchi M, Rose DP, Earashi M, Miyazaki I. The role of fatty acids and eicosanoid synthesis inhibitors in breast carcinoma. Oncology 1995;52:265-71. View abstract.
- Pawelczyk T, Trafalska E, Pawelczyk A, Kotlicka-Antczak M. Differences in omega-3 and omega-6 polyunsaturated fatty acid consumption in people at ultra-high risk of psychosis, first-episode schizophrenia, and in healthy controls. Early Interv Psychiatry 2017;11(6):498-508. View abstract.
- Richardson AJ, Montgomery P. The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder. Pediatrics 2005;115:1360-6. View abstract.
- Rose DP. The mechanistic rationale in support of dietary cancer prevention. Prev Med 1996;25:34-7. View abstract.
- Wu JHY, Marklund M, Imamura F, Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Fatty Acids and Outcomes Research Consortium (FORCE). Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39?740 adults from 20 prospective cohort studies. Lancet Diabetes Endocrinol 2017;5(12):965-74. View abstract.
- Assies, J., Lok, A., Bockting, C. L., Weverling, G. J., Lieverse, R., Visser, I., Abeling, N. G., Duran, M., and Schene, A. H. Fatty acids and homocysteine levels in patients with recurrent depression: an explorative pilot study. Prostaglandins Leukot.Essent.Fatty Acids 2004;70(4):349-356. View abstract.
- Aupperle, R. L., Denney, D. R., Lynch, S. G., Carlson, S. E., and Sullivan, D. K. Omega-3 fatty acids and multiple sclerosis: relationship to depression. J Behav Med 2008;31(2):127-135. View abstract.
- Chiplonkar, S. A., Agte, V. V., Tarwadi, K. V., Paknikar, K. M., and Diwate, U. P. Micronutrient deficiencies as predisposing factors for hypertension in lacto-vegetarian Indian adults. J Am Coll.Nutr 2004;23(3):239-247. View abstract.
- Colter, A. L., Cutler, C., and Meckling, K. A. Fatty acid status and behavioural symptoms of attention deficit hyperactivity disorder in adolescents: a case-control study. Nutr J 2008;7:8. View abstract.
- Conklin, S. M., Manuck, S. B., Yao, J. K., Flory, J. D., Hibbeln, J. R., and Muldoon, M. F. High omega-6 and low omega-3 fatty acids are associated with depressive symptoms and neuroticism. Psychosom.Med. 2007;69(9):932-934. View abstract.
- Cunnane, S. C. Problems with essential fatty acids: time for a new paradigm? Prog.Lipid Res 2003;42(6):544-568. View abstract.
- Farinotti, M., Simi, S., Di, Pietrantonj C., McDowell, N., Brait, L., Lupo, D., and Filippini, G. Dietary interventions for multiple sclerosis. Cochrane.Database.Syst.Rev 2007;(1):CD004192. View abstract.
- Gibson, R. A., Teubner, J. K., Haines, K., Cooper, D. M., and Davidson, G. P. Relationships between pulmonary function and plasma fatty acid levels in cystic fibrosis patients. J Pediatr Gastroenterol Nutr 1986;5(3):408-415. View abstract.
- Godley, P. A., Campbell, M. K., Gallagher, P., Martinson, F. E., Mohler, J. L., and Sandler, R. S. Biomarkers of essential fatty acid consumption and risk of prostatic carcinoma. Cancer Epidemiol.Biomarkers Prev. 1996;5(11):889-895. View abstract.
- Grimble, R. F. Immunonutrition. Curr Opin.Gastroenterol 2005;21(2):216-222. View abstract.
- Harris, W. S., Mozaffarian, D., Rimm, E., Kris-Etherton, P., Rudel, L. L., Appel, L. J., Engler, M. M., Engler, M. B., and Sacks, F. Omega-6 fatty acids and risk for cardiovascular disease: a science advisory from the American Heart Association Nutrition Subcommittee of the Council on Nutrition, Physical Activity, and Metabolism; Council on Cardiovascular Nursing; and Council on Epidemiology and Prevention. Circulation 2-17-2009;119(6):902-907. View abstract.
- Hodge, L., Salome, C. M., Hughes, J. M., Liu-Brennan, D., Rimmer, J., Allman, M., Pang, D., Armour, C., and Woolcock, A. J. Effect of dietary intake of omega-3 and omega-6 fatty acids on severity of asthma in children. Eur Respir.J 1998;11(2):361-365. View abstract.
- Hughes-Fulford, M., Tjandrawinata, R. R., Li, C. F., and Sayyah, S. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis 2005;26(9):1520-1526. View abstract.
- Johnson, M., Ostlund, S., Fransson, G., Kadesjo, B., and Gillberg, C. Omega-3/omega-6 fatty acids for attention deficit hyperactivity disorder: a randomized placebo-controlled trial in children and adolescents. J.Atten.Disord. 2009;12(5):394-401. View abstract.
- Laidler, P., Dulinska, J., and Mrozicki, S. Does the inhibition of c-myc expression mediate the anti-tumor activity of PPAR's ligands in prostate cancer cell lines? Arch.Biochem.Biophys. 6-1-2007;462(1):1-12. View abstract.
- Mamalakis, G., Kiriakakis, M., Tsibinos, G., Hatzis, C., Flouri, S., Mantzoros, C., and Kafatos, A. Depression and serum adiponectin and adipose omega-3 and omega-6 fatty acids in adolescents. Pharmacol.Biochem.Behav. 2006;85(2):474-479. View abstract.
- Margolin, G., Huster, G., Glueck, C. J., Speirs, J., Vandegrift, J., Illig, E., Wu, J., Streicher, P., and Tracy, T. Blood pressure lowering in elderly subjects: a double-blind crossover study of omega-3 and omega-6 fatty acids. Am J Clin Nutr 1991;53(2):562-572. View abstract.
- Martinez-Ramirez, M. J., Palma, S., Martinez-Gonzalez, M. A., Delgado-Martinez, A. D., de la Fuente, C., and Delgado-Rodriguez, M. Dietary fat intake and the risk of osteoporotic fractures in the elderly. Eur.J Clin Nutr 2007;61(9):1114-1120. View abstract.
- Melnik, B. and Plewig, G. Are disturbances of omega-6-fatty acid metabolism involved in the pathogenesis of atopic dermatitis? Acta Derm.Venereol.Suppl (Stockh) 1992;176:77-85. View abstract.
- Munoz, S. E., Piegari, M., Guzman, C. A., and Eynard, A. R. Differential effects of dietary Oenothera, Zizyphus mistol, and corn oils, and essential fatty acid deficiency on the progression of a murine mammary gland adenocarcinoma. Nutrition 1999;15(3):208-212. View abstract.
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