2-Dimethyl Aminoethanol, 2-Dimethylaminoethanol, Acéglumate de Déanol, Acétamido-benzoate de Déanol, Benzilate de Déanol, Bisorcate de Déanol, Cyclohexylpropionate de Déanol, Déanol, Deanol Aceglumate, Deanol Acetamidobenzoate, Deanol Benzilate, Deanol Bisorcate, Deanol Cyclohexylpropionate, Deanol Hemisuccinate, Deanol Pidolate, Deanol Tartrate, Dimethylaminoethanol, Diméthylaminoéthanol, Dimethylaminoethanol Bitartrate, Dimethylethanolamine, DMAE, DMAE Bitartrate, Hémisuccinate de Déanol, Pidolate de Déanol.<br/><br/>


Overview Information

Deanol is a chemical that is involved in a series of reactions that form acetylcholine, a chemical that is found in the brain and other areas of the body. Acetylcholine is a “neurotransmitter” that helps nerve cells communicate.

Deanol is used for treating attention deficit-hyperactivity disorder (ADHD), Alzheimer’s disease, autism, and a movement disorder called tardive dyskinesia. It is also used for improving memory and mood; boosting thinking skills and intelligence; and increasing physical energy, oxygen efficiency, athletic performance, and muscle reflexes. It is also used for preventing aging or liver spots, improving red blood cell function, and extending life span.

Deanol is applied to the skin for reducing signs of aging, particularly loose or sagging skin.

Deanol was previously sold by Riker Laboratories as the prescription drug Deaner. It was prescribed for the management of children with behavior problems and learning difficulties. Deanol is not an approved food additive in the U.S., nor is it an orphan drug, as some advertising suggests.

How does it work?

Deanol is needed to build the chemical choline. Having more choline in the body might increase the production of acetylcholine, which is involved in brain and nervous system function.


Uses & Effectiveness?

Possibly Effective for

  • Improving exercise performance (when used with ginseng, vitamins, and minerals).

Likely InEffective for

  • Alzheimer's disease.
  • Unwanted movements of the face and mouth (tardive dyskinesia).

Insufficient Evidence for

  • Treating aging skin. There is some early evidence that applying a 3% deanol gel to facial skin can tighten sagging skin.
  • Treating attention deficit-hyperactivity disorder (ADHD).
  • Improving memory and mood.
  • Improving intelligence and physical energy.
  • Preventing aging or liver spots.
  • Improving red blood cell function.
  • Improving muscle reflexes.
  • Increasing oxygen efficiency.
  • Extending life span.
  • Treating autism.
  • Other conditions.
More evidence is needed to rate the effectiveness of deanol for these uses.

Side Effects

Side Effects & Safety

Deanol is POSSIBLY SAFE for most people when taken by mouth or applied to the skin.

When taken by mouth, deanol can cause constipation, itching, headache, drowsiness, insomnia, excitation, vivid dreams, confusion, depression, increased blood pressure, an increase in schizophrenia symptoms, and unwanted movements of the face and mouth.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Not enough is known about the use of deanol during pregnancy and breast-feeding. Stay on the safe side and avoid use.

Clonic-tonic seizures: Deanol should not be used by people with clonic-tonic seizure disorders.

Depression: Deanol might make depression worse.

Schizophrenia: Deanol might make schizophrenia symptoms worse.



Minor Interaction

Be watchful with this combination

  • Drying medications (Anticholinergic drugs) interacts with DEANOL

    Some drying medications are called anticholinergic drugs. Deanol might increase chemicals that can decrease the effects of these drying medications.<br/><br/> Some drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).

  • Medications for Alzheimer's disease (Acetylcholinesterase (AChE) inhibitors) interacts with DEANOL

    Deanol might increase a chemical in the body called acetylcholine. Medications for Alzheimer's called acetylcholinesterase inhibitors also increase the chemical acetylcholine. Taking deanol along with medications for Alzheimer's disease might increase effects and side effects of medications for Alzheimer's disease.<br/><br/> Some medications called acetylcholinesterase inhibitors include donepezil (Aricept), tacrine (Cognex), rivastigmine (Exelon), and galantamine (Reminyl, Razadyne).

  • Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs) interacts with DEANOL

    Deanol might increase a chemical in the body called acetylcholine. This chemical is similar to some medications used for glaucoma, Alzheimer's disease, and other conditions. Taking deanol with these medications might increase the chance of side effects.<br/><br/> Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include pilocarpine (Pilocar and others), and others.



The following doses have been studied in scientific research:


  • For improving exercise performance: 300 to 2000 mg of deanol per day.

View References


  • Dalli, E., Valles, J., Cosin-Sales, J., Santos, M. T., Moscardo, A., Milara, J., and Sotillo, J. F. Effects of hawthorn (Crataegus laevigata) on platelet aggregation in healthy volunteers. Thromb.Res 2011;128(4):398-400. View abstract.
  • Eichstadt, H., Stork, T., Mockel, M., and et al. Effectiveness of and tolerance to Crataegus extract WS 1442 in patients with heart insufficiency and reduced left ventricular function. Perfusion 2001;14:212-217.
  • Forster A, Forster K, Buhring M, and et al. Crataegus bei massig reduzierter linksventrikularer Auswurffraktion. Ergospirometrische Verlaufsuntersuchung bei 72 Patienten in doppel-blindem Vergleich mit Plazebo. [Crataegus for moderately reduced left ventricular ejection fraction. Ergospirometric monitoring study with 72 patients in a double-blind comparison with placebo]. Munch Med Wschr 1994;136(suppl 1):s21-s26.
  • Francis, M. J., Doherty, R. R., Patel, M., Hamblin, J. F., Ojaimi, S., and Korman, T. M. Curtobacterium flaccumfaciens septic arthritis following puncture with a Coxspur Hawthorn thorn. J Clin Microbiol. 2011;49(7):2759-2760. View abstract.
  • Furey, A. and Tassell, M. Towards a systematic scientific approach in the assessment of efficacy of an herbal preparation: Hawthorn (Crataegus spp.). Eur J Heart Fail. 2008;10(12):1153-1157. View abstract.
  • Gorret, J., Chevalier, J., Gaschet, A., Fraisse, B., Violas, P., Chapuis, M., and Jolivet-Gougeon, A. Childhood delayed septic arthritis of the knee caused by Serratia fonticola. Knee. 2009;16(6):512-514. View abstract.
  • Hanack T and Bruckel MH. [The treatment of mild stable forms of angina pectoris using Crategutt novo]. Therapiewoche 1983;33:4331-4333.
  • Harris, E. J. Retained Hawthorn fragment in a child's foot complicated by infection: diagnosis and excision aided by localization with ultrasound. J Foot Ankle Surg. 2010;49(2):161-165. View abstract.
  • Holubarsch, C. J., Colucci, W. S., Meinertz, T., Gaus, W., and Tendera, M. Survival and prognosis: investigation of Crataegus extract WS 1442 in congestive heart failure (SPICE)--rationale, study design and study protocol. Eur J Heart Fail. 2000;2(4):431-437. View abstract.
  • Horoz, M., Gok, E., Genctoy, G., Ozcan, T., Olmaz, R., Akca, M., Kiykim, A., and Gurses, I. Crataegus orientalis associated multiorgan hypersensitivity reaction and acute renal failure. Intern.Med 2008;47(23):2039-2042. View abstract.
  • Islam, J., Uretsky, B. F., and Sierpina, V. S. Heart failure improvement with CoQ10, Hawthorn, and magnesium in a patient scheduled for cardiac resynchronization-defibrillator therapy: a case study. Explore.(NY) 2006;2(4):339-341. View abstract.
  • Koller, M., Lorenz, W., Aubke, W., Jensen, A., Gerlach, F. M., Kuhl, J., Pfeil, T., Regitz-Zagrosek, V., Rusche, H., and Rychlik, R. [Crataegus special extract WS 1442 in the treatment of early stages of CHD-associated heart failure]. MMW Fortschr Med 2-9-2006;148(6):42. View abstract.
  • Liu, P., Konstam, M. A., and Force, T. Highlights of the 2004 scientific sessions of the Heart Failure Society of America, Toronto, Canada, September 12 to 15, 2004. Journal of the American College of Cardiology 2005;45(617):625.
  • Loew D, Albrecht M, and Podzuweit H. Efficacy and tolerability of a Hawthorn preparation in patients with heart failure Stage I and II according to NYHA - a surveillance study. Phytomedicine 1996;3(Suppl 1):92.
  • Mahmood, Z. A., Sualeh, M., Mahmood, S. B., and Karim, M. A. Herbal treatment for cardiovascular disease the evidence based therapy. Pak J Pharm Sci 2010;23(1):119-124. View abstract.
  • Min, B. S., Kim, Y. H., Lee, S. M., Jung, H. J., Lee, J. S., Na, M. K., Lee, C. O., Lee, J. P., and Bae, K. Cytotoxic triterpenes from Crataegus pinnatifida. Arch Pharm Res 2000;23(2):155-158. View abstract.
  • Moon, H. I., Kim, T. I., Cho, H. S., and Kim, E. K. Identification of potential and selective collagenase, gelatinase inhibitors from Crataegus pinnatifida. Bioorg.Med Chem Lett. 2-1-2010;20(3):991-993. View abstract.
  • O'Conolly M, Bernhoft G, and Bartsch G. [Treatment of stenocardia (Angina pectoris) pain in advanced age patients with multi-morbidity]. Therapiewoche 1987;37:3587-3600.
  • O'Conolly M, Jansen W, Bernhoft G, and et al. [Treatment of decreasing cardiac performance. Therapy using standardized crataegus extract in advanced age]. Fortschr Med 11-13-1986;104(42):805-808. View abstract.
  • Rakotoarison DA, Gressier B, Trotin F, and et al. Antioxidant activities of polyphenolic extracts from flowers, in vitro callus and cell suspension cultures of Crataegus monogyna. Pharmazie 1997;52(1):60-64. View abstract.
  • Rasmussen, P. Hawthorn--Crataegus monogyna (common hawthorn) or Crataegus laevigata (midland hawthorn; Crataegus oxyacantha); also known as haw, thornapple, maythorn, whitethorn. J Prim.Health Care 2011;3(1):63-64. View abstract.
  • Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. View abstract.
  • Cherkin A, Exkardt MJ. Effects of dimethylaminoethanol upon life-span and behavior of aged Japanese quail. J Gerontol 1977;32:38-45. View abstract.
  • Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  • de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. View abstract.
  • Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. View abstract.
  • Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. View abstract.
  • George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. View abstract.
  • Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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