DEANOL

OTHER NAME(S):

2-Dimethyl Aminoethanol, 2-Dimethylaminoethanol, Acéglumate de Déanol, Acétamido-benzoate de Déanol, Benzilate de Déanol, Bisorcate de Déanol, Cyclohexylpropionate de Déanol, Deaner, Déanol, Deanol Aceglumate, Deanol Acetamidobenzoate, Deanol Benzilate, Deanol Bisorcate, Deanol Cyclohexylpropionate, Deanol Hemisuccinate, Deanol Pidolate, Deanol Tartrate, Dimethylaminoethanol, Diméthylaminoéthanol, Dimethylaminoethanol Bitartrate, Dimethylethanolamine, DMAE, DMAE Bitartrate, Hémisuccinate de Déanol, Pidolate de Déanol.

Overview

Overview Information

Deanol is a chemical that can be converted into choline. Choline is involved in a series of reactions that form acetylcholine, a chemical that is found in the brain and other areas of the body. Acetylcholine is a "neurotransmitter" that helps nerve cells communicate.

Deanol is used for attention deficit-hyperactivity disorder (ADHD), Alzheimer disease, autism, and other conditions, but there is no good scientific evidence to support these uses.

Deanol was previously sold by Riker Laboratories as the prescription drug Deaner. It was prescribed for the management of children with behavior problems and learning difficulties. Deanol is not an approved food additive in the U.S., nor is it an orphan drug, as some advertising suggests.

How does it work?

Deanol is needed to build the chemical choline. Having more choline in the body might increase the production of acetylcholine, which is involved in brain and nervous system function.

Uses

Uses & Effectiveness?

Likely InEffective for

  • Alzheimer disease. Deanol does not seem to improve Alzheimer disease.
  • A movement disorder often caused by antipsychotic drugs (tardive dyskinesia). Deanol does not seem to improve tardive dyskinesia.

Insufficient Evidence for

  • Athletic performance. Early research shows that taking deanol along with ginseng, vitamins, and minerals for 6 weeks might improve athletic performance in some people. However, it's unclear if taking deanol by itself improves athletic performance.
  • Attention deficit-hyperactivity disorder (ADHD). Research on the use of deanol for ADHD-like symptoms is mixed. Some early research shows that taking deanol daily for up to 3 months might improve some ADHD symptoms, but other research suggests that deanol does not treat ADHD in children. The children in these studies were not diagnosed with ADHD using current guidelines. It is not clear how deanol would work in children diagnosed with ADHD.
  • Memory.
  • Aging skin.
  • Extending life span.
  • Autism.
  • Other conditions.
More evidence is needed to rate the effectiveness of deanol for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Deanol is POSSIBLY SAFE for most people when taken short-term. Most people do not experience side effects. But deanol might cause constipation, diarrhea, itching, headache, drowsiness, insomnia, vivid dreams, confusion, mood changes, or increased blood pressure.

When applied to the skin: Deanol is POSSIBLY SAFE when applied to the skin, short-term.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if deanol is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Depression: Deanol might make depression worse.

Schizophrenia: Deanol might make schizophrenia symptoms worse.

Tonic-clonic seizures: Deanol should not be used by people with tonic-clonic seizure disorders.

Interactions

Interactions?

Minor Interaction

Be watchful with this combination

!

  • Drying medications (Anticholinergic drugs) interacts with DEANOL

    Some drying medications are called anticholinergic drugs. Deanol might increase chemicals that can decrease the effects of these drying medications.

    Some drying medications include atropine, scopolamine, and some medications used for allergies (antihistamines), and for depression (antidepressants).

  • Medications for Alzheimer's disease (Acetylcholinesterase (AChE) inhibitors) interacts with DEANOL

    Deanol might increase a chemical in the body called acetylcholine. Medications for Alzheimer's called acetylcholinesterase inhibitors also increase the chemical acetylcholine. Taking deanol along with medications for Alzheimer's disease might increase effects and side effects of medications for Alzheimer's disease.

    Some medications called acetylcholinesterase inhibitors include donepezil (Aricept), tacrine (Cognex), rivastigmine (Exelon), and galantamine (Reminyl, Razadyne).

  • Various medications used for glaucoma, Alzheimer's disease, and other conditions (Cholinergic drugs) interacts with DEANOL

    Deanol might increase a chemical in the body called acetylcholine. This chemical is similar to some medications used for glaucoma, Alzheimer's disease, and other conditions. Taking deanol with these medications might increase the chance of side effects.

    Some of these medications used for glaucoma, Alzheimer's disease, and other conditions include pilocarpine (Pilocar and others), and others.

Dosing

Dosing

The appropriate dose of deanol depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for deanol. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

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View References

REFERENCES:

  • Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. View abstract.
  • Cherkin A, Exkardt MJ. Effects of dimethylaminoethanol upon life-span and behavior of aged Japanese quail. J Gerontol 1977;32:38-45. View abstract.
  • Coleman N, Dexheimer P, DiMascio A, et al. Deanol in the treatment of hyperkinetic children. Psychosomatics 1976;17(2):68-72. View abstract.
  • Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  • de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. View abstract.
  • Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. View abstract.
  • Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. View abstract.
  • George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. View abstract.
  • Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. View abstract.
  • Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. View abstract.
  • Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. View abstract.
  • Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. View abstract.
  • McGrath JJ, Soares KVS. Cholinergic medication for neuroleptic-induced tardive dyskinesia. Cochrane Database Syst Rev 2000;(2):CD000207. View abstract.
  • Oettinger L Jr. Pediatric psychopharmacology. A review with special reference to deanol. Dis Nerv Syst 1977;38:25-31.
  • Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.
  • Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. View abstract.
  • Pfeiffer CC, Jenny EH, Gallagher W, et al. Stimulant effect of 2-dimethylaminoethanol; possible precursor of brain acetylcholine. Science 1957;126(3274):610-1. View abstract.
  • Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82. View abstract.
  • Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  • Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. View abstract.
  • Soares KV, McGrath JJ. The treatment of tardive dyskinesia- a systematic review and meta-analysis. Schizophr Res 1999;39:1-16; discussion 17-18. View abstract.
  • Stenback F, Weisburger JH, Williams GM. Effect of lifetime administration of dimethylaminoethanol on longevity, aging changes, and cryptogenic neoplasms in C3H mice. Mech Ageing Dev 1988;42:129-38. View abstract.
  • Uhoda I, Faska N, Robert C, et al. Split face study on the cutaneous tensile effect of 2-dimethylaminoethanol (deanol) gel. Skin Res Technol 2002;8:164-7. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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