MADDER

OTHER NAME(S):

Bengal Madder, Dyer's Madder, Fäberröte, Garança, Garance, Garance des Teinturiers, Granza, Indian Madder, Krapp, Robbia, Rouge des Teinturiers, Rubia, Rubia de Tintas, Rubia tinctorum, Rubiae Tinctorum Radix.<br/><br/>

Overview

Overview Information

Madder is a plant. The root is used to make medicine.

Despite serious safety concerns, people take madder by mouth for preventing and dissolving kidney stones, as well as and for treating general menstrual disorders, and urinary tract disorders, blood disorders, bruises, jaundice, paralysis, spleen disorders, and sciatica. It is also used to promote urination, as an aphrodiasiac, and as a tonic.

Madder is also applied to the skin for certain skin conditions and to promote wound healing.

How does it work?

Some chemicals in madder might help prevent kidney stones. The chemical in madder known as alizarin might block a protein that is needed by the HIV virus to replicate.

Uses

Uses & Effectiveness?

Insufficient Evidence for

  • Kidney stones.
  • Menstrual problems.
  • Urinary problems.
  • Blood disorders.
  • Bruises.
  • Jaundice.
  • Paralysis.
  • Spleen disorders.
  • Pain along the sciatic nerve (sciatica).
  • Wound healing.
  • Other conditions.
More evidence is needed to rate the effectiveness of madder for these uses.

Side Effects

Side Effects & Safety

Madder is considered LIKELY UNSAFE when taken by mouth. The chemicals in madder may cause cancer. Madder can also cause urine, saliva, perspiration, tears, and breast milk to turn red in color.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It's UNSAFE to take madder by mouth if you are pregnant. It might start your menstrual period and that could cause a miscarriage. Madder might also cause birth defects.

It's also UNSAFE to use madder if you are breast-feeding. It might harm the nursing baby, and it might turn breast milk red.

Interactions

Interactions?

We currently have no information for MADDER Interactions.

Dosing

Dosing

The appropriate dose of madder depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for madder. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Suzuki, I., Itani, T., Ohno, N., Oikawa, S., Sato, K., Miyazaki, T., and Yadomae, T. Antitumor activity of a polysaccharide fraction extracted from cultured fruiting bodies of Grifola frondosa. J Pharmacobiodyn. 1984;7(7):492-500. View abstract.
  • Talpur, N. A., Echard, B. W., Fan, A. Y., Jaffari, O., Bagchi, D., and Preuss, H. G. Antihypertensive and metabolic effects of whole Maitake mushroom powder and its fractions in two rat strains. Mol.Cell Biochem. 2002;237(1-2):129-136. View abstract.
  • Tanaka, H., Tsunematsu, K., Nakamura, N., Suzuki, K., Tanaka, N., Takeya, I., Saikai, T., and Abe, S. Successful treatment of hypersensitivity pneumonitis caused by Grifola frondosa (Maitake) mushroom using a HFA-BDP extra-fine aerosol. Intern.Med. 2004;43(8):737-740. View abstract.
  • Wu, M. J., Cheng, T. L., Cheng, S. Y., Lian, T. W., Wang, L., and Chiou, S. Y. Immunomodulatory properties of Grifola frondosa in submerged culture. J Agric.Food Chem 4-19-2006;54(8):2906-2914. View abstract.
  • Yang, D., Li, S., Wang, H., Li, X., Liu, S., Han, W., Hao, J., and Zhang, H. [Prevention of postoperative recurrence of bladder cancer: a clinical study]. Zhonghua Wai Ke.Za Zhi. 1999;37(8):464-465. View abstract.
  • Adachi K, Nanba H, Kuroda H. Potentiation of host-mediated antitumor activity in mice by beta-glucan obtained from Grifola frondosa (maitake). Chem Pharm Bull (Tokyo) 1987;35:262-70. View abstract.
  • Borchers AT, Stern JS, Hackman RM, et al. Mushrooms, tumors, and immunity. Proc Soc Exp Biol Med 1999;221:281-293. View abstract.
  • Chen JT, Tominaga K, Sato Y, et al. Maitake mushroom (Grifola frondosa) extract induces ovulation in patients with polycystic ovary syndrome: a possible monotherapy and a combination therapy after failure with first-line clomiphene citrate. J Altern Complement Med 2010;16:1295-9. View abstract.
  • Han C, Cui B. Pharmacological and pharmacokinetic studies with agaricoglycerides, extracted from Grifola frondosa, in animal models of pain and inflammation. Inflammation 2012;35(4):1269-75. View abstract.
  • Hanselin MR, Vande Griend JP, Linnebur SA. INR elevation with maitake extract in combination with warfarin. Ann Pharmacother 2010;44:223-4. View abstract.
  • Kabir Y, Kimura S. Dietary mushrooms reduce blood pressure in spontaneously hypertensive rats (SHR). J Nutr Sci Vitaminol (Tokyo) 1989;35:91-4. View abstract.
  • Kabir Y, Yamaguchi M, Kimura S. Effect of shiitake (Lentinus edodes) and maitake (Grifola frondosa) mushrooms on blood pressure and plasma lipids of spontaneously hypertensive rats. J Nutr Sci Vitaminol (Tokyo) 1987;33:341-6. View abstract.
  • Konno S, Tortorelis DG, Fullerton SA, et al. A possible hypoglycaemic effect of maitake mushroom on Type 2 diabetic patients. Diabet Med 2001;18:1010. View abstract.
  • Kubo K, Aoki H, Nanba H. Anti-diabetic activity present in the fruit body of Grifola frondosa (Maitake). I. Biol Pharm Bull 1994;17:1106-10. View abstract.
  • Kubo K, Nanba H. The effect of maitake mushrooms on liver and serum lipids. Alt Ther Health Med 1996;2:62-6. View abstract.
  • Blomeke B, Poginsky B, Schmutte C, Marquardt H, Westendorf J. Formation of genotoxic metabolites from anthraquinone glycosides, present in Rubia tinctorum L. Mutat Res 1992;265(2):263-272.View abstract.
  • Boldizsár I, Szucs Z, Füzfai Z, Molnár-Perl I. Identification and quantification of the constituents of madder root by gas chromatography and high-performance liquid chromatography. J Chromatogr A 2006;1133(1-2):259-74. View abstract.
  • Brinkworth RI, Fairlie DP. Hydroxyquinones are competitive non-peptide inhibitors of HIV-1 proteinase. Biochim Biophys Acta 1995;1253(1):5-8.View abstract.
  • Castelain M, Ducombs G. Contact dermatitis from madder. Contact Dermatitis 1988;19(3):228-229. View abstract.
  • Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.