WILD INDIGO

OTHER NAME(S):

American Indigo, Añil Silvestre, Baptisia Root, Baptisia tinctoria, Baptista, False Indigo, Faux Indigo, Horsefly Weed, Indigo Broom, Indigo Sauvage, Indigo Silvestre, Rattlebush, Yellow Broom, Yellow Indigo.<br/><br/>

Overview

Overview Information

Wild indigo is an herb. The root is used to make medicine.

Wild indigo is used for infections such as diphtheria, influenza (flu), swine flu, the common cold and other upper respiratory tract infections, lymph node infections, scarlet fever, malaria, and typhoid. It is also used for sore tonsils (tonsillitis), sore throat, swelling of the mouth and throat, fever, boils, and Crohn's disease.

Some people apply wild indigo directly to the skin for ulcers, sore and painful nipples, as a douche for vaginal discharge, and for cleaning open and swollen wounds.

How does it work?

There isn't enough information to know how wild indigo works.

Uses

Uses & Effectiveness?

Possibly Effective for

  • Common cold.. Research suggests that taking a specific product containing vitamin C and extracts of wild indigo, echinacea, and thuja (Esberitox) by mouth for 7-9 days improves cold symptom severity and overall well-being in people with moderate cold symptoms.

Insufficient Evidence for

  • Cold sores. Early research suggests that taking a specific product containing vitamin C and extracts of wild indigo, echinacea, and thuja (Esberitox) by mouth reduces itchiness, tension, and pain people with cold sores.
  • Low white blood cell count (leukopenia) Early research suggests that taking a specific product containing vitamin C and extracts of wild indigo, echinacea, and thuja (Esberitox N) by mouth improves white blood cell counts in people with low numbers of white blood cells after having received chemotherapy for 6 months or less. However, it does not seem to improve white blood cell counts in people who received chemotherapy for longer time periods. Also, other research suggests that Esberitox N does not improve white blood cell counts when used by women receiving radiation treatment.
  • Nasal swelling (sinusitis). Early research suggests that taking a specific product containing vitamin C and extracts of wild indigo, echinacea, and thuja (Esberitox) by mouth for 20 days improves nasal blockage and general well-being in people with sinusitis who are also taking antibiotics.
  • Swelling of tonsils (tonsillitis). Early research suggests that taking a specific product containing vitamin C and extracts of wild indigo, echinacea, and thuja (Esberitox) by mouth for 2 weeks, along with the antibiotic drug erythromycin, reduces symptoms and improves well-being and recovery in people with tonsillitis better than taking erythromycin alone.
  • Diphtheria.
  • Influenza (“flu”).
  • Malaria.
  • Typhoid fever.
  • Scarlet fever.
  • Sore throat.
  • Swelling of the mouth and throat.
  • Fever.
  • Crohn's disease.
  • Ulcers.
  • Wounds.
  • Sore and painful nipples.
  • Other conditions.
More evidence is needed to rate the effectiveness of wild indigo for these uses.

Side Effects

Side Effects & Safety

Wild indigo is UNSAFEwhen taken by mouth or applied to the skin, long-term or in large doses. Large doses can cause vomiting, diarrhea, other intestinal problems, and spasms.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Wild indigo is UNSAFE when taken by mouth or applied to the skin. Avoid use.

Stomach or intestinal problems: Wild indigo can be especially harmful to people with stomach or intestinal problems. Avoid use.

Interactions

Interactions?

We currently have no information for WILD INDIGO Interactions.

Dosing

Dosing

The appropriate dose of wild indigo depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for wild indigo. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Classen, B., Thude, S., Blaschek, W., Wack, M., and Bodinet, C. Immunomodulatory effects of arabinogalactan-proteins from Baptisia and Echinacea. Phytomedicine. 2006;13(9-10):688-694. View abstract.
  • Dowlatshahi, K., Jokich, P. M., Schmidt, R., Bibbo, M., and Dawson, P. J. Cytologic diagnosis of occult breast lesions using stereotaxic needle aspiration. A preliminary report. Arch Surg 1987;122(11):1343-1346. View abstract.
  • Egert, D. and Beuscher, N. Studies on antigen specifity of immunoreactive arabinogalactan proteins extracted from Baptisia tinctoria and Echinacea purpurea. Planta Med. 1992;58(2):163-165. View abstract.
  • Forth, H. and Beuscher, N. Beeinflussing der Häufigkeit banaler Erkältungsinfekte durch Esberitox. Zeitschrift für Allgemeinmedizin [Effect on the frequency of banal cold infections by esberitox]. ZFA.(Stuttgart.) 11-20-1981;57(32):2272-2275. View abstract.
  • Gerhardt, P. [Influence of an unspecific stimulation therapy using Esberitox on leukopoiesis during the use of ionizing radiation]. Strahlentherapie. 1972;143(5):549-558. View abstract.
  • Gocan, S., Cimpan, G., and Muresan, L. Automated multiple development thin layer chromatography of some plant extracts. J Pharm Biomed.Anal. 1996;14(8-10):1221-1227. View abstract.
  • Guo, R., Canter, P. H., and Ernst, E. Herbal medicines for the treatment of rhinosinusitis: a systematic review. Otolaryngol.Head Neck Surg. 2006;135(4):496-506. View abstract.
  • Guo, R., Pittler, M. H., and Ernst, E. Herbal medicines for the treatment of COPD: a systematic review. Eur.Respir.J 2006;28(2):330-338. View abstract.
  • Hauke, W., Kohler, G., Henneicke-von Zepelin, H. H., and Freudenstein, J. Esberitox N as supportive therapy when providing standard antibiotic treatment in subjects with a severe bacterial infection (acute exacerbation of chronic bronchitis). A multicentric, prospective, double-blind, placebo-controlled study. Chemotherapy 2002;48(5):259-266. View abstract.
  • HELBIG, G. [Nonspecific therapy with irritants for infection prophylaxis. A study of the therapeutic effect of Esberitox]. Med Klin. 9-1-1961;56:1512-1514. View abstract.
  • Hentschel C, Zeppelin HH Kohnen R Kohler G Wustenberg P Ernst E. Clinical efficacy of Esberitox in common cold - results of a (GCP) randomised double-blind placebo-controlled multicenter study. Focus on Alternative and Complementary Ther 1997;2(4):189.
  • Hentschel, C., Schnitker, J., Kohnen, R., Kohler, G., Lindhauer, I., and Henneicke-von Zepelin, H. H. [Phytotherapeutic drugs for the common cold. Results of a randomized controlled double-blind study]. MMW.Fortschr.Med. 3-2-2000;142(9):46. View abstract.
  • HOFFMANN, R. [Esberitox, an oral remedy for non-specific therapeutic irritation in infectious inflammation]. Ther Ggw. 1952;91(5):186. View abstract.
  • Ikeda, T., Jinno, H., Fujii, H., and Kitajima, M. Recent development of sentinel lymph node biopsy for breast cancer in Japan. Asian J Surg 2004;27(4):275-278. View abstract.
  • Imoto, S., Fukukita, H., Murakami, K., Ikeda, H., and Moriyama, N. Pilot study on sentinel node biopsy in breast cancer. J Surg Oncol 2000;73(3):130-133. View abstract.
  • JOHNE, H. O. and SPERR, A. [Experimental and clinical experiences with stimulation therapy with gluco-lipopolypeptide complexes (esberitox) in dermatology]. Medizinische. 8-25-1956;7(33-34):1145-1147. View abstract.
  • Kindzel'skii, L. P., Zlochevskaia, L. L., Tsyganok, T. V., and Shabaeva, M. M. [The effect of natural immunomodulators on the lymphocytic natural killer activity in patients with malignant lymphoproliferative diseases]. Lik.Sprava. 1995;(1-2):146-148. View abstract.
  • Kleinschmidt, H. [An experiment to decrease susceptibility to infections in young children with Esberitox]. Ther Ggw. 1965;104(9):1258-1262. View abstract.
  • Kohler, G., Bodinet, C., and Freudenstein, J. [Pharmacodynamic effects and clinical effectiveness of a combination of herbal substances comprised of Cone Flower, Wild Indigo and White Cedar]. Wien.Med Wochenschr. 2002;152(15-16):393-397. View abstract.
  • Koster, J., Strack, D., and Barz, W. High Performance Liquid Chromatographic Separation of Isoflavones and Structural Elucidation of Isoflavone 7-O-glucoside 6''-malonates from Cicer arietinum. Planta Med. 1983;48(7):131-135. View abstract.
  • Liesen H, Kleiter K Mucke S Order U Widenmayer W Riedel H. Leucocytes and lymphocyte subpopulations in players of the German Olympic games in 1988. Deutsch Zeitschrift fur Soprtmedizin 1989;1-10.
  • MARION L, OUELLET J. The papilionaceous alkaloids; Baptisia australis (L.) R. Br. J Am Chem Soc. 1948;70(2):691.
  • MARION, L. and COCKBURN, W. F. The papilionaceous alkaloids; Baptisia minor, Lehm. J.Am.Chem.Soc. 1948;70(10):3472-3474. View abstract.
  • MARION, L. and TURCOTTE, F. The papilionaceous alkaloids; Baptisia perfoliata (L.) R. Br. J.Am.Chem.Soc. 1948;70(10):3253. View abstract.
  • Markham, K. R., Swift, W. T., III, and Mabry, T. J. A new isoflavone glycoside from Baptisia australis. J.Org.Chem. 1968;33(1):462-464. View abstract.
  • MULLER, A. [Parenteral esberitox, its biological reactions and therapeutic possibilities]. Hippokrates. 10-15-1956;27(19):627-629. View abstract.
  • Naser, B., Lund, B., Henneicke-von Zepelin, H. H., Kohler, G., Lehmacher, W., and Scaglione, F. A randomized, double-blind, placebo-controlled, clinical dose-response trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold. Phytomedicine. 2005;12(10):715-722. View abstract.
  • Oung-Boran, P., Lebreton, P., and Netien, G. [Biochemical and pharmacological study of Baptisia australis]. Planta Med. 1969;17(4):301-318. View abstract.
  • Piller, N. B. The influence of a non-specific stimulator of host resistance on the number and morphological characteristics of macrophages attaching to subcutaneously implanted coverslips in the rat. Res Exp.Med (Berl) 1981;179(3):255-259. View abstract.
  • Pohl, P. [On the therapy of irradiation-induced leukopenia with Esberitox]. Med.Klin. 1969;64(35):1546-1547. View abstract.
  • Pohl, P. [Treatment of radiation-induced leukopenia with Esberitox]. Ther Ggw. 1970;109(6):902-906. View abstract.
  • Ragosch, V., Hundertmark, S., Hopp, H., Opri, F., and Weitzel, H. K. [Insulin-like-growth-factor-binding-protein 1 (IGFBP-1) and fetal fibronectin in diagnosis of premature rupture of fetal membranes]. Geburtshilfe Frauenheilkd. 1996;56(6):291-296. View abstract.
  • Reitz HD. [Immunomodulation with phytotherapeutic agents: a scientific study on the example of Esberitox]. Notabene medici 1990;20:362-366.
  • Roxas, M. and Jurenka, J. Colds and influenza: a review of diagnosis and conventional, botanical, and nutritional considerations. Altern.Med Rev. 2007;12(1):25-48. View abstract.
  • Sandoval CH, Morfin LL Lopez BB. Preliminary research for testing Baptisia tinctoria 30c effectiveness against salmonellosis in first and second quality broiler chickens. Br Homeopathic J 1998;87:131-134.
  • Sartor, K. J. [Efficacy of Esberitox in the treatment of radiation-induced leukopenia]. Ther Ggw. 1972;111(8):1147-1150. View abstract.
  • SCHWARZ, F. K. [Peroral change of general reaction to infections by esberitox]. Med Klin.(Munich) 10-3-1952;47(40):1320-1322. View abstract.
  • Stolze H and Forth H. [A treatment with antibiotics can be optimized by additional immunostimulation]. Der Kassenartz 1983;23:43-48.
  • Udayama, M., Kinjo, J., and Nohara, T. Triterpenoidal saponins from Baptisia australis. Phytochemistry 1998;48(7):1233-1235. View abstract.
  • Vestweber, A. M., Beuth, J., Ko, H. L., Tunggal, L., Buss, G., and Pulverer, G. [In vitro activity of Mercurius cyanatus complex against relevant pathogenic bacterial isolates]. Arzneimittelforschung. 1995;45(9):1018-1020. View abstract.
  • Vomel, T. [Effect of a plant immunostimulant on phagocytosis of erythrocytes by the reticulohistiocytary system of isolated perfused rat liver]. Arzneimittelforschung. 1985;35(9):1437-1439. View abstract.
  • von Blumroeder W-O. [Angina lacunaris. An investigation on how to stimulate the endogenous defense system] (German). Z.Allg.Med. 1985;61:271-273.
  • VON OETTINGEN, E. N. [Acute diseases of the ear and neck; contribution to the use of esberitox]. Ther Ggw. 1954;93(4):152-153. View abstract.
  • Vorberg G. For colds, stimulate the nonspecific immune system. Arztliche Praxis 1984;6:97-98.
  • Wack, M., Classen, B., and Blaschek, W. An acidic arabinogalactan-protein from the roots of Baptisia tinctoria. Planta Med. 2005;71(9):814-818. View abstract.
  • Wagner, H. and Jurcic, K. [Immunologic studies of plant combination preparations. In-vitro and in-vivo studies on the stimulation of phagocytosis]. Arzneimittelforschung. 1991;41(10):1072-1076. View abstract.
  • Wagner, H., Horhammer, L., Budweg, W., Major, A., and Farkas, L. [Investigation of the glycosides from Baptisia tinctoria. 3. Synthesis of pseudobaptisins]. Chem.Ber. 1969;102(9):3006-3008. View abstract.
  • Wagner, H., Proksch, A., Riess-Maurer, I., Vollmar, A., Odenthal, S., Stuppner, H., Jurcic, K., Le Turdu, M., and Fang, J. N. [Immunostimulating action of polysaccharides (heteroglycans) from higher plants]. Arzneimittelforschung 1985;35(7):1069-1075. View abstract.
  • Wagner, H., Proksch, A., Riess-Maurer, I., Vollmar, A., Odenthal, S., Stuppner, H., Jurcic, K., Le, Turdu M., and Heur, Y. H. [Immunostimulant action of polysaccharides (heteroglycans) from higher plants. Preliminary communication]. Arzneimittelforschung. 1984;34(6):659-661. View abstract.
  • Wink, M., Witte, L., Hartmann, T., Theuring, C., and Volz, V. Accumulation of quinolizidine alkaloids in plants and cell suspension cultures: genera lupinus, cytisus, baptisia, genista, laburnum, and sophora. Planta Med. 1983;48(8):253-257. View abstract.
  • Wustenberg, P., Henneicke-von Zepelin, H. H., Kohler, G., and Stammwitz, U. Efficacy and mode of action of an immunomodulator herbal preparation containing Echinacea, wild indigo, and white cedar. Adv.Ther 1999;16(1):51-70. View abstract.
  • Zimmer M. Specific conservative treatment of acute sinusitis in the ENT practice. Therapiewoche 1985;35:4024-4028.
  • Barrett B, Vohmann M, Calabrese C. Echinacea for upper respiratory infection. J Fam Pract 1999;48:628-35. View abstract.
  • Bendel R, Bendel V, Renner K, et al. [Additional treatment with Esberitox N in patients with chemo- radiotherapy treatment of advanced breast cancer]. Onkologie. 1989;12 Suppl 3:32-8. View abstract.
  • Bendel R, Bendel V, Renner K, et al. [Supplementary treatment with Esberitox of female patients undergoing curative adjuvant irradiation following breast cancer]. Strahlenther.Onkol. 1988;164:278-83. View abstract.
  • Beuscher N, Scheit KH, Bodinet C, Kopanski L. [Immunologically active glycoproteins of Baptisia tinctoria]. Planta Med 1989;55:358-63. View abstract.
  • Bockhorst H, Gollnick N, Guran S, et al. [Therapy of herpes simplex in practice. Report on the treatment of herpes simplex labialis with Esberitox]. ZFA.(Stuttgart.) 11-20-1982;58:1795-98. View abstract.
  • Henneicke-von Zepelin H, Hentschel C, Schnitker J, et al. Efficacy and safety of a fixed combination phytomedicine in the treatment of the common cold (acute viral respiratory tract infection): results of a randomised, double blind, placebo-controlled, multicentre study. Curr Med Res Opin 1999;15:214-27. View abstract.
  • von Blumroeder, W. O. [Angina lacunaris. An investigation on how to stimulate the endogenous defense system] (German). Z Allg Med 1985;61:271-273.
  • Barcz, E., Sommer, E., Nartowska, J., Balan, B., Chorostowska-Wynimko, J., and Skopinska-Rozewska, E. Influence of Echinacea purpurea intake during pregnancy on fetal growth and tissue angiogenic activity. Folia Histochem.Cytobiol. 2007;45 Suppl 1:S35-S39. View abstract.
  • Becker, K. P., Ditter, B., Nimsky, C., Urbaschek, R., and Urbaschek, B. [Endotoxin contents of phytopharmaceuticals: correlation with clinically observed side effects]. Dtsch.Med Wochenschr. 1-22-1988;113(3):83-87. View abstract.
  • Beuscher, N. [On the influence of drugs on cellular mechanism of resistance in the animal experiment. III. Enhancement of leukocyte mobilisation in the mouse by a resistance stimulant on plant base (author's transl)]. Arzneimittelforschung. 1980;30(5):821-825. View abstract.
  • Beuscher, N. [On the influence of drugs on cellular mechanisms of resistance in the animal experiment/Activation of peritoneal macrophages of the mouse by a resistance stimulant on plant base (author's transl)]. Arzneimittelforschung. 1982;32(2):134-138. View abstract.
  • Beuscher, N. and Kopanski, L. [Stimulation of immunity by the contents of Baptisia tinctoria]. Planta Med 1985;(5):381-384. View abstract.
  • Beuscher, N. and Stolze, H. [Endotoxin content of plant drugs]. Dtsch.Med Wochenschr. 5-6-1988;113(18):749-750. View abstract.
  • Beuscher, N., Beuscher, H., Otto, B., and Schafer, B. [Modification by drugs of cellular and humoral resistance mechanisms in animal experiments. I. In-vitro studies of peritoneal leukocytes and serums in rats]. Arzneimittelforschung. 1977;27(9):1655-1660. View abstract.
  • Blunck KD. Susceptibility to infection at children's home-to increase the resistance against infections. Kinderarzt 1983;14:991-992.
  • Bodinet, C. and Freudenstein, J. Effects of an orally applied aqueous-ethanolic extract of a mixture of Thujae occidentalis herba, Baptisiae tinctoriae radix, Echinaceae purpureae radix and Echinaceae pallidae radix on antibody response against sheep red blood cells in mice. Planta Med 1999;65(8):695-699. View abstract.
  • Bodinet, C., Lindequist, U., Teuscher, E., and Freudenstein, J. Effect of an orally applied herbal immunomodulator on cytokine induction and antibody response in normal and immunosuppressed mice. Phytomedicine. 2002;9(7):606-613. View abstract.
  • Bodinet, C., Lindequist, U., Teuscher, E., and Freudenstein, J. Influence of peroral application of a herbal immunomodulator on the antibody production of Peyer's patches cells. Arzneimittelforschung. 2004;54(2):114-118. View abstract.
  • Bodinet, C., Mentel, R., Wegner, U., Lindequist, U., Teuscher, E., and Freudenstein, J. Effect of oral application of an immunomodulating plant extract on Influenza virus type A infection in mice. Planta Med 2002;68(10):896-900. View abstract.
  • Bostelmann, H. C., Bodeker, R. H., Dames, W., Henneicke-von Zepelin, H. H., Siegers, C. P., and Stammwitz, U. [Immunomodulation by herbal agents. A double-blind study in a medical university hospital involving a hepatitis B vaccine adjuvant model]. Fortschr.Med Orig. 12-5-2002;120(4):119-123. View abstract.
  • Bunsupa, S., Katayama, K., Ikeura, E., Oikawa, A., Toyooka, K., Saito, K., and Yamazaki, M. Lysine decarboxylase catalyzes the first step of quinolizidine alkaloid biosynthesis and coevolved with alkaloid production in leguminosae. Plant Cell 2012;24(3):1202-1216. View abstract.
  • Classen, B., Csavas, M., Borbas, A., Dingermann, T., and Zundorf, I. Monoclonal Antibodies against an Arabinogalactan-Protein from Pressed Juice of Echinacea purpurea. Planta Med. 2004;70(9):861-865. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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