CHLOROPHYLLIN

OTHER NAME(S):

Chlorophylline, Chlorophylline de Cuivre Sodique, Chlorophylline de Sodium et Cuivre, Clorofilina, Sel Cuprique de la Chlorophylle, Sodium Copper Chlorophyll, Sodium Copper Chlorophyllin.

Overview

Overview Information

Chlorophyllin is a chemical that is made from chlorophyll. It is sometimes used as medicine.

Some people use chlorophyllin for body odor, urinary odor, reducing the smell of bowel movements, bad breath, cancer, acne, and skinwrinkles from sun damage, but there is no good scientific evidence to support these uses.

In foods and cosmetics, chlorophyllin is used as a green coloring agent.

Don't confuse chlorophyllin with chlorophyll.

How does it work?

Chlorophyllin seems to have antioxidant and anti-inflammatory effects. It might also stop the body from absorbing certain chemicals that can increase a person's risk for cancer.

Uses

Uses & Effectiveness?

Possibly Ineffective for

  • Urinary odor. Research shows that taking chlorophyllin by mouth doesn't reduce urinary odor in older adults who have a urinary catheter.

Insufficient Evidence for

  • Acne. Early research shows that applying a gel containing chlorophyllin to the face might improve acne by a small amount.
  • Low white blood cell count (leukopenia). Early research shows that taking chlorophyllin by mouth might improve white blood cell counts in people with leukopenia.
  • Skinwrinkles from sun damage. Early research shows that applying a gel containing chlorophyllin to the face might improve the appearance of wrinkles by a small amount.
  • Other conditions.
More evidence is needed to rate the effectiveness of chlorophyllin for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Chlorophyllin is POSSIBLY SAFE when taken by mouth daily for up to 3 months. It might make the skin more sensitive to the sun.

When applied to the skin: There isn't enough reliable information to know if chlorophyllin is safe. It might make the skin more sensitive to the sun.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if chlorophyllin is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.

Interactions

Interactions?

We currently have no information for CHLOROPHYLLIN Interactions.

Dosing

Dosing

The appropriate dose of chlorophyllin depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for chlorophyllin. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152. View abstract.
  • Egner, P. A., Munoz, A., and Kensler, T. W. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutat.Res 2003;523-524:209-216. View abstract.
  • Egner, P. A., Wang, J. B., Zhu, Y. R., Zhang, B. C., Wu, Y., Zhang, Q. N., Qian, G. S., Kuang, S. Y., Gange, S. J., Jacobson, L. P., Helzlsouer, K. J., Bailey, G. S., Groopman, J. D., and Kensler, T. W. Chlorophyllin intervention reduces aflatoxin-DNA adducts in individuals at high risk for liver cancer. Proc Natl.Acad.Sci U.S.A 12-4-2001;98(25):14601-14606. View abstract.
  • Shaughnessy, D. T., Gangarosa, L. M., Schliebe, B., Umbach, D. M., Xu, Z., MacIntosh, B., Knize, M. G., Matthews, P. P., Swank, A. E., Sandler, R. S., DeMarini, D. M., and Taylor, J. A. Inhibition of fried meat-induced colorectal DNA damage and altered systemic genotoxicity in humans by crucifera, chlorophyllin, and yogurt. PLoS.One. 2011;6(4):e18707. View abstract.
  • Yamazaki, H., Fujieda, M., Togashi, M., Saito, T., Preti, G., Cashman, J. R., and Kamataki, T. Effects of the dietary supplements, activated charcoal and copper chlorophyllin, on urinary excretion of trimethylamine in Japanese trimethylaminuria patients. Life Sci. 4-16-2004;74(22):2739-2747. View abstract.
  • Amara-Mokrane YA, Lehucher-Michel MP, Balansard G, et al. Protective effects of alpha-hederin, chlorophyllin and ascorbic acid towards the induction of micronuclei by doxorubicin in cultured human lymphocytes. Mutagenesis 1996;11:161-7. View abstract.
  • Dashwood RH, Breinholt V, Bailey GS. Chemopreventive properties of chlorophyllin: Inhibition of aflatoxin B1 (AFB1)-DNA binding in vivo and anti-mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella mutagenicity assay. Carcinogenesis 1991;12:939-42. View abstract.
  • Egner PA, Stansbury KH, Snyder EP, Rogers ME, Hintz PA, Kensler TW. Identification and characterization of chlorin e(4) ethyl ester in sera of individuals participating in the chlorophyllin chemoprevention trial. Chem Res Toxicol. 2000 Sep;13(9):900-6. View abstract.
  • Gao F, Hu XF. Analysis of the therapeutic effect of sodium copper chlorophyllin tablet in treating 60 cases of leukopenia. Chin J Integr Med. 2005 Dec;11(4):279-82. View abstract.
  • John K, Pratt MM, Beland FA, et al. Benzo[a]pyrene (BP) DNA adduct formation in DNA repair-deficient p53 haploinsufficient [Xpa(-/-)p53(+/-)] and wild-type mice fed BP and BP plus chlorophyllin for 28 days. Carcinogenesis. 2012 Nov;33(11):2236-41. View abstract.
  • Jubert C, Mata J, Bench G, et al. Effects of chlorophyll and chlorophyllin on low-dose aflatoxin B(1) pharmacokinetics in human volunteers. Cancer Prev Res (Phila). 2009 Dec;2(12):1015-22. View abstract.
  • Kang MS, Kim JH, Shin BA, Lee HC, Kim YS, Lim HS, Oh JS. Inhibitory effect of chlorophyllin on the Propionibacterium acnes-induced chemokine expression. J Microbiol. 2013 Dec;51(6):844-9. View abstract.
  • Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. View abstract.
  • Moss NH, Morrow BA, et al. Effectiveness of chloresium in wound healing and deodorant effects. J Am Med Assoc. 1949 Aug 27;140(17):1336-9. No abstract available. View abstract.
  • Munch R, Barringer SA. Deodorization of garlic breath volatiles by food and food components. J Food Sci. 2014 Apr;79(4):C526-33. View abstract.
  • Nahata MC, Slencsak CA, Kamp J. Effect of chlorophyllin on urinary odor in incontinent geriatric patients. Drug Intell Clin Pharm 1983;17:732-4. View abstract.
  • Patar AK, Sharma A, Syiem D, Bhan S. Chlorophyllin supplementation modulates hyperglycemia-induced oxidative stress and apoptosis in liver of streptozotocin-administered mice. Biofactors. 2018 Sep;44(5):418-430. View abstract.
  • Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. View abstract.
  • Sarkar D, Sharma A, Talukder G. Clastogenic activity of pure chlorophyll and anticlastogenic effects of equivalent amounts of crude extract of Indian spinach leaf and chlorophyllin following dietary supplementation to mice. Environ Mol Mutagen 1996;28:121-6. View abstract.
  • Sigler ML, Stephens TJ. Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin. J Drugs Dermatol. 2015 Apr;14(4):401-4. View abstract.
  • Solymosi K, Mysliwa-Kurdziel B. Chlorophylls and their Derivatives Used in Food Industry and Medicine. Mini Rev Med Chem. 2017;17(13):1194-1222. View abstract.
  • Stephens TJ, McCook JP, Herndon JH Jr. Pilot Study of Topical Copper Chlorophyllin Complex in Subjects With Facial Acne and Large Pores. J Drugs Dermatol. 2015 Jun;14(6):589-92. View abstract.
  • Tomankova K, Kejlova K, Binder S, et al. In vitro cytotoxicity and phototoxicity study of cosmetics colorants. Toxicol In Vitro. 2011 Sep;25(6):1242-50. View abstract.
  • Toyoda T, Cho YM, Mizuta Y, Akagi J, Nishikawa A, Ogawa K. A 13-week subchronic toxicity study of sodium iron chlorophyllin in F344 rats. J Toxicol Sci. 2014 Feb;39(1):109-19. View abstract.
  • Wu ZL, Chen JK, Ong T, et al. Antitransforming activity of chlorophyllin against selected carcinogens and complex mixtures. Teratog Carcinog Mutagen 1994;14:75-81. View abstract.
  • Young RW, Beregi JS Jr. Use of chlorophyllin in the care of geriatric patients. J Am Geriatr Soc 1980;28:46-7. View abstract.
  • Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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