Hortensia, Hortensia en Arbre, Hortensia de Virginie, Hortension Arborescent, Hydrangea arborscens, Mountain Hydrangea, Seven Barks, Smooth Hydrangea, Viburnum alnifolium, Viburnum americanum, Wild Hydrangea.<br/><br/>


Overview Information

Hydrangea is a plant. The root and rhizome (underground stem) are used to make medicine.

Hydrangea is used for urinary tract problems such as infections of the bladder, urethra and prostate; enlarged prostate; and kidney stones. It is also used for hay fever.

How does it work?

The chemicals in hydrangea may cause increased urine output, which could help some urinary tract problems.


Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of hydrangea for these uses.

Side Effects

Side Effects & Safety

Hydrangea is POSSIBLY SAFE for most people when taken by mouth for only a few days. Side effects include nausea, vomiting, diarrhea, dizziness, and chest tightness.

It’s LIKELY UNSAFE to use more than 2 grams of dried hydrangea rhizome/root at a time. It is also LIKELY UNSAFE to use hydrangea for long period of time.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking hydrangea if you are pregnant or breast-feeding. Stay on the safe side and avoid use.



Moderate Interaction

Be cautious with this combination

  • Lithium interacts with HYDRANGEA

    Hydrangea might have an effect like a water pill or "diuretic." Taking hydrangea might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using this product if you are taking lithium. Your lithium dose might need to be changed.



The appropriate dose of hydrangea depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for hydrangea. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Avenel-Audran, M., Hausen, B. M., le Sellin, J., Ledieu, G., and Verret, J. L. Allergic contact dermatitis from hydrangea--is it so rare? Contact Dermatitis 2000;43(4):189-191. View abstract.
  • Bruynzeel, D. P. Allergic contact dermatitis to hydrangea. Contact Dermatitis 1986;14(2):128. View abstract.
  • Bruynzeel, D. P. and Hausen, B. M. Allergic contact dermatitis to hydrangea. Contact Dermatitis 1987;16(3):181. View abstract.
  • Bruynzeel, D. P. Contact dermatitis from hydrangea. Contact Dermatitis 1991;24(1):78. View abstract.
  • De Rooij, J., Bruynzeel, D. P., and Rustemeyer, T. Occupational allergic contact dermatitis from hydrangea. Contact Dermatitis 2006;54(1):65-66. View abstract.
  • Ishih, A., Miyase, T., and Terada, M. Comparison of antimalarial activity of the alkaloidal fraction of Hydrangea macrophylla var. Otaksa leaves with the hot-water extract in ICR mice infected with Plasmodium yoelii 17 XL. Phytother.Res. 2003;17(6):633-639. View abstract.
  • Kikuchi, M., Kakuda, R., Kikuchi, M., and Yaoita, Y. Three new glycosides from the leaves of Hydrangea macrophylla subsp. serrata (THUNB.) MAKINO. Chem.Pharm.Bull.(Tokyo) 2008;56(4):610-611. View abstract.
  • Kuligowski, M. E., Chang, A., and Leemreize, J. H. Allergic contact hand dermatitis from hydrangea: report of a 10th case. Contact Dermatitis 1992;26(4):269-270. View abstract.
  • Ma, J. M., Liu, S. R., Shi, Z. M., Zhang, Y. D., and Chen, B. Y. [Quantitative analysis of different restoration stages during natural succession processes of subalpine dark brown coniferous forests in western Sichuan, China]. Ying.Yong.Sheng Tai Xue.Bao. 2007;18(8):1695-1701. View abstract.
  • Matsuda, H., Wang, Q., Matsuhira, K., Nakamura, S., Yuan, D., and Yoshikawa, M. Inhibitory effects of thunberginols A and B isolated from Hydrangeae Dulcis Folium on mRNA expression of cytokines and on activation of activator protein-1 in RBL-2H3 cells. Phytomedicine. 2008;15(3):177-184. View abstract.
  • Meijer, P., Coenraads, P. J., and Hausen, B. M. Allergic contact dermatitis from hydrangea. Contact Dermatitis 1990;23(1):59-60. View abstract.
  • Rademaker, M. Occupational contact dermatitis to hydrangea. Australas.J.Dermatol. 2003;44(3):220-221. View abstract.
  • Tsuji, Y., Denda, S., Soma, T., Raftery, L., Momoi, T., and Hibino, T. A potential suppressor of TGF-beta delays catagen progression in hair follicles. J.Investig.Dermatol.Symp.Proc. 2003;8(1):65-68. View abstract.
  • Yang, Q. and Gong, Z. Z. Purification and characterization of an ethylene-induced antifungal protein from leaves of guilder rose (Hydrangea macrophylla). Protein Expr.Purif. 2002;24(1):76-82. View abstract.
  • Yoshida, K., Ito, D., Shinkai, Y., and Kondo, T. Change of color and components in sepals of chameleon hydrangea during maturation and senescence. Phytochemistry 4-16-2008; View abstract.
  • Zhang, H., Matsuda, H., Kumahara, A., Ito, Y., Nakamura, S., and Yoshikawa, M. New type of anti-diabetic compounds from the processed leaves of Hydrangea macrophylla var. thunbergii (Hydrangeae Dulcis Folium). Bioorg.Med.Chem.Lett. 9-1-2007;17(17):4972-4976. View abstract.
  • Hamid S, Rojter S, Vierling J. Protracted cholestatic hepatitis after the use of Prostata. Ann Intern Med 1997;127:169-70. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
© Therapeutic Research Faculty 2018.