Vanadium is used for preventing vanadium deficiency. It is also used for prediabetes and diabetes, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Likely Effective for
- Vanadium deficiency. Taking vanadium by mouth can prevent vanadium deficiency, a condition in which the body doesn't have enough vanadium.
Insufficient Evidence for
- Diabetes. There is some evidence that high doses of vanadyl sulfate might improve the way the body uses insulin in people with type 2 diabetes. High-dose vanadium might also lower blood sugar in people with type 2 diabetes. But there are two big concerns about this evidence. First, the study involved only 40 people, so the conclusions need to be confirmed using a bigger study group. Secondly, even if high-dose vanadium works for diabetes, these high doses might not be safe when used long-term. It's unknown if lower doses work as well. For now, don't use vanadium to treat type 2 diabetes. Wait to see if additional larger studies show benefit and safety.
- Prediabetes. Early research shows that taking high doses of vanadyl sulfate doesn't improve how the body uses insulin in people with prediabetes. It also doesn't seem to lower blood sugar.
- Athletic performance.
- Heart disease.
- High levels of cholesterol or other fats (lipids) in the blood (hyperlipidemia).
- Low levels of sugar in the blood (hypoglycemia).
- Preventing cancer.
- Water retention (edema).
- Other conditions.
Special Precautions and Warnings
Breast-feeding: Vanadium is LIKELY SAFE in food amounts. But don't take vanadium supplements while breast-feeding. There isn't enough reliable information to know if larger doses of vanadium are safe when breast-feeding. Stay on the safe side, and stick to food amounts.
Children: Vanadium is LIKELY SAFE in children when taken in amounts found in foods. But don't give children vanadium supplements. Not enough is known about the safety of these larger doses in children.
Diabetes: The vanadyl sulfate form of vanadium might lower blood sugar in people with type 2 diabetes. Monitor your blood sugar carefully.
Kidney problems: There is developing evidence that vanadium might harm the kidneys. If you have kidney disease, don't use vanadium supplements.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with VANADIUM
Vanadium might slow blood clotting. Taking vanadium along with medications that also slow clotting might increase the chances of bruising and bleeding.
Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.
Medications for diabetes (Antidiabetes drugs) interacts with VANADIUM
Vanadium seems to decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking vanadium along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.
Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.
Be cautious with this combination
Jozsa, L. [Dental care, dental diseases and dentistry in antiquity]. Orvostort.Kozl. 2009;55(1-4):43-57. View abstract.
Mazor, S. S., Mycyk, M. B., Wills, B. K., Brace, L. D., Gussow, L., and Erickson, T. Coca tea consumption causes positive urine cocaine assay. Eur.J Emerg.Med 2006;13(6):340-341. View abstract.
Middleton, R. M. and Kirkpatrick, M. B. Clinical use of cocaine. A review of the risks and benefits. Drug Saf 1993;9(3):212-217. View abstract.
Novak, M., Salemink, C. A., and Khan, I. Biological activity of the alkaloids of Erythroxylum coca and Erythroxylum novogranatense. J Ethnopharmacol. 1984;10(3):261-274. View abstract.
Prance, G. The poisons and narcotics of the Amazonian Indians. J R.Coll.Physicians Lond 1999;33(4):368-376. View abstract.
Reisner, L. Biologic poisons for pain. Curr.Pain Headache Rep. 2004;8(6):427-434. View abstract.
Rivera, M. A., Aufderheide, A. C., Cartmell, L. W., Torres, C. M., and Langsjoen, O. Antiquity of coca-leaf chewing in the south central Andes: a 3,000 year archaeological record of coca-leaf chewing from northern Chile. J Psychoactive Drugs 2005;37(4):455-458. View abstract.
Badmaev, V., Prakash, S., and Majeed, M. Vanadium: a review of its potential role in the fight against diabetes. J Altern Complement Med 1999;5(3):273-291. View abstract.
Beliaeva, N. F., Gorodetskii, V. K., Tochilkin, A. I., Golubev, M. A., Semenova, N. V., and Kovel'man, I. R. [Vanadium compounds--a new class of therapeutic agents for the treatment of diabetes mellitus]. Vopr.Med Khim. 2000;46(4):344-360. View abstract.
Bradley, R., Oberg, E. B., Calabrese, C., and Standish, L. J. Algorithm for complementary and alternative medicine practice and research in type 2 diabetes. J Altern.Complement Med. 2007;13(1):159-175. View abstract.
Chakraborty, T., Chatterjee, A., Rana, A., Rana, B., Palanisamy, A., Madhappan, R., and Chatterjee, M. Suppression of early stages of neoplastic transformation in a two-stage chemical hepatocarcinogenesis model: supplementation of vanadium, a dietary micronutrient, limits cell proliferation and inhibits the formations of 8-hydroxy-2'-deoxyguanosines and DNA strand-breaks in the liver of sprague-dawley rats. Nutr Cancer 2007;59(2):228-247. View abstract.
Cunningham, J. J. Micronutrients as nutriceutical interventions in diabetes mellitus. J Am Coll.Nutr 1998;17(1):7-10. View abstract.
Darvesh, A. S. and Bishayee, A. Selenium in the prevention and treatment of hepatocellular carcinoma. Anticancer Agents Med Chem 2010;10(4):338-345. View abstract.
Goldfine, A. B., Patti, M. E., Zuberi, L., Goldstein, B. J., LeBlanc, R., Landaker, E. J., Jiang, Z. Y., Willsky, G. R., and Kahn, C. R. Metabolic effects of vanadyl sulfate in humans with non-insulin-dependent diabetes mellitus: in vivo and in vitro studies. Metabolism 2000;49(3):400-410. View abstract.
Henquin, J. C. and Brichard, S. M. [Role of vanadium in the treatment of diabetes mellitus. Experimental data and clinical applications]. Presse Med 6-27-1992;21(24):1100-1101. View abstract.
Hosokawa, S. and Yoshida, O. Vanadium in chronic hemodialysis patients. Int J Artif.Organs 1990;13(4):197-199. View abstract.
Kelly, G. S. Insulin resistance: lifestyle and nutritional interventions. Altern.Med Rev 2000;5(2):109-132. View abstract.
Mancinella, A. [Vanadium, an indispensable trace element in living organisms. Current data on biochemical, metabolic levels and therapeutic doses]. Clin Ter. 1993;142(3):251-255. View abstract.
Min, J. A., Lee, K., and Ki, D. J. The application of minerals in managing alcohol hangover: a preliminary review. Curr Drug Abuse Rev 2010;3(2):110-115. View abstract.
Nahas, R. and Moher, M. Complementary and alternative medicine for the treatment of type 2 diabetes. Can Fam.Physician 2009;55(6):591-596. View abstract.
Neyrolles, N., Blickle, J. F., and Brogard, J. M. [New therapies in type 2 diabetes]. Ann Endocrinol.(Paris) 1998;59(2):67-77. View abstract.
Tubek, S. Role of trace elements in primary arterial hypertension: is mineral water style or prophylaxis? Biol.Trace Elem.Res 2006;114(1-3):1-5. View abstract.
Aharon Y, Mevorach M, Shamoon H. Vanadyl sulfate does not enhance insulin action in patients with type 1 diabetes. Diabetes Care 1998;21:2194-5.
Bishayee A, Karmakar R, Mandal A, et al. Vanadium mediated chemoprotection against chemical hepatocarcinogenesis in rats: haematological and histological characteristics. Eur J Cancer Prev 1997;6:58-70. View abstract.
Boden G, Chen X, Ruiz J, et al. Effects of vanadyl sulfate on carbohydrate and lipid metabolism in patients with non-insulin-dependent diabetes mellitus. Metabolism 1996;45:1130-5. View abstract.
Chakraborty A, Chatterjee M. Enhanced erythropoietin and suppression of gamma-glutamyl-transpeptidase (GGT) activity in murine lymphoma following administration of vanadium. Neoplasma 1994;41:291-6. View abstract.
Cohen N, Halberstam M, Shlimovich P, et al. Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus. J Clin Invest 1995;95:2501-9. View abstract.
Cusi K, Cukier S, DeFronzo RA, et al. Vanadyl sulfate improves hepatic and muscle insulin sensitivity in type 2 diabetes. J Clin Endocrinol Metab 2001;86:1410-7. View abstract.
Domingo JL, Gomez M, Llobet JM, et al. Oral vanadium administration to streptozocin-diabetic rats has marked negative side-effects which are independent of the form of vanadium used. Toxicology 1991;66:279-87. View abstract.
Domingo JL, Sanchez DJ, Gomez M, et al. Oral vanadate and Tiron in treatment of diabetes mellitus in rats: improvement of glucose homeostasis and negative side effects. Vet Human Toxicol 1993;35:495-500. View abstract.
Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002. Available at: www.nap.edu/books/0309072794/html/.
Funakoshi T, Shimada H, Kojima S, et al. Anticoagulant action of vanadate. Chem Pharmaceut Bull 1992;40:174-6. View abstract.
Garcia-Nunez I, Algaba-Marmol MA, Suarez-Vergara M, et al. Vanadium contact dermatitis: case report and studies performed. Contact Dermatitis 2019;80(2):127-8. View abstract.
Goldfine AB, Simonson DC, Folli F, et al. Metabolic effects of sodium metavanadate in humans with insulin-dependent and noninsulin-dependent diabetes mellitus in vivo and in vitro studies. J Clin Endocrinol Metab 1995;80:3311-20. View abstract.
Goldwaser I, Li J, Gershonov E, et al. L-Glutamic acid gamma-monohydroxamate. A potentiator of vanadium-evoked glucose metabolism in vitro and in vivo. J Biol Chem 1999;274:26617-24. View abstract.
Gruzewska K, Michno A, Pawelczyk T, Bielarczyk H. Essentiality and toxicity of vanadium supplements in health and pathology. J Physiol Pharmacol. 2014;65(5):603-611. View abstract.
Halberstam M, Cohen N, Shlimovich P, et al. Oral vanadyl sulfate improves insulin sensitivity in NIDDM but not in obese nondiabetic subjects. Diabetes 1996;45:659-66. View abstract.
Harland BF, Harden-Williams BA. Is vanadium of human nutritional importance yet? J Am Diet Assoc 1994;94:891-4. View abstract.
Jacques-Camarena O, et al. Effect of vanadium on insulin sensitivity in patients with impaired glucose tolerance. Ann Nutr Metab. 2008;53(3-4):195-198. View abstract.
Jin S, Xia W, Jiang Y, et al. Urinary vanadium concentration in relation to premature rupture of membranes: A birth cohort study. Chemosphere 2018;210:1035-41. doi: 10.1016/j.chemosphere.2018.07.110. View abstract.
Klaassen CD, ed. Casarett and Doull's Toxicology: The Basic Science of Poisons. fifth ed. New York: McGraw-Hill, 1996.
Leonard A, Gerber GB. Mutagenicity, carcinogenicity and teratogenicity of vanadium Compounds. Mutat Res 1994;317:81-8. View abstract.
Malabu UH, Dryden S, McCarthy HD, et al. Effects of chronic vanadate administration in the STZ-induced diabetic rat. Diabetes 1994;43:9-15. View abstract.
Oster MH, Llobet JM, Domingo JL, et al. Vanadium treatment of diabetic Sprague-Dawley rats results in tissue vanadium accumulation and pro-oxidant effects. Toxicology 1993;83:115-30. View abstract.
Peat F, Coomber R, Rana A, Vince A. Vanadium allergy following total knee arthroplasty. BMJ Case Rep 2018;2018. pii: bcr-2017-222092. doi: 10.1136/bcr-2017-222092. View abstract.
Sitprija V, Tungsanga K, Tosukhowong P, et al. Metabolic problems in northeastern Thailand: possible role of vanadium. Mineral Electrolyte Metab 1998;19:51-6. View abstract.
Stern A, Yin X, Tsang SS, et al. Vanadium as a modulator of cellular regulatory cascades and oncogene expression. Biochem Cell Biol 1993;71:103-12. View abstract.
Yeh GY, Eisenberg DM, Kaptchuk TJ, Phillips RS. Systematic review of herbs and dietary supplements for glycemic control in diabetes. Diabetes Care 2003;26:1277-94. View abstract.
Zhou Y, Zhu Q, Ma W, et al. Prenatal vanadium exposure, cytokine expression, and fetal growth: a gender-specific analysis in Shanghai MCPC study. Sci Total Environ 2019;685:1152-9. View abstract.
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