Blood of the Dragon, Crofelemer, Croton lechleri, Drago, Dragon's Blood, Dragon’s Blood Croton, Lan-Hiqui, Laniqui, Palo de Grado, Sang de Dragon, Sangre de Drago, Sangre de Dragon, Sangre de Grado, Sangue de Agua, Sangue de Drago, SP 303, SP-303, Taspine.


Overview Information

Sangre de grado is a tree that grows in the Amazon region of South America. The tree bark and sap are used to make medicine.

A chemical in sangre de grado known as crofelemer (SP-303) was approved as a drug by the U.S. Food and Drug Administration (FDA) in 2012.

Sangre de grado or crofelemer is used for diarrhea associated with cholera, AIDS, traveling, the bug Clostridium difficile, or treatment with antibiotics. Sangre de grado is also used for treating cancer, irritable bowel syndrome (IBS), lung infections, fever, hemorrhage, bleeding gums, wounds, broken bones, vaginal infections, painful menstrual periods, hemorrhoids, and a skin condition called eczema. Other uses include treating ulcers of the mouth, throat, stomach, or intestine.

Some people apply sangre de grado or crofelemer to the skin for herpes simplex virus (types 1 and 2). It is also applied to the skin for bug bites and skin reactions from plants.

How does it work?

Sangre de grado appears to help diarrhea by slowing down the amount of water that is lost through the intestines. It might also prevent the movement of some viruses into cells. It might also block pain signals in the nerves.


Uses & Effectiveness?

Possibly Effective for

  • AIDS-related diarrhea. Crofelemer is a chemical from sangre de grado. Research shows that taking crofelemer reduces diarrhea in people with AIDS-related diarrhea. This product is approved by the U.S. Food and Drug Administration for this condition.
  • Herpes outbreaks (genital and anal). Crofelemer is a chemical from sangre de grado. Research shows that applying crofelemer to the skin helps treat genital and anal herpes outbreaks in people with AIDS. But it might not be helpful for herpes outbreaks that do not respond to acyclovir, a drug used to treat herpes infections.
  • Traveler's diarrhea. Crofelemer is a chemical from sangre de grado. Research shows that taking crofelemer helps traveler's diarrhea go away about 6-8 hours faster.

Possibly Ineffective for

  • Irritable bowel syndrome (IBS). Crofelemer is a chemical from sangre de grado. Research shows that taking crofelemer does not reduce pain or diarrhea in people with diarrhea-predominant IBS.

Insufficient Evidence for

  • Insect bites and allergic plant reactions. Early research shows that applying sangre de grado to the skin relieves symptoms of insect bites and skin irritation due to plants.
  • Diarrhea caused by cholera, Clostridium difficile, or treatment with antibiotics.
  • Cancer.
  • Lung infections.
  • Mouth and throat ulcers.
  • Stomach and intestinal ulcers.
  • Fever.
  • Wounds.
  • Bleeding gums.
  • Broken bones.
  • Vaginal infections.
  • Painful menstrual periods.
  • Hemorrhoids.
  • A skin condition called eczema.
  • Other conditions.
More evidence is needed to rate the effectiveness of Sangre de Grado for these uses.

Side Effects

Side Effects & Safety

It is LIKELY SAFE to take crofelemer (SP-303), a chemical isolated from sangre de grado, by mouth. It is POSSIBLY SAFE to apply crofelemer (SP-303) directly to the skin. Some people have reported pain and burning when applying crofelemer (SP-303) to the skin. There is not enough information available to know if sangre de grado itself is safe to take for medical conditions.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking sangre de grado if you are pregnant or breast-feeding. Stay on the safe side and avoid use.

A type of blood cancer called leukemia: Sangre de grado might make this condition worse. Avoid using sangre de grado if you have leukemia.



We currently have no information for SANGRE DE GRADO Interactions.



The following doses have been studied in scientific research:



  • For AIDS-related diarrhea: 125 mg of crofelemer (SP-303), a chemical isolated from sangre de grado, has been taken twice daily. This same chemical in a dose of 500 mg every 6 hours for 4 days has also been used.
  • For traveler's diarrhea: 125-500 mg of crofelemer (SP-303), a chemical isolated from sangre de grado, four times daily for 2 days has been used.
  • For herpes (genital and anal): Applying a specific sangre de grado ointment containing 15% crofelemer (SP-303) to herpes lesions three times daily for 21 days has been used.

View References


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