Sangre de grado is a tree that grows in the Amazon region of South America. The tree bark and sap are used to make medicine.

A chemical in sangre de grado known as crofelemer (SP-303) was approved as a drug by the U.S. Food and Drug Administration (FDA) for diarrhea in people with HIV/AIDS. It is also sometimes used for travelers' diarrhea and irritable bowel syndrome (IBS), but it has not been approved by the FDA for these uses. Sangra de grado supplement products have not been studied for these conditions.

Sangre de grado supplements are sometimes used for the common cold, upper airway infections, ulcers, and many other conditions. But there is no good scientific evidence to support these uses.

How does it work ?

Sangre de grado appears to help diarrhea by slowing down the amount of water that is lost through the intestines. It might also prevent the movement of some viruses into cells. It might also block pain signals in the nerves.

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