3-propanoyloxy-4-(trimethylazaniumyl) butanoate, 3-(1oxo-propoxy)-4-trimethyl ammonium chloride) Butanoic Acid, Glycine Propionyl-L-Carnitine, Glycine Propionyl-L-Carnitine HCl, Glycine Propionyl-L-Carnitine Hydrochloride, L-carnitine Propionyl, LPC, PLC, Propionil-L-Carnitina, Propionyl-L-Carnitine Hydrochloride, Propionylcarnitine.<br/><br/>
Overview InformationPropionyl-L-carnitine is a chemical. It is made in the body. Propionyl-L-carnitine is related to two other compounds called L-carnitine and acetyl-L-carnitine.
Propionyl-L-carnitine is commonly used for treating leg pain (intermittent claudication) due to poor blood circulation (peripheral vascular disease, PVD). PVD is often caused by diabetes or “hardening of the arteries” (atherosclerosis). Propionyl-L-carnitine is also used to treat congestive heart failure (CHF), chest pain (angina), and some bowel problems such as ulcerative colitis. A specific kind of propionyl-L-carnitine, called glycine propionyl-L-carnitine, is often used to improve athletic ability. There is limited scientific research that supports taking propionyl-L-carnitine by mouth for other uses..
Healthcare providers may give propionyl-L-carnitine with a needle into the vein (by IV) for treating PVD and intermittent claudication; to improve wound healing in people with PVD; and to treat heart disease, including congestive heart failure, and chest pain (angina).
How does it work?Propionyl-L-carnitine helps the body produce energy. It is important for heart function, muscle movement, and many other body processes. It also seems to help increase circulation.
Uses & Effectiveness
Possibly Effective for
- Treating symptoms of “male menopause,” low levels of testosterone due to aging. Taking propionyl-L-carnitine by mouth in combination with acetyl-L-carnitine for six months seems to improve sexual performance, depression, and tiredness in older men. Taking this combination seems to work about as well as taking the chemical testosterone.
- Chest pain (angina). Taking propionyl-L-carnitine by mouth seems to help people with angina walk farther. In some people, it might reduce how often they feel chest pain.
- A type of heart disease called chronic ischemic heart disease. When given with a needle in the vein, propionyl-L-carnitine helps the heart pump better in people with ischemic heart disease.
- Congestive heart failure (CHF). Taking propionyl-L-carnitine seems to improve how the heart works in people with mild or moderate CHF. It also seems to help people with this disease walk farther.
- Sexual performance problems (erectile dysfunction, ED) in men. Taking propionyl-L-carnitine along with sildenafil (Viagra) may work better than taking sildenafil alone in men with diabetes and ED. Also, taking a specific product that contains propionyl-L-carnitine and other ingredients seems to help with sexual performance in men with ED.
- Poor circulation (peripheral vascular disease) that causes leg pain while walking (intermittent claudication). Propionyl-L-carnitine taken by mouth or given with a needle in the vein seems to help people with leg pain walk farther than they otherwise could. Propionyl-L-carnitine seems to work best for people with more severe disease.
- An increase in hard tissue in the penis (Peyronie's disease). The combination of propionyl-L-carnitine and injection of a medication called verapamil seems to improve sexual performance, slow down worsening of the disease, and possibly prevent surgery in people with Peyronie’s disease.
- A disease of the bowels called ulcerative colitis. Propionyl-L-carnitine might reduce symptoms in people with ulcerative colitis who are also using other medications. It might even help them go into remission, which means that the symptoms go away.
Insufficient Evidence for
- A disease of the bowels called Crohn's disease. Early research suggests that using propionyl-L-carnitine reduces symptoms in people with Crohn's disease.
- Chronic fatigue syndrome (CFS). Developing research suggests that propionyl-L-carnitine might improve general tiredness in patients with CFS. Interestingly, the combination of propionyl-L-carnitine and acetyl-L-carnitine appears to be less effective than either supplement alone.
- Exercise ability. Taking a specific product called glycine propionyl-L-carnitine might increase cycling strength. However, taking too much glycine propionyl-L-carnitine or taking it too often might make exercise harder.
- Circulatory problems caused by diabetes.
- Other conditions.
Side Effects & SafetyPropionyl-L-carnitine is LIKELY SAFE for most people when taken by mouth or given with a needle in the vein by a healthcare professional. It can cause stomach upset, vomiting, stomach pain, diarrhea, weakness, back pain, chest infections, and chest pain (angina). It can also cause a "fishy" smell of the urine, breath, and sweat.
Special Precautions & Warnings:Pregnancy and breast-feeding: Not enough is known about the use of propionyl-L-carnitine during pregnancy and breast-feeding. Stay on the safe side and avoid use.
“Underactive thyroid” (hypothyroidism): There is a concern that propionyl-L-carnitine might make hypothyroidism worse or thyroid hormone treatment less effective. This is because a related chemical, L-carnitine, seems to interfere with thyroid hormone. If you have hypothyroidism, don’t take propionyl-L-carnitine.
Seizures: Some people who have a history of seizures have reported an increase in the number and severity of seizures after taking L-carnitine by mouth or when given with a needle in the vein (by IV). There is a concern that this might also occur with propionyl-L-carnitine, because it is a similar chemical.
Be cautious with this combination
Acenocoumarol (Sintrom) interacts with PROPIONYL-L-CARNITINE
Acenocoumarol (Sintrom) is used to slow blood clotting. Propionyl-L-carnitine might increase the effects of acenocoumarol (Sintrom). Increasing the effects of acenocoumarol (Sintrom) might slow blood clotting too much and cause bruising and bleeding. The dose of your acenocoumarol (Sintrom) might need to be changed.
Warfarin (Coumadin) interacts with PROPIONYL-L-CARNITINE
Warfarin (Coumadin) is used to slow blood clotting. Propionyl-L-carnitine might increase the effects of warfarin (Coumadin) and increase the chances of bruising and bleeding. Be sure to have your blood checked regularly. The dose of your warfarin (Coumadin) might need to be changed.
The following doses have been studied in scientific research:
- For disorders of the blood vessels: 500-2000 mg propionyl-L-carnitine twice daily.
- For congestive heart failure and chest pain due to blood circulation problems (chronic angina): 500 mg propionyl-L-carnitine three times daily.
- For symptoms in older men caused by insufficient levels of testosterone: 2 grams of propionyl-L-carnitine and 2 grams of acetyl-L-carnitine daily.
- For ED (erectile dysfunction): 2 grams of propionyl-L-carnitine daily along with 50 mg of sildenafil (Viagra) given twice weekly. A specific combination of propionyl-L-carnitine 250 mg, niacin 20 mg, and arginine 2500 mg daily.
- For Peyronie's disease: 2 grams of propionyl-L-carnitine daily in combination with injections of a medication called verapamil.
- For ulcerative colitisL: 0.5-1 gram of propionyl-L-carnitine twice daily.
- For blood vessel disorders and heart disease: Healthcare providers give propionyl-L-carnitine with a needle in the vein (by IV).
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