Acide Désoxyribonucléique, Acide Nucléique, Acides Nucléiques, ADN, ADN-ARN, ADN/ARN, ARN et ADN, ARN y ADN, DNA, Deoxynucleic Acid, Deoxyribonucleic Acid, Extrait Ribonucléique, Nuclei Acids, Nucleic, Nucleic Acid, Nucleic Acids, Nucleotides, Nucléotides, Purines, Pyrimidines, Ribonucleotides, RNA, RNA-DNA, RNA/DNA, Ribonucleic Acid, Ribonucleic Extract.


Overview Information

RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) are chemical compounds that are made by the body. They can also be made in a laboratory. RNA and DNA are sometimes used as medicine.

People take RNA and DNA for conditions such as athletic performance, stomach and intestine problems, immune system problems, aging, and many others, but there is no good scientific evidence to support these uses.

How does it work?

RNA (ribonucleic acid) and DNA (deoxyribonucleic acid) contain chemicals called nucleotides that are made by the body. Normally, they are not needed in the diet. However, they appear to be necessary at certain times, such as during surgery or injury, when there are challenges to the immune system, or when more healthy cells in the intestine are needed.

Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of RNA and DNA for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: RNA and DNA are LIKELY SAFE when consumed in the amounts found in food. Also, RNA is safe for most people when taken along with omega-3 fatty acids and L-arginine. There isn't enough reliable information to know if RNA/DNA combinations are safe or what the side effects might be.

When given as a shot: RNA is POSSIBLY SAFE when injected under the skin. Injections of RNA can cause itching, redness, and swelling at the injection site.

Special Precautions & Warnings:

Pregnancy and breast-feeding: It might be UNSAFE to take RNA and DNA as a supplement if you are pregnant. Some evidence suggests that DNA might cross the placenta and cause birth defects.

There isn't enough reliable information to know if RNA and DNA are safe to use when breast-feeding. Stay on the safe side and avoid use.

Children: Infant formulas that contain RNA or DNA compounds are LIKELY SAFE for children during the first 12 months of life.



We currently have no information for RNA AND DNA Interactions.



The appropriate dose of RNA and DNA depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for RNA and DNA. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Bower RH, Cerra FB, Bershadsky B, et al. Early enteral administration of a formula (Impact) supplemented with arginine, nucleotides, and fish oil in intensive care unit patients: results of a multicenter, prospective, randomized clinical trial. Crit Care Med 1995;23:436-49. View abstract.
  • Buck RH, Thomas DL, Winship TR, et al. Effect of dietary ribonucleotides on infant immune status. Part 2: Immune cell development. Pediatr Res. 2004;56(6):891-900. View abstract.
  • Daly JM, Lieberman MD, Goldfine J, et al. Enteral nutrition with supplemental arginine, RNA, and omega-3 fatty acids in patients after operation: immunologic, metabolic and clinical outcome. Surgery 1992;112:56-67. View abstract.
  • Dancey CP, Attree EA, Brown KF. Nucleotide supplementation: a randomised double-blind placebo controlled trial of IntestAidIB in people with Irritable Bowel Syndrome [ISRCTN67764449]. Nutr J. 2006;5:16. View abstract.
  • Gianotti L, Braga M, Fortis C, et al. A prospective, randomized clinical trial on perioperative feeding with an arginine, omega-3-fatty acid, and RNA-enriched enteral diet: effect on host response and nutritional status. JPEN J Parenter Enteral Nutr 1999;23:314-20. View abstract.
  • Hawkes JS, Gibson RA, Roberton D, Makrides M. Effect of dietary nucleotide supplementation on growth and immune function in term infants: a randomized controlled trial. Eur J Clin Nutr. 2006;60(2):254-64. View abstract.
  • Kemen M, Senkal M, Homann HH, et al. Early postoperative enteral nutrition with arginine-omega-3 fatty acids and ribonucleic acid-supplemented diet vs placebo in cancer patients: an immunologic evaluation of impact. Crit Care Med 1995;23:652-9. View abstract.
  • Li L. Erythematous skin reaction to subcutaneous injection of ribonucleic acid. Contact Dermatitis 1999;41:239.
  • Mc Naughton L, Bentley D, Koeppel P. The effects of a nucleotide supplement on the immune and metabolic response to short term, high intensity exercise performance in trained male subjects. J Sports Med Phys Fitness. 2007;47(1):112-8. View abstract.
  • Ostojic SM, Idrizovic K, Stojanovic MD. Sublingual nucleotides prolong run time to exhaustion in young physically active men. Nutrients. 2013;5(11):4776-85. View abstract.
  • Ostojic SM, Obrenovic M. Sublingual nucleotides and immune response to exercise. J Int Soc Sports Nutr. 2012;9(1):31. View abstract.
  • Riera J, Pons V, Martinez-Puig D, et al. Dietary nucleotide improves markers of immune response to strenuous exercise under a cold environment. J Int Soc Sports Nutr. 2013;10(1):20. View abstract.
  • Rudolph FB, Van Buren CT. The metabolic effects of enterally administered ribonucleic acids. Curr Opin Clin Nutr Metab Care 1998;1:527-30. View abstract.
  • Saffle JR, Wiebke G, Jennings K, et al. Randomized trial of immune-enhancing enteral nutrition in burn patients. J Trauma 1997;42:793-802. View abstract.
  • Schaller JP, Kuchan MJ, Thomas DL, et al. Effect of dietary ribonucleotides on infant immune status. Part 1: Humoral responses. Pediatr Res. 2004;56(6):883-90. View abstract.
  • Schubert R, Hohlweg U, Renz D, Doefler W. On the fate of orally ingested foreign DNA in mice: chromosomal association and placental transmission o the fetus. Mol Gen Genet 1998;259:569-76.
  • Senkal M, Kemen M, Homann HH, et al. Modulation of postoperative immune response by enteral nutrition with a diet enriched with arginine, RNA, and omega-3 fatty acids in patients with upper gastrointestinal cancer. Eur J Surg 1995;161:115-22. View abstract.
  • Sterczala AJ, DuPont WH, Comstock BA, et al. Physiological effects of nucleotide supplementation on resistance exercise stress in men and women. J Strength Cond Res. 2016;30(2):569-78. View abstract.
  • Tepaske R, Velthuis H, Oudemans-van Straaten HM, et al. Effect of preoperative oral immune-enhancing nutritional supplement on patients at high risk of infection after cardiac surgery: a randomised placebo-controlled trial. Lancet 2001;358:696-701. View abstract.
  • Van Buren CT, Rudolph F. Dietary nucleotides: a conditional requirement. Nutrition 1997;13:470-2. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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