Bitterhout, Milk Bush, Uzarae Radix, Xysmalobium undulatum, Wild Cotton.


Overview Information

Uzara is a plant used in traditional African medicine. The root is used to make medicine.

People take uzara for diarrhea.

How does it work?

Uzara contains ingredients that might slow the movement of the contents of the intestines.


Uses & Effectiveness?

Insufficient Evidence for

More evidence is needed to rate the effectiveness of uzara for these uses.

Side Effects

Side Effects & Safety

When taken by mouth: Uzara is POSSIBLY SAFE when used by healthy adults for up to 5 days. The common side effects of uzara are unknown. Rarely, uzara can cause worsened heart function, irregular heart rhythm, and difficulty breathing.

Uzara is commonly used for diarrhea. Diarrhea lasting for more than a couple of days should be brought to the attention of your healthcare provider.

When given as a shot: Uzara is UNSAFE when used by injection and has caused death.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information to know if it is safe to use uzara when pregnant or breast-feeding. Stay on the safe side and avoid use.

Heart disease: Don't use uzara if you have a heart condition. It contains chemicals that could make your condition worse or interfere with your treatment.

Low potassium levels: Low potassium levels threaten the health of your heart. Using uzara can drive your potassium levels even lower and raise the risk of heart damage.



Major Interaction

Do not take this combination

  • Digoxin (Lanoxin) interacts with UZARA

    Digoxin (Lanoxin) helps the heart beat more strongly. Uzara also seems to affect the heart. Taking uzara along with digoxin can increase the effects of digoxin and increase the risk of side effects. Do not take uzara if you are taking digoxin (Lanoxin) without talking to your healthcare professional.

Moderate Interaction

Be cautious with this combination

  • Antibiotics (Macrolide antibiotics) interacts with UZARA

    Uzara can affect the heart. Some antibiotics might increase how much uzara the body absorbs. Increasing how much uzara the body absorbs might increase the effects and side effects of uzara.
    Some antibiotics called macrolide antibiotics include erythromycin, azithromycin, and clarithromycin.

  • Antibiotics (Tetracycline antibiotics) interacts with UZARA

    Taking tetracycline antibiotics along with uzara might increase the chance of side effects from uzara.
    Some tetracycline antibiotics include demeclocycline (Declomycin), minocycline (Minocin), and tetracycline (Achromycin).

  • Quinine interacts with UZARA

    Uzara can affect the heart. Quinine can also affect the heart. Taking quinine along with uzara might cause serious heart problems.

  • Stimulant laxatives interacts with UZARA

    Uzara can affect the heart. The heart uses potassium. Laxatives called stimulant laxatives can decrease potassium levels in the body. Low potassium levels can increase the chance of side effects uzara. Some stimulant laxatives include bisacodyl (Correctol, Dulcolax), cascara, castor oil (Purge), senna (Senokot), and others.

  • Water pills (Diuretic drugs) interacts with UZARA

    Uzara might affect the heart. "Water pills" can decrease potassium in the body. Low potassium levels can also affect the heart and increase the risk of side effects from uzara.
    Some "water pills" that can deplete potassium include chlorothiazide (Diuril), chlorthalidone (Thalitone), furosemide (Lasix), hydrochlorothiazide (HCTZ, HydroDiuril, Microzide), and others.



The appropriate dose of uzara depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for uzara. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Abd-El-Maeboud KH, Kortam MA, Ali MS, Ibrahim MI, Mohamed RM. A preliminary pilot randomized crossover study of uzara (Xysmalobium undulatum) versus ibuprofen in the treatment of primary dysmenorrhea. PLoS One. 2014;9(8):e104473. View abstract.
  • Burnham TH, ed. Drug Facts and Comparisons, Updated Monthly. Facts and Comparisons, St. Louis, MO.
  • Schmiedl S, Ritter A, Szymanski J, et al. Cardiovascular effects, pharmacokinetics and cross-reactivity in digitalis glycoside immunoassays of an antidiarrheal uzara root extract. Int J Clin Pharmacol Ther. 2012;50(10):729-40. View abstract.
  • Schulzke JD, Andres S, Amasheh M, Fromm A, Günzel D. Anti-diarrheal mechanism of the traditional remedy Uzara via reduction of active chloride secretion. PLoS One. 2011;6(3):e18107. View abstract.
  • Thürmann PA, Neff A, Fleisch J. Interference of Uzara glycosides in assays of digitalis glycosides. Int J Clin Pharmacol Ther. 2004;42(5):281-4. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.
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