The chemicals in different parts of the celery plant might have many effects on the body, including lowering blood sugar and blood pressure, and causing sleepiness.
People use celery to repel mosquitos, for prediabetes, gout, rheumatoid arthritis, and many other conditions, but there is no good scientific evidence to support these uses.
Uses & Effectiveness ?
Possibly Effective for
- Mosquito repellent. Some research shows that applying a gel containing 5% to 25% celery extract to the skin can repel mosquitos for up to 4.5 hours. Other research shows that applying a specific product containing celery extract 5%, vanillin, eucalyptus oil, orange oil, and citronella oil, repels mosquitoes similarly to other commercial products, such as DEET 25% and Insect Block 28.
When applied to the skin: Celery is possibly safe for most people when used short-term. Some people are allergic to celery. Allergic reactions can range from skin rashes to anaphylaxis. Celery can also cause sensitivity to the sun.
Special Precautions and Warnings
When applied to the skin: Celery is possibly safe for most people when used short-term. Some people are allergic to celery. Allergic reactions can range from skin rashes to anaphylaxis. Celery can also cause sensitivity to the sun. Pregnancy: Celery oil and celery seeds are likely unsafe when taken by mouth during pregnancy in the amounts found in medicine. Large amounts of celery might make the uterus contract and cause a miscarriage. Stick to food amounts.
Breast-feeding: There isn't enough reliable information to know if it is safe to use celery when breast-feeding. Stay on the safe side and stick to food amounts.
Allergies: Celery can cause allergic reactions in people who are sensitive to some other plants and spices, including wild carrot, mugwort, birch, caraway, fennel or coriander seeds, parsley, anise, plantain, and dandelion. This has been called the "celery-carrot-mugwort-spice syndrome," or the "celery-mugwort-birch-spice" syndrome.
Bleeding disorders: Celery root might increase the risk of bleeding when used in medicinal amounts. Don't use celery root if you have a bleeding disorder.
Thyroid conditions: Celery might interfere with thyroid function. Don't use celery if you have high or low thyroid levels or are taking medication for a thyroid disorder.
Levothyroxine (Synthroid, Levothroid, Levoxyl, and others) interacts with CELERY
Levothyroxine is used for low thyroid function. Taking celery seed along with levothyroxine might reduce the effects of levothyroxine.
Lithium interacts with CELERY
Taking celery might decrease how well the body gets rid of lithium. This could increase how much lithium is in the body and result in serious side effects. Talk with your healthcare provider before using celery if you are taking lithium. Your lithium dose might need to be changed.
Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs) interacts with CELERY
Celery root might slow blood clotting. Taking celery root along with medications that also slow blood clotting might increase the risk of bruising and bleeding.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates) interacts with CELERY
Some medications are changed and broken down by the liver. Celery might change how quickly the liver breaks down these medications. This could change the effects and side effects of these medications.
Venlafaxine (Effexor) interacts with CELERY
Celery root extract might decrease how quickly the body breaks down venlafaxine. Taking celery root extract with venlafaxine might increase the effects and side effects of venlafaxine.
Be cautious with this combination
Medications that increase sensitivity to sunlight (Photosensitizing drugs) interacts with CELERY
Some medications might make the skin more sensitive to sunlight. Celery might also make the skin more sensitive to sunlight. Using these products together might increase the risk of sunburn, blistering, or rashes when the skin is exposed to sunlight. Be sure to wear sunblock and protective clothing when spending time in the sun.
Acetaminophen (Tylenol) interacts with CELERY
Taking celery juice with acetaminophen prolongs the effects of acetaminophen. Taking celery juice with acetaminophen might increase the effects and side effects of acetaminophen.
Aminopyrine interacts with CELERY
Celery juice might decrease how quickly the liver breaks down and removes aminopyrine. Taking celery juice with aminopyrine might increase the effects and side effects of aminopyrine.
Be watchful with this combination
As medicine, celery seed powder or extract have most often been used by adults in doses of 1000-1500 mg by mouth daily. Speak with a healthcare provider to find out what dose might be best for a specific condition.
Ballmer-Weber, B. K., Hoffmann, A., Wuthrich, B., Luttkopf, D., Pompei, C., Wangorsch, A., Kastner, M., and Vieths, S. Influence of food processing on the allergenicity of celery: DBPCFC with celery spice and cooked celery in patients with celery allergy. Allergy 2002;57(3):228-235. View abstract.
Beier, R. C., Ivie, G. W., Oertli, E. H., and Holt, D. L. HPLC analysis of linear furocoumarins (psoralens) in healthy celery (Apium graveolens). Food Chem.Toxicol. 1983;21(2):163-165. View abstract.
Boffa, M. J., Gilmour, E., and Ead, R. D. Celery soup causing severe phototoxicity during PUVA therapy. Br.J.Dermatol. 1996;135(2):334. View abstract.
Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery cross-reacting with ragweed]. Allerg.Immunol.(Paris) 1995;27(3):91-93. View abstract.
Bonnin, J. P., Grezard, P., Colin, L., and Perrot, H. [A very significant case of allergy to celery]. Allerg.Immunol.(Paris) 1995;27(6):209. View abstract.
Christensen, L. P. and Brandt, K. Bioactive polyacetylenes in food plants of the Apiaceae family: occurrence, bioactivity and analysis. J Pharm.Biomed.Anal. 6-7-2006;41(3):683-693. View abstract.
DeChamp, C., Michel, J., Deviller, P., and Perrin, L. F. [Anaphylactic shock to celery and sensitization to ragweed and mugwort. Crossed or concomitant allergy?]. Presse Med. 3-31-1984;13(14):871-874. View abstract.
DeLeo, V. A. Photocontact dermatitis. Dermatol Ther 2004;17(4):279-288. View abstract.
Egan, C. L. and Sterling, G. Phytophotodermatitis: a visit to Margaritaville. Cutis 1993;51(1):41-42. View abstract.
Erdmann, S. M., Sachs, B., Schmidt, A., Merk, H. F., Scheiner, O., Moll-Slodowy, S., Sauer, I., Kwiecien, R., Maderegger, B., and Hoffmann-Sommergruber, K. In vitro analysis of birch-pollen-associated food allergy by use of recombinant allergens in the basophil activation test. Int Arch Allergy Immunol 2005;136(3):230-238. View abstract.
Forsbeck, M. and Ros, A. M. Anaphylactoid reaction to celery. Contact Dermatitis 1979;5(3):191. View abstract.
Fraser L and et al. Stalking hypertension. Health 1992;6(5):11.
Gorgus, E., Lohr, C., Raquet, N., Guth, S., and Schrenk, D. Limettin and furocoumarins in beverages containing citrus juices or extracts. Food Chem.Toxicol. 2010;48(1):93-98. View abstract.
Groot, B. J., Belinfante-van Gelder, M. E., and Jans, H. W. [An epidemic of dermatitis caused by blanched celery]. Ned.Tijdschr.Geneeskd. 6-20-1992;136(25):1210-1213. View abstract.
Held, J. L. Phytophotodermatitis. Am Fam.Physician 1989;39(4):143-146. View abstract.
Hoerler, S. and Ukiwe, J. Laryngeal edema from celery allergic reaction. Am.J.Emerg.Med. 1992;10(6):613. View abstract.
Jeanmougin, M., Varroud-Vial, C., and Dubertret, L. [Phototoxic side-effect following celery ingestion during puvatherapy]. Ann.Dermatol Venereol 2005;132(6-7 Pt 1):566-567. View abstract.
Johansson, S. G., Dannaeus, A., and Lilja, G. The relevance of anti-food antibodies for the diagnosis of food allergy. Ann.Allergy 1984;53(6 Pt 2):665-672. View abstract.
Kidd, J. M., III, Cohen, S. H., Sosman, A. J., and Fink, J. N. Food-dependent exercise-induced anaphylaxis. J Allergy Clin Immunol 1983;71(4):407-411. View abstract.
Ljunggren, B. Severe phototoxic burn following celery ingestion. Arch.Dermatol. 1990;126(10):1334-1336. View abstract.
Lombaert, G. A., Siemens, K. H., Pellaers, P., Mankotia, M., and Ng, W. Furanocoumarins in celery and parsnips: method and multiyear Canadian survey. J AOAC Int 2001;84(4):1135-1143. View abstract.
Maso, M. J., Ruszkowski, A. M., Bauerle, J., DeLeo, V. A., and Gasparro, F. P. Celery phytophotodermatitis in a chef. Arch.Dermatol. 1991;127(6):912-913. View abstract.
Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. A new French multicenter study]. Bull.Acad.Natl.Med 1995;179(1):161-184. View abstract.
Moneret-Vautrin, D. A. and Kanny, G. [Food-induced anaphylaxis. A new French multicenter survey]. Ann.Gastroenterol Hepatol (Paris) 1995;31(4):256-263. View abstract.
Peterson, S., Lampe, J. W., Bammler, T. K., Gross-Steinmeyer, K., and Eaton, D. L. Apiaceous vegetable constituents inhibit human cytochrome P-450 1A2 (hCYP1A2) activity and hCYP1A2-mediated mutagenicity of aflatoxin B1. Food Chem.Toxicol. 2006;44(9):1474-1484. View abstract.
Puig, L. and de Moragas, J. M. Enhancement of PUVA phototoxic effects following celery ingestion: cool broth also can burn. Arch.Dermatol. 1994;130(6):809-810. View abstract.
Rose, M. H. and Altman, L. C. Anaphylaxis after ingestion of raw celery. Ann.Allergy 1985;54(2):166. View abstract.
Rueff, F., Eberlein-Konig, B., and Przybilla, B. Oral hyposensitization with celery juice. Allergy 2001;56(1):82-83. View abstract.
Silverstein, S. R., Frommer, D. A., Dobozin, B., and Rosen, P. Celery-dependent exercise-induced anaphylaxis. J.Emerg.Med. 1986;4(3):195-199. View abstract.
Tuetun, B., Choochote, W., Kanjanapothi, D., Rattanachanpichai, E., Chaithong, U., Chaiwong, P., Jitpakdi, A., Tippawangkosol, P., Riyong, D., and Pitasawat, B. Repellent properties of celery, Apium graveolens L., compared with commercial repellents, against mosquitoes under laboratory and field conditions. Trop.Med Int Health 2005;10(11):1190-1198. View abstract.
Tuetun, B., Choochote, W., Pongpaibul, Y., Junkum, A., Kanjanapothi, D., Chaithong, U., Jitpakdi, A., Riyong, D., and Pitasawat, B. Celery-based topical repellents as a potential natural alternative for personal protection against mosquitoes. Parasitol.Res 2008;104(1):107-115. View abstract.
Tuetun, B., Choochote, W., Pongpaibul, Y., Junkum, A., Kanjanapothi, D., Chaithong, U., Jitpakdi, A., Riyong, D., Wannasan, A., and Pitasawat, B. Field evaluation of G10, a celery (Apium graveolens)-based topical repellent, against mosquitoes (Diptera: Culicidae) in Chiang Mai province, northern Thailand. Parasitol.Res 2009;104(3):515-521. View abstract.
Wang, L., Sterling, B., and Don, P. Berloque dermatitis induced by "Florida water". Cutis 2002;70(1):29-30. View abstract.
Weber, I. C., Davis, C. P., and Greeson, D. M. Phytophotodermatitis: the other "lime" disease. J Emerg.Med 1999;17(2):235-237. View abstract.
Wuthrich, B., Borga, A., and Yman, L. Oral allergy syndrome to a jackfruit (Artocarpus integrifolia). Allergy 1997;52(4):428-431. View abstract.
Baek CH, Bae YJ, Cho YS, Moon HB, Kim TB. Food-dependent exercise-induced anaphylaxis in the celery-mugwort-birch-spice syndrome. Allergy. 2010;65(6):792-3. View abstract.
Bauer L, Ebner C, Hirschwehr R, et al. IgE cross-reactivity between birch pollen, mugwort pollen, and celery is due to three distinct cross-reacting allergens: immunoblot investigation of the birch-mugwort-celery syndrome. Clin Exp Allergy 1996;26:1161-70. View abstract.
Ciganda C, and Laborde A. Herbal infusions used for induced abortion. J Toxicol.Clin Toxicol. 2003;41:235-239. View abstract.
Electronic Code of Federal Regulations. Title 21. Part 182 -- Substances Generally Recognized As Safe. Available at: https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=182
Emad AM, Ali SF, Abdel-Rahman EA, et al. Anti-inflammatory and antioxidant effects of Apium graveolens L. extracts mitigate against fatal acetaminophen-induced acute liver toxicity. J Food Biochem 2020:e13399. Online ahead of print. View abstract.
Fetrow CW, Avila JR. Professional's Handbook of Complementary & Alternative Medicines. 1st ed. Springhouse, PA: Springhouse Corp., 1999.
Gral N, Beani JC, Bonnot D, et al. [Plasma levels of psoralens after celery ingestion]. Ann Dermatol Venereol 1993;120:599-603. View abstract.
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm 2000;57:1221-7. View abstract.
Hessami K, Rahnavard T, Hosseinkhani A, et al. Treatment of women's sexual dysfunction using Apium graveolens L. Fruit (celery seed): a double-blind, randomized, placebo-controlled clinical trial. J Ethnopharmacol 2021;264:113400. View abstract.
Hirschfeld G, Weber L, Renkl A, Scharffetter-Kochanek K, Weiss JM. Anaphylaxis after Oseltamivir (Tamiflu) therapy in a patient with sensitization to star anise and celery-carrot-mugwort-spice syndrome. Allergy. 2008;63(2):243-4. View abstract.
Jakovljevic, V., Raskovic, A., Popovic, M., and Sabo, J. The effect of celery and parsley juices on pharmacodynamic activity of drugs involving cytochrome P450 in their metabolism. Eur.J Drug Metab Pharmacokinet. 2002;27(3):153-156. View abstract.
Khalid Z, Osuagwu FC, Shah B, Roy N, Dillon JE, Bradley R. Celery root extract as an inducer of mania induction in a patient on venlafaxine and St John's Wort. Postgrad Med. 2016;128(7):682-3. View abstract.
Li S, Li L, Yan H, et al. Anti-gouty arthritis and anti-hyperuricemia properties of celery seed extracts in rodent models. Mol Med Rep 2019;20(5):4623-33. doi: 10.3892/mmr.2019.10708. View abstract.
Maljaei MB, Moosavian SP, Mirmosayyeb O, Rouhani MH, Namjoo I, Bahreini A. Effect of celery extract on thyroid function; is herbal therapy safe in obesity? Int J Prev Med 2019;10:55. doi: 10.4103/ijpvm.IJPVM_209_17. View abstract.
Moses, G. Thyroxine interacts with celery seed tablets? Australian Prescriber 2001;24:6-7.
Nahid K, Fariborz M, Ataolah G, Solokian S. The effect of an Iranian herbal drug on primary dysmenorrhea: a clinical controlled trial. J Midwifery Womens Health 2009;54:401-4. View abstract.
Palgan K, Götz-Zbikowska M, Tykwinska M, Napiórkowska K, Bartuzi Z. Celery-cause of severe anaphylactic shock. Postepy Hig Med Dosw (Online). 2012;66:132-4. View abstract.
Rouhi-Boroujeni H, Hosseini M, Gharipour M, Rouhi-Boroujeni H. Is herbal therapy safe in obesity? A case of Apium graveolens (Celery) induced hyperthyroidism. ARYA Atheroscler 2016;12(5):248-9. View abstract.
Sarshar S, Sendker J, Qin X, et al. Antiadhesive hydroalcoholic extract from Apium graveolens fruits prevents bladder and kidney infection against uropathogenic E. coli. Fitoterapia. 2018;127:237-244. View abstract.
Sohrabi F, Niazmand S, Mahmoudabady M, Niazmand MJ. The vasodilatory effect of Apium graveolens L (celery) seed in isolated rat aorta: the roles of endothelium, calcium and potassium channels. Avicenna J Phytomed 2021;11(1):44-53. View abstract.
Vu N, Nguyen TTT, Parmenter BH, Thouas GA. Safety, efficacy and tolerability of a combination micronutrient and polyherbal preparation (GoutFighter TM) for gout: a single-arm open-label pilot study. J Complement Integr Med 2020;18(1):113-21. View abstract.
Yusni Y, Zufry H, Meutia F, Sucipto KW. The effects of celery leaf (apium graveolens L.) treatment on blood glucose and insulin levels in elderly pre-diabetics. Saudi Med J. 2018;39(2):154-160. View abstract.
Zegota Z, Gozdzik J, Glogowska-Szelag J. Prospective, multicenter evaluation of a polyherbal supplement alongside standard-of-care treatment for mild knee osteoarthritis. Adv Orthop. 2021;2021:5589597. View abstract.
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