Arctic Root, Extrait de Rhodiole, Golden Root, Hongjingtian, King's Crown, Lignum Rhodium, Orpin Rose, Racine d'Or, Racine Dorée, Racine de Rhadiola, Rhodiola rosea, Rhodiole, Rhodiole Rougeâtre, Rodia Riza, Rose Root, Rose Root Extract, Rosenroot, Roseroot, Rosewort, Sedum rhodiola, Sedum rosea, Siberian Golden Root, Siberian Rhodiola Rosea, Snowdown Rose.<br/><br/>


Overview Information

Rhodiola is a plant. The root is used as medicine.

Rhodiola is used for many conditions, but so far, there isn't enough scientific evidence to determine whether it is effective for any of them.

Rhodiola is most commonly used for increasing energy, endurance, strength, and mental capacity. It is also used as a so-called "adaptogen" to help the body adapt to and resist physical, chemical, and environmental stress.

Rhodiola is native to the arctic regions of Europe, Asia, and Alaska. It has a long history of use as a medicinal plant in Iceland, Sweden, France, Russia, and Greece. It is mentioned by the Greek physician Dioscorides as early as the first century AD.

Some people use the term "arctic root" as the general name for this product; however, arctic root is actually a trademarked name for a specific commercial extract.

How does it work?

Rhodiola extracts might help protect cells from damage, regulate heartbeat, and have the potential for improving learning and memory.


Uses & Effectiveness?

Insufficient Evidence for

  • Altitude sickness. Early research shows that taking rhodiola four times per day for 7 days doesn't improve blood oxygen or oxidative stress in people in high-altitude conditions.
  • Improving athletic performance. There is conflicting evidence on the effectiveness of rhodiola for improving athletic performance. Overall, it seems that short-term but not long-term doses of rhodiola might improve some measurements of athletic performance. However, neither short-term nor long-term doses appear to improve muscle function or reduce muscle damage due to exercise.
  • Bladder cancer. Early research suggests that rhodiola might provide some benefits in bladder cancer. However, rhodiola does not reduce the risk for relapse.
  • Depression. Early research shows that taking rhodiola extract might improve symptoms of depression after 6 weeks of treatment in people with mild-to-moderately severe depression.
  • Heart damage caused by the drug epirubicin. Early research suggests that taking a rhodiola constituent called salidroside starting one week before chemotherapy and continuing throughout chemotherapy reduces heart damage caused by the chemotherapy drug epirubicin.
  • Fatigue. Early research suggests that rhodiola might decrease fatigue in stressful situations. A specific rhodiola extract seems to decrease fatigue and increase a sense of well-being in students taking exams, night-shift workers, and sleep-deprived military cadets. Another rhodiola extract also seems to reduce mental fatigue in first-year college students. There is conflicting evidence regarding a combination product containing rhodiola extract, schisandra berry extract, and Siberian ginseng extract. Some research shows it improves mental performance in tired individuals performing mental tasks. Other research shows it doesn't work.
  • Anxiety. Early evidence suggests that specific rhodiola extract might lower anxiety and depression in people with a condition called generalized anxiety disorder.
  • Stress. Early research shows that taking a specific rhodiola extract before breakfast and lunch can improve stress symptoms in people with life-stress.
  • Aging.
  • Cancer.
  • Diabetes.
  • Hearing loss.
  • High cholesterol.
  • Increasing energy.
  • Irregular heartbeat.
  • Sexual problems.
  • Stress-associated heart disorders.
  • Other conditions.
More evidence is needed to rate the effectiveness of rhodiola for these uses.

Side Effects

Side Effects & Safety

Rhodiola is POSSIBLY SAFE when taken by mouth, short-term. Twice daily doses of rhodiola extract have been used safely for 6-10 weeks. The safety of long-term use is not known. Rhodiola might cause dizziness, dry mouth, or excessive saliva production.

Special Precautions & Warnings:

Pregnancy and breast-feeding: There isn't enough reliable information about the safety of taking Rhodiola if you are pregnant or breast feeding. Stay on the safe side and avoid use.

Autoimmune diseases: Rhodiola might simulate the immune system. In theory, it might worsen autoimmune diseases, such as multiple sclerosis (MS), rheumatoid arthritis (RA), and others.

Diabetes: Rhodiola might reduce blood sugar levels. In theory, rhodiola might increase the risk of blood sugar levels becoming too low, especially in patients taking insulin or other diabetes medications.

Low blood pressure: Rhodiola might lower blood pressure. In theory, rhodiola might cause blood pressure to become too low, especially in people who already have low blood pressure.



We currently have no information for RHODIOLA Interactions.



The appropriate dose of rhodiola depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for rhodiola. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References


  • Abidov, M., Crendal, F., Grachev, S., Seifulla, R., and Ziegenfuss, T. Effect of extracts from Rhodiola rosea and Rhodiola crenulata (Crassulaceae) roots on ATP content in mitochondria of skeletal muscles. Bull Exp.Biol.Med 2003;136(6):585-587. View abstract.
  • Baranov VB. Experimental trials of herbal adaptogen effect on the quality of operation activity, mental and professional work capacity. Contract 93-11-615 Stage 2 Phase I. Moscow, Russia: Russian Federation Ministry of Health Institute of Medical and Biological Problems 1994;
  • Bawa, A. S. and Khanum, F. Anti-inflammatory activity of Rhodiola rosea--"a second-generation adaptogen". Phytother.Res 2009;23(8):1099-1102. View abstract.
  • Blomkvist, J., Taube, A., and Larhammar, D. Perspective on Roseroot (Rhodiola rosea) studies. Planta Med 2009;75(11):1187-1190. View abstract.
  • Brichenko VS, Kupriyanova IE Skorokhova TF. The use of herbal adaptogens with tricyclic antidepressants in patients with psychogenic depression. Modern Problems of Pharmacology and Search for New Medicines.Tomsk, Russia: Tomsk State University Press 1986;58-60.
  • Calcabrini, C., De, Bellis R., Mancini, U., Cucchiarini, L., Potenza, L., De, Sanctis R., Patrone, V., Scesa, C., and Dacha, M. Rhodiola rosea ability to enrich cellular antioxidant defences of cultured human keratinocytes. Arch Dermatol Res 2010;302(3):191-200. View abstract.
  • Challem, J. Medical journal watch:context and applications. Rhodiola may help treat anxiety. Alternative & Complementary Therapies 2008;14(4):220-221.
  • Chen, Q. G., Zeng, Y. S., Qu, Z. Q., Tang, J. Y., Qin, Y. J., Chung, P., Wong, R., and Hagg, U. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine. 2009;16(9):830-838. View abstract.
  • Chen, T. S., Liou, S. Y., and Chang, Y. L. Antioxidant evaluation of three adaptogen extracts. Am J Chin Med 2008;36(6):1209-1217. View abstract.
  • Chen, Z. G., Lu, Y., Wang, Z. T., Tao, X. Y., and Wei, D. Z. Protective effects of salidroside on hypoxia/reoxygenation injury by sodium hydrosulfite in PC12 cells. Pharmaceutical Biology (Netherlands) 2007;45:604-612.
  • De Sanctis, R., De Bellis, R., Scesa, C., Mancini, U., Cucchiarini, L., and Dacha, M. In vitro protective effect of Rhodiola rosea extract against hypochlorous acid-induced oxidative damage in human erythrocytes. Biofactors 2004;20(3):147-159. View abstract.
  • Dement'eva, L. A. and Iaremenko, K. V. [Effect of a Rhodiola extract on the tumor process in an experiment]. Vopr.Onkol 1987;33(7):57-60. View abstract.
  • Duhan, O. M., Baryliak, I. R., Nester, T. I., Dvornyk, A. S., and Kunakh, V. A. [The antimutagenic activity of biomass extracts from the cultured cells of medicinal plants in the Ames test]. Tsitol.Genet. 1999;33(6):19-25. View abstract.
  • Earnest, C. P., Morss, G. M., Wyatt, F., Jordan, A. N., Colson, S., Church, T. S., Fitzgerald, Y., Autrey, L., Jurca, R., and Lucia, A. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc. 2004;36(3):504-509. View abstract.
  • Evdokimov, V. G. [Effect of cryopowder Rhodiola rosae L. on cardiorespiratory parameters and physical performance of humans]. Aviakosm.Ekolog.Med 2009;43(6):52-56. View abstract.
  • Evstatieva, L., Todorova, M., Antonova, D., and Staneva, J. Chemical composition of the essential oils of Rhodiola rosea L. of three different origins. Pharmacogn.Mag. 2010;6(24):256-258. View abstract.
  • Fintelmann, V. and Gruenwald, J. Efficacy and tolerability of a Rhodiola rosea extract in adults with physical and cognitive deficiencies. Adv.Ther 2007;24(4):929-939. View abstract.
  • Gupta, V., Lahiri, S. S., Sultana, S., Tulsawani, R. K., and Kumar, R. Anti-oxidative effect of Rhodiola imbricata root extract in rats during cold, hypoxia and restraint (C-H-R) exposure and post-stress recovery. Food Chem.Toxicol. 2010;48(4):1019-1025. View abstract.
  • Hu, X., Lin, S., Yu, D., Qiu, S., Zhang, X., and Mei, R. A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol. 2010;26(6):499-507. View abstract.
  • Hu, X., Zhang, X., Qiu, S., Yu, D., and Lin, S. Salidroside induces cell-cycle arrest and apoptosis in human breast cancer cells. Biochem.Biophys.Res Commun. 7-16-2010;398(1):62-67. View abstract.
  • Huang, S. C., Lee, F. T., Kuo, T. Y., Yang, J. H., and Chien, C. T. Attenuation of long-term Rhodiola rosea supplementation on exhaustive swimming-evoked oxidative stress in the rat. Chin J Physiol 10-31-2009;52(5):316-324. View abstract.
  • Hung, S. K., Perry, R., and Ernst, E. The effectiveness and efficacy of Rhodiola rosea L.: A systematic review of randomized clinical trials. Phytomedicine. 2-15-2011;18(4):235-244. View abstract.
  • Iovieno, N., Dalton, E. D., Fava, M., and Mischoulon, D. Second-tier natural antidepressants: review and critique. J Affect.Disord. 2011;130(3):343-357. View abstract.
  • Ip, S. P., Che, C. T., and Leung, P. S. Association of free radicals and the tissue renin-angiotensin system: prospective effects of Rhodiola, a genus of Chinese herb, on hypoxia-induced pancreatic injury. JOP. 2001;2(1):16-25. View abstract.
  • Jafari, M., Felgner, J. S., Bussel, I. I., Hutchili, T., Khodayari, B., Rose, M. R., Vince-Cruz, C., and Mueller, L. D. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation.Res 2007;10(4):587-602. View abstract.
  • Jeong, H. J., Ryu, Y. B., Park, S. J., Kim, J. H., Kwon, H. J., Kim, J. H., Park, K. H., Rho, M. C., and Lee, W. S. Neuraminidase inhibitory activities of flavonols isolated from Rhodiola rosea roots and their in vitro anti-influenza viral activities. Bioorg.Med Chem. 10-1-2009;17(19):6816-6823. View abstract.
  • Kiefer, D. Rhodiola rosea for General Anxiety Disorder. Alternative Medicine Alert 2008;11(6):61-65.
  • Kobayashi, K., Yamada, K., Murata, T., Hasegawa, T., Takano, F., Koga, K., Fushiya, S., Batkhuu, J., and Yoshizaki, F. Constituents of Rhodiola rosea showing inhibitory effect on lipase activity in mouse plasma and alimentary canal. Planta Med 2008;74(14):1716-1719. View abstract.
  • Krasik ED, Morozova ES Petrova KP Ragulina GA Shemetova LA Shuvaev VP. Therapy of asthenic conditions: clinical perspectives of application of Rhodiola rosea extract (golden root). Proceedings Modern problems in psycho-pharmacology.Kemerovo-city, Russia: Siberian Branch of Russian Academy of Sciences 1970;298-330.
  • Lazarova, M. B., Petkov, V. D., Markovska, V. L., Petkov, V. V., and Mosharrof, A. Effects of meclofenoxate and Extr. Rhodiolae roseae L. on electroconvulsive shock-impaired learning and memory in rats. Methods Find.Exp.Clin.Pharmacol. 1986;8(9):547-552. View abstract.
  • Lee, F. T., Kuo, T. Y., Liou, S. Y., and Chien, C. T. Chronic Rhodiola rosea extract supplementation enforces exhaustive swimming tolerance. Am J Chin Med 2009;37(3):557-572. View abstract.
  • Li, H. B., Ge, Y. K., Zheng, X. X., and Zhang, L. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. Eur J Pharmacol 7-7-2008;588(2-3):165-169. View abstract.
  • Li, X., Ye, X., Li, X., Sun, X., Liang, Q., Tao, L., Kang, X., and Chen, J. Salidroside protects against MPP(+)-induced apoptosis in PC12 cells by inhibiting the NO pathway. Brain Res 1-15-2011; View abstract.
  • Mao, G. X., Wang, Y., Qiu, Q., Deng, H. B., Yuan, L. G., Li, R. G., Song, D. Q., Li, Y. Y., Li, D. D., and Wang, Z. Salidroside protects human fibroblast cells from premature senescence induced by H(2)O(2) partly through modulating oxidative status. Mech.Ageing Dev 2010;131(11-12):723-731. View abstract.
  • Mao, Y., Zhang, X., Zhang, X., and Lu, G. Development of an HPLC method for the determination of salidroside in beagle dog plasma after administration of salidroside injection: application to a pharmacokinetics study. J Sep.Sci 2007;30(18):3218-3222. View abstract.
  • Maslov, L. N., Lishmanov, Y. B., Arbuzov, A. G., Krylatov, A. V., Budankova, E. V., Konkovskaya, Y. N., Burkova, V. N., and Severova, E. A. Antiarrhythmic activity of phytoadaptogens in short-term ischemia-reperfusion of the heart and postinfarction cardiosclerosis. Bull Exp.Biol Med 2009;147(3):331-334. View abstract.
  • Narimanian, M., Badalyan, M., Panosyan, V., Gabrielyan, E., Panossian, A., Wikman, G., and Wagner, H. Impact of Chisan (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia. Phytomedicine 2005;12(10):723-729. View abstract.
  • Noreen, E., Buckley, J., and Lewis, S. The effects of an acute dose of Rhodiola rosea on exercise performance and cognitive function. Journal of the International Society of Sports Nutrition 2009;6(Suppl 1):14p.
  • Panossian, A., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats. Phytother.Res 2009;23(3):351-357. View abstract.
  • Panossian, A., Nikoyan, N., Ohanyan, N., Hovhannisyan, A., Abrahamyan, H., Gabrielyan, E., and Wikman, G. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine. 2008;15(1-2):84-91. View abstract.
  • Panossian, A., Wikman, G., and Sarris, J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493. View abstract.
  • Provino, R. The role of adaptogens in stress management. Australian Journal of Medical Herbalism 2010;22(2):41-49.
  • Qian, E. W., Ge, D. T., and Kong, S. K. Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin. J Ethnopharmacol. 1-27-2011;133(2):308-314. View abstract.
  • Qu, Z. Q., Zhou, Y., Zeng, Y. S., Li, Y., and Chung, P. Pretreatment with Rhodiola rosea extract reduces cognitive impairment induced by intracerebroventricular streptozotocin in rats: implication of anti-oxidative and neuroprotective effects. Biomed.Environ Sci 2009;22(4):318-326. View abstract.
  • Rohloff, J. Volatiles from rhizomes of Rhodiola rosea L. Phytochemistry 2002;59(6):655-661. View abstract.
  • Schriner, S. E., Abrahamyan, A., Avanessian, A., Bussel, I., Maler, S., Gazarian, M., Holmbeck, M. A., and Jafari, M. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic.Res 2009;43(9):836-843. View abstract.
  • Schriner, S. E., Avanesian, A., Liu, Y., Luesch, H., and Jafari, M. Protection of human cultured cells against oxidative stress by Rhodiola rosea without activation of antioxidant defenses. Free Radic.Biol Med 9-1-2009;47(5):577-584. View abstract.
  • Schulzz, V. Rhodiola rosea radix extract for the treatment of mild to moderate depression? Results of a placebo-controlled clinical study. KIM - Komplementare und Integrative Medizin, Artztezeitschrift fur Naturheilverfahren 2009;3(2):36-41.
  • Scott, I. M., Leduc, R. I., Burt, A. J., Marles, R. J., and Foster, B. C. The inhibition of human cytochrome P450 by ethanol extracts of North American botanicals. Pharmaceutical Biology (Netherlands) 2006;44:315-327.
  • Skarpanska-Stejnborn, A., Pilaczynska-Szczesniak, L., Basta, P., and Deskur-Smielecka, E. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int J Sport Nutr Exerc.Metab 2009;19(2):186-199. View abstract.
  • Ssaratikov, A. S., Krasnov, E. A., Chnikina, L. A., Duvidson, L. M., Sotova, M. I., Marina, T. F., Nechoda, M. F., Axenova, R. A., and Tscherdinzeff, S. G. [Rhodiolosid, a new glycoside from Rhodiola rosea and its pharmacological properties]. Pharmazie 1968;23(7):392-395. View abstract.
  • Tan, C. B., Gao, M., Xu, W. R., Yang, X. Y., Zhu, X. M., and Du, G. H. Protective effects of salidroside on endothelial cell apoptosis induced by cobalt chloride. Biol Pharm Bull 2009;32(8):1359-1363. View abstract.
  • Udintsev, S. N. and Schakhov, V. P. Decrease of cyclophosphamide haematotoxicity by Rhodiola rosea root extract in mice with Ehrlich and Lewis transplantable tumors. Eur.J Cancer 1991;27(9):1182. View abstract.
  • Udintsev, S. N. and Shakhov, V. P. The role of humoral factors of regenerating liver in the development of experimental tumors and the effect of Rhodiola rosea extract on this process. Neoplasma 1991;38(3):323-331. View abstract.
  • van, Diermen D., Marston, A., Bravo, J., Reist, M., Carrupt, P. A., and Hostettmann, K. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 3-18-2009;122(2):397-401. View abstract.
  • Walker, T., Altobelli, S., Caprihan, A., and Robergs, R. Muscle phosphate kinetics following Rhodiola Rosea ingestion. Journal of Exercise Physiology Online 2006;9(2):11.
  • Wang, H., Ding, Y., Zhou, J., Sun, X., and Wang, S. The in vitro and in vivo antiviral effects of salidroside from Rhodiola rosea L. against coxsackievirus B3. Phytomedicine. 2009;16(2-3):146-155. View abstract.
  • Wiegant, F. A., Surinova, S., Ytsma, E., Langelaar-Makkinje, M., Wikman, G., and Post, J. A. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology. 2009;10(1):27-42. View abstract.
  • Wu, T., Zhou, H., Jin, Z., Bi, S., Yang, X., Yi, D., and Liu, W. Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. Eur J Pharmacol 6-24-2009;613(1-3):93-99. View abstract.
  • Wu, Y. L., Piao, D. M., Han, X. H., and Nan, J. X. Protective effects of salidroside against acetaminophen-induced toxicity in mice. Biol Pharm Bull 2008;31(8):1523-1529. View abstract.
  • Xu, K. J., Zhang, S. F., and Li, Q. X. [Preventive and treatment effect of composite Rhodiolae on acute lung injury in patients with severe pulmonary hypertension during extracorporeal circulation]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2003;23(9):648-650. View abstract.
  • Yu, S., Liu, L., Wen, T., Liu, Y., Wang, D., He, Y., Liang, Y., Liu, X., Xie, L., Wang, G., and Wei, W. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics study. J Chromatogr.B Analyt.Technol.Biomed.Life Sci 1-1-2008;861(1):10-15. View abstract.
  • Zaiteva, S. I., Matveeva, S. L., Gerasimova, T. G., Pashkov, Y. N., Butov, D. A., Pylypchuck, V. S., Frolov, V. M., and Kutsyna, G. A. Efficacy and safety of phytoconcentrate Dzherelo (Immunoxel) in treatment of patients with multi-drug resistant TB (MDR-TB) in comparison to standartd chemotherapy. Research Journal of Medical Sciences 2009;3(2):36-41.
  • Zhang, L., Yu, H., Zhao, X., Lin, X., Tan, C., Cao, G., and Wang, Z. Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells. Neurochem.Int 2010;57(5):547-555. View abstract.
  • Zhang, Z. H., Feng, S. H., Hu, G. D., Cao, Z. K., and Wang, L. Y. [Effect of Rhodiola kirilowii (Regel.) Maxim on preventing high altitude reactions. A comparison of cardiopulmonary function in villagers at various altitudes]. Zhongguo Zhong.Yao Za Zhi. 1989;14(11):687-90, 704. View abstract.
  • Zheng, K. Y., Guo, A. J., Bi, C. W., Zhu, K. Y., Chan, G. K., Fu, Q., Xu, S. L., Zhan, J. Y., Lau, D. T., Dong, T. T., Choi, R. C., and Tsim, K. W. The Extract of Rhodiolae Crenulatae Radix et Rhizoma Induces the Accumulation of HIF-1alpha via Blocking the Degradation Pathway in Cultured Kidney Fibroblasts. Planta Med 12-14-2010; View abstract.
  • Zhong, H., Xin, H., Wu, L. X., and Zhu, Y. Z. Salidroside attenuates apoptosis in ischemic cardiomyocytes: a mechanism through a mitochondria-dependent pathway. J Pharmacol Sci 2010;114(4):399-408. View abstract.
  • Zhu, J., Wan, X., Zhu, Y., Ma, X., Zheng, Y., and Zhang, T. Evaluation of salidroside in vitro and in vivo genotoxicity. Drug Chem.Toxicol. 2010;33(2):220-226. View abstract.
  • Zotova MI. The effect of Rhodiola rosea extract on mental working activity in man. In Collection of Reports at 3rd Scientific Conference of Physiologists, Biochemists and Pharmacologists of Western Siberia, Tomsk 1965;298-299.
  • Abidov M, Grachev S, Seifulla RD, Ziegenfuss TN. Extract of Rhodiola rosea radix reduces the level of C-reactive protein and creatinine kinase in the blood. Bull Exp Biol Med 2004;138:63-4. View abstract.
  • Akgul Y, Ferreira D, Abourashed EA, Khan IA. Lotaustralin from Rhodiola rosea roots. Fitoterapia 2004;75:612-4. View abstract.
  • Apostolidis E, Kwon YI, Shetty K. Potential of cranberry-based herbal synergies for diabetes and hypertension management. Asia Pac J Clin Nutr 2006;15:433-41. View abstract.
  • Aslanyan G, Amroyan E, Gabrielyan E, et al. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions. Phytomedicine 2010;17:494-9. View abstract.
  • Azizov, A. P. and Seifulla, R. D. [The effect of elton, leveton, fitoton and adapton on the work capacity of experimental animals]. Eksp Klin Farmakol 1998;61(3):61-63. View abstract.
  • Bocharova OA, Matveev BP, Baryshnikov AI, et al. [The effect of a Rhodiola rosea extract on the incidence of recurrences of a superficial bladder cancer]. Urol Nefrol (Mosk) 1995;:46-7. View abstract.
  • Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med 2008;14:175-80. View abstract.
  • Colson SN, Wyatt FB, Johnston DL, et al. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation. J Strength Cond Res 2005;19:358-63. View abstract.
  • Darbinyan G, Aslanyan G, Amroyan E. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry 2007;61:343-8. View abstract.
  • Darbinyan V, Kteyan A, Panossian A, et al. Rhodiola rosea in stress induced fatigue - a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7:365-71. View abstract.
  • De Bock K, Eijnde BO, Ramaekers M, Hespel P. Acute Rhodiola rosea intake can improve endurance exercise performance. Int J Sport Nutr Exerc Metab 2004;14:298-307. View abstract.
  • Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms--results of an open-label study. Phytother Res 2012;26(8):1220-5. View abstract.
  • Ha Z, Zhu Y, Zhang X, et al. The effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude. Zhonghua Jie He He Hu Xi Za Zhi 2002;25:527-30. View abstract.
  • Hellum BH, Tosse A, Hoybakk K, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med 2010;76:331-8. View abstract.
  • Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev 2001;6:293-302. View abstract.
  • Kim SH, Hyun SH, Choung SY. Antioxidative effects of Cinnamomi cassiae and Rhodiola rosea extracts in liver of diabetic mice. Biofactors 2006;26:209-19. View abstract.
  • Kormosh, N., Laktionov, K., and Antoshechkina, M. Effect of a combination of extract from several plants on cell-mediated and humoral immunity of patients with advanced ovarian cancer. Phytother Res 2006;20(5):424-425. View abstract.
  • Kwon YI, Jang HD, Shetty K. Evaluation of Rhodiola crenulata and Rhodiola rosea for management of type II diabetes and hypertension. Asia Pac J Clin Nutr 2006;15:425-32. View abstract.
  • Li HX, Sze SC, Tong Y, Ng TB. Production of Th1- and Th2-dependent cytokines induced by the Chinese medicine herb, Rhodiola algida, on human peripheral blood monocytes. J Ethnopharmacol 2009;123:257-66. View abstract.
  • Li T, Xu L, Sun C. Pharmacological studies on the sedative and hypnotic effect of salidroside from the Chinese medicinal plant Rhodiola sachalinensis. Phytomedicine 2007;14:601-4. View abstract.
  • Lishmanov IB, Maslova LV, Maslov LN, Dan'shina EN. [The anti-arrhythmia effect of Rhodiola rosea and its possible mechanism]. Bull Eksp Biol Med 1993;116:175-6. View abstract.
  • Lishmanov IB, Naumova AV, Afanas'ev SA, Maslov LN. [Contribution of the opioid system to realization of inotropic effects of Rhodiola rosea extracts in ischemic and reperfusion heart damage in vitro]. Eksp Klin Farmakol 1997;60:34-6. View abstract.
  • Ma G, Li W, Dou D, et al. Rhodiolosides A-E, monoterpene glycosides from Rhodiola rosea. Chem Pharm Bull 2006;54:1229-33. View abstract.
  • Maimeskulova LA, Maslov LN, Lishmanov IB, Krasnov EA. [The participation of the mu-, delta- and kappa-opioid receptors in the realization of the anti-arrhythmia effect of Rhodiola rosea]. Eksp Klin Farmakol 1997;60:38-9. View abstract.
  • Majewska A, Hoser G, Furmanowa M, et al. Antiproliferative and antimitotic effect, S phase accumulation and induction of apoptosis and necrosis after treatment of extract from Rhodiola rosea rhizomes on HL-60 cells. J Ethnopharmacol 2006;103:43-52. View abstract.
  • Maslova LV, Kondrat'ev BI, Maslov LN, Lishmanov IB. [The cardioprotective and antiadrenergic activity of an extract of Rhodiola rosea in stress]. Eksp Klin Farmakol 1994;57:61-3. View abstract.
  • McGovern E, McDonnell TJ. Herbal medicine-sets the heart racing! Ir Med J 2010;103:219. View abstract.
  • Ming DS, Hillhouse BJ, Guns ES, et al. Bioactive compounds from Rhodiola rosea (Crassulaceae). Phytother Res 2005;19:740-3. View abstract.
  • Mishra KP, Chanda S, Shukla K, Ganju L. Adjuvant effect of aqueous extract of Rhodiola imbricate rhizome on the immune responses to tetanus toxoid and ovalbumin in rats. Immunopharmacol Immunotoxicol 2010;32:141-6. View abstract.
  • Mishra KP, Ganju L, Chanda S, et al. Aqueous extract of Rhodiola imbricate rhizome stimulates Toll-like receptor 4, granzyme-B and Th1 cytokines in vitro. Immunobiology 2009;214:27-31. View abstract.
  • Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. J Strength Cond Res 2013;27(3):839-47. View abstract.
  • Olsson EM, von Scheele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardized extract shr-5 of the roots of Rhodiola rosea in the treatment of subjects with stress related fatigue. Planta Med 2009;75:105-12. View abstract.
  • Parisi A, Tranchita E, Duranti G, et al. Effects of chronic Rhodiola Rosea supplementation on sport performance and antioxidant capacity in trained male: preliminary results. J Sports Med Phys Fitness 2010;50:57-63. View abstract.
  • Perfumi M, Mattioli L. Adaptogenic and central nervous system effects of single doses of 3% rosavin and 1% salidroside Rhodiola rosea L. extract in mice. Phytother Res 2007;21:37-43. View abstract.
  • Petkov VD, Yonkov D, Mosharoff A, et al. Effects of alcohol aqueous extract from Rhodiola rosea L. roots on learning and memory. Acta Physiol Pharmacol Bulg 1986;12:3-16. View abstract.
  • Salikhova RA, Aleksandrova IV, Mazurik VK, et al. [Effect of Rhodiola rosea on the yield of mutation alterations and DNA repair in bone marrow cells]. Patol Fiziol Eksp Ter 1997;:22-4. View abstract.
  • Schutgens FW, Neogi P, van Wijk EP, et al. The influence of adaptogens on ultraweak biophoton emission: a pilot-experiment. Phytother Res 2009;23:1103-8. View abstract.
  • Shanely RA, Nieman DC, Zwetsloot KA, et al. Evaluation of Rhodiola rosea supplementation on skeletal muscle damage and inflammation in runners following a competitive marathon. Brain Behav Immun 2014;39:204-10. View abstract.
  • Shevtsov VA, Zholus BI, Shervarly VI, et al. A randomized trial of two different doses of a SHR-5 Rhodiola rosea extract versus placebo and control of capacity for mental work. Phytomedicine 2003;10:95-105. View abstract.
  • Skopriska-Rozewska E, Wojcik R, Siwicki AK, et al. The effect of Rhodiola quadrifida extracts on cellular immunity in mice and rats. Pol J Vet Sci 2008;11:105-11. View abstract.
  • Spasov AA, Mandrikov VB, Mironova IA. The effect of a preparation rodakson on the psychophysiological and physical adaptation of students to an academic load. Eksp Klin Farmakol 2000;63:76-8. View abstract.
  • Spasov AA, Wikman GK, Mandrikov VB, et al. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 2000;7:85-89. View abstract.
  • Udintsev SN, Krylova SG, Fomina TI. [The enhancement of the efficacy of adriamycin by using hepatoprotectors of plant origin in metastases of Ehrlich's adenocarcinoma to the liver in mice]. Vopr Onkol 1992;38:1217-22. View abstract.
  • Udintsev SN, Shakhov VP. [Changes in clonogenic properties of bone marrow and transplantable mice tumor cells during combined use of cyclophosphane and biological response modifiers of adaptogenic origin]. Eksp Onko 1990;12:55-6. View abstract.
  • Walker TB, Altobelli SA, Caprihan A, Robergs RA. Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men. Metabolism 2007;56:1111-7. View abstract.
  • Wiedenfeld H, Dumaa M, Malinowski M, et al. Phytochemical and analytical studies of extracts from Rhodiola rosea and Rhodiola quadrifida. Pharmazie 2007;62:308-11. View abstract.
  • Wing SL, Askew EW, Luetkemeier MJ, et al. Lack of effect of Rhodiola or oxygenated water supplementation on hypoxemia and oxidative stress. Wilderness Environ Med 2003;14:9-16. View abstract.
  • Zhang H, Shen WS, Gao CH, Deng LC, Shen D. Protective effects of salidroside on epirubicin-induced early left ventricular regional systolic dysfunction in patients with breast cancer. Drugs R D 2012;12(2):101-6. View abstract.
  • Zhang L, Yu H, Sun Y, et al. Protective effects of salidroside on hydrogen peroxide-induced apoptosis in SH-SY5Y human neuroblastoma cells. Eur J Pharmacol. 2007;564:18-25. View abstract.
  • Zhang ZJ, Tong Y, Zou J, et al. Dietary supplement with a combination of Rhodiola crenulata and Ginkgo biloba enhances the endurance performance in healthy volunteers. Chin J Integr Med 2009;15:177-83. View abstract.
  • Zubeldia JM, Nabi HA, Jimenez del Río M, Genovese J. Exploring new applications for Rhodiola rosea: can we improve the quality of life of patients with short-term hypothyroidism induced by hormone withdrawal? J Med Food 2010;13:1287-92. View abstract.

More Resources for RHODIOLA

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Information from this source is evidence-based and objective, and without commercial influence. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. © Therapeutic Research Faculty 2009.