EUROPEAN MISTLETOE

OTHER NAME(S):

All-Heal, Banda, Birdlime Mistletoe, Blandeau, Bois de Sainte-Croix, Bouchon, Devil&apos;s Fuge, Drudenfuss, Eurixor, Gu&eacute;rit-Tout, Gui, Gui Blanc, Gui Blanc d&apos;Europe, Gui des Feuillus, Gui d&apos;Europe, Gui Europ&eacute;en, Helixor, Herbe de Ch&egrave;vre, Hexenbesen, Hurchu, Iscador, Isorel, Leimmistel, Mistlekraut, Mistletein, Mistletoe, Mu&eacute;rdago Europeo, Mystyldene, Nid de Sorci&egrave;re, Pain de Biques, Rini, Verquet, Vert-Bois, Vert de Pommier, Visci, Visci Albi Folia, Visci Albi Fructus, Visci Albi Herba, Visci Albi Stipites, Vogelmistel, Vysorel, Viscum album.<br/><br/>

Overview

Overview Information

European mistletoe is a plant that grows on several different trees. The berries, leaf, and stem of European mistletoe are used to make medicine.

Interest in mistletoe for cancer has grown in North America, ever since Suzanne Somers announced on Larry King Live that she is using it to treat her breast cancer. European mistletoe has been used for treating cancer since the 1920s, especially in Europe. Several brand name mistletoe extracts are available there: Iscador, Eurixor, Helixor, Isorel, Vysorel, and ABNOBAviscum. So far these products are not readily available in North America. There is no proof they work for breast or other cancers. Avoid these products and stick with proven cancer treatments.

European mistletoe is also used for heart and blood vessel conditions including high blood pressure, "hardening of the arteries" (atherosclerosis), internal bleeding, and hemorrhoids; epilepsy and infantile convulsions; gout; psychiatric conditions such as depression and anxiety; sleep disorders; headache; absence of menstrual periods; symptoms of menopause; and for "blood purifying."

Some people use European mistletoe for treating mental and physical exhaustion; to reduce side effects of chemotherapy and radiation therapy; as a tranquilizer; and for treating whooping cough, asthma, dizziness, diarrhea, chorea, and liver and gallbladder conditions.

European mistletoe injections are used for cancer and for failing joints.

How does it work?

European mistletoe has several active chemicals. It might stimulate the immune system and kill certain cancer cells in a test tube, but it doesn't seem to work in people.

Uses

Uses & Effectiveness?

Possibly Ineffective for

  • Head and neck cancer. Injecting European mistletoe extract into the skin before or after surgery or radiation for head and neck cancers does not improve survival.

Insufficient Evidence for

  • Bladder cancer. Some early research suggests that administering European mistletoe extract into the bladder for 6 weeks might reduce bladder cancer recurrence in people who have had bladder cancer surgery. Injecting European mistletoe into the skin for several months might slow the progression of bladder cancer.
  • Breast cancer. Some research suggests that injecting certain brands of European mistletoe extract into the skin might reduce tumor growth and improve survival in people with breast cancer. But these results have been questioned. So far, there isn't enough reliable evidence to support using European mistletoe for this type of cancer. Stick to proven treatments.
  • Colon cancer. Early research suggests that certain specific European mistletoe extracts, given by injection alone or with conventional therapy, might improve survival in people with colon cancer. But these results have been questioned. So far, there isn't enough reliable evidence to support using European mistletoe for this type of cancer. Stick to proven treatments.
  • Common cold. Early research suggests that a specific European mistletoe extract, given by injection for 12 weeks, might not treat or prevent the common cold.
  • Stomach cancer. Early research suggests that a specific European mistletoe extract, given by injection under the skin, might improve survival in people with stomach cancer. It might also increase immune function. Benefits of European mistletoe have been questioned. So far, there isn't enough reliable evidence to support using European mistletoe for this type of cancer. Stick to proven treatments.
  • Hepatitis C. Research about the effectiveness of European mistletoe in people with hepatitis C is conflicting. Some research suggests that injecting a specific extract of European mistletoe may help to fight the infection that causes hepatitis C and improve quality of life in some people. Other research shows that injecting a different European mistletoe product does not help fight the hepatitis C infection but may improve symptoms of hepatitis C.
  • High blood pressure. Early research suggests taking European mistletoe extract orally in a homeopathic tincture might reduce blood pressure.
  • Leukemia. Early research suggests that injecting a specific European mistletoe extract might increase the survival of people with chronic myeloid leukemia by more than 2 years.
  • Liver cancer. Early research suggests that treatment with certain specific European mistletoe extracts may improve survival in people with liver cancer. But these results have been questioned. So far, there isn't enough reliable evidence to support using European mistletoe for this type of cancer. Stick to proven treatments.
  • Lung cancer. There is contradictory evidence about the effectiveness of European mistletoe on survival in people with lung cancer. Some evidence suggests that injecting European mistletoe extract can improve overall survival in people with lung cancer. But other evidence suggests that this treatment does not improve survival time or cancer response. So far, there isn't enough reliable evidence to support using European mistletoe for this type of cancer. Stick to proven treatments.
  • Cancer of the tissue layer covering each lung, or malignant pleural effusions. Early research suggests that giving a specific European mistletoe extract into the pleural tissue decreases cancer in those with cancer of that area.
  • Melanoma, a type of skin cancer. Early research suggests that injecting a specific European mistletoe extract into the skin does not improve survival or increase the time period without the disease in people with melanoma.
  • Ovarian cancer. Early research suggests injecting a specific European mistletoe extract into the skin might help patients with ovarian cancer and undergoing other treatments live longer.
  • Pancreatic cancer. Injecting European mistletoe extract into the skin does not seem to increase remission rates in people with advanced pancreatic cancer. But it might improve survival by about 2 months in people with pancreatic cancer who are no longer able to receive chemotherapy treatment. European mistletoe extract might also help improve survival time when injected into the tumor in people with pancreatic cancer who are receiving chemotherapy.
  • Quality of life. Early research suggests that injecting various European mistletoe extracts into the skin might improve quality of life and well-being in people with cancer when given alone or with chemotherapy.
  • Radiation exposure. Early research suggests that injecting a specific type of European mistletoe extract into the skin for 5 weeks might reduce lung infections and improve symptoms, such as fatigue, sweating, headache, joint pain, emotional instability, and muscle pain in children with repeated lung infections caused by radiation exposure during the Chernobyl nuclear accident.
  • Cancer of the uterus. Early research suggests that injecting a specific type of European mistletoe extract into the skin may to improve survival in people with cancer of the uterus.
  • Anxiety.
  • Depression.
  • Gout.
  • Headache.
  • Hemorrhoids.
  • High cholesterol.
  • Internal bleeding.
  • Menstrual disorders.
  • Seizures.
  • Side effects of chemotherapy and radiation therapy.
  • Sleep disorders.
  • Other conditions.
More evidence is needed to rate the effectiveness of European mistletoe for these uses.

Side Effects

Side Effects & Safety

European mistletoe is POSSIBLY SAFE when used by mouth or when injected beneath the skin in appropriate amounts. Taking three berries or two leaves or less by mouth does not seem to cause serious side effects. However, larger amounts are LIKELY UNSAFE and cause serious side effects. European mistletoe can cause vomiting, diarrhea, cramping, and other side effects. Short-term, frequent use of European mistletoe might cause liver damage.

Injecting European mistletoe beneath the skin or into the vein can cause fever, chills, skin rashes, pain, allergic reactions, and other side effects.

Because the correct amount is sometimes hard to determine, do not take European mistletoe without the advice of your healthcare professional.

Special Precautions & Warnings:

Pregnancy and breast-feeding: European mistletoe is LIKELY UNSAFE when taken by mouth or inject under the skin during pregnancy. It might stimulate the uterus and cause a miscarriage.

There is not enough reliable information about the safety of taking European mistletoe if you are breast-feeding. Stay on the safe side and avoid use.

"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: European mistletoe might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using European mistletoe.

Heart disease: There is some evidence European mistletoe might make heart disease worse. Don't use it if you have a heart problem.

Leukemia: Some test tube studies suggested European mistletoe might be effective against childhood leukemia. But benefits have not been shown in people. In fact, European mistletoe might make leukemia worse. If you have leukemia, don't take European mistletoe.

Liver disease: There is some concern that taking European mistletoe might harm the liver. In theory, European mistletoe might make liver diseases, such as hepatitis, worse. People with liver disease or a history of liver disease should avoid European mistletoe.

Organ transplant: European mistletoe might make the immune system more active. This would be a problem for people who have received an organ transplant. A more active immune system might increase the risk of organ rejection. If you have had an organ transplant, avoid European mistletoe.

Surgery: European mistletoe might affect blood pressure. There is a concern that it might interfere with blood pressure control during and after surgery. Stop taking European mistletoe at least 2 weeks before a scheduled surgery.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!
  • Medications for high blood pressure (Antihypertensive drugs) interacts with EUROPEAN MISTLETOE

    European mistletoe seems to decrease blood pressure. Taking European mistletoe along with medications for high blood pressure might cause your blood pressure to go too low.<br/><br/> Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others.

  • Medications that decrease the immune system (Immunosuppressants) interacts with EUROPEAN MISTLETOE

    European mistletoe seems to increase the immune system. By increasing the immune system European mistletoe might decrease the effectiveness of medications that decrease the immune system.<br/><br/> Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing

Dosing

The appropriate dose of European mistletoe depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for European mistletoe. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.

View References

REFERENCES:

  • Bauer C, Oppel T, Rueff F, Przybilla B. Anaphylaxis to viscotoxins of mistletoe (Viscum album) extracts. Ann Allergy Asthma Immunol 2005;94:86-9. View abstract.
  • Boie D and Gutsch J. [Helixor treatment in patients with liver metastases and liver cancer]. Krebsgeschehen 1979;11(5):141-144.
  • Bussing A, Regnery A, Schweizer K. Effects of Viscum album L. on cyclophosphamide-treated peripheral blood mononuclear cells in vitro: sister chromatid exchanges and activation/proliferation marker expression. Cancer Lett 1995;94:199-205.. View abstract.
  • Cazacu, M., Oniu, T., Lungoci, C., Mihailov, A., Cipak, A., Klinger, R., Weiss, T., and Zarkovic, N. The influence of isorel on the advanced colorectal cancer. Cancer Biother.Radiopharm. 2003;18(1):27-34. View abstract.
  • Chernyshov VP, Omelchenko LI, Heusser P, and et al. Immunomodulatory actions of Viscum album (Iscador) in children with recurrent respiratory disease as a result of the Chernobyl nuclear accident. Complementary Therapies in Medicine 1997;5(3):141-146.
  • Chernyshov, V. P., Heusser, P., Omelchenko, L. I., Chernyshova, L. I., Vodyanik, M. A., Vykhovanets, E. V., Galazyuk, L. V., Pochinok, T. V., Gaiday, N. V., Gumenyuk, M. E., Zelinsky, G. M., Schaefermeyer, H., and Schaefermeyer, G. Immunomodulatory and clinical effects of Viscum album (Iscador M and Iscador P) in children with recurrent respiratory infections as a result of the Chernobyl nuclear accident. Am J Ther. 2000;7(3):195-203. View abstract.
  • Deliorman D, Calis I, Ergun F. A new acyclic monoterpene glucoside from Viscum album ssp. album. Fitoterapia 2001;72:101-5.
  • Elsasser-Beile U, Leiber C, Wolf P, et al. Adjuvant intravesical treatment of superficial bladder cancer with a standardized mistletoe extract. J Urol 2005;174:76-9. View abstract.
  • Enesel, M. B., Acalovschi, I., Grosu, V., Sbarcea, A., Rusu, C., Dobre, A., Weiss, T., and Zarkovic, N. Perioperative application of the Viscum album extract Isorel in digestive tract cancer patients. Anticancer Res 2005;25(6C):4583-4590. View abstract.
  • Ernst E, Schmidt K, Steuer-Vogt MK. Mistletoe for cancer? A systematic review of randomised clinical trials. Int J Cancer 2003;107:262-7.. View abstract.
  • Evans M, Bryant S, Huntley AL, Feder G. Cancer Patients' Experiences of Using Mistletoe (Viscum album): A Qualitative Systematic Review and Synthesis. J Altern Complement Med. 2016 Feb;22(2):134-44. View abstract.
  • Finall AI, McIntosh SA, Thompson WD. Subcutaneous inflammation mimicking metastatic malignancy induced by injection of mistletoe extract. BMJ 2006;333:1293-4. View abstract.
  • Friess H, Beger HG, Kunz J, et al. Treatment of advanced pancreatic cancer with mistletoe: results of a pilot trial. Anticancer Res 1996 Mar-Apr;16:915-20. View abstract.
  • Gorter, R. W., van Wely, M., Reif, M., and Stoss, M. Tolerability of an extract of European mistletoe among immunocompromised and healthy individuals. Altern.Ther.Health Med 1999;5(6):37-38. View abstract.
  • Grossarth-Maticek R, Ziegler R. Prospective controlled cohort studies on long-term therapy of ovairian cancer patients with mistletoe (Viscum album L.) extracts iscador. Arzneimittelforschung. 2007;57(10):665-78. View abstract.
  • Grossarth-Maticek, R. and Ziegler, R. Randomized and non-randomized prospective controlled cohort studies in matched pair design for the long-term therapy of corpus uteri cancer patients with a mistletoe preparation (Iscador). Eur.J Med Res 3-31-2008;13(3):107-120. View abstract.
  • Grossarth-Matichek R, Kiene H, Baumgartner SM, Ziegler R. Use of Iscador, an extract of European mistletoe (Viscum album), in cancer treatment: prospective nonrandomized and randomized matched-pair studies nested within a cohort study. Altern Ther Health Med 2001;7:57-66, 68-72, 74-6 passim. View abstract.
  • Gutsch J. [On the state of therapy of chronic myeloid leukemia in adults with the mistletoe preparation Helixor]. Ärztezeitschrift für Naturheilverfahren Physikalische Medizin Und Rehabilitation 1982;23(9):523-544.
  • Harvey J, Colin-Jones DG. Mistletoe hepatitis. Br Med J (Clin Res Ed) 1981;282:186-7. View abstract.
  • Heinzerling L, von Baehr V, Liebenthal C, et al. Immunologic effector mechanisms of a standardized mistletoe extract on the function of human monocytes and lymphocytes in vitro, ex vivo, and in vivo. J Clin Immunol 2006;26:347-59. View abstract.
  • Hoffmann J. [Iscador treatment of patients with liver metastasis]. Krebsgeschehen 1979;6:172-175.
  • Huber R, Barth H, Schmitt-Graff A, Klein R. Hypereosinophilia induced by high-dose intratumoral and peritumoral mistletoe application to a patient with pancreatic carcinoma. J Altern Complement Med 2000;6:305-10. View abstract.
  • Huber R, Klein R, Lüdtke R, Werner M. [Frequency of the common cold in healthy subjects during exposure to a lectin-rich and a lectin-poor mistletoe preparation in a randomized, double-blind, placebo-controlled study]. Forsch Komplementarmed Klass Naturheilkd. 2001 Dec;8(6):354-8. View abstract.
  • Huber, R., Ludtke, R., Klassen, M., Muller-Buscher, G., Wolff-Vorbeck, G., and Scheer, R. Effects of a mistletoe preparation with defined lectin content on chronic hepatitis C: an individually controlled cohort study. Eur.J Med Res 9-28-2001;6(9):399-405. View abstract.
  • Jung ML, Baudino S, Ribereau-Gayon G, et al. Characterization of cytotoxic proteins from mistletoe (Viscum album L.). Cancer Lett 1990;51:103-8.. View abstract.
  • Kaegi E. Unconventional therapies for cancer: 3. Iscador. Task Force on Alternative Therapies of the Canadian Breast Cancer Research Initiative. CMAJ 1998;158:1157-9. View abstract.
  • Kienle GS, Grugel R, Kiene H. Safety of higher dosages of Viscum album L. in animals and humans--systematic review of immune changes and safety parameters. BMC Complement Altern Med. 2011 Aug 28;11:72. View abstract.
  • Kim HJ, Kim H, Ahn JH, Suk JH. Liver injury induced by herbal extracts containing mistletoe and kudzu. J Altern Complement Med 2015;21(3):180-5. View abstract.
  • Kim KC, Yook JH, Eisenbraun J, Kim BS, Huber R. Quality of life, immunomodulation and safety of adjuvant mistletoe treatment in patients with gastric carcinoma - a randomized, controlled pilot study. BMC Complement Altern Med. 2012 Oct 3;12:172. View abstract.
  • Kim M, Park Y, Lee S, and et al. [Comparative study on the effects of a Viscum album (L.) extract (mistletoe) and doxycycline for pleurodesis in patients with malignant pleural effusion]. Korean Journal of Medicine 1999;57(suppl 2):s121.
  • Kleeberg, U. R., Suciu, S., Brocker, E. B., Ruiter, D. J., Chartier, C., Lienard, D., Marsden, J., Schadendorf, D., and Eggermont, A. M. Final results of the EORTC 18871/DKG 80-1 randomised phase III trial. rIFN-alpha2b versus rIFN-gamma versus ISCADOR M versus observation after surgery in melanoma patients with either high-risk primary (thickness >3 mm) or regional lymph node metastasis. Eur.J Cancer 2004;40(3):390-402. View abstract.
  • Kuttan G, Kuttan R. Immunological mechanism of action of the tumor reducing peptide from mistletoe extract (NSC 635089) cellular proliferation. Cancer Lett 1992;66:123-30.. View abstract.
  • Kuttan G, Vasudevan DM, Kuttan R. Isolation and identification of a tumour reducing component from mistletoe extract (Iscador). Cancer Lett 1988;41:307-14.. View abstract.
  • Kuttan G, Vasudevan DM, Kuttan R. Presence of a receptor for the active component of Iscador in ascites fluid of tumour bearing mice. Cancer Lett 1989;48:223-7.. View abstract.
  • Natl Cancer Inst. Mistletoe (PDQ). CancerNet. www.cancernet.nci.nih.gov/cam/mistletoe.htm#7 (Accessed 30 March 2001).
  • Nazaruk J, Orlikowski P. Phytochemical profile and therapeutic potential of Viscum album L. Nat Prod Res. 2016;30(4):373-85. View abstract.
  • Olsnes S, Stirpe F, Sandvig K, Pihl A. Isolation and characterization of viscumin, a toxic lectin from Viscum album L. (mistletoe). J Biol Chem 1982;257:13263-70.. View abstract.
  • Piao, B. K., Wang, Y. X., Xie, G. R., Mansmann, U., Matthes, H., Beuth, J., and Lin, H. S. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer Res 2004;24(1):303-309. View abstract.
  • Salzer G. [Practice of mistletoe therapy in surgical diseases]. Der Kassenarzt 1985;25(9):42, 45, 48.
  • Salzer, G. and Havelec, L. [Prevention of recurrence of bronchial carcinomas after surgery by means of the mistletoe extract Iscador. Results of a clinical study from 1969-1971]. Onkologie. 1978;1(6):264-267. View abstract.
  • Schad F, Atxner J, Buchwald D, Happe A, Popp S, Kröz M, Matthes H. Intratumoral Mistletoe (Viscum album L) Therapy in Patients With Unresectable Pancreas Carcinoma: A Retrospective Analysis. Integr Cancer Ther. 2014 Jul;13(4):332-40. View abstract.
  • Schaefermeyer G, Schaefermeyer H. Treatment of pancreatic cancer with Viscum album (Iscador): a retrospective study of 292 patients 1986-1996. Complement Ther Med 1998;6:172-7.
  • Schoffski P, Breidenbach I, Krauter J, et al. Weekly 24 h infusion of aviscumine (rViscumin): A phase I study in patients with solid tumours. Eur J Cancer 2005;41:1431-8. View abstract.
  • Semiglazov, V. F., Stepula, V. V., Dudov, A., Schnitker, J., and Mengs, U. Quality of life is improved in breast cancer patients by Standardised Mistletoe Extract PS76A2 during chemotherapy and follow-up: a randomised, placebo-controlled, double-blind, multicentre clinical trial. Anticancer Res 2006;26(2B):1519-1529. View abstract.
  • Steele ML, Axtner J, Happe A, Kröz M, Matthes H, Schad F. Adverse Drug Reactions and Expected Effects to Therapy with Subcutaneous Mistletoe Extracts (Viscum album L.) in Cancer Patients. Evid Based Complement Alternat Med. 2014;2014:724258. View abstract.
  • Steele ML, Axtner J, Happe A, Kröz M, Matthes H, Schad F. Safety of Intravenous Application of Mistletoe (Viscum album L.) Preparations in Oncology: An Observational Study. Evid Based Complement Alternat Med. 2014;2014:236310. View abstract.
  • Steuer-Vogt MK, Bonkowsky V, Ambrosch P, et al. The effect of an adjuvant mistletoe treatment programme in resected head and neck cancer patients: a randomised controlled clinical trial. Eur J Cancer 2001;37:23-31.. View abstract.
  • Stirpe F, Sandvig K, Olsnes S, et al. Action of viscumin, a toxic lectin from mistletoe, on cells in culture. J Biol Chem 1982;257:13271-7.. View abstract.
  • Styczynski J, Wysocki M. Alternative medicine remedies might stimulate viability of leukemic cells. Pediatr Blood Cancer 2006;46:94-8. View abstract.
  • Timoshenko AV, Cherenkevich SN, Gabius HJ. Viscum album agglutinin-induced aggregation of blood cells and the lectin effects on neutrophil function. Biomed Pharmacother 1995;49:153-8.. View abstract.
  • Tröger W, Galun D, Reif M, Schumann A, Stankovic N, Milicevic M. Viscum album [L.] extract therapy in patients with locally advanced or metastatic pancreatic cancer: a randomised clinical trial on overall survival. Eur J Cancer. 2013 Dec;49(18):3788-97. View abstract.
  • Tusenius KJ, Spoek JM, Kramers CW. Iscador Qu for chronic hepatitis C: an exploratory study. Complement Ther Med 2001;9:12-6.. View abstract.
  • van Wely, M., Stoss, M., and Gorter, R. W. Toxicity of a standardized mistletoe extract in immunocompromised and healthy individuals. Am.J.Ther. 1999;6(1):37-43. View abstract.
  • von Schoen-Angerer T, Wilkens J, Kienle GS, Kiene H, Vagedes J. High-Dose Viscum album Extract Treatment in the Prevention of Recurrent Bladder Cancer: A Retrospective Case Series. Perm J. 2015 Fall;19(4):76-83. View abstract.

More Resources for EUROPEAN MISTLETOE

CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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