American Yam, Atlantic Yam, Barbasco, China Root, Chinese Yam, Colic Root, Devil's Bones, DHEA Naturelle, Dioscorea, Dioscoreae, Dioscorea alata, Dioscorea batatas, Dioscorea composita, Dioscorea floribunda, Dioscorea hirticaulis, Dioscorea japonica, Dioscorea macrostachya, Dioscorea mexicana, Dioscorea opposita, Dioscorea tepinapensis, Dioscorea villosa, Dioscorée, Igname Sauvage, Igname Velue, Mexican Yam, Mexican Wild Yam, Ñame Silvestre, Natural DHEA, Phytoestrogen, Phyto-œstrogène, Rheumatism Root, Rhizoma Dioscorae, Rhizoma Dioscoreae, Shan Yao, Wild Mexican Yam, Yam, Yuma.<br/><br/>
Overview InformationWild yam is a plant. It contains a chemical called diosgenin. This chemical can be made in the laboratory into various steroids, such as estrogen and dehydroepiandrosterone (DHEA). The root and the bulb of the plant are used as a source of diosgenin, which is prepared as an “extract,” a liquid that contains concentrated diosgenin.
There are over 600 species of wild yam. Some species are grown specifically as a source of diosgenin for laboratories to use in making steroids. These species are generally not eaten due to a bitter flavor. Only about 12 of the 600 species are considered edible.
Diosgenin or wild yam is often promoted as a “natural alterative” to estrogen therapy, so you will see it used for estrogen replacement therapy, vaginal dryness in older women, PMS (premenstrual syndrome), menstrual cramps, weak bones (osteoporosis), increasing energy and sexual drive in men and women, and breast enlargement. Wild yam does seem to have some estrogen-like activity, but it is not actually converted into estrogen in the body. It takes a laboratory to do that.
Similarly, you will also see wild yam and diosgenin promoted as a “natural DHEA.” This is because in the laboratory DHEA is made from diosgenin, but this chemical reaction is not believed to occur in the human body. So taking wild yam extract will not increase DHEA levels in people. Individuals who are interested in taking DHEA should avoid wild yam products labeled as "natural DHEA."
Wild yam is also used for treating a disorder of the intestines called diverticulosis, gallbladder pain, rheumatoid arthritis, and for increasing energy.
Some women apply wild yam creams to the skin to reduce menopausal symptoms such as hot flashes.
How does it work?Wild yam contains a chemical that can be made into various steroids, such as estrogen, in the laboratory. However, the body can't change wild yam to estrogen.
Uses & Effectiveness
Possibly Ineffective for
- Menopausal symptoms. Applying wild yam cream to the skin for 3 months does not seem to relieve menopausal symptoms such as hot flashes and night sweats. It also does not seem to affect levels of hormones that play a role in menopause.
Insufficient Evidence for
- Use as a natural alternative to estrogens.
- Postmenopausal vaginal dryness.
- PMS (Premenstrual syndrome).
- Weak bones (osteoporosis).
- Increasing energy and sexual desire in men and women.
- Gallbladder problems.
- Painful menstrual periods.
- Rheumatoid arthritis.
- Menstrual disorders.
- Other conditions.
Side Effects & SafetyWild yam is POSSIBLY SAFE when taken by mouth or applied to the skin. Large amounts can cause vomiting.
Special Precautions & Warnings:Pregnancy and breast-feeding: There is not enough reliable information about the safety of taking wild yam if you are pregnant or breast feeding. Stay on the safe side and avoid use.
Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Wild yam might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, do not use wild yam.
Protein S deficiency: People with protein S deficiency have an increased risk of forming clots. There is some concern that wild yam might increase the risk of clot formation in these people because it might act like estrogen. There is one case report of a patient with protein S deficiency and systemic lupus erythematosus (SLE) who developed a clot in the vein serving the retina in her eye 3 days after taking a combination product containing wild yam, dong quai, red clover, and black cohosh. If you have protein S deficiency, it is best to avoid using wild yam until more is known.
We currently have no information for WILD YAM Interactions.
The appropriate dose of wild yam depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for wild yam. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
- Araghiniknam M, Chung S, Nelson-White T, and et al. Antioxidant activity of Dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996;59:L147-L157.
- Cayen, M. N. and Dvornik, D. Effect of diosgenin on lipid metabolism in rats. J Lipid Res 1979;20(2):162-174. View abstract.
- Cayen, M. N., Ferdinandi, E. S., Greselin, E., and Dvornik, D. Studies on the disposition of diosgenin in rats, dogs, monkeys and man. Atherosclerosis 1979;33(1):71-87. View abstract.
- Hudson t, Standish L, Breed C, and et al. Clinical and endocrinological effects of a menopausal botanical formula. Journal of Naturopathic Medicine 1997;7:73-77.
- Juarez-Oropeza, M. A., Diaz-Zagoya, J. C., and Rabinowitz, J. L. In vivo and in vitro studies of hypocholesterolemic effects of diosgenin in rats. Int J Biochem 1987;19(8):679-683. View abstract.
- Malinow, M. R., Elliott, W. H., McLaughlin, P., and Upson, B. Effects of synthetic glycosides on steroid balance in Macaca fascicularis. J Lipid Res 1987;28(1):1-9. View abstract.
- Nervi, F., Bronfman, M., Allalon, W., Depiereux, E., and Del Pozo, R. Regulation of biliary cholesterol secretion in the rat. Role of hepatic cholesterol esterification. J Clin Invest 1984;74(6):2226-2237. View abstract.
- Nervi, F., Marinovic, I., Rigotti, A., and Ulloa, N. Regulation of biliary cholesterol secretion. Functional relationship between the canalicular and sinusoidal cholesterol secretory pathways in the rat. J Clin Invest 1988;82(6):1818-1825. View abstract.
- Odumosu, A. How vitamin C, clofibrate and diosgenin control cholesterol metabolism in male guinea-pigs. Int J Vitam.Nutr Res Suppl 1982;23:187-195. View abstract.
- Rosenberg Zand, R. S., Jenkins, D. J., and Diamandis, E. P. Effects of natural products and nutraceuticals on steroid hormone-regulated gene expression. Clin Chim.Acta 2001;312(1-2):213-219. View abstract.
- Uchida, K., Takase, H., Nomura, Y., Takeda, K., Takeuchi, N., and Ishikawa, Y. Changes in biliary and fecal bile acids in mice after treatments with diosgenin and beta-sitosterol. J Lipid Res 1984;25(3):236-245. View abstract.
- Ulloa, N. and Nervi, F. Mechanism and kinetic characteristics of the uncoupling by plant steroids of biliary cholesterol from bile salt output. Biochim.Biophys.Acta 11-14-1985;837(2):181-189. View abstract.
- Zagoya JCD, Laguna J, and Guzman-Garcia J. Studies on the regulation of cholesterol metabolism by the use of structural analogue, diosgenin. Biochemical Pharmacology 1971;20:3471-3480.
- Zakharov, V. N. [Hypolipemic effect of diosponine in ischemic heart disease depending on the type of hyperlipoproteinemia]. Kardiologiia. 1977;17(6):136-137. View abstract.
- Accatino L, Pizarro M, Solis N, Koenig CS. Effects of diosgenin, a plant-derived steroid, on bile secretion and hepatocellular cholestasis induced by estrogens in the rat. Hepatology 1998;28:129-40. View abstract.
- Aradhana AR, Rao AS, Kale RK. Diosgenin-a growth stimulator of mammary gland of ovariectomized mouse. Indian J Exp Biol 1992;30:367-70. View abstract.
- Aumsuwan P, Khan SI, Khan IA, et al. Evaluation of wild yam (Dioscorea villosa) root extract as a potential epigenetic agent in breast cancer cells. In Vitro Cell Dev Biol Anim 2015;51(1):59-71. View abstract.
- Cheong JL, Bucknall R. Retinal vein thrombosis associated with a herbal phytoestrogen preparation in a susceptible patient. Postgrad Med J 2005;81:266-7.. View abstract.
- Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.
- Foster S, Tyler VE. Tyler's Honest Herbal, 4th ed., Binghamton, NY: Haworth Herbal Press, 1999.
- Komesaroff PA, Black CV, Cable V, et al. Effects of wild yam extract on menopausal symptoms, lipids and sex hormones in healthy menopausal women. Climacteric 2001;4:144-50.. View abstract.
- Pengelly A, Bennett K. Appalachian plant monographs: Dioscorea villosa L., Wild Yam. Available at: http://www.frostburg.edu/fsu/assets/File/ACES/Dioscorea%20villosa%20-%20FINAL(4).pdf
- Skolnick AA. Scientific verdict still out on DHEA. JAMA 1996;276:1365-7. View abstract.
- Wu WH, Liu LY, Chung CJ, et al. Estrogenic effect of yam ingestion in healthy postmenopausal women. J Am Coll Nutr 2005;24:235-43. View abstract.
- Yamada T, Hoshino M, Hayakawa T, et al. Dietary diosgenin attenuates subacute intestinal inflammation associated with indomethacin in rats. Am J Physiol 1997;273:G355-64. View abstract.
- Zava DT, Dollbaum CM, Blen M. Estrogen and progestin bioactivity of foods, herbs, and spices. Proc Soc Exp Biol Med 1998;217:369-78. View abstract.