BEE VENOM

OTHER NAME(S):

Apis mellifera, Apis Venenum Purum, Apitoxin, Apitoxine, Bald-faced Hornet, Bee Sting Venom, Bombus terrestis, Bumblebee Venom, Frelon à Face Blanche, Frelon Jaune, Guêpe à Taches Blanches, Honeybee Venom, Mixed Vespids, Pure Bee Venom, Veneno de Abeja, Venin d'Abeille, Venin d'Abeille Mellif&egrave;re, Venin d'Abeille Pure, Venin de Bourdon, Venin de Guêpe, Vespula maculata, Wasp Venom, White-Faced Hornet, Yellow Hornet, Yellow-Jacket Venom.<br/><br/>

Overview

Overview Information

Bee venom is made by bees. This is the poison that makes bee stings painful. Bee venom is used to make medicine. Don't confuse bee venom with bee pollen, honey, or royal jelly. Other venoms are derived from related members of the insect order Hymenoptera.

Bee venom is given as a shot for rheumatoid arthritis, nerve pain (neuralgia), multiple sclerosis (MS), reducing the reaction to bee stings in people who are allergic (desensitization) to them (venom immunotherapy), swollen tendons (tendonitis), and muscle conditions such as fibromyositis and enthesitis.

How does it work?

Giving repeated and controlled injections of bee venom under the skin causes the immune system to get used to bee venom, and helps reduce the severity of an allergy to bee venom.

Uses

Uses & Effectiveness?

Likely Effective for

  • Reducing the severity of allergic reactions to bee stings. A series of bee venom shots under the skin (bee venom immunotherapy) seems to be effective for reducing reactions to bee stings in people with severe allergy to bee stings. Bee venom immunotherapy provides 98% to 99% protection from reactions to bee stings. Once immunotherapy is stopped, the risk of reaction over the next 5 to 10 years is about 5% to 15%. Purified bee venom for under-the-skin injection is an FDA approved product.

Possibly Ineffective for

  • Multiple sclerosis (MS). Administering live bee stings in gradually increasing doses up to 20 stings given three times weekly does not seem to improve multiples sclerosis. Treatment for 24 weeks does not seem to improve fatigue, disability, or quality of life.
  • Osteoarthritis. People used to think that bee venom might be a useful treatment for arthritis. This theory was largely due to supposed swelling-reducing (anti-inflammatory) effects of bee venom and the observation that many beekeepers don't develop arthritis. However, research results have not supported this.

Insufficient Evidence for

  • Frozen shoulder. Early research suggests that receiving dilute bee venom injections might improve pain and disability in people with frozen shoulder. But it doesn't seem to improve range of motion. Also, very dilute bee venom injects don't seem to be beneficial.
  • Parkinson's disease. Early research shows that dilute bee venom injections may improve symptoms in people with Parkinson's disease. But if the dose of bee venom is too low, it might not help.
  • Stroke. Bee venom acupuncture seems to improve pain but not movement in people with shoulder pain after stroke.
  • Nerve pain.
  • Painful, swollen tendons (tendonitis).
  • Muscle swelling (inflammation).
More evidence is needed to rate the effectiveness of bee venom for these uses.

Side Effects

Side Effects & Safety

Bee venom is safe for most people when injected under the skin by a trained medical professional. Some people might get redness and swelling where the injection is given. Side effects include itching, anxiety, trouble breathing, chest tightness, heart palpitations, dizziness, nausea, vomiting, diarrhea, sleepiness, confusion, fainting, and low blood pressure.

Side effects are more common in people with the worst allergies to bee stings, in people treated with honeybee venom, and in women. Serious allergic reactions such as anaphylaxis can occur.

Live bee stings have been safely administered under medical supervision in doses up to 20 bee stings three times weekly for up to 24 weeks.

Special Precautions & Warnings:

Pregnancy and breast-feeding: Bee venom seems to be safe when injected under the skin by a trained medical professional at recommended doses. Though harmful effects at usual doses have not been reported, some healthcare providers decrease the maintenance dose by half during pregnancy. High doses of bee venom are UNSAFE during pregnancy because they can increase release of a chemical called histamine, which can cause the uterus to contract. This might lead to miscarriage. Avoid high doses of bee venom if you are pregnant.

"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Bee venom might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using bee venom.

Interactions

Interactions?

Moderate Interaction

Be cautious with this combination

!

  • Medications that decrease the immune system (Immunosuppressants) interacts with BEE VENOM

    Bee venom might increase the immune system. By increasing the immune system, bee venom might decrease the effectiveness of medications that decrease the immune system.<br /> Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.

Dosing

Dosing

The following doses have been studied in scientific research:

INTRAMUSCULAR:

  • For reducing the severity of allergic reactions to bee stings: Healthcare providers give bee venom as a shot (by injection) to "desensitize" people who are allergic to bee stings. Purified bee venom for under-the-skin injection is an FDA approved product.

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View References

REFERENCES:

  • Abdulsalam MA, Ebrahim BE, Abdulsalam AJ. Immune thrombocytopenia after bee venom therapy: a case report. BMC Complement Altern Med. 2016;16:107. View abstract.
  • Birnbaum J, Charpin D, Vervloet D. Rapid hymenoptera venom immunotherapy: comparative safety of three protocols. Clin Exp Allergy 1993;23:226-30. View abstract.
  • Bomalaski JS, Ford T, Hudson AP, Clark MA. Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes. J Immunol 1995;154:4027-31. View abstract.
  • Bousquet J, Muller UR, Dreboro S, et al. Immunotherapy with hymenoptera venoms. Allergy 1987;42:401-13. View abstract.
  • Caldwell JR. Venoms, copper, and zinc in the treatment of arthritis. Rheum Dis Clin North Am 1999;25:919-28. View abstract.
  • Cho SY, Shim SR, Rhee HY, et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord. 2012;18(8):948-52. View abstract.
  • Cuende E, Fraguas J, Pena JE, et al. Beekeepers' arthropathy. J Rheumatol 1999;26:2684-90. View abstract.
  • de Jong NW, Vermeulen AM, de Groot H. Allergy to bumblebee venom. III. Immunotherapy follow-up study (safety and efficacy) in patients with occupational bumblebee-venom anaphylaxis. Allergy 1999;54:980-4. View abstract.
  • Doo KH, Lee JH, Cho SY, et al. A Prospective Open-Label Study of Combined Treatment for Idiopathic Parkinson's Disease Using Acupuncture and Bee Venom Acupuncture as an Adjunctive Treatment. J Altern Complement Med. 2015;21(10):598-603. View abstract.
  • Ewan PW. ABC of allergies. Venom allergy. BMJ 1998;316:1365-8. View abstract.
  • Gennari C, Agnusdei D, Crepaldi G, et al. Effect of ipriflavone-a synthetic derivative of natural isoflavones-on bone mass loss in the early years after menopause. Menopause 1998;5:9-15. View abstract.
  • Golden DB, Kagey-Sobotka A, Lichtenstein LM. Survey of patients after discontinuing venom immunotherapy. J Allergy Clin Immunol 2000;105(2 Pt 1):385-90. View abstract.
  • Hartmann A, Müllner J, Meier N, et al. Bee Venom for the Treatment of Parkinson Disease - A Randomized Controlled Clinical Trial. PLoS One. 2016;11(7):e0158235. View abstract.
  • Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
  • Hider RC. Honeybee venom: A rich source of pharmacologically active peptides. Endeavour 1988;12:60-5.. View abstract.
  • Hollister-Stier Laboratories LLC. Instructions and dosing schedule for allergenic extracts hymenoptera venom prodcts. No. 355120-HD1.
  • Koh PS, Seo BK, Cho NS, Park HS, Park DS, Baek YH. Clinical effectiveness of bee venom acupuncture and physiotherapy in the treatment of adhesive capsulitis: a randomized controlled trial. J Shoulder Elbow Surg. 2013;22(8):1053-62. View abstract.
  • Lee HJ, Park IS, Lee JI, Kim JS. Guillain-Barré syndrome following bee venom acupuncture. Intern Med. 2015;54(8):975-8. View abstract.
  • Li JT, Yunginger JW. Management of insect sting hypersensitivity. Mayo Clin Proc 1992;67:188-94. View abstract.
  • Lim SM, Lee SH. Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review and meta-analysis. J Integr Med. 2015;13(4):241-7. View abstract.
  • Mosbech H, Muller U. Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. Allergy 2000;55:1005-10. View abstract.
  • Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLoS One. 2015;10(5):e0126971. View abstract.
  • Petroianu G, Liu J, Helfrich U, et al. Phosholipase A2-induced coagulation abnormalities after bee sting. Am J Emerg Med 2000;18:22-7. View abstract.
  • Somerfield SD. Bee venom and arthritis: magic, myth, or medicine? N Z Med J 1986;99:281-3.. View abstract.
  • Subbalakshmi C, Nagaraj R, Sitaram N. Biological activities of C-terminal 15-residue synthetic fragment of melittin: design of an analog with improved antibacterial activity. FEBS Lett 1999;448:62-6. View abstract.
  • Vick JA, Mehlman B, Brooks R, et al. Effect of bee venom and melittin on plasma cortisol in the unanesthetized monkey. Toxicon 1972;10:581-6.
  • Vick JA, Shipman WH. Effects of whole bee venom and its fractions (apamin and melittin) of plasma cortisol levels in the dog. Toxicon 1972;10:377-80.
  • Wesselius T, Heersema DJ, Mostert JP, et al. A randomized crossover study of bee sting therapy for multiple sclerosis. Neurology 2005;65:1764-8. View abstract.

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CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

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© Therapeutic Research Faculty 2018.