Overview
Bee venom is given as a shot for bee sting allergy. It is also used for osteoarthritis, Parkinson disease, multiple sclerosis (MS), nerve pain, and other conditions, but there is no good scientific evidence to support these uses.
How does it work ?
Uses & Effectiveness ?
Likely Effective for
- Bee sting allergy. A series of bee venom shots under the skin (bee venom immunotherapy) seems to be effective for reducing reactions to bee stings in people with severe allergy to bee stings. Bee venom immunotherapy provides 98% to 99% protection from reactions to bee stings. Once immunotherapy is stopped, the risk of reaction over the next 5 to 10 years is about 5% to 15%. Purified bee venom for under-the-skin injection is an FDA approved product.
Possibly Ineffective for
- Multiple sclerosis (MS). Administering live bee stings in gradually increasing doses up to 20 stings given three times weekly does not seem to improve multiples sclerosis. Treatment for 24 weeks does not seem to improve fatigue, disability, or quality of life.
Insufficient Evidence for
- Stiffness and pain in the shoulderjoint (frozen shoulder). Early research suggests that receiving dilute bee venom injections might improve pain and disability in people with frozen shoulder. But it doesn't seem to improve range of motion. Also, very dilute bee venom injects don't seem to be beneficial.
- Osteoarthritis. Early research on the use of bee venom for osteoarthritis is mixed. But one large study shows that injecting bee venom into the skin at certain points in the knees and back might improve pain and function in people with osteoarthritis of the knee.
- Parkinson disease. Early research shows that dilute bee venom injections may improve symptoms in people with Parkinson disease. But if the dose of bee venom is too low, it might not help.
- Stroke. Bee venom acupuncture seems to improve pain but not movement in people with shoulder pain after stroke.
- A condition that causes nerve pain, itching, and dark patches of skin on the upper back (notalgia paresthetica).
- Fibromyalgia.
- Nerve pain.
- Painful conditions caused by overuse of tendons (tendinopathy).
- Rheumatoid arthritis (RA).
- Other conditions.
Side Effects
Bee venom is POSSIBLY SAFE when given by live bee stings. Live bee stings have been safely administered under medical supervision in doses up to 20 bee stings three times weekly for up to 24 weeks.
When applied to the skin: There isn't enough reliable information to know if bee venom is safe or what the side effects might be.
Special Precautions and Warnings
Bee venom is POSSIBLY SAFE when given by live bee stings. Live bee stings have been safely administered under medical supervision in doses up to 20 bee stings three times weekly for up to 24 weeks.
When applied to the skin: There isn't enough reliable information to know if bee venom is safe or what the side effects might be. Pregnancy and breast-feeding: Bee venom is POSSIBLY SAFE when injected under the skin by a trained medical professional at recommended doses. Though harmful effects at usual doses have not been reported, some healthcare providers decrease the maintenance dose by half during pregnancy. High doses of bee venom are POSSIBLY UNSAFE during pregnancy because they can increase release of a chemical called histamine, which can cause the uterus to contract. This might lead to miscarriage. Avoid high doses of bee venom if you are pregnant.
"Auto-immune diseases" such as multiple sclerosis (MS), lupus (systemic lupus erythematosus, SLE), rheumatoid arthritis (RA), or other conditions: Bee venom might cause the immune system to become more active, and this could increase the symptoms of auto-immune diseases. If you have one of these conditions, it's best to avoid using bee venom.
Interactions ?
Medications that decrease the immune system (Immunosuppressants) interacts with BEE VENOM
Bee venom might increase the immune system. By increasing the immune system, bee venom might decrease the effectiveness of medications that decrease the immune system.
Some medications that decrease the immune system include azathioprine (Imuran), basiliximab (Simulect), cyclosporine (Neoral, Sandimmune), daclizumab (Zenapax), muromonab-CD3 (OKT3, Orthoclone OKT3), mycophenolate (CellCept), tacrolimus (FK506, Prograf), sirolimus (Rapamune), prednisone (Deltasone, Orasone), corticosteroids (glucocorticoids), and others.
Moderate Interaction
Be cautious with this combination
Dosing
INTRAMUSCULAR:
- For reducing the severity of allergic reactions to bee stings: Healthcare providers give bee venom as a shot (by injection) to "desensitize" people who are allergic to bee stings. Purified bee venom for under-the-skin injection is an FDA approved product.
Webber, R. Benign prostatic hyperplasia. Clin Evid. 2005;(14):1076-1091. View abstract.
Weisser, H., Tunn, S., Behnke, B., and Krieg, M. Effects of the sabal serrulata extract IDS 89 and its subfractions on 5 alpha-reductase activity in human benign prostatic hyperplasia. Prostate 1996;28(5):300-306. View abstract.
Yeu, E. and Grostern, R. Saw palmetto and intraoperative floppy-iris syndrome. J Cataract Refract.Surg 2007;33(5):927-928. View abstract.
Ziegler H and Holscher U. Efficacy of saw palmetto fruit special extract WS1473 in patients with Alken stage I-II benign prostatic hyperplasia--open multicentre study. Jatros Uro 1998;14(3):34-43.
Adriazola-Semino M, Lozano-Ortega JL, Garcia-Cobo E, et al. [Symptomatic treatment of benign hypertrophy of the prostate. Comparative study of prazosin and serenoa repens]. Arch Esp Urol 1992; 45:211-3. View abstract.
Alcaraz A, Rodríguez-Antolín A, Carballido-Rodríguez J, et al. Efficacy and tolerability of the hexanic extract of Serenoa repens compared to tamsulosin in moderate-severe LUTS-BPH patients. Sci Rep 2021;11(1):19401. View abstract.
Alcaraz A, Rodríguez-Antolín A, Carballido-Rodríguez J, et al. The Qualiprost Study Group. Clinical benefit of tamsulosin and the hexanic extract of Serenoa repens, in combination or as monotherapy, in patients with moderate/severe LUTS-BPH: a subset analysis of the QUALIPROST study. J Clin Med 2020;9(9):E2909. View abstract.
Argirovic A, Argirovic D. Does the addition of Serenoa repens to tamsulosin improve its therapeutical efficacy in benign prostatic hyperplasia? Vojnosanit Pregl 2013;70(12):1091-6. View abstract.
Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. View abstract.
Abdulsalam MA, Ebrahim BE, Abdulsalam AJ. Immune thrombocytopenia after bee venom therapy: a case report. BMC Complement Altern Med. 2016;16:107. View abstract.
Birnbaum J, Charpin D, Vervloet D. Rapid hymenoptera venom immunotherapy: comparative safety of three protocols. Clin Exp Allergy 1993;23:226-30. View abstract.
Bomalaski JS, Ford T, Hudson AP, Clark MA. Phospholipase A2-activating protein induces the synthesis of IL-1 and TNF in human monocytes. J Immunol 1995;154:4027-31. View abstract.
Bousquet J, Muller UR, Dreboro S, et al. Immunotherapy with hymenoptera venoms. Allergy 1987;42:401-13. View abstract.
Caldwell JR. Venoms, copper, and zinc in the treatment of arthritis. Rheum Dis Clin North Am 1999;25:919-28. View abstract.
Cho SY, Lee YE, Doo KH, et al. Efficacy of combined treatment with acupuncture and bee venom acupuncture as an adjunctive treatment for Parkinson's disease. J Altern Complement Med 2018;24(1):25-32. View abstract.
Cho SY, Shim SR, Rhee HY, et al. Effectiveness of acupuncture and bee venom acupuncture in idiopathic Parkinson's disease. Parkinsonism Relat Disord. 2012;18(8):948-52. View abstract.
Conrad VJ, Hazan LL, Latorre AJ, Jakubowska A, Kim CMH. Efficacy and safety of honey bee venom (Apis mellifera) dermal injections to treat osteoarthritis knee pain and physical disability: a randomized controlled trial. J Altern Complement Med 2019;25(8):845-55. View abstract.
Cuende E, Fraguas J, Pena JE, et al. Beekeepers' arthropathy. J Rheumatol 1999;26:2684-90. View abstract.
de Jong NW, Vermeulen AM, de Groot H. Allergy to bumblebee venom. III. Immunotherapy follow-up study (safety and efficacy) in patients with occupational bumblebee-venom anaphylaxis. Allergy 1999;54:980-4. View abstract.
Doo KH, Lee JH, Cho SY, et al. A Prospective Open-Label Study of Combined Treatment for Idiopathic Parkinson's Disease Using Acupuncture and Bee Venom Acupuncture as an Adjunctive Treatment. J Altern Complement Med. 2015;21(10):598-603. View abstract.
Ewan PW. ABC of allergies. Venom allergy. BMJ 1998;316:1365-8. View abstract.
Gennari C, Agnusdei D, Crepaldi G, et al. Effect of ipriflavone-a synthetic derivative of natural isoflavones-on bone mass loss in the early years after menopause. Menopause 1998;5:9-15. View abstract.
Golden DB, Kagey-Sobotka A, Lichtenstein LM. Survey of patients after discontinuing venom immunotherapy. J Allergy Clin Immunol 2000;105(2 Pt 1):385-90. View abstract.
Hartmann A, Müllner J, Meier N, et al. Bee Venom for the Treatment of Parkinson Disease - A Randomized Controlled Clinical Trial. PLoS One. 2016;11(7):e0158235. View abstract.
Hebel SK, ed. Drug Facts and Comparisons. 52nd ed. St. Louis: Facts and Comparisons, 1998.
Hider RC. Honeybee venom: A rich source of pharmacologically active peptides. Endeavour 1988;12:60-5.. View abstract.
Hollister-Stier Laboratories LLC. Instructions and dosing schedule for allergenic extracts hymenoptera venom prodcts. No. 355120-HD1.
Koh PS, Seo BK, Cho NS, Park HS, Park DS, Baek YH. Clinical effectiveness of bee venom acupuncture and physiotherapy in the treatment of adhesive capsulitis: a randomized controlled trial. J Shoulder Elbow Surg. 2013;22(8):1053-62. View abstract.
Lee EJ, Ahn YC, Kim YI, Oh MS, Park YC, Son CG. Incidence rate of hypersensitivity reactions to bee-venom acupuncture. Front Pharmacol 2020;11:545555. View abstract.
Lee HJ, Park IS, Lee JI, Kim JS. Guillain-Barré syndrome following bee venom acupuncture. Intern Med. 2015;54(8):975-8. View abstract.
Li JT, Yunginger JW. Management of insect sting hypersensitivity. Mayo Clin Proc 1992;67:188-94. View abstract.
Lim SM, Lee SH. Effectiveness of bee venom acupuncture in alleviating post-stroke shoulder pain: a systematic review and meta-analysis. J Integr Med. 2015;13(4):241-7. View abstract.
Mosbech H, Muller U. Side-effects of insect venom immunotherapy: results from an EAACI multicenter study. Allergy 2000;55:1005-10. View abstract.
Park JH, Yim BK, Lee JH, Lee S, Kim TH. Risk associated with bee venom therapy: a systematic review and meta-analysis. PLoS One. 2015;10(5):e0126971. View abstract.
Park YC, Koh PS, Seo BK, et al. Long-term effectiveness of bee venom acupuncture and physiotherapy in the treatment of adhesive capsulitis: a one-year follow-up analysis of a previous randomized controlled trial. J Altern Complement Med 2014;20(12):919-24. View abstract.
Petroianu G, Liu J, Helfrich U, et al. Phosholipase A2-induced coagulation abnormalities after bee sting. Am J Emerg Med 2000;18:22-7. View abstract.
Rosman Y, Nashef F, Cohen-Engler A, Meir-Shafrir K, Lachover-Roth I, Confino-Cohen R. Exclusive bee venom allergy: risk factors and outcome of immunotherapy. Int Arch Allergy Immunol 2019;180(2):128-34. View abstract.
Senel E, Holt S, Demir E. Treatment of notalgia paresthetica with bee venom and capsaicin: a pilot study with 20 patients. Skinmed 2019;17(6):370-2. View abstract.
Shen L, Lee JH, Joo JC, Park SJ, Song YS. Bee venom acupuncture for shoulder pain: a systematic review and meta-analysis of randomized controlled trials. J Pharmacopuncture 2020;23(2):44-53. View abstract.
Somerfield SD. Bee venom and arthritis: magic, myth, or medicine? N Z Med J 1986;99:281-3.. View abstract.
Subbalakshmi C, Nagaraj R, Sitaram N. Biological activities of C-terminal 15-residue synthetic fragment of melittin: design of an analog with improved antibacterial activity. FEBS Lett 1999;448:62-6. View abstract.
Vick JA, Mehlman B, Brooks R, et al. Effect of bee venom and melittin on plasma cortisol in the unanesthetized monkey. Toxicon 1972;10:581-6.
Vick JA, Shipman WH. Effects of whole bee venom and its fractions (apamin and melittin) of plasma cortisol levels in the dog. Toxicon 1972;10:377-80.
Wesselius T, Heersema DJ, Mostert JP, et al. A randomized crossover study of bee sting therapy for multiple sclerosis. Neurology 2005;65:1764-8. View abstract.
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