In 2004, the FDA banned ephedra due to serious effects on the heart. Since then, many weight loss and bodybuilding products have used bitter orange and caffeine in its place. Bitter orange contains many chemicals that affect the nervous system. These chemicals might cause heart problems in healthy adults.
Bitter orange is used for obesity, athletic performance, and many other purposes, but there is no good scientific evidence to support its use.
Bitter orange (synephrine) is considered a banned substance by the National Collegiate Athletic Association (NCAA). Don't confuse bitter orange with other orange species such as sweet orange and bergamot.
How does it work ?
Uses & Effectiveness ?
We currently have no information for BITTER ORANGE overview.
When applied to the skin: Bitter orange essential oil is possibly safe. The oil can cause sensitivity to the sun. Wear sunblock outside, especially if you are light-skinned.
When inhaled: Bitter orange essential oil is possibly safe when inhaled as aromatherapy.
Special Precautions and Warnings
Breast-feeding: There isn't enough reliable information to know if bitter orange is safe to use when breast-feeding. Stay on the safe side and avoid use.
Headache: Taking bitter orange might trigger headaches, including migraines and cluster headaches.
High blood pressure: Taking bitter orange, especially together with caffeine, might increase blood pressure in healthy people. Avoid using bitter orange, especially in combination with stimulants such as caffeine, if you have high blood pressure.
Glaucoma: Bitter orange might worsen glaucoma. Avoid using it if you have this condition.
Heart disease: Taking bitter orange, especially together with caffeine or other stimulants, might increase the risk of serious side effects in people with a particular heart problem called "long QT interval syndrome".
Irregular heartbeat (heart arrhythmia): Taking bitter orange, especially together with caffeine, can increase heart rate in healthy people. Avoid using bitter orange, especially with stimulants such as caffeine, if you have an irregular heartbeat.
Surgery: Bitter orange acts like a stimulant, so it might interfere with surgery by increasing heart rate and blood pressure. Stop taking bitter orange at least 2 weeks before a scheduled surgery.
Medications for depression (MAOIs) interacts with BITTER ORANGE
Bitter orange contains chemicals that stimulate the body. Some medications used for depression can increase these chemicals. Taking bitter orange with these medications used for depression might cause serious side effects including fast heartbeat, high blood pressure, seizures, nervousness, and others.
Some of these medications used for depression include phenelzine (Nardil), tranylcypromine (Parnate), and others.
Midazolam (Versed) interacts with BITTER ORANGE
The body breaks down midazolam (Versed) to get rid of it. Bitter orange can decrease how quickly the body breaks down midazolam (Versed). Taking bitter orange along with midazolam (Versed) might increase the effects and side effects of midazolam (Versed).
Do not take this combination
Caffeine (Excedrin, Anacin, Vivarin, and others) interacts with BITTER ORANGE
Bitter orange is a stimulant. Caffeine is also a stimulant. In combination, they can increase blood pressure and cause the heart to beat rapidly. This can cause serious adverse effects such as heat attack and stroke.
Dextromethorphan (Robitussin DM, and others) interacts with BITTER ORANGE
The body breaks down dextromethorphan (Robitussin DM, others) to get rid of it. Bitter orange might decrease how quickly the body breaks down dextromethorphan (Robitussin DM, others). Taking bitter orange along with dextromethorphan (Robitussin DM, others) might increase the effects and side effects of dextromethorphan (Robitussin DM, others).
Felodipine (Plendil) interacts with BITTER ORANGE
Felodipine (Plendil) is used to lower blood pressure. The body breaks down felodipine (Plendil) to get rid of it. Bitter orange might decrease how quickly the body gets rid of felodipine (Plendil). Taking bitter orange along with felodipine (Plendil) might increase the effects and side effects of felodipine (Plendil).
Indinavir (Crixivan) interacts with BITTER ORANGE
Indinavir (Crixivan) is used to treat HIV/AIDS. The body breaks down indinavir (Crixivan) to get rid of it. Bitter orange might decrease how quickly the body breaks down indinavir (Crixivan). Taking bitter orange along with indinavir (Crixivan) might increase the effects and side effects of indinavir (Crixivan).
Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates) interacts with BITTER ORANGE
Some medications are changed and broken down by the liver.
Bitter orange might decrease how quickly the liver breaks down some medications. Taking bitter orange along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking bitter orange, talk to your healthcare provider if you are taking any medications that are changed by the liver.
Some medications changed by the liver include lovastatin (Mevacor), ketoconazole (Nizoral), itraconazole (Sporanox), fexofenadine (Allegra), triazolam (Halcion), and many others.
Medications that can cause an irregular heartbeat (QT interval-prolonging drugs) interacts with BITTER ORANGE
Bitter orange might increase the speed of your heartbeat. Taking bitter orange along with medications that can cause an irregular heartbeat might cause serious side effects including heart arrhythmias.
Some medications that can cause an irregular heartbeat include amiodarone (Cordarone), disopyramide (Norpace), dofetilide (Tikosyn), ibutilide (Corvert), procainamide (Pronestyl), quinidine, sotalol (Betapace), thioridazine (Mellaril), and many others.
Stimulant drugs interacts with BITTER ORANGE
Stimulant drugs speed up the nervous system. By speeding up the nervous system, stimulant medications can make you feel jittery and speed up your heartbeat. Bitter orange might also speed up the nervous system. Taking bitter orange along with stimulant drugs might cause serious problems including increased heart rate and high blood pressure. Avoid taking stimulant drugs along with bitter orange.
Some stimulant drugs include diethylpropion (Tenuate), epinephrine, phentermine (Ionamin), pseudoephedrine (Sudafed), and many others.
Be cautious with this combination
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