Pregnenolone is used for autism, back pain, bipolar disorder, schizophrenia, and many other conditions, but there is no good scientific evidence to support its use.
How does it work ?
Uses & Effectiveness
Insufficient Evidence for
- Autism. Early research shows that taking pregnenolone for 10-12 weeks may improve some symptoms of autism.
- Back pain. Early research shows that taking pregnenolone for 4 weeks may improve low back pain by a very small amount in some people.
- Bipolar disorder. Early research shows that taking pregnenolone for 12 weeks may improve symptoms of depression in people with bipolar disorder.
- Schizophrenia. Taking pregnenolone as add-on therapy for 8 weeks might improve some negative symptoms of schizophrenia, such as the inability to feel pleasure, lack of emotion, and limited speech. But not all research agrees. Taking pregnenolone as add-on therapy doesn't seem to improve positive symptoms of schizophrenia such as hallucinations or delusions.
- Endometriosis (abnormal thickening of the lining of uterus).
- Multiple sclerosis (MS).
- Premenstrual syndrome (PMS).
- Scaly, itchy skin (psoriasis).
- Slowing or reversing aging.
- Other conditions.
There isn't enough reliable information to know if pregnenolone is safe when used for longer than 12 weeks.
Special Precautions and Warnings
There isn't enough reliable information to know if pregnenolone is safe when used for longer than 12 weeks. Pregnancy and breast-feeding: There isn't enough reliable information to know if pregnenolone is safe to use when pregnant or breast-feeding. Stay on the safe side and avoid use.
Hormone-sensitive conditions such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Pregnenolone is converted by the body to estrogen. If you have any condition that might be made worse by exposure to estrogen, don't take supplemental pregnenolone.
Estrogens interacts with PREGNENOLONE
Pregnenolone is used in the body to make hormones including estrogen. Taking estrogen along with pregnenolone might cause too much estrogen to be in the body.
Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.
Progestin interacts with PREGNENOLONE
Pregnenolone is used in the body to make hormones. Progestins are hormones. Taking pregnalone along with hormones such as progestins might cause too much hormones in the body. This could increase the effects and side effects of progestins.
Some progestin pills include norethindrone (Micronor, Camila), levonorgestrel (Plan B), and others.
Testosterone interacts with PREGNENOLONE
The body changes pregnenolone into testosterone. Taking pregnenolone along with testosterone might cause too much testosterone in the body. This might increase the chance of testosterone side effects.
Sedative medications (Benzodiazepines) interacts with PREGNENOLONE
Pregnenolone may decrease the sedative effects of diazepam (Valium). It may also decrease the sedative effects of other benzodiazepines such as lorazepam (Ativan), alprazolam (Xanax), clonazepam (Klonopin), and others.
Progesterone interacts with PREGNENOLONE
Pregnenolone is used in the body to make hormones including progesterone. Taking progesterone along with pregnenolone might cause too much progesterone to be in the body.
Some progesterone drugs include Prometrium, Endometrin, and others.
Be cautious with this combination
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© Therapeutic Research Faculty 2020.