BLUE COHOSH - Uses, Side Effects, and More

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Ganzera, M., Dharmaratne, H. R., Nanayakkara, N. P., and Khan, I. A. Determination of saponins and alkaloids in Caulophyllum thalictroides (blue cohosh) by high-performance liquid chromatography and evaporative light scattering detection. Phytochem.Anal. 2003;14(1):1-7. View abstract.

Gunn, T. R. and Wright, I. M. The use of black and blue cohosh in labour. N.Z Med J 10-25-1996;109(1032):410-411. View abstract.

Jhoo, J. W., Sang, S., He, K., Cheng, X., Zhu, N., Stark, R. E., Zheng, Q. Y., Rosen, R. T., and Ho, C. T. Characterization of the triterpene saponins of the roots and rhizomes of blue cohosh (Caulophyllum thalictroides). J.Agric.Food Chem. 2001;49(12):5969-5974. View abstract.

Kennelly, E. J., Flynn, T. J., Mazzola, E. P., Roach, J. A., McCloud, T. G., Danford, D. E., and Betz, J. M. Detecting potential teratogenic alkaloids from blue cohosh rhizomes using an in vitro rat embryo culture. J.Nat.Prod. 1999;62(10):1385-1389. View abstract.

Low, D. T. Blue cohosh and neonatal myocardial toxicity. Journal of the American Herbalists Guild 2001;2(2):9-10.

Rao, R. B. and Hoffman, R. S. Nicotinic toxicity from tincture of blue cohosh (Caulophyllum thalictroides) used as an abortifacient. Vet.Hum.Toxicol. 2002;44(4):221-222. View abstract.

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Baillie N, Rasmussen P. Black and blue cohosh in labour. N Z Med J 1997;110:20-1.

Datta S, Mahdi F, Ali Z, et al. Toxins in botanical dietary supplements: blue cohosh components disrupt cellular respiration and mitochondrial membrane potential. J Nat Prod. 2014;77(1):111-7. View abstract.

Dugoua JJ, Perri D, Seely D, et al. Safety and efficacy of blue cohosh (Caulophyllum thalictroides) during pregnancy and lactation. Can J Clin Pharmacol. 2008;15(1):e66-73. View abstract.

Eagon PK, Elm MS, Hunter DS, et al. Medicinal herbs: modulation of estrogen action. Era of Hope Mtg, Dept Defense; Breast Cancer Res Prog, Atlanta, GA 2000;Jun 8-11.

Edmunds J. Blue cohosh and newborn myocardial infarction? Midwifery Today Int Midwife 1999;52:34-5. View abstract.

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Finkel RS, Zarlengo KM. Blue cohosh and perinatal stroke. N Engl J Med 2004;351:302-3. View abstract.

Gunn TR, Wright IM. The use of black and blue cohosh in labour. N Z Med J 1996;109:410-1.

Irikura B, Kennelly E. American Health Consultants. Blue Cohosh: a word of caution. 1999. Available at: https://www.ahcmedia.com/articles/50424-blue-cohosh-a-word-of-caution.

Jones TK, Lawson BM. Profound neonatal congestive heart failure caused by maternal consumption of blue cohosh herbal medication. J Pediatr 1998;132:550-2. View abstract.

Lee Y, Jung JC, Ali Z, et al. Anti-Inflammatory Effect of Triterpene Saponins Isolated from Blue Cohosh (Caulophyllum thalictroides). Evid Based Complement Alternat Med. 2012;2012:798192. View abstract.

Madgula VL, Ali Z, Smillie T, et al. Alkaloids and saponins as cytochrome P450 inhibitors from blue cohosh (Caulophyllum thalictroides) in an in vitro assay. Planta Med. 2009;75(4):329-32. View abstract.

McFarlin BL, Gibson MH, O'Rear J, Harman P. A national survey of herbal preparation use by nurse-midwives for labor stimulation. Review of the literature and recommendations for practice. J Nurse Midwifery 1999;44:205-16. View abstract.

Rader JI, Pawar RS. Primary constituents of blue cohosh: quantification in dietary supplements and potential for toxicity. Anal Bioanal Chem. 2013;405(13):4409-17. View abstract.

Reichert, R. Neonatal congestive heart failure associated with maternal use of blue cohosh. Quarterly Review of Natural Medicine 1998;Winter:265-267.

Sirtori CR, Triolo M, Bosisio R, et al. Hypocholesterolaemic effects of lupin protein and pea protein/fibre combinations in moderately hypercholesterolaemic individuals. Br J Nutr 2012;107:1176-83. View abstract.

Wright IM. Neonatal effects of maternal consumption of blue cohosh. J Pediatr 1999;134:384-5. View abstract.