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Depression Health Center

Coping With Side Effects of Antidepressants

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Like any medication, antidepressants can cause side effects. The specific problems vary from drug to drug -- and from person to person.

In fact, side effects are one of the main reasons that people with depression stop taking their medicine during their recovery. One study found that 65% of the 1,000 people surveyed said they had stopped taking their medicine, and half of those people cited side effects as the reason.

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Antidepressant. A drug used to treat depression. Selective serotonin reuptake inhibitors (SSRIs) are a class of antidepressants that includes drugs like Celexa (citalopram), Lexapro (escitalopram), Paxil (paroxetine), Prozac (fluoxetine), and Zoloft (sertraline.) Anxiety disorder. A chronic condition that causes anxiety so severe it interferes with your life. Some people with depression also have overlapping anxiety disorders. Bipolar disorder. A type of depression that causes sometimes...

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Yet it's important to keep in mind that antidepressants can help you recover. The American Psychiatric Association recommends that people keep taking their medicine at least for four to five months after they recover from a first depressive episode in order to reduce the risk of relapse. And for people who have had multiple previous episodes, the recommendation is often longer (or sometimes even to continue indefinitely).

Newer antidepressants such as SSRIs (Zoloft, Lexapro, Viibryd), SNRIs (Cymbalta, Pristiq, Fetzima), and novel medications such as Wellbutrin, Remeron, and Brintellix generally have fewer and less severe side effects than older drugs (for instance, tricyclic antidepressants such as Elavil or Tofranil). The side effects vary depending on the drug but can include:

  • Insomnia
  • Sleepiness
  • Increased anxiety
  • Nausea or vomiting
  • Diarrhea
  • Sexual problems, such as delayed ejaculations in men and lack of orgasm in women
  • Headaches
  • Dizziness
  • Weight gain or loss

Other more serious side effects are rare but possible. Antidepressants have been linked to an increase in suicidal thinking and behavior in children and adolescents. Talk to your doctor about what symptoms to watch for during your depression recovery.

Some of the older tricyclic antidepressants such as Elavil, Pamelor, and Tofranil can have severe side effects or cause dangerous interactions with other drugs or foods. They can cause blurred vision and fatigue. They may not be safe for people with heart problems. High doses can be toxic and potentially life-threatening. For these reasons, tricyclic antidepressants are less often used for the treatment of depression. 

Monoamine oxidase inhibitors (MAOIs) such as Nardil, Parnate, Marplan and Emsam are among the most effective of all known antidepressants. But they can cause serious interactions with some foods -- like aged meats and cheeses, fermented products like soy sauce, and broad flat beans -- as well as other medicines. For instance, they can be hazardous when combined with medicines such as Sudafed (pseudoephedrine) that can raise blood pressure, and the interactions can lead to such effects as high blood pressure that is potentially fatal. They can also be dangerous with most other antidepressants, which can then raise levels of the neurotransmitter serotonin excessively.

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