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Fish Oil to Treat Depression?

Omega-3's may have an affect on serotonin levels.

WebMD Feature

Dave thinks a lot about fish these days. Study after study has suggested benefits for omega-3 fatty acids, which are plentiful in certain fish oils. But what intrigues Dave isn't that omega-3's might reduce his risk of heart attack, or ease the pain of arthritis. He's hoping to lubricate his mind.

A handful of small studies have suggested that omega-3 fatty acids can help smooth out the mood swings of bipolar disorder. There are few effective treatments against the disease, so the news is a hot topic now at support groups for manic-depressives, like the Berkeley, CA, group in which Dave participates.

The first news to attract attention was a 1998 report in the Journal of Affective Disorders. Researchers noted significantly lower levels of omega-3's in the red blood cell membranes of patients with depression.

Then in the May 1999 Archives of General Psychiatry, Andrew Stoll, M.D., and colleagues reported a study of fish oil in 30 manic-depressive patients. Sixty-four percent of those who took 10 grams of fish oil per day for four months reported a marked improvement in their symptoms. By contrast, only 19 percent of those receiving the placebo benefited.

Cell Softeners?

These studies aren't the only research that points to the benefits of fish oil for mood problems. "There are a lot of reasons to believe it works," says Stoll. "In countries where the average fish consumption is high we see lower rates of depression."

On the biochemical front, researchers point out that cell membranes are made up partly of omega-3's. It is possible that increasing the omega-3 levels makes it easier for serotonin -- a chemical that carries messages from one brain cell to another -- to pass through cell membranes. "Research still needs to be done on the exact mechanisms involved," Stoll notes, "but we do know that omega-3 does affect the membranes and changes functioning." And increasing omega-3 "has direct effects on serotonin levels."

Diet and Depression

Joseph Hibbeln, M.D., a psychiatrist at the National Institute of Health, thinks omega-3's might explain why the rate of depression is rising in the United States.

In a health-conscious push to rid our diets of saturated fats and cholesterol, Americans have been eating less red meat and eggs -- two good sources of omega-3's. Furthermore, we have been switching to the polyunsaturated fats, such as corn, soybean, and sunflower oils, which are relatively low in omega-3's.

Supplement or Go Fish

But just how to mend that situation remains controversial. Omega-3's might worsen some chronic illnesses. (Check with a doctor if you have such a condition before starting to take supplements.) The Food and Drug Administration is now considering what quantity of omega-3's to recommend; currently it has no recommendation but classifies three grams per day as "safe."

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