Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Dexamethasone causes the metabolism of praziquantel to be increased.
What might happen:
Praziquantel may not be as effective.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together or if you have taken dexamethasone in the previous four weeks. Your doctor may want to change your medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Biltricide (praziquantel) US prescribing information. Bayer HealthCare Pharmaceuticals Inc. February, 2014.
2.Biltricide (praziquantel) Australian prescribing information. Bayer November 30, 2003.
3.Vazquez ML, Jung H, Sotelo J. Plasma levels of praziquantel decrease when dexamethasone is given simultaneously. Neurology 1987 Sep;37(9):1561-2.