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Osteoporosis Health Center

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Spinal Fracture: Cement No Better Than Sham

Studies Raise Questions About Popular Treatment for Osteoporosis-Related Spinal Compression Fractures
WebMD Health News
Reviewed by Louise Chang, MD

Aug. 5, 2009 -- A popular treatment for painful spinal compression fractures works no better than sham therapy in patients with osteoporosis, according to two new studies published today in the New England Journal of Medicine.

Researchers compared outcomes among patients who received injections of medical-grade cement to stabilize collapsed vertebra with those of patients who received a sham treatment.

Both treatments seemed to work, but patients injected with the cement showed no more improvement in pain and function than patients who received the sham treatment.

Cement injection, known medically as vertebroplasty, has become a leading treatment for osteoporosis-related spinal fractures. By one estimate, the number of vertebroplasties performed in the United States doubled between 2001 and 2007.

Same Outcome, Different Interpretations

The new studies are the most rigorously designed trials ever to examine the effectiveness of the cement treatment for the treatment of spinal compression fractures.

The two lead researchers differed in their interpretation of the implications for clinical practice.

“Our trial found no benefit for this treatment, so it should not be used in clinical practice,” says Rachelle Buchbinder, PhD, who led a team of researchers from Melbourne, Australia’s Monash University.

Interventional neuroradiologist David F. Kallmes, MD, of the Mayo Clinic, who led the second study, says more research is needed to determine if certain patients respond better to the cement injections than to other treatments.

“I think it’s fair to say that vertebroplasty does not work in the way that we thought it does, but it does work,” he tells WebMD. “It’s just that the (sham) treatment worked just as well and we can’t say why.”

The Australian study involved 78 patients with severe pain from osteoporosis-related vertebral fractures treated with either cement injections or a sham. Neither the patients nor the researchers knew which treatment was being given.

Both sets of patients received the same hospital care and local anesthetic before treatment. But those who did not get the cement treatment received cues such as pressure placed on the back and exposure to the smell of the bone cement.

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